1,824 research outputs found
Model-independent constraints on new physics in b --> s transitions
We provide a comprehensive model-independent analysis of rare decays
involving the b --> s transition to put constraints on dimension-six Delta(F)=1
effective operators. The constraints are derived from all the available
up-to-date experimental data from the B-factories, CDF and LHCb. The
implications and future prospects for observables in b --> s l+l- and b --> s
nu nu transitions in view of improved measurements are also investigated. The
present work updates and generalises previous studies providing, at the same
time, a useful tool to test the flavour structure of any theory beyond the SM.Comment: 1+39 pages, 12 figures, 3 tables. v2: minor modifications, typos
corrected, references added, version to be published in JHE
Supersymmetric contributions to and decays in SCET
We study the decay modes and using Soft Collinear Effective Theory. Within Standard Model and
including the error due to the SU(3) breaking effect in the SCET parameters we
find that BR and BR
corresponding to
solution 1 and solution 2 of the SCET parameters respectively.For the decay
mode , we find that BR and BR corresponding to solution 1 and
solution 2 of the SCET parameters respectively. We extend our study to include
supersymmetric models with non-universal A-terms where the dominant
contributions arise from diagrams mediated by gluino and chargino exchanges. We
show that gluino contributions can not lead to an enhancement of the branching
ratios of and . In
addition, we show that SUSY contributions mediated by chargino exchange can
enhance the branching ratio of by about 14% with
respect to the SM prediction. For the branching ratio of , we find that SUSY contributions can enhance its value by about 1% with
respect to the SM prediction.Comment: 25 pages,5 figures, version accepted for publicatio
Exploring New Physics in the C7-C7' plane
The Wilson coefficient C7 governing the radiative electromagnetic decays of B
meson has been calculated to a very high accuracy in the Standard Model, but
experimental bounds on either the magnitude or the sign of C7 are often
model-dependent. In the present paper, we attempt at constraining both the
magnitude and sign of C7 using a systematic approach. We consider already
measured observables like the branching ratios of B \rightarrow Xs mu+ mu- and
B \rightarrow Xs gamma, the isospin and CP asymmetries in B \rightarrow K*
gamma, as well as AFB and FL in B \rightarrow K*l+l-. We also discuss the
transverse observable AT2 which, once measured, may help to disentangle some of
the scenarios considered. We explore the constraints on C7, C9, C10 as well as
their chirality-flipped counterparts. Within our framework, we find that we
need to extend the constraints up to 1.6 sigma to allow for the "flipped-sign
solution" of C7. The SM solution for C7 exhibits a very mild tension if New
Physics is allowed in dipole operators only. We provide semi-numerical
expressions for all these observables as functions of the relevant Wilson
coefficients at the low scale.Comment: 54 pages, 16 figures, 15 tables. Normalization factor introduced for
the integrated AFB and FL in Sec.2.5 (Eq.2.35-2.38). Conclusions unchanged.
Not updated in JHE
Bayesian Fit of Exclusive Decays: The Standard Model Operator Basis
We perform a model-independent fit of the short-distance couplings
within the Standard Model set of and operators. Our analysis of , and decays is the first to harness the full
power of the Bayesian approach: all major sources of theory uncertainty
explicitly enter as nuisance parameters. Exploiting the latest measurements,
the fit reveals a flipped-sign solution in addition to a Standard-Model-like
solution for the couplings . Each solution contains about half of the
posterior probability, and both have nearly equal goodness of fit. The Standard
Model prediction is close to the best-fit point. No New Physics contributions
are necessary to describe the current data. Benefitting from the improved
posterior knowledge of the nuisance parameters, we predict ranges for currently
unmeasured, optimized observables in the angular distributions of .Comment: 42 pages, 8 figures; v2: Using new lattice input for f_Bs,
considering Bs-mixing effects in BR[B_s->ll]. Main results and conclusion
unchanged, matches journal versio
Human Integrin α3ÎČ1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments
Toll-like receptor (TLR)-2/TLR1 heterodimers recognize bacterial lipopeptides and initiate the production of inflammatory mediators. Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-receptors function, are still being discovered.Using shRNA, blocking antibodies, and fluorescent microscopy, we show that U937 macrophage responses to the TLR2/1 ligand, Pam(3)CSK(4), are dependent upon an integrin, α(3)ÎČ(1). The mechanism for integrin α(3)ÎČ(1) involvement in TLR2/1 signaling is through its role in endocytosis of lipopeptides. Using inhibitors of endosomal acidification/maturation and physical tethering of the ligand, we show that the endocytosis of Pam(3)CSK(4) is necessary for the complete TLR2/1-mediated pro-inflammatory cytokine response. We also show that TLR2/1 signaling from the endosome results in the induction of different inflammatory mediators than TLR2/1 signaling from the plasma membrane.Here we identify integrin α(3)ÎČ(1) as a novel regulator for the recognition of bacterial lipopeptides. We demonstrate that induction of a specific subset of cytokines is dependent upon integrin α(3)ÎČ(1)-mediated endocytosis of the ligand. In addition, we address an ongoing controversy regarding endosomal recognition of bacterial lipopeptides by demonstrating that TLR2/1 signals from within endosomal compartments as well as the plasma membrane, and that downstream responses may differ depending upon receptor localization. We propose that the regulation of endosomal TLR2/1 signaling by integrin α(3)ÎČ(1) serves as a mechanism for modulating inflammatory responses
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Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles
Mesenchymal stromal cells (MSCs) are adult stem cells able to give rise to bone, cartilage and fat cells. In addition,
they possess immunomodulatory and immunosuppressive properties that are mainly mediated through secretion
of extracellular vesicles (EVs). In a previous issue of Journal of Translational Medicine, Ti and colleagues demonstrated
that preconditioning of MSCs with bacterial lipopolysaccharides results in secretion of EVs that can polarise macâ
rophages towards anti-inflammatory M2 phenotype. Moreover, the authors suggest that EVs of lipopolysaccharide
(LPS)-treated MSCs are superior to EVs of untreated MSCs concerning their ability to support wound healing. Our
commentary critically discusses parallel efforts of other laboratories to generate conditioned media from stem cells
for therapeutic applications, and highlights impact and significance of the study of Ti et al. Finally, we summarise its
limitations and spotlight areas that need to be addressed to better define the underlying molecular mechanisms
Search for rare quark-annihilation decays, B --> Ds(*) Phi
We report on searches for B- --> Ds- Phi and B- --> Ds*- Phi. In the context
of the Standard Model, these decays are expected to be highly suppressed since
they proceed through annihilation of the b and u-bar quarks in the B- meson.
Our results are based on 234 million Upsilon(4S) --> B Bbar decays collected
with the BABAR detector at SLAC. We find no evidence for these decays, and we
set Bayesian 90% confidence level upper limits on the branching fractions BF(B-
--> Ds- Phi) Ds*- Phi)<1.2x10^(-5). These results
are consistent with Standard Model expectations.Comment: 8 pages, 3 postscript figues, submitted to Phys. Rev. D (Rapid
Communications
Childhood emotional trauma and cyberbullying perpetration among emerging adults: a multiple mediation model of the role of problematic social media use and psychopathology
Research suggests that a small minority of social media users experience problems as a result of their online use. The purpose of the present study was to examine the association of cyberbullying perpetration and problematic social media use with childhood emotional trauma, Cluster B (narcissistic, histrionic, antisocial, and borderline) personality traits, dissociative experiences (DEs), depression, and self-esteem in a nonclinical undergraduate sample. A total of 344 university students volunteered to complete a questionnaire that included measures on the aforementioned dimensions. Thirty-eight percent of the participants had emotional neglect and 27% had emotional abuse, while 44% of them demonstrated at least one cyberbullying perpetration behavior. Results indicated that cyberbullying perpetrators had higher scores on problematic social media use, dissociative experiences, Cluster B traits, depression and childhood emotional trauma, and lower on self-esteem. Path analysis demonstrated that, while adjusting for gender and age, childhood emotional trauma was directly and indirectly associated with cyberbullying perpetration via Cluster B traits. Moreover, depression and dissociation were directly associated with problematic social media use. The findings of this study emphasize the important direct role of childhood emotional trauma and pathological personality traits on cyberbullying perpetration
Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis through the Induction of Tolerance
The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is essential for an effective activation of the immune response to this pathogen. The intracellular, cytosolic receptor Nod2 has been shown to play varying roles in either enhancing or attenuating inflammation in response to different infectious agents. We examined the role of Nod2 in responses to B. burgdorferi. In vitro stimulation of Nod2 deficient bone marrow derived macrophages (BMDM) resulted in decreased induction of multiple cytokines, interferons and interferon regulated genes compared with wild-type cells. However, B. burgdorferi infection of Nod2 deficient mice resulted in increased rather than decreased arthritis and carditis compared to control mice. We explored multiple potential mechanisms for the paradoxical response in in vivo versus in vitro systems and found that prolonged stimulation with a Nod2 ligand, muramyl dipeptide (MDP), resulted in tolerance to stimulation by B. burgdorferi. This tolerance was lost with stimulation of Nod2 deficient cells that cannot respond to MDP. Cytokine patterns in the tolerance model closely paralleled cytokine profiles in infected Nod2 deficient mice. We propose a model where Nod2 has an enhancing role in activating inflammation in early infection, but moderates inflammation after prolonged exposure to the organism through induction of tolerance
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
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