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Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
Adamoli L.
Addae-Boateng E.
Aderombi A.
Adeyeye A.
Adiamah A.
Adishesh M.
Agapov M.
Aggarwal A.
Aghayeva A.
Agilinko J.
Agnes A.
Agostini C.
Agoston P.
Agrawal A.
Agresta F.
Aguado H.
Aguilar Gonzalez M.
Aguzzoli L.
Ahad S.
Ahmadi N.
Ahmeidat A.
Ahn J. H.
Aiken T.
Aime A.
Ajlan A.
Akalin M.
Akaydin E.
Akeel N.
Akgor U.
Akhtar M. A.
Akhter Rahman M. M.
Akilli H.
Akin E.
Akkour K.
Akmenkalne L.
Al Abdallah M.
Al Awwad S.
Al Habes H.
Al Maadany F. S.
Al Raddadi R.
Al-Habib A.
Al-Habsi R.
Al-Ishaq Z.
Al-Khayal K.
Al-Masri M.
Al-Mohammad A.
Al-Mukhtar A.
Al-Najjar H.
Al-Omishy H.
Al-Sarireh B.
AL-Sayed M.
Al-Tamimi Y.
Alaa S.
AlAamer O.
Aladeojebi A.
Alam F.
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Alamri A.
Alanbuki A.
Alatar A.
Alawneh F.
Alazawi D.
Albertsmeier M.
Albi Martin B.
Alburakan A.
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Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

Author: Aawsaj Y.
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Abad-Motos A.
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Whelan P.
Whisker L.
Whitehall E.
Whitmore H.
Wilkin R.
Wilkins A.
Williams G.
Williams J.
Williams K.
Williams M. A.
Williams T.
Williamson K.
Wilson M.
Wimberger P.
Wimmer A.
Winnand P.
Winter D.
Winter S.
Wolfer S.
Wong M. P. K.
Wong S.
Wong W. J.
Woodham A.
Woodun H.
Worku D.
Wright G.
Wullschleger M.
Wustrack R.
Xenaki S.
Xu M. J.
Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

Author: Abdallah Elhassan
Abdullahi Shehu U.
Abdulqader Rula A.
Abdulrahaman Aminatu A.
Abouelnaga Sherif
Ademola-Popoola Dupe S.
Adio Adedayo
Afifi Mahmoud A.
Afshar Armin R.
Aggarwal Priyanka
Aghaji Ada E.
Ahmad Alia
Akib Indonesia Marliyanti N.R.
Akinsete Adeseye
Al Ani Mouroge H.
Al Harby Lamis
Al Mesfer Saleh
Al-Badri Safaa A.F.
Al-Dahmash Saad A.
Al-Haddad Christiane E.
Al-Hussaini Hamoud H.Y.
Al-Jadiry Mazin F.
Al-Janabi Allawi N. Hussein
Al-Jumaily Usama
Al-Mafrachi Ali A.R.M.
Al-Shaheen Athar A.S.M.
Al-Shammary Entissar H.
Alcasabas Ana Patricia A.
Aldana David Garcia
Alejos Amanda
Alemany-Rubio Ernesto
Alfa Bio Amadou I.
Ali Amany M.
Alia Donjeta B.
Alkatan Hind M.
All-Eriksson Charlotta
Almeida Argentino A.
Alsawidi Khalifa M.
Amankwaa-Frempong Doreen
Amiruddin Primawita O.
Anchaya Jacqueline Karina Vasquez
Armytasari Inggar
Astbury Nicholas J.
Atalay Hatice T.
Atchaneeyasakul La-ongsri
Atsiaya Rose
Autrata Rudolf
Balaguer Julia
Balayeva Ruhengiz
Barranco Honorio
Bartoszek Paulina
Bartuma Katarina
Bascaran Covadonga
Bechrakis Nikolaos E.
Begimkulova Ainura S.
Benmiloud Sarra
Berete Rokia C.
Berry Jesse L.
Bhaduri Anirban
Bhat Sunil
Bhattacharyya Arpita
Biewald Eva M.
Binkley Elaine
Blum Sharon
Bobrova Nadia
Boldt H.C.
Bonanomi Maria Teresa B.C.
Bouda Gabrielle C.
Bouguila Hedi
Bowman Richard
Bowman Richard
Brennan Rachel C.
Brichard Benedicte G.
Buaboonnam Jassada
Budiongo Aleine
Burton Matthew J.
Calderon-Sotelo Patricia
Calvo Jesus Peralta
Camuglia Jayne E.
Cano Miriam R.
Capra Michael
Carreras Yvania Alfonso
Caspi Shani
Cassoux Nathalie
Castela Guilherme
Castillo Luis
Catala-Mora Jaume
Cavieres Isabel
Chafla Edwin G. Villacis
Chandramohan Arthika
Chantada Guillermo L.
Chantada Guillermo L.
Chantada Guillermo L.
Chaudhry Shabana
Chawla Bhavna
Chen Wensi
Chiwanga Faraja S.
Chuluunbat Tsengelmaa
Cieslik Krzysztof
Clark Antony
Cockcroft Ruellyn L.
Comsa Codruta
Coronado Rosdali Y. Díaz
Corson Timothy W.
Couitchere Line
Cowan-Lyn Kristin E.
Csoka Monika
Dangboon Wantanee
Das Anirban
Das Pranab
Das Sima
Davanzo Jacquelyn M.
Davidson Alan
De Francesco Sonia
De Potter Patrick
Demirci Hakan
Desjardins Laurence
Dimaras Helen
Dod Charlotte Wolley
Dodgshun Andrew J.
Dragomir Monica D.
Du Bruyn Magritha
Du Plessis Johannes
Du Yi
Dudeja Gagan
Eerme Katrin
El Kettani Asmaa
Elbahi Amal M.
Elder James E.
Elhaddad Alaa M.
Elhassan Moawia M.A.
Elzembely M.
Ericksen Connor
Essuman Vera A.
Evina Ted Grimbert A.
Ezegwui Ifeoma R.
Fabian Ido Didi
Fabian Ido Didi
Fadoo Zehra
Fandiño Adriana C.
Faranoush Mohammad
Fasina Oluyemi
Fernandez Delia D.P.G.
Fernandez-Teijeiro Ana
Foster Allen
Frenkel Shahar
Fu Ligia D.
Fuentes-Alabi Soad L.
Garcia Juan L.
Geel Jennifer A.
Ghassemi Fariba
Giron Ana V.
Goenz Marco A.
Gold Aaron S.
Goldberg Hila
Gomel Nir
Gonzalez Efren
Gonzalez-Rodriguez Liudmira
Gopinathan Nair Akshay
Gorfine Malka
Graells Jaime
Gregersen Pernille A.
Grigorovski Nathalia D.A.K.
Groznik Alenka Lavric
Guedenon Koffi M.
Gunasekera D. Sanjeeva
Gupta Himika
Gupta Sanjiv
Gupta Vineeta
Gündüz Ahmet K.
Hadjistilianou Theodora
Hamel Patrick
Hamid Syed A.
Hamzah Norhafizah
Hansen Eric D.
Harbour William
Hartnett M. Elizabeth
Hasanreisoglu Murat
Hassan Muhammad
Hassan Sadiq
Hassan Shadab
Hautz Wojciech
Haydar Huda
Hederova Stanislava
Hessissen Laila
Hongeng Suradej
Hordofa Diriba F.
Hubbard G. Baker
Hummelen Marlies
Husakova Kristina
Ibanga Affiong
Ida Russo
Ilic Vesna R.
Islamia Ispahani
Islamov Ziyavuddin
Jairaj Vivekaraj
Jara Doris A. Calle
Jeeva Irfan
Ji Xunda
Jo Dong Hyun
Jones Michael M.
Kabesha Amani Theophile B.
Kabore Rolande L.
Kaliki Swathi
Kalinaki Abubakar
Kamsang Pius
Kapelushnik Noa
Kardava Tamar
Kebudi Rejin
Keomisy Jonny
Kepak Tomas
Ketteler Petra
Khan Zohora
Khaqan Hussain A.
Khetan Vikas
Khodabande Alireza
Khotenashvili Zaza
Kim Jeong Hun
Kim Jonathan W.
Kiratli Hayyam
Kivela Tero T.
Klett Artur
Kosh Komba Palet Jess Elio
Ko~ Irem
Krivaitiene Dalia
Kruger Mariana
Kulvichit Kittisak
Kuntorini Mayasari W.
Kyara Alice
Lam Geoffrey C.
Larson Scott A.
Latinovic Slobodanka
Laurenti Kelly D.
Lavy Yotam
Leiva Fanny F. Tarrillo
Leverant Amy A.
Li Cairui
Li Kaijun
Limbu Ben
Liu Chun-Hsiu
Llano Maria G. Correa
Lopez Arturo M. Zapata
Lopez Juan P.
Lukamba Robert M.
Luna-Fineman Sandra
Lutfi Delfitri
Lysytsia Lesia
Macedo Carla R. Donato
Madgar Shiran
Magrath George N.
Mahajan Amita
Maitra Puja
Maka Erika
Makimbetov Emil K.
Maktabi Azza
Maldonado Carlos
Mallipatna Ashwin
Manudhane Rebecca
Manzhuova Lyazat
Martin-Begue Nieves
Masud Sidra
Matende Ibrahim O.
Mattosinho Clarissa C.D.S.
Matua Marchelo
Mayet Ismail
Mbumba Freddy B.
McKenzie John D.
Mehrvar Azim
Mengesha Aemero A.
Menon Vikas
Mercado Gary John V.
Mets Marilyn B.
Midena Edoardo
Midena Edoardo
Miller Audra
Mishra Divyansh K.C.
Mndeme Furahini G.
Mohamedani Ahmed A.
Mohammad Mona T.
Moll Annette C.
Montero Margarita M.
Morales Claudia R. Pascual
Moreira Claude
Mruthyunjaya Prithvi
Msina Mchikirwa S.
Msukwa Gerald
Mudaliar Sangeeta S.
Muma Kangwa I.M.
Munier Francis L.
Murray Timothy G.
Musa Kareem O.
Mushtaq Asma
Musika Anne A.
Mustak Hamzah
Mustapha Tajudeen
Muyen Okwen M.
Myezo Khumo H.
Naidu Gita
Naidu Natasha
Nair Akshay Gopinathan
Natarajan Sundaram
Naumenko Larisa
Nency Yetty M.
Neroev Vladimir
Ng Yvonne
Nikitovic Marina
Nkanga Elizabeth D.
Nkumbe Henry E.
Numbi Marcel N.
Nummi Kalle
Nuruddin Murtuza
Nyaywa Mutale
Nyirenda Chinsisi
Obono-Obiang Ghislaine
Oliver Scott C .
Oporto Joaquin
Orozco Alma Janeth Sanchez
Ortega-Hernández Miriam
Oscar Alexander H.
Ossandon Diego
Pacheco Henry N. Garcia
Pacheco Sonsoles San Roman
Paintsil Vivian
Paiva Luisa
Palanivelu Mahesh Shanmugam
Papyan Ruzanna
Parrozzani Raffaele
Paton Katherine E.
Perez Graciela Gonzalez
Peric Sanja
Pe’er Jacob
Pham Chau T.M.
Philbert Remezo
Plager David A.
Pochop Pavel
Polania Rodrigo A.
Polyakov Vladimir
Pompe Manca Tekavcic
Ponce Jimena
Popovic Maja Beck
Portabella Silvia Alarcon
Qadir Ali O.
Qayyum Seema
Qian Jiang
Quah BoonLong
Quintero D Karina
Rahman Ardizal
Rajkarnikar Purnima
Ramanjulu Rajesh
Ramasubramanian Aparna
Ramirez-Ortiz Marco A.
Randhawa Jasmeen K.
Randrianarisoa Hoby Lalaina
Raobela Lea
Rashid Riffat
Reddy M. Ashwin
Refaeli David
Renner Lorna A.
Reynders David
Ribadu Dahiru
Ritter-Sovinz Petra
Rogowska Anna
Rojanaporn Duangnate
Romero Livia
Roth Paule Aida Ndoye
Roy Soma R.
Saab Raya H.
Saakyan Svetlana
Sabhan Ahmed H.
Sagoo Mandeep S.
Said Azza M.A.
Saiju Rohit
Salas Beatriz
Sanchez Gissela L.
Sayalith Phayvanh
Scanlan Trish A.
Schluter Sabrina
Schwab Christoph
Sedaghat Ahad
Seth Rachna
Sgroi Mariana
Shah Ankoor S.
Shakoor Shawkat A.
Sharma Manoj K.
Sherief Sadik T.
Shields Carol L.
Sia David
Siddiqui Sorath Noorani
Sidi cheikh Sidi
Silva Sonia
Singh Arun D.
Singh Usha
Singha Penny
Sitorus Rita S.
Skalet Alison H.
Soebagjo Hendrian D.
Sorochynska Tetyana
Ssali Grace
Stacey Andrew W.
Staffieri Sandra E.
Stahl Erin D.
Steinberg David M.
Stones David K.
Strahlendorf Caron
Suarez Maria Estela Coleoni
Sultana Sadia
Sun Xiantao
Superstein Rosanne
Supriyadi Eddy
Surukrattanaskul Supawan
Sutyawan I. Wayan Eka
Suzuki Shigenobu
Svojgr Karel
Sylla Fatoumata
Tamamyan Gevorg
Tan Deborah
Tandili Alketa
Tang Jing
Tashvighi Maryam
Tateshi Bekim
Teh Kok Hoi
Tehuteru Edi S.
Teixeira Luiz F.
Thawaba Abdullah Dahan M.
Theophile Tuyisabe
Toledano Helen
Trang Doan L.
Traore Fousseyni
Tripathy Devjyoti
Tuncer Samuray
Tyau-Tyau Harba
Umar Ali B.
Unal Emel
Uner Ogul E.
Urbak Steen F.
Ushakova Tatiana L.
Usmanov Rustam H.
Valeina Sandra
Valente Paola
Van Hoefen Wijsard Milo
Vaughan Leon O.
Veleva-Krasteva Nevyana V.
Verma Nishant
Victor Andi A.
Viksnins Maris
Villegas Victor M.
Vishnevskia-Dai Victoria
Waddell Keith
Wali Amina H.
Wang Yi-Zhuo
Wangtiraumnuay Nutsuchar
Wetter Julie
Widiarti Widiarti
Wilson Matthew W.
Wime Amelia D.C.
Wiwatwongwana Atchareeya
Wiwatwongwana Damrong
Wong Emily S.
Wongwai Phanthipha
Wu Si-qi
Xiang Daoman
Xiao Yishuang
Xu Bing
Xue Kang
Yaghy Antonio
Yam Jason C.
Yang Huasheng
Yanga Jenny M.
Yarovaya Vera A.
Yarovoy Andrey A.
Ye Huijing
Yee Roberto I.
Yousef Yacoub A.
Yuliawati Putu
Zein Ekhtelbenina
Zhang Yi
Zhilyaeva Katsiaryna
Zia Nida
Ziko Othman A.O.
Zondervan Marcia
Publication venue: Elsevier
Publication date: 23/08/2022
Field of study

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

UPSpace at the University of Pretoria

Glycan processing in gut microbiomes

Author: Eijsink VG
La Rosa SL
Larsbrink J
Lowe EC
Martens EC
McKee LS
Ostrowski MP
Pope PB
Vera-Ponce de Leon A
Publication venue: Elsevier Ltd
Publication date
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Newcastle University E-Prints

Consistency Analysis of Genome-Scale Models of Bacterial Metabolism: A Metamodel Approach

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The diversity of symbiotic systems in scale insects

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Jagiellonian Univeristy Repository

Genomic evidence for the Pleistocene and recent population history of Native Americans

Author: Albrechtsen A.
Albrechtsen M
Allentoft M.
Archer David
Arriaza Bernardo
Avila-Arcos M.
Balanovska E.
Balanovska M
Balanovsky M
Balanovsky O.
Balloux François
Bergstrom A.
Bergström Anders
Bogunov M
Bogunov Y.
Bustamante Carlos,
Campos Paul
Cornejo Omar
Crawford Michael
Cybulski Jerome
Damgaard P.
Davis Loren
de Barros Damgaard Peter
Deal John
Deal M.
Degiorgio Michael
Derenko M.
Durbin Richard
Eriksson Anders
Fedorova M
Fedorova S.
Friend Andrew
Fuller M
Fuller T.
Goebel Ted
Grimes John
Grimes V.
Gubina M.
Guidon M
Guidon N.
Harris K.
Harris M
Henrickson Celeste
Heyer E.
Heyer M
Homburger J.
Homburger M
Jakobsson Mattias
Johnson John
Karmin M.
Kemp Brian,
Kemp M.
Khusnutdinova E.
Khusnutdinova M
Kivisild Toomas
Korneliussen M
Korneliussen S.
Lavryashina M.
Leboreiro I.
Leboreiro M
Lindo John
Litvinov Sergey
Luiselli Donata
Luz M.
Malaspinas M
Malaspinas S.
Malhi Ripan
Malhi S.
Malmstrom H.
Malmström M
Malyarchuk B.
Malyarchuk M
Manica Andrea
Mansilla J.
Mansilla M
Meltzer David
Meltzer J.
Metspalu E.
Metspalu M.
Mitchell Joycelynn
Moltke I.
Moltke M
Moreno-Estrada A.
Moreno-Estrada M
Moreno-Mayar J.
Moreno-Mayar M
Mosher M.
Nielsen Rasmus
Norman J.
Norman Paul
Osipova Ludmila
Parham Peter
Pettener David
Petzelt Barbara
Pierre M
Pierre T.
Pike John
Pike K.
Ponce de Leon M.
Ponce de León M
Posukh Olga
Raghavan M.
Rangel-Villalobos H.
Rangel-Villalobos M
Rasmussen M.
Rasmussen Rasmus
Rasmussen S.
Ricaut F.
Ricaut M
Rodriguez-Varela R.
Rodríguez-Varela Carlos
Sandhu Manjinder,
Schiffels Stephan
Seguin-Orlando A.
Seguin-Orlando M
Shringarpure M
Shringarpure S.
Singarayer J.
Singarayer M
Smith Chris
Smith David
Smith M
Song S.
Song Yun
Stafford M
Stafford T.
Standen Vivien
Steinrucken M.
Steinrücken M
Tambets Kristiina
Valdes Paul
Valdiosera C.
Valdiosera M
Vera J.
Vera M
Vera Vera
Villems Richard
Voevoda M.
Wall Jeff
Warmuth V.
Waters Michael
Willerslev Eske
Worl Rosita
Xue Yali
Zollikofer Chris
Ávila-Arcos M
Publication venue
Publication date: 01/01/2015
Field of study

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we find that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (KYA), and after no more than 8,000-year isolation period in Beringia. Following their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 KYA, one that is now dispersed across North and South America and the other is restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative ‘Paleoamerican’ relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model

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Central Archive at the University of Reading

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eScholarship - University of California

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

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COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms

Author: Agatha Treveil
Akira Funahashi
Alberto Valdeolivas
Alexander R Pico
Alexander Mazein
Alfonso Valencia
Alina Renz
Anastasia Nesterova
Anders Riutta
Andrea Senff Ribeiro
Andreas Dräger
Andreas Ruepp
Angela Bauch
Anita de Waard
Anna Niarakis
Anton Yuryev
Arnau Montagud
Augustin Luna
Aurelio Orta‐Resendiz
Aurélien Dugourd
Aurélien Naldi
Barbara Brauner
Benjamin M Gyori
Bertrand De Meulder
Bhanwar Lal Puniya
Bijay Jassal
Carlos Vega
Carole Goble
Charles Auffray
Chris T Evelo
Chris Sander
Corinna Montrone
Cristoffer Sevilla
Daniela Börnigen
Denes Turei
Denise Slenter
Devasahayam Arokia Balaya Rex
Dezso Modos
Dieter Maier
Ebru Kocakaya
Egon L Wilighagen
Emek Demir
Emily E Ackerman
Emmanuel Barillot
Enrico Glaab
Ewa Smula
Falk Schreiber
Francesca Sacco
Francesco Messina
Franck Augé
Friederike Ehrhart
Gisela Fobo
Goar Frishman
Guanming Wu
Gökçe Yağmur Summak
Hanna Borlinghaus
Henning Hermjakob
Hiroaki Kitano
Inna Kuperstein
Jacques S Beckmann
Jakob Vanhoefer
Jan Hasenauer
Jason E Shoemaker
Jean‐Marie Ravel
Jeremy Teuton
Jeremy Zucker
Joaquin Dopazo
John A Bachman
Julia Scheel
Julia Somers
Julio Saez‐Rodriguez
Karen Rothfels
Kinza Rian
Kristie Oxford
Kristina Hanspers
Lars Eijssen
Laurence Calzone
Laurent Heirendt
Leonard Schmiester
Liam Fergusson
Lincoln D Stein
Lisa Matthews
Luana Licata
Luis Cristóbal Monraz Gómez
Marc E Gillespie
Marcio Luis Acencio
Marek Ostaszewski
Maria Peña‐Chilet
Marija Orlic‐Milacic
Marina Esteban‐Medina
Marius Rameil
Marta Conti
Marta Iannuccelli
Martin Golebiewski
Martina Kutmon
Marton Olbei
Marvin Martens
Matti Hoch
Miguel Ponce de Leon
Miguel Vazquez
Muhammad Naveez
Muying Wang
Nhung Pham
Noriko Hiroi
Olaf Wolkenhauer
Ozgun Babur
Pablo Porras
Peter D'Eustachio
Piotr Gawron
Ralf Stephan
Reinhard Schneider
Robert Phair
Robin Haw
Rudi Balling
Rupert W Overall
Rupsha Fraser
Sara Sadat Aghamiri
Shailendra Kumar Gupta
Silvia Marchesi
Stephane Ballereau
Stuart Owen
Susan Coort
Sylvain Soliman
Takahiro G Yamada
Tamas Korcsmaros
Thawfeek Varusai
Tobias Czauderna
Tom C Freeman
Tomáš Helikar
Valentin Grouès
Vanessa Nakonecnij
Venkata Satagopam
Vera Ortseifen
Veronica Shamovsky
Vidisha Singh
Vincent Noël
Xiaoming Hu
Yusuke Hiki
Zsolt Bocskei
Publication venue: 'EMBO'
Publication date: 01/01/2021
Field of study

We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective

Institutional Repositories DataBase (IRDB)

ART

Delaying surgery for patients with a previous SARS-CoV-2 infection

Author: A A Ali Karar
A A Kerawala
A A Marra
A Abad Gurumeta
A Abad-Motos
A Abdelmajeed
A Abdelrahman
A Abdelsamed
A Abdulkareem
A Aboelkassem Ibrahim
A Abouassi
A Abreu da Silva
A Abubakar
A Acher
A Aderombi
A Adeyeye
A Adiamah
A Aggarwal
A Aghayeva
A Agnes
A Agrawal
A Ahmeidat
A Aimé
A Ajlan
A Al-Habib
A Al-Mohammad
A Al-Mukhtar
A Aladeojebi
A Alamri
A Alanbuki
A Alatar
A Alburakan
A Alfaro-Goldaracena
A Alhamed
A Alhefdhi
A Almeciga
A Almeida
A Alomair
A Alonso Poza
A Alsaif
A Anastasi
A Antic
A Anzak
A Aprile
A Arminio
A Arulanantham
A Askari
A Asqalan
A Athanasiou
A Ayhan
A Ayman
A Ayubi
A Azizi
A B Martins
A Bacon
A Baker
A Balakrishnan
A Bandiera
A Banerjee
A Barrabe
A Beamish
A Bellacci
A Belli
A Belvedere
A Benkabbou
A Bhalla
A Bhangu
A Billè
A Bin Nasser
A Biondi
A Blatt
A Blazquez Martin
A Boddy
A Bokhari
A Bondurri
A Boulton
A Boutall
A Branquinho
A Brunelli
A Brunt
A Bruscino
A Budacan
A Burahee
A Böttcher
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A C Deus
A C Roslani
A C Soares
A C Vieira Paiva Lopes
A Caiado
A Camillo
A Canas-Martinez
A Cano
A Carabias
A Chandock
A Charalabopoulos
A Che Jusoh
A Chebaro
A Chessa
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A Chitul
A Choudhry
A Chowdhury
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A Cordova
A Costanzi
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Antonio Ramos-De la Medina
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Arnav Agarwal
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Bandara Gbk
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EuroSurg
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F Noll
F Notte
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F Petraglia
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F Policarpo
F Popovic
F R Pruvot
F Rasoaherinomenjanahary
F Raspagliesi
F Rodriguez-Covarrubias
F Rosa
F Ruggiero
F S Al Maadany
F S Ledesma
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F Sauvat
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F Sorbi
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F Tirotta
F Toia
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Fabio Tirotta
Faith Robertson
Faris Ayasra
Faustin Ntirenganya
Felix Alakaloko
Ferrari F
Francesco Pata
Franco Servadei
G A Beltramini
G A Buerba
G Alemanno
G Alkadeeki
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Giana H Davidson
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Grant D Stewart
Grant D Stewart
Gustavo Grecinos
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H A Dincer
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Haytham Ma Kaafarani
Helen M Mohan
I A Aneke
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J A Benavides Buleje
J A Elliott
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J A Martínez Alonso
J A Posada
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J A Tan
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J Y Soh
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J Á González García
J Žatecký
Jagdeep K Singh
Jalid Sehouli
James C Glasbey
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James C Glasbey
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Janet Martin
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Jonathan P Evans
Joshua Burke
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K Akkour
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K Ang
K Angelou
K Antoniades
K Bagraith
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K Beatson
K Beyer
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K Brown
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K Gash
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K Gözal
K H Hamdan
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K Hassell
K Hirose
K Huynh
K Ishiyama
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K Shah
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Kacimi Oussama
Karl Schaller
Keiiji Fujiwara
Keith Roberts
Keith Roberts
Kenneth A McLean
Kerry A Breen
Kjetil Soreide
Knut Magne Augestad
Ko Kyk
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Kwabena Siaw-Acheampong
L A Reyes Figueroa
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L Vitone
L Webber
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Laura Lippa
Lee Rxn
Liao Ccl
Luis Chiva
M A Akhtar
M A Boeck
M A Bozkurt
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M A Hernandez Bartolome
M A Huertas Fernandez
M A Nageh
M A Onan
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M A Steiner
M A Williams
M Abdalla
M Abdallah
M Abdelkarim
M Abdou
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M Adamina
M Adishesh
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M Akalin
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M Arigoni
M Assaf
M Azam
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M Bordenave
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M Buta
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M Casati
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M Chand
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M Claro
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M E Elsayed Hewalla
M Edmond
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M Estaire Gómez
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M F Chowdhry
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M F Ho
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M Fahim
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M Fenton
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M Ferrari
M Figari
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M Franza
M Frasson
M G Azizeldine
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M Guaglio
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M Hague
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M Hernández-García
M Herrero Lopez
M Ho
M Hollyman
M I Antonopoulou
M I Bhatti
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M Ibrahim
M Idle
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M J Amaral
M J Battista
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M J Xu
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M Jones
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M Kumar
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M Lanner
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M Lee
M Lidsky
M Lim
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M Loubani
M M Abdelkarem
M M Akhter Rahman
M M Carvello
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M M Rashid
M M Saad
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M Mohammed
M Mohan
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M Monteleone
M Morgom
M Mourad
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M N Ringressi
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M Ng
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M O'Shea
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M Quante
M R Alvarez
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M Ragab
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M Read
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M Rodrigues
M Romano
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M Ruiz Soriano
M Ruiz-Marín
M Rutegård
M Ryan
M S Babar
M S Elqasabi
M S Qatora
M S Santero-Ramirez
M S Uyanik
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M Sait
M Salah
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M Salem
M Salvati
M Santas
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M Shackcloth
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M Sherief
M Silva
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M Sparavigna
M Sund
M Szpytma
M Sánchez-Rubio
M T González-Nicolás Trébol
M T Hasan
M T Montella
M T Subhi
M Taffurelli
M Taggarsi
M Tagliabue
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M Teves
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M Thomas
M Thornhill
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M Tolani
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M Tuveri
M Umair
M Umar
M Uno
M Usandivaras
M V Simón Sanz
M V Sosa
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M Van Heinsbergen
M Varma
M Vatish
M Velidedeoglu
M Venn
M Vilatoba
M Von Papen
M W Hii
M W Löffler
M Waris Farooka
M Whelan
M Wilson
M Wullschleger
M Y Oudrhiri
M Youssef
M Zambon
M Zegarac
M Zelić
M Zese
M Zivanovic
M Zivkovic
M Zizzo
M Á Mercado
M Ângelo
Madalegna Gründl
Mak Jkc
Mak Twc
Malin Sund
Marco Fiore
Marco Fiore
Marco Fiore
Maria Aguilera Lorena
Maria Marta Madolo
Maria Picciochi
Maricarmen Olivos
Marie Dione Parreno-Sacdalanm
Markus Albertsmeiers
Markus W Löffler
Martin Batstone
Martin Rutegård
Mary L Venn
Max Almond
Mayaba Maimbo
Mdc De Miguel Ardevines
Mfi De La Cruz Monroy
Michael D Jenkinson
Michael D Jenkinson
Michael Ho
Michel Adamina
Miguel F Cunha
Milagros Niquen
Mohammad Chaar
Moises Cukier
Muhammad Alshaar
Muhammed Elhadi
Murat Gutelkin
N Abbassi-Ghadi
N Ahmadi
N Akeel
N Alam
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N Beasley
N Beech
N Borges
N Burnside
N Caminsky
N Campain
N Cardoso
N Chavarrias
N Cirocchi
N Dafnios
N Danias
N Dawe
N Depalma
N Donlon
N Dunne
N E Abosamak
N Eardley
N Egoroff
N Elabbadi
N Elson
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Naomi Wright
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O Alaamer
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Tabassum Khan
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Thomas D Pinkney
Thomas Konney
Thomas M Drake
Tobias Klatte
Tom Ef Abbott
U Akgor
U Andaleeb
U Bork
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X De Sousa
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Y Aawsaj
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Z Seymour
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Á De la Hoz Rodríguez
Á Fernández Camuñas
É Ryan
Ž Grubač
А Камалов
Publication venue: 'Wiley'
Publication date: 01/01/2020
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Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Author: Aawsaj Y
Abad Gurumeta A
Abad-Motos A
Abate E
Abatini C
Abbadessa F
Abbas AM
Abbassi-Ghadi N
Abbott D
Abbott T
Abbott TEF
Abd Elazeem HAS
Abdalla M
Abdallah M
Abdelaal SA
Abdeldayem H
Abdelkarem MM
Abdelkarim M
Abdelmajeed A
Abdelrahman A
Abdelrahman S
Abdelsamed A
Abdou M
Abdulkareem A
Abdulwahed E
Abdur-Rahman L
Abel MK
Abellan M
Abosamak NE
Abou Chaar MK
Abou-Khalil J
Abouassi A
Aboulkassem H
Abreu da Silva A
Abu Za'nouneh FJ
Abu J
Abu-Nayla I
Abubakar A
Abukhalaf S
Acebes Garcia F
Achalandabaso Boira M
Acher A
Acrich E
Adamina M
Adamina M
Adamoli L
Addae-Boateng E
Ademuyiwa AO
Aderombi A
Adeyeye A
Adiamah A
Adishesh M
Agapov M
Agarwal A
Aggarwal A
Aghayeva A
Agilinko J
Agnes A
Agostini C
Agoston P
Agrawal A
Agresta F
Aguado H
Aguzzoli L
Ahad S
Ahmadi N
Ahmed NR
Ahmeidat A
Ahn JH
Aiken T
Aime A
Ajlan A
Akalin M
Akaydin E
Akeel N
Akgor U
Akhtar MA
Akilli H
Akin E
Akkour K
Akkulak M
Akmenkalne L
Al Abdallah M
Al Abdel S
Al Awwad S
Al Habes H
Al Maadany FS
Al Raddadi R
AL Sayed M
Al-Habib A
Al-Habsi R
Al-Ishaq Z
Al-Khayal K
Al-Masri M
Al-Mohammad A
Al-mukhtar A
Al-Najjar H
Al-omishy H
Al-Sarireh B
Al-Tamimi Y
Alaa S
AlAamer O
Aladeojebi A
Alakaloko F
Alam F
Alam N
Alam R
Alameer E
Alamri A
Alamri A
Alanbuki A
Alatar A
Alawneh F
Alazawi D
Albertsmeier M
Albertsmeiers M
Albi Martin B
Alburakan A
Alcaide Matas F
Alconchel F
Aldayri Z
Aldecoa Ansorregui I
Alderson D
Aldokali N
Aleksic L
Alemanno G
Alexoudi V
Alfaro-Goldaracena A
Alfieri S
Alga A
Alghamdi M
Alhalal H
Alhamed A
Alharthi M
Alharthi R
Alhassan B
Alhassan N
Alhefdhi A
Ali AK
Ali M
Ali MF
Ali S
Aliyeva Z
Aljanadi F
Aljiffry M
Alkadeeki GZ
Alkarak S
Allemand C
Allison J
Almalik O
Almasri M
Almeciga A
Almeida A
Almeida AC
Almeida JI
Almgla N
Almond M
Almond M
Alnumani T
Alobeed O
Alomair A
Alonso de la Fuente N
Alonso Poza A
Alonso-Lamberti L
Alotaibi N
Alqannas M
Alresaini F
Alriyees L
Alsaif A
Alsaif F
Alsalamah R
Alsaraireh O
Alselaim N
Alser O
Alshaar M
Alshahrani M
Alshammari S
Alshareea E
Alsharif F
Alshaygy I
Alshryda S
Alsobhi S
Althobaiti W
Altintoprak F
Alurralde C
Alvarez E
Alvarez MR
Alyami M
Alzamanan M
Amaral MJ
Ameerally P
Amira G
Amonkar S
Amorim E
Ampollini L
Amrani L
Anania G
Anastasi A
Anchuelo Latorre J
Andaleeb U
Andaya V
Andrade AK
Andrade R
Andrijasevic S
Aneke IA
Ang K
Angele M
Angelo M
Angelou D
Angelou K
Annamalai S
Annessi V
Ansarin M
Anthoulakis C
Antic A
Antic S
Antonakis P
Antoniades K
Antonopoulou MI
Anula R
Anwar S
Anzak A
Aoun S
Aprile A
Aquila F
Aragon Achig EJ
Aremu I
Aremu M
Aresu G
Aribi N
Aribi S
Arican C
Arif T
Arigoni M
Arikan AE
Arkadopoulos N
Arkha Y
Armao T
Armatura G
Arminio A
Arnaud AP
Arrangoiz R
Arrowsmith L
Artigues E
Arulanantham A
Asaad P
Ascensao J
Ashcroft J
Ashmore C
Ashoush F
ASiT AS
Askari A
Asqalan A
Assaf M
Assalaarachchi H
Asti E
Astreidis I
Athanasakis E
Athanasiou A
Athayde Nemesio R
Atherton R
Athwal R
Atici DS
Atta R
Attia D
Augestad KM
Australasian T
Avci EK
Avlund T
Awad S
Ayasra F
Ayasra F
Ayasra Y
Aydin C
Ayhan A
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Buarque IL
Budacan A
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Cagigal Ortega EP
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Caja Vivancos P
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Cano A
Cano-Valderrama O
Canonico G
Canotilho R
Cantalejo Diaz M
Cao H
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Capitan-Morales L
Capizzi V
Capoglu R
Capolupo GT
Carabias A
Caram EL
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Cardoso P
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Carrano FM
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Caruana EJ
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Castillejos-Molina RA
Catala Bauset JC
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Cavalle Busquets P
Cayetano Paniagua L
Cazador Labat M
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Cecire J
Celebi F
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Cenciarelli S
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Ceretti PA
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Cervera I
Ceyhan GO
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Chai AKW
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Chakrabortee S
Challacombe B
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Chia Z
Chiappini A
Chiarella V
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Chidambaram S
Chiesa-Estomba CM
Chiozza M
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Choong P
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Chowdhury A
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Christensen P
Christidis P
Christoforidis D
Christou C
Chrysos E
Chu F
Chumbinho B
Chung E
Cianflocca D
Ciccarone F
Cicerchia PM
Cimenoglu B
Cintas Catena J
Cioffi SPB
Ciofic E
Cipriani R
Cirillo B
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Cisternino G
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Clifford R
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Coffey JC
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Colombari RC
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Colquhoun A
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Comini LV
Conesa A
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Connelly T
Connolly EM
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Coonar AS
Cope D
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Correia de Sa T
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Corte Real J
Corvera C
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Cosimelli M
Cossu ML
Costa Santos D
Costa M
Costa MJMA
Costanzi A
Costeira B
Costigan F
Cotoia A
Cotsoglou C
Cotte E
Cotter A
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Coughlin P
Cox D
Coza I
Cozza V
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Cribb G
Crichton A
Cristian D
Cros B
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Cuadrado-Garcia A
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Cullinane C
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D'Amore A
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D'Angelo G
D'Ugo D
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D'Urso A
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Daiko H
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Dakpe S
Daliya P
Daly A
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Daniels I
Davidson B
Davidson GH
Davies A
Davies E
Davies E
Davies RJ
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Dawson BE
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De Andres Olabarria U
De Barros J
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De la Hoz Rodriguez A
De la Rosa Abaroa MA
De Lacy FB
De Miguel Ardevines MDC
De Nardi P
De Oliveira Lopez AL
De Pablo Garcia-Cuenca A
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De Pastena M
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De Simone V
de Solorzano Aurusa OFJ
De Sousa X
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De Virgilio A
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Del Valle E
Delgado Fernandez J
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Delimpalta C
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Di Bella A
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Di Chiara F
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Di Giuseppe M
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Di Somma A
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Diamantis A
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Diaz Del Gobbo R
Diaz Pena P
Diaz Perez D
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Domingues JC
Dominguez I
Dominguez-Rosado I
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Duran-Valles F
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Edwards JG
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Egbuchulem IK
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El Ahmadi B
El Bouazizi Y
El Ouahabi A
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Elawad A
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Elbe P
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Elena GDCR
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Elghazaly MS
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Elkhayat H
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Espino Segura-Illa M
Espinosa CA
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Esteban Sinovas O
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Eveno C
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Feo CF
Feo CV
Fernandes U
Fernandes V
Fernandez Bernabe P
Fernandez Camunas A
Fernandez Pablos FJ
Fernandez Rodriguez P
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Fernandez PV
Fernandez-Lopez A
Fernando D
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Ferraz I
Ferreira Pinto AP
Ferreira C
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Figari M
Figueiredo de Barros I
Findlay L
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Fiore M
Fiore M
Fiore M
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Fitzgerald C
Fitzgerald JE
Fitzjohn H
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Frena A
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Fritzmann J
Frongia F
Fruscio R
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Garcia Escudero D
Garcia Gutierrez JJ
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Garcia Pineda V
Garcia Porcel VJ
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Garcia Santos EP
Garcia Senorans PM
Garcia Septiem J
Garcia Soria V
Garcia Villayzan JE
Garcia JS
Garcia PM
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Garcia-Quijada J
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Gata V
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Gavalda Pellice MGP
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Gerchunoff JI
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Ghebre R
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Gialamas E
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Ginesu GC
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Giuliani G
Gkekas I
Gklavas A
Gkrinia E
Glasbey JC
Glasbey JC
Glasbey JC
Glasbey JC
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Glencer A
GlobalPaedSurg
GlobalSurg
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Gomes GMA
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Gomez Diaz CJ
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Gomez Latorre L
Gomez Portugal PE
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Gomez Sanz T
Gomez P
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Gomez-Rosado J
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Gonzalez Valverde FM
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Gonzalez J
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Gonzalez-Nicolas Trebol MT
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Gracia I
Gracia M
Gracia-Roche C
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Grama F
Granata V
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Grassi T
Grau-Talens EJ
Graystone J
Grechenig M
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Gricks B
Grieco C
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Griffiths E
Griffiths EA
Griffiths EA
Griffiths O
Grigoroiu M
Grilo JV
Grimaldi DMS
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Guariglia CA
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Guerra GR
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Publication venue: Br J Surg
Publication date: 11/11/2020
Field of study

BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas

Ezid

Crossref

AIR Universita degli studi di Milano

UCL Discovery

eScholarship - University of California

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Apollo (Cambridge)

Bern Open Repository and Information System (BORIS)

Queen Mary Research Online

White Rose Research Online

Archivio istituzionale della ricerca - Università di Palermo