Undesirable events in the use of high-alert medicine geriatric patients at RSUPN Dr. Cipto Mangunkusumo

High-Alert Medications (HAM) are drugs that have a high risk of causing significant harm to patients if misused. It is estimated that one in ten geriatric patients experiences undesirable events during hospitalization related to medication use. Detect undesirable events due to the use of high-alert insulin and high-alert heparin drugs in geriatric patients at Rumah Sakit Umum Pusat Nasional (RSUPN) Dr Cipto Mangunkusumo using the trigger tool method based on positive predictive value (PPV) and determine the effect of using high-alert insulin and high alert heparin drugs on undesirable events. A retrospective cohort study will review secondary data from patient medical records (MR). The sample used was from 300 geriatric patients, 82 patients used insulin and 79 patients used heparin which met the inclusion criteria. Data were analyzed in the form of frequencies and percentages (%), calculation of PPV values, and the effect of using high-alert insulin and high-alert heparin on undesirable events using the Chi-Square test. There were 8 trigger-positive patients with undesirable events in the form of hypoglycemia from 82 insulin patients and 4 trigger-positive patients with undesirable events in the form of extended activated partial thromboplastin time (aPTT) values from 79 heparin patients. Based on the PPV value, both insulin (9.75%) and heparin (5.33%), the trigger tool has not been able to detect undesirable events when using high-alert insulin and high-alert heparin. Based on statistical tests, the p-value= 0.033 (p<0.05) for insulin and heparin p-value= 0.043 (p<0.05) meaning that there is an influence of the use of high-alert insulin and high-alert heparin on undesirable events when using both drugs. The trigger tool method cannot detect undesirable events when using high-alert insulin and high-alert heparin drugs based on laboratory triggers

Antioxidant activity of silver nanoparticles synthesized using Tulak wood leaf extract (schefflera elliptica harms)

Nanoparticles have been used in therapies applied to target specific parts. By delivering electrons to free radicals, silver nanoparticles (AgNPs) can reduce their activity and stop a chain reaction that would otherwise result in the creation of more free radicals. But the most common way to create silver nanoparticles is to use a variety of organic and inorganic reducing agents to chemically reduce silver precursors, usually silver salts. Various stabilizing or capping agents are frequently used to this process. Green synthesis and other ecologically friendly synthesis techniques are becoming more popular for producing metal nanoparticles that adhere to biodiversity principles. Accordingly, this study has determined that the tulak tree is a plant that effectively reduces green space. This study uses different concentrations of AgNO3 solution at 1 mM and 2 mM. A Particle Size Analyzer's (PSA), The distribution of sizes of the artificially produced AgNPs was examined. The particles measuring between 1 and 100 nm made from the Tulak wood leaf extract with the corresponding AgNO3 concentrations had average diameters of 88.2 nm and 16.9 nm. AgNPs were also shown to exist in a range of shapes, encompassing sphere, hexagonal, and triangular ones, according to Transmission Electron Microscopy (TEM) examination. Antioxidant qualities are displayed by AgNPs made with Tulak wood leaf extract. These antioxidant properties were assessed utilizing DPPH, which has 517 nm is the greatest absorption. Furthermore, the antioxidant activity's outcomes tests show that the AgNPs made using Tulak wood leaf extract biosynthesis have comparatively low antioxidant activity

A Design and Evaluation of a SNEDDS-Based System for Temu Ireng (Curcuma aeruginosa Roxb.) Extract: Enhancing Antioxidant Efficacy Using the SLD Technique

Temu Ireng (Curcuma aeruginosa Roxb.) is known for its strong antioxidant properties, primarily due to its bioactive compounds such as curcumin. However, these chemicals' lipophilia and instability in traditional formulations frequently limit their bioavailability. To address these challenges, a Self-Nanoemulsifying Drug Delivery System (SNEDDS) was developed using the Simple Lattice Design (SLD) method to improve the chemical and physical properties of Temu Ireng extract by forming a stable nanoemulsion that is uniformly distributed in the digestive system. This study aimed to formulate and evaluate a SNEDDS of Temu Ireng extract using the SLD approach, with a focus on enhancing its antioxidant activity. The formulation involved selecting suitable oils, surfactants, and cosurfactants, followed by optimization based on solubility studies, phase diagrams, and thermodynamic stability tests. The SNEDDS was characterized for physical properties such as emulsification time, transmittance, particle size, zeta potential, and polydispersity index. The optimized SNEDDS formulation exhibited excellent characteristics, including an emulsification time of less than 1 minute, near 100% transmittance, a particle size of 9.77 ± 1.33 nm, zeta potential of 0.9 ± 0.1 mV, and a polydispersity index of 0.302 ± 0.033. Antioxidant testing using the DPPH method showed that the 0.1% SNEDDS formulation of Temu Ireng extract had an inhibition concentration (IC50) value of 58.482 mg/L, indicating strong antioxidant activity. The results suggest that the SNEDDS formulation using the SLD method could be an effective strategy to enhance the bioavailability and therapeutic efficacy of Temu Ireng extract as an antioxidant agent

Development and implementation of kintung-based learning media in elementary music education

The limited availability of contextual and culture-based music learning media in elementary schools restricts students’ understanding of musical concepts and diminishes engagement with local cultural values. This study aims to develop and implement Kintung-based music learning media by utilizing the traditional bamboo musical instrument of the Banjar community to enhance students’ musical skills and cultural appreciation. The research adopted a Research and Development (R&D) design using the ADDIE model, with qualitative techniques embedded in each stage. During the Analysis phase, data were collected through interviews, observations, and documentation of Kintung practices in community and school settings involving musicians, art teachers, and elementary school students. The Design and Development stages involved selecting appropriate bamboo materials, cutting and shaping resonant tubes, tuning instruments to the diatonic scale, and preparing instructional materials aligned with learning objectives. The Implementation stage consisted of learning activities structured into preparation, presentation, practice, and performance, through which students learned instrument-playing techniques, rhythmic patterns, and traditional Banjar songs such as Ampar-Ampar Pisang and Ampat Si Ampat Lima. Evaluation results indicate that the media effectively improved students’ technical performance, rhythmic accuracy, ecological awareness, and appreciation of local culture. This study concludes that Kintung-based music learning media provides a culturally grounded and pedagogically relevant innovation for integrating traditional music into elementary education, supporting students’ musical skill development, and contributing to the preservation of local cultural identity

TekenToken Development: IoT based Cartesian Robot System for Prepaid Electricity Token Recharging Automation

Manual input of the prepaid token on the electricity meter is prone to several drawbacks, such as the possibility of entering incorrect numbers or dealing with an electricity meter that is hard to reach, which makes the process inefficient and reduces precision. This may result in billing issues or an interrupted power supply. Automating the electricity recharging process will eliminate the need for manual input, making it much more efficient and significantly improving accuracy. TekenToken is an innovation in the field of robotics designed to automate the process of electricity recharging through prepaid tokens. This system utilizes a Cartesian robot, which enables precise movement along the X, Y, and Z axes to press the buttons on the electricity meter. TekenToken also incorporates an IoT system using an online database like Firebase, connecting the system to a mobile application that allows for long-distance remote control. By implementing a flexible system such as a Cartesian robot and IoT, TekenToken can also be modified for application in many other fields

Association between Hormonal Contraceptive Use and Hypertension Risk among Reproductive-Age Women: A Cross-sectional Study at Cileungsi Public Health Center, Indonesia

Hypertension remains a major public health problem that may be influenced by hormonal contraceptive use, particularly oral and injectable methods commonly used by women of reproductive age. These contraceptives have raised concerns about their potential impact on blood pressure regulation. This study aimed to investigate the association between hormonal contraceptive use and the occurrence of hypertension among women of reproductive age at the Cileungsi Public Health Centre, Bogor Regency, Indonesia. A cross-sectional study was conducted in 2024 using retrospectively collected medical record data of all hormonal contraceptive users at the facility. Total sampling was applied, and data on contraceptive type, duration of use, age, parity, and the most recent blood pressure readings were analyzed. The chi-square test was employed to examine associations between hormonal contraceptive characteristics and hypertension, with a significance level set at p < 0.05. The results revealed a significant association between contraceptive type and hypertension (p = 0.01, OR = 0.27), showing that users of oral contraceptive pills were more likely to develop hypertension than injectable users. Duration of use (p = 0.03, OR = 3.06), age (p = 0.04, OR = 0.12), and parity (p = 0.01, OR = 0.21) were also significantly associated with hypertension. Women aged ≥45 years, those with longer contraceptive use, and multiparous users exhibited a higher risk of elevated blood pressure. These findings highlight that both contraceptive-related and demographic factors contribute to hypertension risk among hormonal contraceptive users. Regular blood pressure monitoring and individualized counseling are essential, especially for oral and long-term users. This study contributes local evidence supporting safer contraceptive practices and cardiovascular risk management within primary healthcare settings

Adaptation and Psychometric Evaluation of the Indonesian Version of the Career Aspirations Scale-Revised (CAS-R) among Adolescents

The dynamic changes within the world of work require individuals to engage in robust career planning. In this context, career aspiration is understood as a psychological construct reflecting an individual’s hopes, motivations, and goals related to their future employment. This study aimed to adapt and evaluate the psychometric properties of the Career Aspirations Scale-Revised (CAS-R) into Indonesian to provide a valid and reliable measurement tool. The respondents comprised 549 Indonesian adolescents. The adaptation process followed the ITC (2018) guidelines, encompassing content validation, construct validation through Confirmatory Factor Analysis (CFA) and Rasch analysis, as well as reliability testing. The CFA results supported a three-factor structure (RMSEA = 0.034; CFI = 0.990; TLI = 0.990), with 18 items meeting the factor loading criteria. Cronbach’s alpha of 0.910 indicated high reliability. Rasch analysis further supported the instrument’s validity and internal consistency, with 19 items deemed to fit the model. These findings confirm that the Indonesian version of CAS-R is a suitable instrument for measuring adolescents’ career aspirations in Indonesia. It can be used by schools, counselors, and psychological institutions to support career assessment and planning

The effect of spiritual intelligence and self-control on nomophobia in Islamic Education Students at Muhammadiyah University

Nomophobia, the fear of being without a smartphone, is increasingly prevalent among university students and may be influenced by psychological factors such as spiritual intelligence and self-control. Several studies have demonstrated that these psychological factors play a significant role in nomophobic tendencies among college students. This quantitative study employs multiple regression analysis to examine the influence of spiritual intelligence and self-control on nomophobia in a sample of 99 Islamic Education students at Muhammadiyah University of Yogyakarta, selected through simple random sampling. Data were collected using validated instruments the NoMoPhobia Questionnaire (NMP-Q), the Spiritual Intelligence Self-Report Inventory, and a self-control self-report scale. Data analysis included descriptive statistics, classical assumption tests, and multiple linear regression using SPSS version 26. Descriptive analysis revealed that 67.68% of students exhibited high spiritual intelligence, 67.67% demonstrated moderate self-control, and 92.92% experienced high levels of nomophobia. Multiple regression analysis revealed that spiritual intelligence had a significant positive effect on nomophobia (β=0.277, p=0.004), whereas self-control had a significant negative effect (β=-1.015, p<0.001). The model explained 67% of the variance in nomophobia (R²=0.670, Adjusted R²=0.663), indicating a strong influence. However, the R² value of 0.276 mentioned elsewhere suggests moderate explanatory power, which may require clarification. Both spiritual intelligence and self-control significantly affected nomophobia among university students. These findings underscore the importance of developing spiritual intelligence and self-control to reduce nomophobia levels in this population

Characterization and dissolution test of recrystallized mefenamic acid by fast cooling methods

Mefenamic acid, classified as a Biopharmaceutics Classification System (BCS) Class II drug, exhibits high permeability but low dissolution rates, limiting its bioavailability. This study aims to enhance the dissolution rate of mefenamic acid through crystal structure modification using fast cooling recrystallization with three distinct solvents: acetone (AMA), ether (AMEt), and ethyl acetate (AME). The recrystallized crystals were characterized using advanced techniques, including polarized microscopy, X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, and Differential Scanning Calorimetry (DSC), alongside solubility and dissolution testing. Recrystallization yielded crystals with varied morphologies and sizes, achieving high crystal yields of 92.66% (AMA), 85.54% (AMEt), and 94.59% (AME). FTIR analysis revealed that AME crystals exhibited stronger OH bonding, indicated by the highest peak intensity. XRD diffractograms demonstrated distinct peak patterns at specific 2θ positions for AME crystals, suggesting internal structural changes (polymorphism) while maintaining identical chemical composition. DSC thermograms further confirmed variations in melting points between recrystallized crystals and pure mefenamic acid. Dissolution tests revealed that recrystallized mefenamic acid exhibited significantly improved solubility and dissolution rates compared to its pure form. These findings highlight that rapid cooling recrystallization can produce mefenamic acid polymorphs with optimized dissolution properties, potentially enhancing its pharmacological performance and also provides a promising approach to improving the bioavailability of poorly soluble drugs, offering significant implications for pharmaceutical formulation development

Exploring the Subjective Well-Being of Mothers Raising Children with ADHD: A Mediation Model of Resilience, Parenting Self-Efficacy, and Social Support

Mothers of children with ADHD face complex parenting challenges that directly impact their subjective well-being (SWB). This study aims to examine the influence of parenting self-efficacy (PSE) and social support on SWB, with resilience serving as a mediating variable. A quantitative approach with a causal-comparative design was applied, and data were analyzed using Structural Equation Modeling (SEM). A total of 419 mothers of children with ADHD enrolled in inclusive elementary schools in Surabaya were selected through purposive sampling. The results revealed that PSE did not have a direct effect on SWB but showed a significant indirect effect through resilience. Similarly, social support did not directly influence SWB, but indirectly contributed to it via increased resilience. These findings suggest that resilience plays a central role as a psychological mechanism linking internal (PSE) and external (social support) resources to maternal well-being. This study offers practical contributions for developing family-based psychological interventions that prioritize resilience enhancement, as well as theoretical contributions by modeling multivariate relationships among psychological constructs in the context of neurodivergent families