Thinking locally: reflections on Dynamical Mean-Field Theory from a high-temperature/high energy perspective

When spatial correlations are short-range, the physics of strongly correlated systems is controlled by local quantum fluctuations. In those regimes, Dynamical Mean-Field Theory can be viewed as a `compass' which provides guidance on the relevant degrees of freedom and their effective dynamics over intermediate energy scales. These intermediate energy scales and associated crossovers play a crucial role in the physics of strongly correlated materials.Comment: Contribution to Dieter Vollhardt's Festschrift Volum

Mapping the multi-decadal mangrove dynamics of the Australian coastline

Mangroves globally provide a diverse array of ecosystem services but these are impacted upon by both natural and anthropogenic drivers of change. In Australia, mangroves are protected by law and hence the natural drivers predominate. To determine annual national level changes in mangroves between 1987 and 2016, their extent (by canopy cover type)and dynamics were quantified using dense time-series (nominally every 16 days cloud permitting)of 25 m spatial resolution Landsat sensor data available within Digital Earth Australia (DEA). The potential area that mangroves occupied over this period was established as the union of mangrove maps generated for 1996, 2007–2010 and 2015/16 through the Global Mangrove Watch (GMW). Within this area, the green vegetation fractional cover (GVpc)was retrieved from each available cloud-masked Landsat scene through linear spectral unmixing. The 10th percentile (GVpc10)was then determined for each calendar year by comparing these data in a time-series. The percentage Planimetric Canopy Cover (PCC%)for each Landsat pixel was then estimated using a relationship between GVpc10 and LiDAR-derived PCC% (20%; resolvable at the Landsat resolution)varied from a minima of 10,715 ± 36 km (95% confidence interval)in 1992 to a maxima of 11,388 km ± 38 km (95% CI)in 2010, declining to 11,142 ± 57 km (95% CI)in 2017. In 2010 (maximum extent), the forests were classified as closed canopy (38.8%), open canopy (49.0%)and woodland mangrove (12.2%). The majority of change occurred along the northern Australian coastline and was concentrated in the major gulfs and sounds. The 30 national maps of annual mangrove extent represent a reference dataset, which is publicly available through the Terrestrial Environment Research Network (TERN)landscapes portal. Future efforts are focusing on the routine production of annual mangrove maps beyond 2019 as part of Australia's efforts to monitor the coastal environment

Carbon combustion synthesis of Janus-like particles of magnetoelectric cobalt ferrite and barium titanate

Carbon combustion synthesis of oxides was applied for quick and energy efficient production of multiferroic composite of cobalt ferrite and barium titanate to form Janus-like particles matrix structure. The exothermic oxidation of carbon nanoparticles with an average size of 5 nm and a specific surface area of 110 m2/g generates a self-propagating thermal wave with peak temperature of up to 1000 °C. The thermal front rapidly propagates through the mixture of solid reactants (magnetic- CoFe2O4 and ferroelectric-BaTiO3) and results in localized hot-spot sintering of magneto-electric phases to form a nanocomposite structure. Carbon is not incorporated in the product and is emitted as a gaseous CO2. Existence of discrete CoFe2O4 and BaTiO3phases in the composites nanostructures was confirmed using X-ray powder diffraction along with SEM and TEM analysis. We estimated the activation energy for the combustion synthesis of Janus-like particles to be 112 ± 3.3 kJ/mol, indicating that the barium titanate and cobalt ferrite presence decrease the activation energy barrier of carbon oxidation and facilitate the ignition process of the combustion synthesis. We observe that the as-synthesized samples show magnetoelectric coupling on multiferroic cobalt ferrite–barium titanate ceramic composites

The Absence of Stars in Compact High-Velocity Clouds

We present the results of our search for faint Local Group dwarf galaxies in compact high-velocity clouds (HVCs). We used digitized Palomar Observatory Sky Survey (POSS) data to examine 1 square degree of sky around each of ~250 northern hemisphere HVCs. The POSS images were processed to remove foreground stars and large-scale backgrounds, smoothed to enhance arcminute-sized low surface brightness features, and then compared to the original plates. Using this technique, we located 60 candidate dwarf galaxies in the ~250 square degrees that we surveyed. Followup observations of these candidates have revealed several distant clusters of galaxies and a number of possible Galactic cirrus clouds, but no Local Group dwarfs. It appears that many of the low surface brightness features in the sky survey data are plate flaws. The second-generation red POSS plates are sensitive down to surface brightness levels of 25-26 magnitudes per square arcsecond, and our followup images reached 10-sigma limiting magnitudes of R = 21-23 for point sources. Given these limits, all known Local Group galaxies except four of the very diffuse, extended dwarf spheroidals located within 100 kpc of the Milky Way would have been detected had they been in our survey. Therefore, we can rule out the possibility that these HVCs are associated with normal but faint dwarf galaxies. If compact HVCs do contain stars, they must have surface brightnesses > 1 magnitude per square arcsecond fainter than most known Local Group galaxies.Comment: 17 pages, 6 figures, 2 tables, submitted to Ap

U-Limb: A multi-modal, multi-center database on arm motion control in healthy and post-stroke conditions

BACKGROUND: Shedding light on the neuroscientific mechanisms of human upper limb motor control, in both healthy and disease conditions (e.g., after a stroke), can help to devise effective tools for a quantitative evaluation of the impaired conditions, and to properly inform the rehabilitative process. Furthermore, the design and control of mechatronic devices can also benefit from such neuroscientific outcomes, with important implications for assistive and rehabilitation robotics and advanced human-machine interaction. To reach these goals, we believe that an exhaustive data collection on human behavior is a mandatory step. For this reason, we release U-Limb, a large, multi-modal, multi-center data collection on human upper limb movements, with the aim of fostering trans-disciplinary cross-fertilization. CONTRIBUTION: This collection of signals consists of data from 91 able-bodied and 65 post-stroke participants and is organized at 3 levels: (i) upper limb daily living activities, during which kinematic and physiological signals (electromyography, electro-encephalography, and electrocardiography) were recorded; (ii) force-kinematic behavior during precise manipulation tasks with a haptic device; and (iii) brain activity during hand control using functional magnetic resonance imaging

B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens

Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent. Coincidental infections in endemic BL, and specific extra‐nodal sites suggest antigenic triggers. To explore this hypothesis, BCRs of BL cell lines and cases were screened for reactivities against a panel of bacterial lysates, lysates of Plasmodium falciparum, a custom‐made virome array and against self‐antigens, including post‐translationally modified antigens. An atypically modified, SUMOylated isoform of Bystin, that is, SUMO1‐BYSL was identified as the antigen of the BCR of cell line CA46. SUMO1‐BYSL was exclusively expressed in CA46 cells with K139 as site of the SUMOylation. Secondly, an atypically acetylated isoform of HSP40 was identified as the antigen of the BCR of cell line BL41. K104 and K179 were the sites of immunogenic acetylation, and the acetylated HSP40 isoform was solely present in BL41 cells. Functionally, addition of SUMO1‐BYSL and acetylated HSP40 induced BCR pathway activation in CA46 and BL41 cells, respectively. Accordingly, SUMO1‐BYSL‐ETA’ immunotoxin, produced by a two‐step intein‐based conjugation, led to the specific killing of CA46 cells. Autoantibodies directed against SUMO1‐BYSL were found in 3 of 14 (21.4%), and autoantibodies against acetylated HSP40 in 1/14(7.1%) patients with sporadic Burkitt‐lymphoma. No reactivities against antigens of the infectious agent spectrum could be observed. These results indicate a pathogenic role of autoreactivity evoked by immunogenic post‐translational modifications in a subgroup of sporadic BL including two EBV‐negative BL cell lines

Remote interspecies interactions: Improving humans and animals wellbeing through mobile playful spaces

[EN] Play is an essential activity for both humans and animals as it provides stimulation and favors cognitive, physical and social development. This paper proposes a novel pervasive playful environment that allows hospitalized children to participate in remote interspecies play with dogs in a dog daycare facility, while it also allows the dogs to play by themselves with the pervasive system. The aim of this playful interactive space is to help improving both children¿s and animal¿s wellbeing and their relationships by means of technologically mediated play, while creating a solid knowledge base to define the future of pervasive interactive environments for animals.This work is supported by the European Development Regional Fund (EDRF-FEDER), Spain and Spanish MINECO (TIN2014-60077-R). The work of Patricia Pons is supported by the Spanish MECD (FPU13/03831). Special thanks to the dogs and children who participated in our study, the dogs' owners and the children's families. The authors also gratefully acknowledge the teachers of the Unidad Pedagogica Hospitalaria La Fe and Oncologia Pediatrica La Fe and also Olga and Astrid from Buma's Doggy Daycare facility, for their invaluable support, collaboration and dedication.Pons Tomás, P.; Carrion-Plaza, A.; Jaén Martínez, FJ. (2019). Remote interspecies interactions: Improving humans and animals wellbeing through mobile playful spaces. Pervasive and Mobile Computing. 52:113-130. https://doi.org/10.1016/j.pmcj.2018.12.003S1131305

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLADRB1*07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver- and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA’-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL

Measurements of branching fraction ratios and CP-asymmetries in suppressed B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^- decays

We report the first reconstruction in hadron collisions of the suppressed decays B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^-, sensitive to the CKM phase gamma, using data from 7 fb^-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B^- -> D(-> K^+ pi^-)K^- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 \pm 8.6(stat)\pm 2.6(syst)]\times 10^-3, R^+(K) = [42.6\pm 13.7(stat)\pm 2.8(syst)]\times 10^-3, R^-(K)= [3.8\pm 10.3(stat)\pm 2.7(syst]\times 10^-3, as well as the direct CP-violating asymmetry A(K) = -0.82\pm 0.44(stat)\pm 0.09(syst) of this mode. Corresponding quantities for B^- -> D(-> K^+ pi^-)pi^- decay are also reported.Comment: 8 pages, 1 figure, accepted by Phys.Rev.D Rapid Communications for Publicatio

Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease : An Individual-Level Meta-Analysis

Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the PPARGC1A gene on the risk of subsequent CHD in a population with established CHD.Methods: We employed an individual-level meta-analysis using 23 studies from the GENetIcs of sUbSequent Coronary Heart Disease (GENIUS-CHD) consortium, which included participants (n = 80,900) with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. Three variants in the PPARGC1A gene (rs8192678, G482S; rs7672915, intron 2; and rs3755863, T528T) were tested for their associations with subsequent events during the follow-up using a Cox proportional hazards model adjusted for age and sex. The primary outcome was subsequent CHD death or myocardial infarction (CHD death/myocardial infarction). Stratified analyses of the participant or study characteristics as well as additional analyses for secondary outcomes of specific cardiovascular disease diagnoses and all-cause death were also performed.Results: Meta-analysis revealed no significant association between any of the three variants in the PPARGC1A gene and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline: rs8192678, hazard ratio (HR): 1.01, 95% confidence interval (CI) 0.98-1.05 and rs7672915, HR: 0.97, 95% CI 0.94-1.00; rs3755863, HR: 1.02, 95% CI 0.99-1.06. Similarly, no significant associations were observed for any of the secondary outcomes. The results from stratified analyses showed null results, except for significant inverse associations between rs7672915 (intron 2) and the primary outcome among 1) individuals aged >= 65, 2) individuals with renal impairment, and 3) antiplatelet users.Conclusion: We found no clear associations between polymorphisms in the PPARGC1A gene and subsequent CHD events in patients with established CHD at baseline.Peer reviewe