107 research outputs found
Identification of Nucleases and Phosphatases by Direct Biochemical Screen of the Saccharomyces cerevisiae Proteome
- Author
- A Cheng
- A Constantinou
- A Constantinou
- AA Davies
- AC Gavin
- Alicia F. Lam
- Anja-Katrin Bielinsky
- AW Johnson
- BN Ames
- BO Krogh
- Chu Kwen Ho
- DC Amberg
- DJ Rigden
- DJ Rigden
- DM Gelperin
- DP Sullivan
- EA Toh
- EP Mimitou
- F Osman
- GD Fairn
- H Zhu
- HJ Dunderdale
- JE Jackman
- L Davies
- L Wu
- L Wu
- Lorraine S. Symington
- LS Symington
- MN Boddy
- P Fiorentini
- P Garg
- S Gravel
- S Kleff
- S Liao
- S Raynard
- SA Bastin-Shanower
- SC Ip
- T de los Santos
- T Lindahl
- V Kaliraman
- Y Lindqvist
- Y Xue
- Z Zhu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
The availability of yeast strain collections expressing individually tagged proteins to facilitate one-step purification provides a powerful approach to identify proteins with particular biochemical activities. To identify novel exo- and endo-nucleases that might function in DNA repair, we undertook a proteomic screen making use of the movable ORF (MORF) library of yeast expression plasmids. This library consists of 5,854 yeast strains each expressing a unique yeast ORF fused to a tripartite tag consisting of His6, an HA epitope, a protease 3C cleavage site, and the IgG-binding domain (ZZ) from protein A, under the control of the GAL1 promoter for inducible expression. Pools of proteins were partially purified on IgG sepharose and tested for nuclease activity using three different radiolabeled DNA substrates. Several known nucleases and phosphatases were identified, as well as two new members of the histidine phosphatase superfamily, which includes phosphoglycerate mutases and phosphatases. Subsequent characterization revealed YDR051c/Det1 to be an acid phosphatase with broad substrate specificity, whereas YOR283w has a broad pH range and hydrolyzes hydrophilic phosphorylated substrates. Although no new nuclease activities were identified from this screen, we did find phosphatase activity associated with a protein of unknown function, YOR283w, and with the recently characterized protein Det1. This knowledge should guide further genetic and biochemical characterization of these proteins
Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy
- Author
- Aawsaj Y
- Abayomi M
- Acharya V
- Aggarwal SK
- Ahmad A
- Ahmed I
- Ahmed J
- Ahmed J
- Ahmed T
- Ainley P
- Akhtar M
- Al Amari K
- Al-Abed YA
- Al-Akash M
- Al-Bahrani AZ
- Al-Khyatt W
- Al-Muhktar A
- Al-Sarireh B
- Al-Taan O
- Alagaratnam S
- Alam I
- Alberts J
- Alderson D
- Aldridge RC
- Aleksandrov D
- Ali H
- Ali S
- Amin K
- Andrew DR
- Appleton S
- Arhi C
- Aroori S
- Aryal K
- Asad M
- Aseem R
- Asprou FM
- Awan A
- Ayaani S
- Aymon
- Babu BI
- Bajwa DS
- Bajwa FM
- Baker AL
- Balfe P
- Ball WR
- Ballance L
- Banwell V
- Barnes J
- Barrie J
- Bartlett F
- Basheer M
- Bashir G
- Basra M
- Basu S
- Basynat P
- Batt J
- Bausbacher H
- Bawa S
- Beasley WD
- Belding R
- Bellini MI
- Bennett SP
- Bhandari CTS
- Bhattacharya V
- Blane C
- Blazeby JM
- Boal M
- Boddy A
- Boland M
- Bond-Smith G
- Booth MI
- Borowski DW
- Bowen L
- Boyce KM
- Boyd AT
- Bradley D
- Bradley N
- Brennan S
- Brett D
- Broadhurst J
- Brooke E
- Brown TH
- Bryant A
- Buchan J
- Bullen N
- Bunnell C
- Bunting DM
- Burke P
- Byrne JP
- Byrnes CK
- Campbell W
- Carney K
- Carney K
- Carroll P
- Carter CR
- Carter NC
- Carty N
- Cassidy JT
- Chambers A
- Chambers A
- Chambers A
- Chan WM
- Chang J
- Charalabopoulos A
- Chauhan N
- Cheung M
- Chishti IA
- Chitre V
- CholeS Study Grp
- CholeS Study Grp
- CholeS Study Grp
- CholeS Study Grp
- Choy A
- Cieplucha K
- Clements JM
- Coats M
- Cockbain AJ
- Coe PO
- Connelly M
- Cooke F
- Courtney MJ
- Cowley JB
- Cross KS
- Cuming T
- Cunha P
- D'Costa C
- Dalgaty F
- Dar F
- Date R
- Dave RV
- Davey P
- Davies J
- Dawson S
- De Marchi JA
- de Siqueira J
- Deguara J
- Delisle TG
- Dennison AR
- Derbyshire L
- Devoto L
- Dhillon A
- Diamond T
- Dickson-Lowe R
- Digney R
- Dindyal S
- Dobbins B
- Doe M
- Dorrian E
- Doulias T
- Downing J
- Downing J
- Drake B
- Driscoll PJ
- Duke D
- Durkin D
- Dwerryhouse SJ
- Ebdewi H
- Ebied H
- Eisawi A
- El-Dhuwaib APY
- El-Hasani SS
- Elkheir N
- Elmasry M
- Elsayed M
- Elshaer M
- Emesih S
- Farag SF
- Farooq A
- Farouk M
- Fasih T
- Fawole AS
- Fenwick S
- Ferguson G
- Ferris P
- Finch D
- Finch JG
- Finch JG
- Finlay I
- Fleming K
- Fletcher T
- Fordham IJ
- Forouzanfar A
- Forrest CR
- Forster L
- Fothergill L
- Frame RJ
- Francombe J
- Frank L
- Fusai G
- Galanopoulos G
- Gallagher PV
- Garcea G
- Gardner-Thorpe J
- Geoghegan JG
- Geogloma I
- Gerakopoulos S
- Ghareeb E
- Ghazanfar MA
- Gibson S
- Giles M
- Giovinazzo F
- Giwa L
- Goh YL
- Gopalswamy S
- Goscimski A
- Gossage JA
- Gough M
- Gould L
- Gould L
- Grant AJ
- Gravante G
- Griffiths EA
- Griffiths EA
- Gull S
- Gunasekera RT
- Gurung K
- Guthrie GJK
- Hafiz S
- Halkias C
- Hall C
- Hamady Z
- Hamdan A
- Hamdan MF
- Hamilton E
- Hancorn K
- Haque M
- Haque SU
- Hardy TJ
- Hargreaves A
- Harilingam ACM
- Harris A
- Harrison E
- Hawkins H
- Heath J
- Hebbar M
- Henderson LT
- Henley N
- Heshaishi M
- Hewes J
- Hewes JC
- Heywood N
- Higgs SM
- Hill ADK
- Hill ADK
- Hindley C
- Hirst NA
- Hisham E
- Ho W-M
- Hoban JR
- Hodgkins KA
- Hodson J
- Holroyd DJ
- Hooks G
- Hopwood B
- Hornby ST
- Hornsby J
- Hosie KB
- Hosie KB
- Hossack MR
- Hossain T
- Hoti E
- Hou D
- Hrycaiczuk A
- Hughes M
- Hunter DI
- Hussain A
- Hussain A
- Hussain AA
- Hussain N
- Iftikhar SY
- Iqbal N
- Iskandar E
- Issa E
- Ivanovski I
- Jackson A
- Jackson C
- Jafferbhoy SF
- Jambulingam P
- Jamdar S
- Jamel S
- Janeczko A
- Jaunoo S
- Jayanthi NVG
- Jelley C
- Jennings NA
- Joel A
- Johnpulle MA
- Johnston D
- Johnstone M
- Johnstone M
- Joji N
- Jones C
- Jones E
- Jones GH
- Jones MA
- Jones MJ
- Jones RP
- Jones SM
- Kadhim A
- Kadirkamanathan S
- Kallaway C
- Kanakala V
- Kanavati O
- Kansal N
- Kaptanis S
- Karavadra B
- Karim L
- Karunakaran P
- Katbeh T
- Kaur P
- Kausar A
- Kelly ME
- Kendal C
- Kennedy D
- Kenny R
- Keogh K
- Khalil AM
- Khan A
- Khan MA
- Khan MAS
- Khan RB
- Khan S
- Khan S
- Khawaja A
- Khawaja Z
- Khogali E
- Kimble A
- Kinghorn A
- Kirkham AJ
- Knight B
- Knight K
- Kourkulos M
- Krysztopik R
- Kumar P
- Kynaston J
- Kyriakidis D
- Lalla K
- Lambert J
- Lammy S
- Lane R
- Larkin D
- Law J
- Lawther R
- Lazim T
- Lee K
- Lee M
- Leeder P
- Lennon H
- Lewis M
- Lim HCC
- Lim PJ
- Lindsay D
- Lloyd D
- Lo C
- Lodhia J
- Longbotham DA
- Loughlin P
- Lovett B
- Luhmann A
- Luther AA
- Lyons EM
- Macano CAW
- MacArtney M
- Macdonald A
- Madanipour S
- Madbak K
- Madurska M
- Magee CJ
- Maguire D
- Maharaj G
- Majeed A
- Malcolm C
- Malde D
- Malik NS
- Mallik M
- Mansour S
- Manu M
- Manzelli A
- Marriott P
- Marriott P
- Martin J
- Martin S
- Martin ST
- Marudanayagam R
- Mason D
- Mathur P
- Mawhinney A
- Mbuvi J
- McAree B
- McCain S
- McCallum IJD
- McClarey A
- McCune K
- McDermott F
- McEntee GP
- McGlone ER
- McGuigan A
- McIlmunn C
- McKay D
- McKenzie S
- McNair AGK
- Mealy K
- Menzies D
- Mercer SJ
- Milburn J
- Mirza AK
- Mirza D
- Miu V
- Mockford KA
- Mohamed S
- Mohan HM
- Mok KWJ
- Monk D
- Morcous P
- Morrison TEM
- Mothe BS
- Mowbray N
- Mozolowski KL
- Mukherjee D
- Murphy JO
- Murtaza G
- Nally DM
- Napetti S
- Nassar AH
- Nassar AHM
- Naumann D
- Nedujchelyn Y
- Needham PJ
- Newton K
- Newton RC
- Ngu WS
- Nicholson GA
- Nicholson J
- Nicholson JA
- Nicol L
- Nicolay CR
- Nieto T
- Nijjar RS
- Nilsen-Nunn A
- Nilsson F
- Noble F
- Nofal E
- Noor N
- Nunes QM
- O'Dwyer P
- O'Neill MA
- O'Neill S
- O'Reilly DA
- O'shea KM
- O'Sullivan AW
- Obeidallah MR
- Ogedegbe A
- Old OJ
- Orchard P
- Orizu MN
- Packer JR
- Padwick R
- Panteleimonitis S
- Parappally CP
- Parmar J
- Pasquali S
- Patel A
- Patel K
- Patel S
- Pati P
- Pearce B
- Pearson KL
- Peirce C
- Pellen M
- Peter MB
- Peterson M
- Pezzuto R
- Photi E
- Phull M
- Pinho-Gomes AC
- Pollock S
- Popplewell M
- Pore N
- Porter J
- Prasad AR
- Prasad R
- Preston SR
- Preziosi G
- Prince S
- Psica A
- Puig S
- Puntis DJ
- Puri Y
- Qandeel H
- Rabie M
- Radwan R
- Rae DM
- Rahman S
- Rajaganeshan R
- Rajendran I
- Ramage MI
- Rao STV
- Rate AJ
- Raza S
- Read E
- Reddy M
- Reece-Bolton O
- Reed J
- Reid A
- Rengifo C
- Rhys T
- Richards CH
- Riera M
- Ritchie J
- Robb W
- Roberts GP
- Robinson S
- Robinson S
- Robinson SJ
- Rodriguez D
- Rodriguez DU
- Roebuck A
- Rogers PN
- Rolph RC
- Roy S
- Rutherford CL
- Sadat MM
- Sakai N
- Sampat K
- Samuel N
- Sarmah PB
- Sarvananthan K
- Sarveswaran J
- Satheesan S
- Saunders M
- Sayegh M
- Segaran A
- Sekhar H
- Sen G
- Seymour K
- Shabo W
- Shah N
- Shah R
- Shahin Y
- Sheel ARG
- Shenoy H
- Shetty V
- Shier D
- Shingler GM
- Shiwani MH
- Shrestha AK
- Siddiqi N
- Siddiqui MN
- Siddiqui Z
- Sillo TO
- Silva M
- Simpson DJ
- Singh S
- Singh-Ranger D
- Sinha S
- Skelly BL
- Slavin JP
- Slawinski C
- Sloane J
- Smith SR
- Smith SR
- Spearman J
- Spence G
- Spreadborough P
- Spreadborough P
- Starmer BZ
- Stevenson TEJ
- Stewart DJ
- Stirland E
- Subramanium D
- Sufi PA
- Sukha A
- Sutcliffe R
- Suttie S
- Sutton CMLR
- Szentpali K
- Tang C-B
- Tanner N
- Tate S
- Tayeh S
- Taylor GW
- Teasdale RL
- Templeton A
- Terrace J
- Thakkar R
- Thomas G
- Thompson RLE
- Tilston MP
- Toh SKC
- Tolofari S
- Tomlinson MA
- Trevatt AEJ
- Trotter M
- Tsang A
- Tsavellas G
- Tuck L
- Turner P
- Tutton MG
- Ullah MF
- Upchurch EA
- Urbonas T
- Varghase J
- Vass DG
- Vaughan EM
- Vijay V
- Vijayan D
- Vijayanand D
- Villatoro E
- Virupaksha S
- Vitone LJ
- Vohra RS
- Vohra RS
- Wadley M
- Wainwright D
- Wajed S
- Wallace T
- Wardle S
- Warren C
- Watkin H
- Watson AJM
- Watson NF
- Wayman J
- Weaver S
- Weber B
- Weber B
- Weerasinghe C
- Welbourn H
- West Midlands Research Collaborative
- Wheatley K
- White TJ
- Wijetunga I
- Wild JRL
- Wilkinson MD
- Williams SV
- Williamson TK
- Willson PD
- Wilson MSJ
- Wilson TR
- Winter DC
- Winter H
- Wood CPJ
- Wood P
- Wood S
- Woodman T
- Yahya S
- Yao C
- Yeldham G
- Yoganathan T
- Youssef H
- Zafar S
- Zafrani Z
- Zarsadias P
- Zeeshan S
- Zhang C
- Zino S
- Ziprin P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background
A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets.
Methods
Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis.
Results
A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001).
Conclusion
We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty
Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects
- Author
- A Djimdé
- A Teklehaimanot
- Abdunoor M Kabanywanyi
- AW Boddy
- Baraka Amuri
- C Falade
- C Falade
- C Souppart
- Ching-Ming Yeh
- Christine Reynolds
- Committee for Medicinal products for Human Use (CHMP)
- D Matsui
- David Ubben
- EA Mueller
- F Ezzet
- Food and Drug Administration: Guidance for industry
- G Lefèvre
- G Lefèvre
- G Lefèvre
- G Lefèvre
- G Magueur
- Gilbert Lefèvre
- Günther Kaiser
- M Makanga
- M Makanga
- Marja Nuortti
- ML Angelilli
- NJ White
- PI German
- Romain Séchaud
- S Abdulla
- S Abdulla
- S Winnick
- Salim Abdulla
- Serge Fitoussi
- Steve Pascoe
- World Health Organization
- World Health Organization
- World Health Organization
- ZG Premji
- ZG Premji
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
BACKGROUND\ud
\ud
Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L) crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L. During early development of this new formulation, two studies were performed in healthy subjects, one to evaluate the palatability of three flavours of A-L, and a second one to compare the bioavailability of active principles between the dispersible tablet and the tablet (administered crushed and intact).\ud
\ud
METHODS\ud
\ud
Study 1 was performed in 48 healthy schoolchildren in Tanzania. Within 1 day, all subjects tasted a strawberry-, orange- and cherry-flavoured oral A-L suspension for 10 seconds (without swallowing) in a randomized, single-blind, crossover fashion. The palatability of each formulation was rated using a visual analogue scale (VAS). Study 2 was an open, randomized crossover trial in 48 healthy adults given single doses of A-L (80 mg artemether + 480 mg lumefantrine) with food. The objectives were to compare the bioavailability of artemether, dihydroartemisinin (DHA) and lumefantrine between the dispersible tablet and the tablet administered crushed (primary objective) and intact (secondary objective).\ud
\ud
RESULTS\ud
\ud
Study 1 showed no statistically significant difference in VAS scores between the three flavours but cherry had the highest score in several ratings (particularly for overall liking). Study 2 demonstrated that the dispersible and crushed tablets delivered bioequivalent artemether, DHA and lumefantrine systemic exposure (area under the curve [AUC]); mean ± SD AUC0-tlast were 208 ± 113 vs 195 ± 93 h.ng/ml for artemether, 206 ± 81 vs 199 ± 84 h.ng/ml for DHA and 262 ± 107 vs 291 ± 106 h x μg/ml for lumefantrine. Bioequivalence was also shown for peak plasma concentrations (Cmax) of DHA and lumefantrine. Compared with the intact tablet, the dispersible tablet resulted in bioequivalent lumefantrine exposure, but AUC and Cmax values of artemether and DHA were 20-35% lower.\ud
\ud
CONCLUSIONS\ud
\ud
Considering that cherry was the preferred flavour, and that the novel A-L dispersible tablet demonstrated similar pharmacokinetic performances to the tablet administered crushed, a cherry-flavoured A-L dispersible tablet formulation was selected for further development and testing in a large efficacy and safety study in African children with malaria
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
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- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck GA
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
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- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
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- Benchekroun D
- Benchouk C
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- Bentvelsen S
- Beretta M
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- Berglund E
- Beringer J
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- Bernhard R
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- Bertolucci F
- Besana MI
- Besson N
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- Bhimji W
- Bianchi RM
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- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
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- Bingul A
- Bini C
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- Blair RE
- Blanchard J-B
- Blanchot G
- Blazek T
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeriu OEV
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bona M
- Bondarenko VG
- Bondioli M
- Boonekamp M
- Boorman G
- Booth CN
- Bordoni S
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Zhemchugov A
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- Zhuravlov V
- Zieminska D
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- Ziolkowski M
- Zitoun R
- Zivkovic L
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- Zobernig G
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- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Population‐based cohort study of outcomes following cholecystectomy for benign gallbladder diseases
- Author
- Aawsaj Y
- Abayomi M
- Acharya V
- Aggarwal SK
- Ahmad A
- Ahmed I
- Ahmed J
- Ahmed J
- Ahmed T
- Ainley P
- Akhtar M
- Al Amari K
- Al-Abed YA
- Al-Akash M
- Al-Bahrani AZ
- Al-Khyatt W
- Al-Muhktar A
- Al-Taan O
- Alagaratnam S
- Alam I
- Alberts J
- Alderson D
- Aldridge RC
- Aleksandrov D
- Ali A
- Ali H
- Ali S
- Amin K
- Andrew DR
- Appleton S
- Arhi C
- Aroori S
- Aryal K
- Asad M
- Aseem R
- Asprou FM
- Awan A
- Ayaani S
- Babu BI
- Bajwa DS
- Bajwa FM
- Baker AL
- Balfe P
- Ball WR
- Ballance L
- Banwell V
- Barnes J
- Barrie J
- Bartlett F
- Basheer M
- Bashir G
- Basra M
- Basu S
- Basynat P
- Batt J
- Bausbacher H
- Bawa S
- Beasley WD
- Belding R
- Bellini MI
- Bennett SP
- Bhandari S
- Bhattacharya V
- Blane C
- Blazeby JM
- Boal M
- Boddy A
- Boland M
- Bond-Smith G
- Booth MI
- Borowski DW
- Bowen L
- Boyce KM
- Boyd AT
- Bradley D
- Bradley N
- Brennan S
- Brett D
- Broadhurst J
- Brooke E
- Brown TH
- Bryant A
- Buchan J
- Bullen N
- Bunnell C
- Bunting DM
- Burke P
- Byrne JP
- Byrnes CK
- Campbell W
- Carney K
- Carney K
- Carroll P
- Carter CR
- Carter NC
- Carty N
- Cassidy JT
- Chambers A
- Chambers A
- Chambers A
- Chan WM
- Chang J
- Chauhan N
- Cheung M
- Chishti IA
- Chitre V
- Choy A
- Cieplucha K
- Clements JM
- Coats M
- Cockbain AJ
- Coe PO
- Collaborative WMR
- Connelly M
- Cooke F
- Courtney MJ
- Cowley JB
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- Zeeshan S
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- Ziprin P
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2016
- Field of study
Background The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all‐cause 30‐day readmissions and complications in a prospective population‐based cohort. Methods Data were collected on consecutive patients undergoing cholecystectomy in acute UK and Irish hospitals between 1 March and 1 May 2014. Potential explanatory variables influencing all‐cause 30‐day readmissions and complications were analysed by means of multilevel, multivariable logistic regression modelling using a two‐level hierarchical structure with patients (level 1) nested within hospitals (level 2). Results Data were collected on 8909 patients undergoing cholecystectomy from 167 hospitals. Some 1451 cholecystectomies (16·3 per cent) were performed as an emergency, 4165 (46·8 per cent) as elective operations, and 3293 patients (37·0 per cent) had had at least one previous emergency admission, but had surgery on a delayed basis. The readmission and complication rates at 30 days were 7·1 per cent (633 of 8909) and 10·8 per cent (962 of 8909) respectively. Both readmissions and complications were independently associated with increasing ASA fitness grade, duration of surgery, and increasing numbers of emergency admissions with gallbladder disease before cholecystectomy. No identifiable hospital characteristics were linked to readmissions and complications. Conclusion Readmissions and complications following cholecystectomy are common and associated with patient and disease characteristics
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
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- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang J
- Zhang L
- Zhang R
- Zhang X
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √s=8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT>120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between EmissT>150 GeV and EmissT>700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presented
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at root s = 8 TeV with the ATLAS detector (vol 75, 299, 2015)
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
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- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
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- Akimov AV
- Alberghi GL
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- Alconada Verzini MJ
- Aleksa M
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- Chafaq A
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- Chalupkova I
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- Chapman JD
- Charfeddine D
- Charlton DG
- Chau CC
- Cheatham S
- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
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- Zhemchugov A
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- Zinonos Z
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- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
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- Zarzhitsky P
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- Zhemchugov A
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- Zieminska D
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- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
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- Zsenei A
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
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