721 research outputs found
Development of an item bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT)
Development of an item bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT)
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain
Apolipoprotein E (APOE) is the major risk factor for sporadic Alzheimer's disease. Among other functions, APOE is proposed to sequester neurotoxic amyloid-{beta} (A{beta}) peptides in the brain, delivering them to cellular catabolism via neuronal APOE receptors. Still, the receptors involved in this process remain controversial. Here, we identified the pro-neurotrophin receptor sortilin as major endocytic pathway for clearance of APOE/A{beata} complexes in neurons. Sortilin binds APOE with high affinity. Lack of receptor expression in mice results in accumulation of APOE and of A{beta} in the brain and in aggravated plaque burden. Also, primary neurons lacking sortilin exhibit significantly impaired uptake of APOE/A{beta} complexes despite proper expression of other APOE receptors. Despite higher than normal brain APOE levels, sortilin-deficient animals display anomalies in brain lipid metabolism (e.g., accumulation of sulfatides) seen in APOE-deficient mice, indicating functional deficiency in cellular APOE uptake pathways. Together, our findings identified sortilin as an essential neuronal pathway for APOE-containing lipoproteins in vivo and suggest an intriguing link between A{beta} catabolism and pro-neurotrophin signaling converging on this receptor
Optimized loading of an optical dipole trap for the production of Chromium BECs
We report on a strategy to maximize the number of chromium atoms transferred
from a magneto-optical trap into an optical trap through accumulation in
metastable states via strong optical pumping. We analyse how the number of
atoms in a chromium Bose Einstein condensate can be raised by a proper handling
of the metastable state populations. Four laser diodes have been implemented to
address the four levels that are populated during the MOT phase. The individual
importance of each state is specified. To stabilize two of our laser diode, we
have developed a simple ultrastable passive reference cavity whose long term
stability is better than 1 MHz
Quantum Mechanics from Focusing and Symmetry
A foundation of quantum mechanics based on the concepts of focusing and
symmetry is proposed. Focusing is connected to c-variables - inaccessible
conceptually derived variables; several examples of such variables are given.
The focus is then on a maximal accessible parameter, a function of the common
c-variable. Symmetry is introduced via a group acting on the c-variable. From
this, the Hilbert space is constructed and state vectors and operators are
given a clear interpretation. The Born formula is proved from weak assumptions,
and from this the usual rules of quantum mechanics are derived. Several
paradoxes and other issues of quantum theory are discussed.Comment: 26 page
Measurement of the J/Psi Production Cross Section in 920 GeV/c Fixed-Target Proton-Nucleus Interactions
The mid-rapidity (dsigma_(pN)/dy at y=0) and total sigma_(pN) production
cross sections of J/Psi mesons are measured in proton-nucleus interactions.
Data collected by the HERA-B experiment in interactions of 920 GeV/c protons
with carbon, titanium and tungsten targets are used for this analysis. The
J/Psi mesons are reconstructed by their decay into lepton pairs. The total
production cross section obtained is sigma_(pN)(J/Psi) = 663 +- 74 +- 46
nb/nucleon. In addition, our result is compared with previous measurements
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
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