A Ripple-Turned-Tidal Wave: \u3cem\u3eSEC v. Ripple Labs\u3c/em\u3e as an Inflection Point in the Regulatory Approach to Innovation in Complex Systems

This Comment makes both an observation and an argument about the SEC v. Ripple Labs, Inc. litigation. First, this Comment observes that the facts of the case constitute a challenge to the lack of clarity surrounding the current regulatory regime governing blockchains and initial coin offerings (ICOs). Second, this Comment argues that the Ripple case provides regulators an opportunity to, if they choose, use complexity theory to address technological innovation—such as blockchain—as an emergent phenomenon in a complex system rather than as a binary policy choice to be either encouraged or discouraged. Ripple, the U.S. company behind one of the world’s largest crypto assets by capitalization, deployed a blockchain network designed to remove the traditional friction points of intermediation and settlement from money transfer systems. To obtain widespread adoption of its crypto asset, XRP, both Ripple and its executives sold XRP to speculators and professional investors, but more than five years later—and following a rash of enforcement actions against other blockchain companies—the U.S. Security and Exchange Commission (SEC) brought Ripple and its executives into federal court for allegedly violating U.S. securities laws. The lawsuit is unique because it was not only brought against the company and personnel behind one of the most successful iterations of a novel technology, but effectively, it was brought against a widely held cryptocurrency at a time when pandemic- driven economic and social pressure and billions of dollars in main-street investment in new blockchain technologies was occurring in the wider U.S. economy. But as important as the result of the case is, this Comment suggests that the long view of the case’s impact should be understood through the lens of complexity theory: regulators should, in cases of innovative technology, use this discipline to see the case as both an emergent phenomenon and a point in the trajectory of the larger U.S. economy where innovation and consumer protection are not binary, opposed considerations. To flesh this out, this Comment offers a broad, high-level overview informed by complexity science of the basic operation and recent history of blockchain technology and ICOs as well as the economic forces at work in the U.S. and an explanation of Ripple’s use case. This Comment then will turn to the regulatory history between the SEC and Ripple and analyze the merits of the investment contract approach necessary for SEC jurisdiction. Understanding the history, the parties, and the litigation as parts of a complex system, this Comment concludes by listing several expert suggestions regarding blockchain technologies consistent with obtaining short term stability that the court can take up in dealing with the facts of the case in the light of existing precedent

Jung and Deleuze: Enchanted Openings to the Other: A Philosophical Contribution

This paper draws from resources in the work of Deleuze to critically examine the notion of organicism and holistic relations that appear in historical forerunners that Jung identifies in his work on synchronicity. I interpret evidence in Jung's comments on synchronicity that resonate with Deleuze's interpretation of repetition and time and which challenge any straightforward foundationalist critique of Jung's thought. A contention of the paper is that Jung and Deleuze envisage enchanted openings onto relations which are not constrained by the presupposition of a bounded whole, whether at the level of the macrocosm or the microcosm. Openings to these relations entail the potential for experimental transformation beyond sedentary habits of thought which are blocked by a disenchanting ‘image of thought’ that stands in need of critique. Other examples of enchanted openings in Jung's work are signposted in an effort to counter their marginalisation in some post-Jungian critiques and to signal their potential value from a Deleuzian perspective

Discovery of Tantalum, Rhenium, Osmium, and Iridium Isotopes

Currently, thirty-eight tantalum, thirty-eight rhenium, thirty-nine osmium, and thirty-eight iridium, isotopes have been observed and the discovery of these isotopes is discussed here. For each isotope a brief synopsis of the first refereed publication, including the production and identification method, is presented.Comment: To be published in At. Data Nucl. Data Table

Response of ocean ecosystems to climate warming

Author Posting. © American Geophysical Union, 2004. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Global Biogeochemical Cycles 18 (2004): GB3003, doi:10.1029/2003GB002134.We examine six different coupled climate model simulations to determine the ocean biological response to climate warming between the beginning of the industrial revolution and 2050. We use vertical velocity, maximum winter mixed layer depth, and sea ice cover to define six biomes. Climate warming leads to a contraction of the highly productive marginal sea ice biome by 42% in the Northern Hemisphere and 17% in the Southern Hemisphere, and leads to an expansion of the low productivity permanently stratified subtropical gyre biome by 4.0% in the Northern Hemisphere and 9.4% in the Southern Hemisphere. In between these, the subpolar gyre biome expands by 16% in the Northern Hemisphere and 7% in the Southern Hemisphere, and the seasonally stratified subtropical gyre contracts by 11% in both hemispheres. The low-latitude (mostly coastal) upwelling biome area changes only modestly. Vertical stratification increases, which would be expected to decrease nutrient supply everywhere, but increase the growing season length in high latitudes. We use satellite ocean color and climatological observations to develop an empirical model for predicting chlorophyll from the physical properties of the global warming simulations. Four features stand out in the response to global warming: (1) a drop in chlorophyll in the North Pacific due primarily to retreat of the marginal sea ice biome, (2) a tendency toward an increase in chlorophyll in the North Atlantic due to a complex combination of factors, (3) an increase in chlorophyll in the Southern Ocean due primarily to the retreat of and changes at the northern boundary of the marginal sea ice zone, and (4) a tendency toward a decrease in chlorophyll adjacent to the Antarctic continent due primarily to freshening within the marginal sea ice zone. We use three different primary production algorithms to estimate the response of primary production to climate warming based on our estimated chlorophyll concentrations. The three algorithms give a global increase in primary production of 0.7% at the low end to 8.1% at the high end, with very large regional differences. The main cause of both the response to warming and the variation between algorithms is the temperature sensitivity of the primary production algorithms. We also show results for the period between the industrial revolution and 2050 and 2090.J. L. Sarmiento and R. Slater were supported by the NOAA Office of Global Programs grant NA56GP0439 to the Carbon Modeling Consortium for model development and by NSF grant OCE00973166 for model and observational interpretations as part of the JGOFS Synthesis and Modeling Project. R. Barber was supported by NSF grant OCE 0136270 as part of the JGOFS Synthesis and Modeling Project. S. Doney and J. Kleypas wish to thank the Community Climate System Model science team and the Climate Simulation Laboratory at NCAR and acknowledge support from NOAA-OGP grant NOAA-NA96GP0360S. Spall is funded through the UK Department for Environment, Food and Rural Affairs contract PECD 7/12/37

Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations.

Background: Empathic communication and positive messages are important components of "placebo" effects and can improve patient outcomes, including pain. Communicating empathy and optimism to patients within consultations may also enhance the effects of verum, i.e., non-placebo, treatments. This is particularly relevant for osteoarthritis, which is common, costly and difficult to manage. Digital interventions can be effective tools for changing practitioner behavior. This paper describes the systematic planning, development and optimization of an online intervention-"Empathico"-to help primary healthcare practitioners enhance their communication of clinical empathy and realistic optimism during consultations. Methods: The Person-Based Approach to intervention development was used. This entailed integrating insights from placebo and behavior change theory and evidence, and conducting primary and secondary qualitative research. Systematic literature reviews identified barriers, facilitators, and promising methods for enhancing clinical empathy and realistic optimism. Qualitative studies explored practitioners' and patients' perspectives, initially on the communication of clinical empathy and realistic optimism and subsequently on different iterations of the Empathico intervention. Insights from the literature reviews, qualitative studies and public contributor input were integrated into a logic model, behavioral analysis and principles that guided intervention development and optimization. Results: The Empathico intervention comprises 7 sections: Introduction, Empathy, Optimism, Application of Empathico for Osteoarthritis, Reflection on my Consultations, Setting Goals and Further Resources. Iterative refinement of Empathico, using feedback from patients and practitioners, resulted in highly positive feedback and helped to (1) contextualize evidence-based recommendations from placebo studies within the complexities of primary healthcare consultations and (2) ensure the intervention addressed practitioners' and patients' concerns and priorities. Conclusions: We have developed an evidence-based, theoretically-grounded intervention that should enable practitioners to better harness placebo effects of communication in consultations. The extensive use of qualitative research throughout the development and optimization process ensured that Empathico is highly acceptable and meaningful to practitioners. This means that practitioners are more likely to engage with Empathico and make changes to enhance their communication of clinical empathy and realistic optimism in clinical practice. Empathico is now ready to be evaluated in a large-scale randomized trial to explore its impact on patient outcomes

New simulants for martian regolith: Controlling iron variability

Existing martian simulants are predominantly based on the chemistry of the average ‘global’ martian regolith as defined by data on chemical and mineralogical variability detected by orbiting spacecraft, surface rovers and landers. We have therefore developed new martian simulants based on the known composition of regolith from four different martian surface environments: an early basaltic terrain, a sulfur-rich regolith, a haematite-rich regolith and a contemporary Mars regolith. Simulants have been developed so that the Fe2+/Fe3+ ratios can be adjusted, if necessary, leading to the development of four standard simulants and four Fe-modified simulants. Characterisation of the simulants confirm that all but two (both sulfur-rich) are within 5 wt% of the martian chemistries that they were based on and, unlike previous simulants, they have Fe2+/Fe3+ ratios comparable to those found on Mars. Here we outline the design, production and characterisation of these new martian regolith simulants. These are to be used initially in experiments to study the potential habitability of martian environments in which Fe may be a key energy source

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10(-8)), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.[Please see the Supplementary Note for acknowledgments.]This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ng.337

Optical Nanoantennas for Multiband Surface-Enhanced Infrared and Raman Spectroscopy

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The observing self: Diminishing egocentrism through brief mindfulness meditation

Reflecting the egocentrism that permeates contemporary society, people often believe they stand out in the eyes of others (i.e., the spotlight effect), a conviction that is entirely misplaced. Although considerable efforts have focused on elucidating the consequences of the spotlight effect, much less is known about factors that may attenuate this illusory perception. Accordingly, the current study explored the possibility that, via shifts in perspectives on the self (i.e., first person vs. third person), brief mindfulness-based meditation may reduce a future-oriented variant of this bias. The results revealed that, compared with responses in the control conditions (i.e., control meditation or no mediation), brief mindfulness-based meditation fostered the adoption of a third-person vantage point during mental imagery and diminished perceptions of personal salience

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology