139 research outputs found
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Addressing nodal constraints on the capacity of railways
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/05/2017
- Field of study
As demand for passenger and freight transport on Britain’s railways increases, providing additional capacity and making the best use of the existing infrastructure are priorities for the industry. Since the stations and junctions forming the nodes of the railway network tend to form the constraints on route and network capacity, improved understanding of their operation and capacity characteristics is particularly important.
This paper describes research undertaken to improve the understanding of nodal capacity and capacity utilisation, and to route and schedule trains more efficiently through nodes, thus improving service quality and/or releasing capacity for additional train service
Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient
- Author
- A Kassem
- A Rector
- AE Gorbalenya
- AE Gorbalenya
- AG Murzin
- AJ Drummond
- AJ Drummond
- AJ Wyatt
- Alexander E. Gorbalenya
- AM Dworkin
- AM Gaynor
- Chris Lauber
- CL Haycox
- CS Sullivan
- D Ahuja
- EJ Verschoor
- Els van der Meijden
- GM Sadler
- H Feng
- H Stevens
- H zur Hausen
- HJ Kwun
- I Rogozin
- J Soding
- Jan Nico Bouwes Bavinck
- JCS Noble
- JJ Carter
- JM Kean
- JM Pipas
- JR Abend
- JS Lee
- KD Pruitt
- LC Sperling
- M Babakir-Mina
- M de Koning
- M Jiang
- MA Chastain
- Mariet C. W. Feltkamp
- MD Bennett
- Michael J. Imperiale
- MJ Groenewoud
- MK White
- MNC de Koning
- MR Heaphy Jr
- MS Maginnis
- R Johne
- R Johne
- RC Edgar
- René W. A. Janssens
- S Goh
- S Whelan
- SM Mount
- SN Goodman
- SS Osswald
- T Allander
- T Dalianis
- T Ramqvist
- U Moens
- U Wieland
- V Foulongne
- X Huang
- Publication venue
- Public Library of Science
- Publication date
- 29/07/2010
- Field of study
The Polyomaviridae constitute a family of small DNA viruses infecting a variety of hosts. In humans, polyomaviruses can cause infections of the central nervous system, urinary tract, skin, and possibly the respiratory tract. Here we report the identification of a new human polyomavirus in plucked facial spines of a heart transplant patient with trichodysplasia spinulosa, a rare skin disease exclusively seen in immunocompromized patients. The trichodysplasia spinulosa-associated polyomavirus (TSV) genome was amplified through rolling-circle amplification and consists of a 5232-nucleotide circular DNA organized similarly to known polyomaviruses. Two putative “early” (small and large T antigen) and three putative “late” (VP1, VP2, VP3) genes were identified. The TSV large T antigen contains several domains (e.g. J-domain) and motifs (e.g. HPDKGG, pRb family-binding, zinc finger) described for other polyomaviruses and potentially involved in cellular transformation. Phylogenetic analysis revealed a close relationship of TSV with the Bornean orangutan polyomavirus and, more distantly, the Merkel cell polyomavirus that is found integrated in Merkel cell carcinomas of the skin. The presence of TSV in the affected patient's skin was confirmed by newly designed quantitative TSV-specific PCR, indicative of a viral load of 105 copies per cell. After topical cidofovir treatment, the lesions largely resolved coinciding with a reduction in TSV load. PCR screening demonstrated a 4% prevalence of TSV in an unrelated group of immunosuppressed transplant recipients without apparent disease. In conclusion, a new human polyomavirus was discovered and identified as the possible cause of trichodysplasia spinulosa in immunocompromized patients. The presence of TSV also in clinically unaffected individuals suggests frequent virus transmission causing subclinical, probably latent infections. Further studies have to reveal the impact of TSV infection in relation to other populations and diseases
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
- Dale Anders M.
- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
- Fernández-Aranda Fernando
- Ferrier I. Nicol
- Fichter Manfred M.
- Fichter Manfred M.
- Finucane Hilary K.
- Fiorentino Alessia
- Fischer Krista
- Florez Hermes
- Floyd James A. B.
- Foo Jerome C.
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Forzan Monica
- Frank Josef
- Frank Josef
- Frank Josef
- Franklin Christopher S.
- Frei Oleksandr
- Freimer Nelson B.
- Frisén Louise
- Frye Mark
- Frye Mark
- Fullerton Janice M.
- Fullerton Janice M.
- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
- Gallinger Steven
- Gambaro Giovanni
- Gandal Michael
- Gandal Michael J.
- Gappy Saib
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gatt Justine M.
- Gawlik Micha
- Gaziano J. Michael
- Gaziano J. Michael
- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
- Grabe Hans J.
- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Grant
- Huckins Laura
- Huckins Laura M.
- Hudson James I.
- Huffman Jennifer E.
- Hultman Christina M.
- Humphries Donald E.
- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- Hübel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
- Jones Lisa A.
- Jonsson Lina
- Jordan Jennifer
- Jorgenson Eric
- Julià Antonio
- Jungkunz Martin
- Kahn René S.
- Kahn René S.
- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- Kaminská Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
- Kaye Walter H.
- Keel Pamela K.
- Kelsoe John R.
- Kelsoe John R.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Kessler Ronald C.
- Kiezebrink Kirsty
- Kim Minsoo
- Kim Minsoo
- Kim Youl-Ri
- Kimbrel Nathan A.
- Kinlay Scott
- Kirk Katherine M.
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klein Jon
- Kloiber Stefan
- Kloiber Stefan
- Klump Kelly L.
- Klump Kelly L.
- Knowles James A.
- Knowles James A.
- Knudsen Gun Peggy S.
- Koenen Karestan C.
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S.
- Konte Bettina
- Koromina Maria
- Kraft Julia
- Kranz Thorsten M.
- Kranzler Henry R.
- Kranzler Henry R.
- Krebs Kristi
- Krebs Marie-Odile
- Kretzschmar Warren W.
- Kubo Michiaki
- Kuo Po-Hsiu
- Kupka Ralph
- Kushner Steven A.
- Kutalik Zoltán
- Landén Mikael
- Landén Mikael
- Landén Mikael
- Larsen Janne T.
- Lavebratt Catharina
- Lawrence Jacob
- Lawrence Jacob
- Le Hellard Stephanie
- Leber Markus
- Leboyer Marion
- Leboyer Marion
- Lee Heon-Jeong
- Lee Phil H.
- Lee Phil H.
- Leppä Virpi M.
- Levey Daniel F.
- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Catrin
- Lewis Glyn
- Li Dong
- Li Dong
- Li Qingqin S.
- Li Qingqin S.
- Li Qingqin S.
- Li Yihan
- Liangpunsakul Suthat
- Liao Calwing
- Liao Calwing
- Liao Shih-Cheng
- Lichtenstein Paul
- Lichy Jack
- Lieb Klaus
- Lieb Klaus
- Lilenfeld Lisa
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lindquist Jennifer H.
- Lissowska Jolanta
- Lissowska Jolanta
- Lissowska Jolanta
- Liu Chih-Min
- Lochner Christine
- Lori Adriana
- Loughland Carmel
- Lucae Susanne
- Lucae Susanne
- Lucae Susanne
- Lundberg Martin
- Lundervold Astri
- Luykx Jurjen
- MacIntyre Donald J.
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela A. F.
- Madduri Ravi
- Magistretti Pierre J.
- Magistretti Pierre J.
- Magnusson Patrik K.
- Magnusson Sigurdur H.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Maihofer Adam
- Maj Mario
- Malaspina Dolores
- Mann J. John
- Mannik Katrin
- Maratou Eirini
- Marchini Jonathan
- Marsal Sara
- Marshall Christian R.
- Marshall Christian R.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martinez Elisa Docampo
- Martinsson Lina
- Mastorides Stephen
- Mathew Roy
- Mathews Carol A.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mattocks Kristin
- Mayora Monica Gratacos
- Mayoral Fermin
- Mayoral Fermin
- Mbarek Hamdi
- McArdle Rachel
- McDevitt Sara
- McElroy Susan L.
- McElroy Susan L.
- McGrath Patrick
- McGrath Patrick
- McGregor Nathaniel W.
- McGuffin Peter
- McGuffin Peter
- McGuffin Peter
- McGuffin Peter
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McKay James D.
- McMahon Benjamin
- McMahon Francis J.
- McQuillin Andrew
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E.
- Medland Sarah E.
- Medland Sarah E.
- Medland Sarah E.
- Mehta Divya
- Mehta Divya
- Melle Ingrid
- Melle Ingrid
- Metspalu Andres
- Metspalu Andres
- Meulenbelt Ingrid
- Meyer Laurence
- Meyer Paul
- Micali Nadia
- Michie Patricia
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Millischer Vincent
- Mirza Saira Saeed
- Mitchell James
- Mitchell James E.
- Mitchell Karen
- Mitchell Philip B.
- Mitchell Philip B.
- Mobascher Arian
- Molina Esther
- Mondimore Francis M.
- Monson Eric T.
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W.
- Montgomery Grant W.
- Montgomery Grant W.
- Moorman Jonathan
- Moran Jennifer L.
- Morgan Timothy
- Morken Gunnar
- Morken Gunnar
- Morris Derek W.
- Mors Ole
- Mors Ole
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- Mortensen Preben Bo
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mortensen Preben Bo
- Moser Jennifer
- Mostafavi Sara
- Mowry Bryan
- Mullins Niamh
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- Mullins Niamh
- Munn-Chernoff Melissa A.
- Muralidhar Sumitra
- Muralidhar Sumitra
- Murdoch Maureen
- Myers Richard M.
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- Mühleisen Thomas W.
- Müller-Myhsok Bertram
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- Müller-Myhsok Bertram
- Nacmias Benedetta
- Nauck Matthias
- Navratilova Marie
- Neale Benjamin M.
- Ng Bernard
- Nievergelt Caroline
- Nievergelt Caroline M.
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- Nivard Michel G.
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- Nordentoft Merete
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- Nurnberger John I.
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- Nöthen Markus M.
- Nöthen Markus M.
- Oedegaard Ketil J.
- Okazaki Satoshi
- Okusaga Olaoluwa
- Olde Loohuis Loes M.
- Olsen Catherine M.
- Olsen Catherine M.
- Olsen Maren K.
- Olsson Tomas
- Ophoff Roel A.
- Ophoff Roel A.
- Ophoff Roel A.
- Oruc Lilijana
- Oskarsson Hogni
- Oslin David W.
- Otsuka Ikuo
- Oursler Kris Ann
- Owen Michael J.
- Owen Michael J.
- Owen Michael J.
- O’Brien Niamh
- O’Connell Kevin S.
- O’Donnell Christopher J.
- O’Donnell Christopher J.
- O’Donnell Christopher J.
- O’Donovan Claire
- O’Donovan Michael C.
- O’Donovan Michael C.
- O’Donovan Michael C.
- O’Reilly Paul F.
- O’Toole Julie K.
- Paciga Sara A.
- Paciga Sara A.
- Padyukov Leonid
- Painter Jodie N.
- Palotie Aarno
- Panagiotaropoulou Georgia
- Pantel Jacques
- Pantelis Chris
- Papezova Hana
- Papiol Sergi
- Pardiñas Antonio F.
- Parker Richard
- Pato Carlos
- Pato Carlos
- Pato Michele T.
- Pato Michele T.
- Patrinos George P.
- Pearson John F.
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L.
- Pedersen Nancy L.
- Penninx Brenda W. J. H.
- Penninx Brenda W. J. H.
- Perica Vesna Boraska
- Perlis Roy H.
- Perlis Roy H.
- Perry Amy
- Pestian John
- Petersen Liselotte V.
- Peterson Roseann E.
- Peyrot Wouter J.
- Pfennig Andrea
- Pimm Jonathan
- Pinto Dalila
- Pinto Dalila
- Pistis Giorgio
- Pistis Giorgio
- Porichi Evgenia
- Porteous David
- Porteous David J.
- Posthuma Danielle
- Posthuma Danielle
- Potash James B.
- Potash James B.
- Potash James B.
- Power Robert A.
- Powers Abigail
- Preisig Martin
- Preisig Martin
- Purves Kirstin L.
- Pyarajan Saiju
- Pyarajan Saiju
- Qiao Zhen
- Qin Xuejun
- Quested Digby
- Quested Digby
- Quiroz Jorge A.
- Qvist Per
- Raevuori Anu
- Raj Towfique
- Ramoni Rachel
- Ramos-Quiroga Josep Antoni
- Ramos-Quiroga Josep Antoni
- Ramoz Nicolas
- Ramoz Nicolas
- Rapaport Mark H.
- Ratcliffe Nora
- Rauchman Michael
- Regeer Eline J.
- Reichborn-Kjennerud Ted
- Reif Andreas
- Reif Andreas
- Reininghaus Eva Z.
- Rentería Miguel E.
- Ribasés Marta
- Ribasés Marta
- Ricca Valdo
- Rice John P.
- Rice John P.
- Richarte Vanesa
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P.
- Ripatti Samuli
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Ritschel Franziska
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Rivera Margarita
- Roberts Andrea
- Roberts Gloria
- Roberts Marion
- Robey Brooks
- Roepke Stefan
- Roepke Stefan
- Romero J. P. Casas
- Ross George
- Roth Julian
- Rouleau Guy A.
- Rouleau Guy A.
- Roussos Panos
- Rovaris Diego L.
- Rozanov Vsevolod
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Rybakowski Filip
- Saito Takeo
- Sanders Alan R.
- Santonastaso Paolo
- Schaefer Catherine
- Schall Ulrich
- Schalling Martin
- Scherag André
- Scherer Stephen W.
- Scherer Stephen W.
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- Schmahl Christian
- Schmahl Christian
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- Seitz Jochen
- Selva Luis E.
- Senner Fanny
- Serretti Alessandro
- Serretti Alessandro
- Servatius Richard
- Shabalin Andrey
- Shannon Weickert Cynthia
- Sharma Satish
- Sharp Sally
- Shayan Shahpoor
- Shen Ling
- Sherman Scott
- Shi Jianxin
- Shi Jianxin
- Shilling Paul D.
- Shyn Stanley I.
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sinnamon Grant C. B.
- Sirignano Lea
- Sirignano Lea
- Sklar Pamela
- Slachtova Lenka
- Slagboom P. Eline
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- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Spalletta Gianfranco
- Spijker Anne T.
- Sriram Peruvemba
- Stahl Eli A.
- Stahl Eli A.
- Stapley Todd
- Starnawska Anna
- Steen Vidar W.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Stein Dan J.
- Stein Murray B.
- Steinberg Stacy
- Steinberg Stacy
- Stephens Brady
- Stordal Eystein
- Strauss John S.
- Strauss John S.
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Striker Robert
- Strober Michael
- Strober Michael
- Strohmaier Jana
- Strollo Patrick
- Stuber Garret D.
- Su Mei-Hsin
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sun Yan
- Szatkiewicz Jin P.
- Sánchez-Mora Cristina
- Sánchez-Mora Cristina
- Tachmazidou Ioanna
- Tandon Neeraj
- Tansey Katherine E.
- Teismann Henning
- Tenconi Elena
- Terao Chikashi
- Teumer Alexander
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Thorgeirsson Thorgeir E.
- Thornton Laura M.
- Thornton Laura M.
- Tiemeier Henning
- Toma Claudio
- Tooney Paul
- Tortorella Alfonso
- Tozzi Federica
- Traylor Matthew
- Treasure Janet
- Treasure Janet
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Tsao Philip
- Tsao Philip S.
- Tsao Philip S.
- Tsao Philip S.
- Tsermpini Evangelia-Eirini
- Tsitsika Artemis
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- Turecki Gustavo
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- Vieta Eduard
- Viktorin Alexander
- Vilar-Ribó Laura
- Villareal Gerardo
- Vincent John B.
- Vincent John B.
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- Völzke Henry
- Wade Tracey D.
- Wagner Gudrun
- Waldman Irwin D.
- Wallbom Agnes
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- Walters James T. R.
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- Werge Thomas
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- Werge Thomas
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- Whiteman David C.
- Whittle Jeffrey
- Whooley Mary
- Wichmann H. Erich
- Widen Elisabeth
- Willemsen Gonneke
- Williams Leanne M.
- Willour Virginia
- Wilson Peter
- Winsvold Bendik S.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Search for stop and higgsino production using diphoton Higgs boson decays
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
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- Bacchetta Nicola
- Bachmair Felix
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- Bagliesi Giuseppe
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- Chakaberia Irakli
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- Chang You-Hao
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- Chanon Nicolas
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- Charlot Claude
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- Chasserat Julien
- Chatrchyan S.
- Chatterjee Avishek
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- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
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- Christiansen Tim
- Christopher Grant
- Chuang Shan-Huei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
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- Ciocci Maria Agnese
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
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- CMS Collaboration
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- Cockerill David JA
- Codispoti Giuseppe
- Colafranceschi Stefano
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- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
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- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
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- Couderc Fabrice
- Coughlan John A
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
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- Cremaldi Lucien Marcus
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- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Dahmes Bryan
- Dahms Torsten
- Dalchenko Mykhailo
- Dallavalle Gaetano-Marco
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- Das Souvik
- Daskalakis Georgios
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- Daubie Evelyne
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- De Almeida Dias Flavia
- de Barbaro Pawel
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- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
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- Degano Alessandro
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- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demiragli Zeynep
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- Dermenev Alexander
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- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
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- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dissertori Günther
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- Dobrzynski Ludwik
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- Würthwein Frank
- Xiao Hong
- Xie Si
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- Xu Lingshan
- Yagil Avraham
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- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zou Wei
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- American Physical Society
- Publication date
- 01/01/2013
- Field of study
Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass
Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Almeida Nuno
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Beernaert Kelly
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W
- Bellan Riccardo
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
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- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialkowska Helena
- Bian Jian-Guo
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- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Brown Robert M
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bucinskaite Inga
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- Bunn Julian
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- Burgmeier Armin
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- Butler Joel Nathan
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- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Böser Christian
- Cabrillo Iban Jose
- Caebergs Thierry
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- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan S.
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
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- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
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- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
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- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Christiansen Tim
- Christopher Grant
- Chuang Shan-Huei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
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- Clement Emyr
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- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David JA
- Codispoti Giuseppe
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- de Barbaro Pawel
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- De La Cruz Begona
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- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wolf Eddi A
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delgado Peris Antonio
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
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- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Descroix Alexis
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
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- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dissertori Günther
- Dittmann Jay
- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobson Marc
- Dobur Didar
- Doesburg Robert
- Dolen James
- Dominguez Aaron
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- Donegà Mauro
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- Doroba Krzysztof
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- Dozen Candan
- Dragicevic Marko
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- Drozdetskiy Alexey
- Du Pree Tristan
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- Dubinin Mikhail
- Duchardt Deborah
- Dudero Phillip Russell
- Dudko Lev
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- Duric Senka
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- Eckstein Doris
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- Publication venue
- Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia.
- Publication date
- 01/01/2011
- Field of study
Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension
and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions
available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression
to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity
in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia
by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids
to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh
the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance.
This thesis opens with a review of the literature on identifiable risk factors of preeclampsia
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
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- Bo Tang
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- Burckhardt Nele
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- Dvorkin Steve
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- Ehrenworth Amy
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- Farny Natalie G.
- Farrell Jennifer
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- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
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- Figueroa Jose Arnulfo Juarez
- Fikry Clara
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- Fischer Matthew
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- Friedman Yonatan
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- Gokul [NO FIRST NAME IN SCOPUS]
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- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
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- Yong Zhangxiang
- Yongjie Lin
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- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
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- Zhang Jige
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- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Systems responses to progressive water stress in durum wheat
- Author
- A Aprile
- A Harb
- A Moumeni
- AG Condon
- Ahmad Abdulkader
- B Bahar
- B Usadel
- BJ Miflin
- C Hayano-Kanashiro
- C Pinheiro
- Chris Rawlings
- D Fleury
- David W. Lawlor
- Dimah Z. Habash
- DW Lawlor
- DW Lawlor
- DZ Habash
- F Giunta
- GP Xue
- GP Xue
- H Kitano
- H Konno
- HD Barr
- I Ahuja
- J Kilian
- J Zheng
- JC Moura
- JM Claverie
- JM Whitacre
- Jose L. Araus
- JP Brennan
- JT van Dongen
- K Mochida
- K Nakashima
- K Shinozaki
- K Yamaguchi-Shinozaki
- Kawther Latiri
- L Cattivelli
- L Gautier
- M Gasca
- M Hoerling
- M Maccaferri
- M Reguera
- M Rosa
- Mansoor Saqi
- Marcela Baudo
- Matthew Hindle
- Michael Defoin-Platel
- Miloudi M. Nachit
- MM Nachit
- N Fernandez-Garcia
- NN Khamssi
- NZ Ergen
- O Thimm
- P Monneveux
- PF Scholander
- Pilar Hernandez
- R Cramer G
- R Tuberosa
- RA Fischer
- RA Moinuddin Fischer
- Roberto Tuberosa
- Rowan Mitchell
- S Alvarez
- SM Swarbreck
- Stephen J. Powers
- T Degenkolbe
- T Hirayama
- T Krugman
- V Talamè
- W Wang
- WJ Guo
- X Gan
- Y Benjamini
- Z Bar-Joseph
- ZJ Wu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
Durum wheat is susceptible to terminal drought which can greatly decrease grain yield. Breeding to improve crop yield is hampered by inadequate knowledge of how the physiological and metabolic changes caused by drought are related to gene expression. To gain better insight into mechanisms defining resistance to water stress we studied the physiological and transcriptome responses of three durum breeding lines varying for yield stability under drought. Parents of a mapping population (Lahn x Cham1) and a recombinant inbred line (RIL2219) showed lowered flag leaf relative water content, water potential and photosynthesis when subjected to controlled water stress time transient experiments over a six-day period. RIL2219 lost less water and showed constitutively higher stomatal conductance, photosynthesis, transpiration, abscisic acid content and enhanced osmotic adjustment at equivalent leaf water compared to parents, thus defining a physiological strategy for high yield stability under water stress. Parallel analysis of the flag leaf transcriptome under stress uncovered global trends of early changes in regulatory pathways, reconfiguration of primary and secondary metabolism and lowered expression of transcripts in photosynthesis in all three lines. Differences in the number of genes, magnitude and profile of their expression response were also established amongst the lines with a high number belonging to regulatory pathways. In addition, we documented a large number of genes showing constitutive differences in leaf transcript expression between the genotypes at control non-stress conditions. Principal Coordinates Analysis uncovered a high level of structure in the transcriptome response to water stress in each wheat line suggesting genome-wide co-ordination of transcription. Utilising a systems-based approach of analysing the integrated wheat's response to water stress, in terms of biological robustness theory, the findings suggest that each durum line transcriptome responded to water stress in a genome-specific manner which contributes to an overall different strategy of resistance to water stress
Sacrificing the Holy Cows: A Firm-Level Study of Using Willingness-to-Cannibalize to Drive Innovative Software Project Management
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2009
- Field of study
Effective Virtual Teams through Communities of Practice
- Author
- A R Townsend A A M Demarie
- Alexis Barlow
- Chris Kimble
- D J Grimshaw
- E Wenger
- E Wenger
- Feng Li
- Grabowski Martha
- H Clark
- J Naisbitt
- J Seely Brown
- J Seely Brown
- K Friedman
- K Knoll
- Li Feng
- Li Feng
- Li Feng
- M Castells
- M Igbaria
- M K Ahuja
- M O&apos
- N Simonson
- P Hildreth
- P Hildreth
- R Hightower
- R O&apos
- S L Jarvenpaa
- T Benson-Armer R
- T Mandeville
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2000
- Field of study
Oral potassium supplement use and outcomes in chronic heart failure: A propensity-matched study
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- Ahmed
- Ahmed
- Ahmed
- Ahmed
- Ahuja
- Ali Ahmed
- Bertram Pitt
- Chris Adamopoulos
- Coats
- Collins
- D'Agostino
- David S. Siscovick
- Delgado
- Gennari
- George Bakris
- Gilbert J. Perry
- Hunt
- James B. Young
- Jerome L. Fleg
- Laragh
- Macdonald
- Michell
- Michell
- Mustafa I. Ahmed
- Normand
- O. James Ekundayo
- Packer
- Petch
- Pitt
- Pitt
- Rosenbaum
- Rosenbaum
- Rosenbaum
- Rubin
- Rubin
- Siegel
- Siscovick
- SPSS for Windows
- Thomas E. Love
- Weber
- Xuemei Sui
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
- …