Uji Aktivitas Antioksidan Minyak Argan (Argania spinosa L.) Dalam Bentuk Sediaan Mikroemulsi

Argan oil (Argania spinosa L.) is an oil that has benefits as a natural antioxidant which is good for health. Microemulsion is a thermodynamically stable delivery system;  transparent;  has a small globule size and consists of a mixture of oil, water, surfactant and co-surfactant which has great potential in delivering dermal active substances by increasing transdermal permeability in topical drug delivery. This research aimed to formulate argan (Argania spinosa L.) oil into microemulsion dosage form and determine the antioxidant activity using DPPH method. The study began with the optimization of base into several concentration variations of surfactant and co-surfactant. The formula made into 7 namely F1, F2, F3, F4, F5, F6 and F7, evaluated using organoleptic test and centrifugation test. The results showed the base of F6 which had the clear, transparent physical appearance and no separation occured. The F6 base was then made into microemulsion dosage with 3 concentration variations of argan (Argania spinosa L.) oil, namely F1 (0.5%), F2 (1%) and F3 (1.5%). The 3 formulas were tested for the physical stability which included pH test, viscosity test, centrifugation test and freeze-thaw test.  The testing of antioxidant activity carried out by in vitro using the DPPH method which then calculated for the IC50 value on t0 and t28. From the results of the physical stability test at room temperature and freeze-thaw, the 3 formulas met the organoleptic, pH and centrifugation tests. The antioxidant activity values of IC50 were F1 (t0 = 291.14 g/mL; t28 = 230.43 g/mL), F2 (t0 = 89.02 g/mL; t28 = 129.01 g/mL), F3 (t0 = 81.07 g/mL; t28 = 116.30 g/mL). The statistical test result of T test showed the p value = 0,896, (more than 0.05), which indicated that there was no significance difference in the antioxidant activity result between the 3 formulas on t0and t28

Attitude Determination System For Nano Satellite Using Extended Kalman Filter On ARM7TDMI Platform

Extended Kalman Filter (EKF) has been successfully utilized in satellites missions. However, in comparison to other attitude determination methods developed, it is one of the most computationally burdening algorithm and with the new development of using nano satellites which have limited electrical power, mass, space and usually budget, it is essential to design an Attitude Determination System (ADS) which conforms to this limitation. Therefore, in this thesis, as a computational improvement on the InnoSAT project, the RCM3400 microcontroller of the ADS is replaced with the ARM7TDMI based microprocessor to test its capability. Penapisan Kalman Lanjutan (PKL) telah digunakan dengan jayanya di dalam misi satelit. Akan tetapi, jika dibandingkan dengan kaedah penentuan kedudukan lain yang telah dihasilkan, ia adalah salah satu daripada algoritma yang memiliki komputasi yang paling berat dan dengan perkembangan terkini yang menggunakan satelit nano yang mempunyai kuasa elektrik, berat, ruang dan biasanya peruntukan yang terhad, adalah menjadi satu keutamaan untuk merekabentuk sebuah Sistem Penentuan Kedudukan (SPK) yang dapat mematuhi kekangan ini

Deterministic and Recursive Approach in Attitude Determination for InnoSAT

Attitude determination system (ADS) was indispensable in attitude control of satellite. Especially for InnoSAT due to the limitation of budget, weight, and power, the attitude was determined using onboard position sensors. Previous research has successfully implemented the attitude determination using only Earth's magnetic field sensors for small attitude angle, but the approach produced quite big error for large attitude angle. This paper presents attitude determination for InnoSAT using combination of sun sensors and earth's magnetic field for large attitude angle. The attitude was determined using a deterministic (QUEST) and recursive (EKF) approach. A problem arises when using the sun sensors while the satellite experiencing eclipse. Consequently, the accuracy of both approaches was analyzed at eclipse and no eclipse conditions. The result shows that deterministic approach produced better accuracy at no eclipse but recursive approach produced better accuracy at eclipse. The strategy to apply the both approaches and eclipse conditions also discussed in this paper

Deflection of beam / Fadzli Mohammad Ngimriti, Hurul Ain Abdul Nasher and Haryana Adam

The FL160 is designed to examine the bending of cantilevers. It enables experiments to be performed in relation to pure bending, cross bending, oblique bending and shear center. The relatively complex theory of beam bending can thus be appropriately supplemented by way of experimental results. The horizontal arrangement of the specimen beam produces a clear-out, readily understandable test set-up. The deflection of the beam can be observed from the end face, thus clearly illustrating the relationship between load plane, principle axes and deflection/torsion. The system is suitable both for lecture-theatre demonstration and for practical experimentation in small group

Deterministic and Recursive Approach in Attitude Determination for InnoSAT.

Attitude determination system (ADS) was indispensable in attitude control of satellite. Especially for InnoSAT due to the limitation of budget, weight, and power, the attitude was determined using onboard position sensors. Previous research has successfully implemented the attitude determination using only Earth´s magnetic field sensors for small attitude angle, but the approach produced quite big error for large attitude angle. This paper presents attitude determination for InnoSAT using combination of sun sensors and earth´s magnetic field for large attitude angle. The attitude was determined using a deterministic (QUEST) and recursive (EKF) approach. A problem arises when using the sun sensors while the satellite experiencing eclipse. Consequently, the accuracy of both approaches was analyzed at eclipse and no eclipse conditions. The result shows that deterministic approach produced better accuracy at no eclipse but recursive approach produced better accuracy at eclipse. The strategy to apply the both approaches and eclipse conditions also discussed in this paper

Fundamentals of Entrepreneurship (ENT300) Brain Freeze / Adam Fikri Norman... [et al.]

Introducing the name of our business is Brainfreeze, we are in the market to engage in the business of Popsicle cool ice cream in Kota Samarahan. Brainfreeze is a limited liability partnership business established by 5 members. The reason why we choose Brainfreeze is because the name is simple, catchy, easy to remember and pronounce

Characterization of bioactive compounds in patchouli oil using microwave-assisted and traditional hydrodistillation methods

This study addressed the need for improved methods for the extraction of bioactive compounds from patchouli oil, focusing on the characterization and comparison of microwave-assisted hydrodistillation (MAHD) and traditional hydrodistillation techniques. Traditional hydrodistillation methods for the extraction of essential oils are less efficient in terms of time and yield. This research aims to bridge the knowledge gap regarding extraction efficiency, duration, and chemical composition. This study aimed to directly compare microwave-assisted hydrodistillation and traditional hydrodistillation for the extraction of bioactive compounds from patchouli oil and to evaluate the efficacy, efficiency, and chemical composition of these methods. The study reviews Advanced analytical tools such as Gas Chromatography and Mass Spectrometry (GC-MS), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-Q-TOF-MS), and Gas Chromatography-Mass Spectrometry (GCMS) have been used to analyze the chemical makeup of patchouli oil. The results indicate that microwave-assisted hydrodistillation may offer benefits over traditional hydrodistillation, including reduced extraction times and increased yields. Differences were noted in the chemical composition of patchouli oil obtained through MAHD, particularly in the prevalence of bioactive compounds, such as patchoulol, α- bulnesene, and caryophyllene. This study explored the potential biological activities, stability, safety, and cost-effectiveness of MAHD compared to traditional methods. It also examines the implications of these findings for industries reliant on the quality of essential oils, such as pharmaceuticals, cosmetics, and perfumes. This study provides significant insights into the extraction of essential oils, supporting industrial innovation, and contributing to Sustainable Development Goals (SDGs) related to health, wellbeing, responsible production, and life on land. The differences in the chemical composition between MAHD and traditional methods could have substantial implications for the essential oils industry

Assessment of Academic Resilience and its associated factors among Pharmacy Students in Twelve Countries

Objective Academic resilience, a critical determinant of academic achievement, is affected by various factors. There is a paucity of large-scale international assessments of academic resilience among pharmacy students. Therefore, this study aimed to assess academic resilience among pharmacy students in 12 countries and to evaluate factors associated with their academic resilience levels. Methods A cross-sectional online survey-based study was conducted among randomly selected pharmacy students in 12 countries: Egypt, Türkiye, Indonesia, Pakistan, Bangladesh, Iraq, Jordan, Nigeria, Malaysia, Saudi Arabia, Sudan, and the United Arab Emirates. After pilot testing, the validated 30-item academic resilience scale (ARS) was used for the assessment. The data were collected between November 1, 2022 and April 15, 2023. Descriptive and inferential statistics were performed, as appropriate. Results A total of 3950 were received from the 12 participating countries. The mean age was 21.68 ± 2.62 years. About two-thirds of the responses were from female participants and those studying for Bachelor of Pharmacy degrees. Overall, the findings show moderate academic resilience, which varied across countries. The median (IQR) of the total ARS-30 was 114 (103−124). Females exhibited lower negative affective and emotional response subscale levels than males. There were significant cross-country variations in the ARS-30 and all subscales. The highest overall levels were reported for Sudan, Pakistan, and Nigeria and the lowest were reported for Indonesia and Türkiye. Students in private universities tended to have higher overall ARS levels than public university students. Higher academic performance was significantly associated with ARS levels, whereas those with excellent performance exhibited the highest ARS levels. Students with exercise routines had higher ARS levels than those without exercise routines. Finally, students who were engaged in extracurricular activities had higher ARS levels than those who did not participate in these activities. Conclusion The study offers insights into the factors affecting academic resilience in pharmacy students across several countries. The findings could guide interventions and support activities to improve resilience and academic outcomes

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Thermal Degradation And Mechanical Characteristics Of Sugarcane Bagasse Reinforced Biodegradable Potato Starch Composites

Global pollution due to the overwhelming usage of non-biodegradable plastics is getting severe nowadays. Hence, the aim of this paper is to develop an environmentally friendly composite material from potato starch and sugarcane bagasse. The composites were prepared by hot pressing at 145℃ for 60 min. The composites were characterized for their mechanical and thermal properties. In terms of thermal properties, thermogravimetric analysis shows that incorporation of sugarcane fiber has improved the thermal stability of the composites. Meanwhile, incorporation of sugarcane fibre from 0 to 15 wt.% has significantly improved the tensile (202.7%) and flexural (198%) strength of the composites. Scanning electron micrograph of the tensile fracture showed the fibre fracture and fibre “pull-out” from the composite. Overall, the biodegradable composites have shown improved functional characteristic than the origin material. This finding shows that this Sugarcane/Potato starch composites are potential alternative material for biodegradable product i.e. biodegradable plastic packaging