Reply With: Proactive Recommendation of Email Attachments

Email responses often contain items-such as a file or a hyperlink to an external document-that are attached to or included inline in the body of the message. Analysis of an enterprise email corpus reveals that 35% of the time when users include these items as part of their response, the attachable item is already present in their inbox or sent folder. A modern email client can proactively retrieve relevant attachable items from the user's past emails based on the context of the current conversation, and recommend them for inclusion, to reduce the time and effort involved in composing the response. In this paper, we propose a weakly supervised learning framework for recommending attachable items to the user. As email search systems are commonly available, we constrain the recommendation task to formulating effective search queries from the context of the conversations. The query is submitted to an existing IR system to retrieve relevant items for attachment. We also present a novel strategy for generating labels from an email corpus---without the need for manual annotations---that can be used to train and evaluate the query formulation model. In addition, we describe a deep convolutional neural network that demonstrates satisfactory performance on this query formulation task when evaluated on the publicly available Avocado dataset and a proprietary dataset of internal emails obtained through an employee participation program.Comment: CIKM2017. Proceedings of the 26th ACM International Conference on Information and Knowledge Management. 201

Zmienność odstępu QTc. Czy jeden pomiar QTc wystarczy do podjęcia decyzji terapeutycznych i stratyfikacji ryzyka u chorych z zespołem długiego QT?

We described a case of 30 year-old woman with episodes of syncope primarily diagnosed as epilepsy, and finally recognisedas long QT syndrome. Based on QTc prolongation > 600 ms in series of electrocardiograms and Holter monitoring the patientwas implanted with cardioverter-defibrillator (ICD). During follow-up many appropriate ICD shocks due to ventricularfibrillation occurred

Clinical classification of rare cardiac arrhythmogenic and conduction disorders, and rare arrhythmias

Rare cardiovascular diseases and disorders (RCDDs) constitute an important clinical problem, and their proper classification is crucial for expanding knowledge in the field of RCDDs. The aim of this paper is to provide an updated classification of rare arrhythmogenic and conduction disorders, and rare arrhythmias (RACDRAs). We performed a search for RACDRAs using the Orphanet inventory of rare diseases, which includes diseases with a prevalence of no more than 5 per 10 000 in the general population. We supplemented this with a search of PubMed and Scopus databases according to a wider definition proposed by the European Parliament and the Council of the European Union. RACDRAs are categorized into 2 groups, primary electrical disorders of the heart and arrhythmias in specific clinical settings. The first group is further divided into subgroups of major clinical presentation: disorders predisposing to supraventricular tachyarrhythmias, ventricular tachyarrhythmias, bradyarrhythmias, and others. The second group includes iatrogenic arrhythmias or heart rhythm disturbances related to medical treatment, arrhythmias associated with metabolic disorders, and others. We provide a classification of RACDRAs and supplement them with respective RCDDs codes. The clinical classification of RACDRAs may form a basis to facilitate research and progress in clinical practice, both in diagnostic and therapeutic approaches

Prevalence and characteristic of adrenal glands’ abnormalities assessed by computed tomography in hypertensive patients with elevated plasma aldosterone to renin activity ratio

Wstęp Wartość współczynnika aldosteronowo-reninowego (ALDO/ARO) większa niż 50 u chorych na nadciśnienie tętnicze (w tym również u chorych bez towarzyszącej hipokaliemii) jest uznawana przez wielu badaczy za wystarczające kryterium do rozpoznania pierwotnego hiperaldosteronizmu. Celem pracy była ocena częstości występowania i charakteru zmian morfologicznych w nadnerczach wykrywanych przy użyciu tomografii komputerowej (CT) spiralnej u chorych na nadciśnienie tętnicze z podwyższonym (&#8805; 50) współczynnikiem ALDO/PRA.Materiał i metody U 1367 pacjentów dwukrotnie oznaczano aktywność reninową osocza (PRA) &#8212; po 3 dniach stosowania diety zawierającej 100&#8211;120 mmol sodu na dobę i 8-godzinnym przebywaniu w pozycji leżącej (PRA1) oraz po kolejnych 3 dniach diety z ograniczeniem sodu do 10&#8211;20 mmol/dobę i 3-godzinnej pionizacji ciała (PRA2). Stężenie aldosteronu w osoczu oznaczano tylko u pacjentów z niskoreninowym profilem nadciśnienia tętniczego (PRA1 < 1 ng/ml/h i PRA2/PRA1 < 1,5 ng/ml/h), również dwukrotnie &#8212; przed stymulacją i po stymulacji dietą ubogosodową i pionizacją (ALDO1 i ALDO2). U pacjentów, u których stwierdzono wartości współczynnika &#8805; 50 wykonano badanie CT jamy brzusznej metodą spiralną oraz test dożylnego obciążenia solą. Wyniki U 36 pacjentów stwierdzono wartość współczynnika ALDO/PRA &#8805; 50 (2,6% wszystkich badanych chorych na nadciśnienie tętnicze). W tej podgrupie znamiennie częściej obserwowano hipokaliemię (< 3,5 mmol/l). U 34 pacjentów wykonano CT. Najczęściej stwierdzanymi zmianami były: guz i obustronny przerost nadnerczy. U 44,1% chorych (n = 15) nie uwidoczniono żadnej patologii w obrębie gruczołów nadnerczowych. U 24 pacjentów wykonano test obciążenia solą. Wynik dodatni uzyskano w 15 przypadkach. Analiza ROC wykazała, że przy wartości współczynnika powyżej 147 zmiany w CT stwierdza się u 66,7% chorych, a jedynie 21,1% zmian pozostaje niewykrytych. Wnioski 1. Częstość hiperaldosteronizmu pierwotnego w ogólnej populacji chorych na nadciśnienie tętnicze oceniana wyłącznie na podstawie podwyższonej wartości współczynnika ALDO/PRA (&#8805; 50) wynosi 2,6%. 2. Współczynnik ALDO/PRA jest szczególnie przydatny w rozpoznawaniu zespołu Conna o niewielkim stopniu zaawansowania klinicznego i bez podwyższonego stężenia aldosteronu w surowicy. 3. Wartość współczynnika ALDO/PRA powyżej 147 jest charakterystyczna dla chorych ze zmianami morfologicznymi nadnerczy wykrywanymi za pomocą CT spiralnej.Background The plasma aldosterone to renin activity (ALDO/PRA) ratio over 50 in hypertensive patients is widely recognized as a cut-off value for identification of primary hyperaldosteronism (especially in patients without hypokalaemia). The aim of this study was to evaluate prevalence and characteristic of adrenal glands&#8217; abnormalities in hypertensive patients with an elevated plasma aldosteron to plasma renin activity ratio. Material and methods In 1367 subsequent adult patients with arterial hypertension plasma renin activity was estimated twice: first in patients receiving normally salted diet (100&#8211;120 mmol sodium per day) after 8 hours of recumbent position (PRA1) and a second time after 3 days of sodium restriction (10&#8211;20 mmol sodium per day) and 3 hours of upright position (PRA2). Plasma aldosterone concentration was assessed only in patients with low PRA1 (< 1 ng/ml/h) and without or only marginal reaction of PRA to salt restriction and upright position (PRA2/PRA1 < 1.5). Plasma aldosteron concentration was assessed also twice on normally salted diet and after sodium retriction (ALDO1 and ALDO2). In patients with ALDO/PRA &#8805; 50 a CT scan of adrenal glands and a saline infusion test were performed. Results ALDO/PRA &#8805; 50 was found in 36 patients (2.6% of the entire hypertensive group). In that subgroup frequency of hypokaliaemia (< 3,5 mmol/l) was significantly higher than in hypertensive patients with a lower ALDO/PRA ratio. Computed tomography was performed in 34 out of these 36 patients. The scans revealed no abnormalities in 44.1% (n = 15). The most frequent abnormalities were: isolated adrenal tumour and bilateral adrenal enlargement. Saline infusion test was performed in 24 patients. A positive result was obtained in 15 cases. The ROC analysis revealed, that a ALDO/PRA ratio over 147 is connected with adrenal abnormalities in 66.7% of patients and only 21.1% changes remain unrevealed. Conclusions 1. The prevalence of primary hyperaldosteronism in general population of hypertensive patients estimated according to the raised plasma aldosterone to plasma renin activity ratio (&#8805; 50) is 2.6%. 2. The ALDO/PRA ratio is especially useful in diagnosis of Conn syndrome in hypertensive patients without elevated serum aldosterone concentration. 3. The ALDO/PRA over 147 is highly specific for patients with morfological changes observed in computed tomography

Satisfaction and discontent of Polish patients with biological therapy of rheumatic diseases : results of a multi-center questionnaire study

Objectives: Biologics are medications widely applied in the management of inflammatory rheumatic diseases. The drugs were found to be effective but their application is associated with some disadvantages. Medication with biologics is relatively expensive, and in Poland, it is carried out in specialized centers. The study was designed to evaluate various aspects of satisfaction and dissatisfaction of Polish patients treated with biologics. Material and methods: An anonymous questionnaire was distributed in 23 Polish rheumatological centers involved in the treatment; 1212 returned questionnaires were used for analysis. Responses were received from 606 patients with rheumatoid arthritis, 427 with ankylosing spondylitis, 117 psoriatic arthritis, and 62 adult patients with juvenile idiopathic arthritis (in whom administration of the drugs had been introduced before they were 18 years old). The investigated group constituted about one-fifth of all rheumatic patients on biologics in Poland. Results: A beneficial or very beneficial influence of the medication on the state of physical health was found mostly in patients with rheumatoid arthritis (51.3 and 30.5%) and ankylosing spondylitis (51.0 and 36.8%). Family life was improved by the treatment especially in patients with ankylosing spondylitis (40.7 and 35.6% beneficial and very beneficial, respectively), sleep quality and sexual life mostly in those with ankylosing spondylitis (beneficial/very beneficial influence 41.5/38.4, and 38.7/23.9, respectively). There was a rather small influence of biological treatment on the financial situation of the patients. In general, satisfaction with the treatment was evaluated as positive or very positive in 88% of all investigated patients. In a significant part of the patients, transportation to the medical center was considered as a disadvantage of the treatment. About one-third of the patients considered laboratory and imaging tests to be done before initiation of the medication as a difficulty, and for about 40% waiting time for qualification for the medication was a significant disadvantage. The route of drug administration was without importance for 4/5 of the patients. Conclusions: Summing up, the results were similar in the patients suffering from various diseases although those with psoriatic arthritis felt the highest satisfaction (possibly due to the positive aesthetic effect), and those with ankylosing spondylitis had significant improvement in sexual life (probably due to younger age). Relatively low satisfaction was found in patients with juvenile idiopathic arthritis. There was a small influence of medication on financial status of the patients. Application of biologics has few disadvantages and most of them are associated with the organization of health services (waiting time for the tests, transportation to the medical centers)

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements