67 research outputs found
Toll-like receptor 4 mediates tubular inflammation in diabetic nephropathy
published_or_final_versionThe 15th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 39, abstract no. 6
Non-invasive single-cell biomechanical analysis using live-imaging datasets
The physiological state of a cell is governed by a multitude of
processes and can be described by a combination of mechanical,
spatial and temporal properties. Quantifying cell dynamics at multiple
scales is essential for comprehensive studies of cellular function, and
remains a challenge for traditional end-point assays. We introduce an
efficient, non-invasive computational tool that takes time-lapse
images as input to automatically detect, segment and analyze
unlabeled live cells; the program then outputs kinematic cellular
shape and migration parameters, while simultaneously measuring
cellular stiffness and viscosity. We demonstrate the capabilities of the
program by testing it on human mesenchymal stem cells (huMSCs)
induced to differentiate towards the osteoblastic (huOB) lineage, and
T-lymphocyte cells (T cells) of naïve and stimulated phenotypes. The
program detected relative cellular stiffness differences in huMSCs
and huOBs that were comparable to those obtained with studies that
utilize atomic force microscopy; it further distinguished naïve from
stimulated T cells, based on characteristics necessary to invoke an
immune response. In summary, we introduce an integrated tool to
decipher spatiotemporal and intracellular dynamics of cells, providing
a new and alternative approach for cell characterization
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The cost of proactive interference is constant across presentation conditions
Proactive interference (PI) severely constrains how many items people can remember. For example, Endress and Potter (2014a) presented participants with sequences of everyday objects at 250 ms/picture, followed by a yes/no recognition test. They manipulated PI by either using new images on every trial in the unique condition (thus minimizing PI among items), or by re-using images from a limited pool for all trials in the repeated condition (thus maximizing PI among items). In the low-PI unique condition, the probability of remembering an item was essentially independent of the number of memory items, showing no clear memory limitations; more traditional working memory-like memory limitations appeared only in the high-PI repeated condition. Here, we ask whether the effects of PI are modulated by the availability of long-term memory (LTM) and verbal resources. Participants viewed sequences of 21 images, followed by a yes/no recognition test. Items were presented either quickly (250 ms/image) or sufficiently slowly (1500 ms/image) to produce LTM representations, either with or without verbal suppression. Across conditions, participants performed better in the unique than in the repeated condition, and better for slow than for fast presentations. In contrast, verbal suppression impaired performance only with slow presentations. The relative cost of PI was remarkably constant across conditions: relative to the unique condition, performance in the repeated condition was about 15% lower in all conditions. The cost of PI thus seems to be a function of the relative strength or recency of target items and interfering items, but relatively insensitive to other experimental manipulations
Enhanced Memory for Scenes Presented at Behaviorally Relevant Points in Time
What determines whether a scene is remembered or forgotten? Our results show how visual scenes are encoded into memory at behaviorally relevant points in time
Motivated cognition: effects of reward, emotion, and other motivational factors across a variety of cognitive domains
A growing body of literature has demonstrated that motivation influences cognitive processing. The breadth of these effects is extensive and span influences of reward, emotion, and other motivational processes across all cognitive domains. As examples, this scope includes studies of emotional memory, value-based attentional capture, emotion effects on semantic processing, reward-related biases in decision making, and the role of approach/avoidance motivation on cognitive scope. Additionally, other less common forms of motivation–cognition interactions, such as self-referential and motoric processing can also be considered instances of motivated cognition. Here I outline some of the evidence indicating the generality and pervasiveness of these motivation influences on cognition, and introduce the associated ‘research nexus’ at Collabra: Psychology
Application of U-Net with global convolution network module in computer-aided tongue diagnosis
202208 bcwwVersion of RecordOthers“Research on Teaching Reform and Practice Based on First-Class Curriculum Construction” of the China Society of Higher Education (2020JXD01); a Special Project in the Key Field of “Artificial Intelligence” in Colleges and Universities in Guangdong Province (2019KZDZX1027); Provincial Key platforms and major scientific research projects of Guangdong Universities (major scientific research projects-Characteristic Innovation) (2017KTSCX048); Scientific research project of Guangdong Bureau of Traditional Chinese Medicine (20191411); Construction Project of Guangdong University Industrial College (AI Robot Education Industrial College).Publishe
The relationship between spatial working memory precision and attention and inhibitory control in young children
Efficient multichannel acoustic echo cancellation using constrained tap selection schemes in the subband domain
Visual memory and sustained attention impairment in youths with autism spectrum disorders
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