1,857 research outputs found
Eficacia del tratamiento conservador en las fracturas mandibulares / Effectiveness of the conservative procedure in mandibular fractures
- Author
- Publication venue
- Centro Provincial de Ciencias Médicas de Pinar del Río
- Publication date
- 16/10/2012
- Field of study
Se realizó un estudio en 30 pacientes con fractura mandibular, que fueron atendidos en el servicio de cirugía máxilofacial del Hospital Universitario "Abel Santamaría Cuadrado", en el periodo comprendido desde el 1ro de noviembre del 2002 hasta el 28 de febrero del 2006, con el objetivo de demostrar la eficacia del tratamiento conservador en las fracturas mandibulares según los resultados obtenidos con la reducción de la fractura, fijación y oclusión dentaria. Se plantean y analizan los resultados obtenidos, encontrando una mayor incidencia de estas fracturas de 25 a 34 años de edad, siendo las fracturas con desplazamiento y factor dentario favorable las de mayor incidencia y existiendo en el 100 % de los pacientes, al realizar el tratamiento conservador una reducción anatómica, adecuada fijación y buena oclusión. Palabras Clave: FRACTURAS MANDIBULARES/Cirugía/Terapia ABSTRACT A study of 30 patients suffering from mandibular fracture attended at the Oral Surgery Office was carried out at "Abel Santamaría Cuadrado" General hospital during November 1, 2002 to February 28, 2006. It was aimed at demonstrating the effectiveness of the findings obtained with the reduction of the fracture, fixation and dental occlusion. Findings were analyzed showing a higher incidence in 25 -34 year-old subjects, having the dislocated fractures and the dental factor a higher incidence. In 100% of cases it was observed an anatomic reduction and a proper fixation as well as a good occlusion when the conservative procedure was done. Key words: MANDIBULAR FRACTURES/Surgery/Therap
Eficacia del tratamiento conservador en las fracturas mandibulares / Effectiveness of the conservative procedure in mandibular fractures
- Author
- Publication venue
- Centro Provincial de Ciencias Médicas de Pinar del Río
- Publication date
- 16/10/2012
- Field of study
Se realizó un estudio en 30 pacientes con fractura mandibular, que fueron atendidos en el servicio de cirugía máxilofacial del Hospital Universitario "Abel Santamaría Cuadrado", en el periodo comprendido desde el 1ro de noviembre del 2002 hasta el 28 de febrero del 2006, con el objetivo de demostrar la eficacia del tratamiento conservador en las fracturas mandibulares según los resultados obtenidos con la reducción de la fractura, fijación y oclusión dentaria. Se plantean y analizan los resultados obtenidos, encontrando una mayor incidencia de estas fracturas de 25 a 34 años de edad, siendo las fracturas con desplazamiento y factor dentario favorable las de mayor incidencia y existiendo en el 100 % de los pacientes, al realizar el tratamiento conservador una reducción anatómica, adecuada fijación y buena oclusión. Palabras Clave: FRACTURAS MANDIBULARES/Cirugía/Terapia ABSTRACT A study of 30 patients suffering from mandibular fracture attended at the Oral Surgery Office was carried out at "Abel Santamaría Cuadrado" General hospital during November 1, 2002 to February 28, 2006. It was aimed at demonstrating the effectiveness of the findings obtained with the reduction of the fracture, fixation and dental occlusion. Findings were analyzed showing a higher incidence in 25 -34 year-old subjects, having the dislocated fractures and the dental factor a higher incidence. In 100% of cases it was observed an anatomic reduction and a proper fixation as well as a good occlusion when the conservative procedure was done. Key words: MANDIBULAR FRACTURES/Surgery/Therap
Cultura de consumo y tendencias de Marketing en Guayaquil: compendio de artículos
- Author
- Andrade Ávila Andrea Elizabeth
- Arévalo Martínez José Gregorio
- Ascencio Burgos Karina
- Ascencio Burgos Karina Anabella
- Báez Lindao Luis Adrián
- Cazares Pérez Tatiana Angelina
- Correa Cabrera Ana Luisa
- Escandón Loor Flérida María
- Franco Cedeño Ercilia María
- Franco Cedeño Ercilia María
- Franco Cedeño Ercilia María
- Gruezo Schneider Cindy Paulette
- Hernández Buenaño Annabelle Fátima
- Lozano Castillo Aurora
- López Chila Roberto David
- Mejía Orellana Fabricio Alberto
- Moreno Delgado MBA Juan Pablo
- Zambrano Honores Xavier Eduardo
- Publication venue
- Publication date
- 13/06/2020
- Field of study
Esta recopilación de artículos académicos aborda diversas estrategias manejadas por las pymes ecuatorianas. Temas como neuromarketing, marketing digital, cultura de consumo y comportamiento de compra, son claves para dar respuestas a los consumidores. Con estudios de caso —desde lo que compran clientes de supermercados, consumo de bebidas o prendas de vestir— los textos que acá se recogen establecen perfiles
de consumo en el Ecuador.
Dieciocho autores que —como parte de su trabajo de titulación de Administración de Empresas de la Universidad Politécnica Salesiana— ponen sobre la mesa variables de creatividad e innovación que requieren las empresas para que el cliente busque y encuentre lo que el mercado le ofrece.
Los investigadores plantean temas como el creciente comercio electrónico o los servicios bancarios en línea y las preferencias del consumidor ecuatoriano, dando así pistas a las pequeñas empresas sobre la cultura de compra del consumidor en el país
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
- Author
- Abecasis Goncalo
- Abedi Maryam
- Alistair TY
- Amin Najaf
- Arking Dan E
- Attia John
- Ayers Kristin L
- Barbieri Caterina M
- Barnes Michael R
- Batini Chiara
- Beilby John
- Betholdson J-P
- Bis Joshua C
- Blake Tineka
- Bochud Murielle
- Boehnke Michael
- Boomsma Dorret I
- Bottinger Erwin P
- Braund Peter S
- Brown Morris
- Brumat Marco
- Cabrera Claudia P
- Campbell Archie
- Campbell Harry
- Caulfield Mark J
- Chakravarti Aravinda
- Chambers John C
- Chasman Daniel I
- Chauhan Ganesh
- Ciullo Marina
- Cocca Massimiliano
- Collins Francis
- Conen David
- Connell John
- Consortium BIOS
- Cordell Heather J
- Damman Jeffrey J
- Davies Gail
- de Borst Martin H
- de Geus Eco J
- de Mutsert Renee
- Deary Ian J
- Debette Stephanie
- Deelen Joris
- Del Greco M Fabiola
- Demirkale Yusuf
- Doney Alex SF
- Dorr Marcus
- Ehret Georg B
- Elliott Paul
- Elosua Roberto
- Enroth Stefan
- Erzurumluoglu A Mesut
- Esko Tonu
- Evangelou Evangelos
- Farrall Martin
- Ferreira Teresa
- Franberg Mattias
- Franco Oscar H
- Gandin Ilaria
- Gao He
- Gasparini Paolo
- Giedraitis Vilmantas
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Gow Alan J
- Grp Understanding Soc Sci
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf
- Hamsten Anders
- Harris Sarah E
- Harris Tamara B
- Hartman Catharina A
- Havulinna Aki S
- Hayward Caroline
- Hicks Andrew A
- Hofer Edith
- Hofman Albert
- Holliday Elizabeth G
- Hottenga Jouke-Jan
- Huffman Jennifer E
- Hui Jennie
- Hwang Shih-Jen
- Ingelsson Erik
- Jackson Anne U
- James Alan
- Jansen Rick
- Jarvelin Marjo-Riitta
- Joehanes Roby
- Johansson Asa
- Johnson Andrew D
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Jula Antti
- Kahonen Mika
- Kathiresan Sekar
- Keavney Bernard D
- Khaw Kay-Tee
- Knekt Paul
- Knight Joanne
- Kolcic Ivana
- Kooner Jaspal S
- Koskinen Seppo
- Kristiansson Kati
- Kutalik Zoltan
- Laan Maris
- Langenberg Claudia
- Larson Marty
- Launer Lenore J
- Lehne Benjamin
- Lehtimaki Terho
- Levy Daniel
- Li-Gao Ruifang
- Liewald David CM
- Lin Li
- Lind Lars
- Lindgren Cecila M
- Liu YongMei
- Loos Ruth JF
- Lopez Lorna M
- Lu Yingchang
- Luan Jian'an
- Lyytikainen Leo-Pekka
- Mach Francois
- Mahajan Anubha
- Mamasoula Chrysovalanto
- Mangino Massimo
- Marrugat Jaume
- Marten Jonathan
- Menni Cristina
- Metspalu Andres
- Mifsud Borbala
- Milaneschi Yuri
- Mook-Kanamori Dennis O
- Morgan Anna
- Morris Andrew D
- Morris Andrew P
- Morrison Alanna C
- Munroe Patricia B
- Munson Peter J
- Nalls Mike A
- Nandakumar Priyanka
- Nelson Christopher P
- Newton-Cheh Christopher
- Nguyen Quang Tri
- Niiranen Teemu
- Nolte Ilja M
- Nutile Teresa
- O'Reilly Paul F
- Oldehinkel Albertine J
- Oldmeadow Christopher
- Oostra Ben A
- Org Elin
- Padmanabhan Sandosh
- Palmas Walter
- Palmer Colin NA
- Palotie Aarno
- Pare Guillaume
- Pattie Alison
- Penninx Brenda WJH
- Perola Markus
- Peters Annette
- Polasek Ozren
- Poulter Neil
- Pramstaller Peter P
- Prins Bram P
- Psaty Bruce M
- Raitakari Olli T
- Ren Meixia
- Rettig Rainer
- Rice Kenneth
- Ridker Paul M
- Ried Janina S
- Riese Harriette
- Ripatti Samuli
- Robino Antonietta
- Rose Lynda M
- Rotter Jerome I
- Rudan Igor
- Ruggiero Daniela
- Saba Yasaman
- Saint Pierre Aude
- Sala Cinzia F
- Salomaa Veikko
- Samani Nilesh J
- Sarin Antti-Pekka
- Schmidt Helena
- Schmidt Reinhold
- Scott Robert A
- Scott Rodney
- Seelen Marc A
- Sever Peter
- Shah Nabi
- Shields Denis C
- Shrine Nick
- Siscovick David
- Smith Albert V
- Snieder Harold
- Sober Siim
- Sorice Rossella
- Spector Tim D
- Stanton Alice
- Starr John M
- Stott David J
- Strachan David P
- Strawbridge Rona J
- Study Lifelines Cohort
- Sundstrom Johan
- Swertz Morris
- Taylor Kent D
- Teumer Alexander
- Theriault Sebastien
- Thom Simon
- Tobin Martin D
- Toniolo Daniela
- Traglia Michela
- Trompet Stella
- Tuomilehto Jaakko
- Tzoulaki Ioanna
- Tzourio Christophe
- Uitterlinden Andre G
- Vaez Ahmad
- van der Harst Pim
- van der Most Peter J
- van Duijn Cornelia M
- Vergnaud Anne-Claire
- Verwoert Germaine C
- Vitart Veronique
- Volker Uwe
- Vollenweider Peter
- Vuckovic Dragana
- Wain Louise V
- Wareham Nicholas J
- Warren Helen R
- Watkins Hugh
- Wild Sarah
- Willemsen Gonneke
- Wilson James F
- Wright Alan F
- Xiao Limin
- Yao Jie
- Zeggini Eleftheria
- Zemunik Tatijana
- Zhang Weihua
- Zhao Jing Hua
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2017
- Field of study
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
- Author
- Absher Devin
- Adair Linda S.
- Amin Najaf
- Arking Dan E.
- Assimes Themistocles L.
- Axelsson Tomas
- Baldassarre Damiano
- Balkau Beverley
- Bandinelli Stefania
- Barnes Michael R.
- Barroso Inês
- Bevan Stephen
- Bis Joshua C.
- Bjornsdottir Gyda
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Bornstein Stefan R.
- Bouatia-Naji Nabila
- Bovet Pascal
- Brown Morris J.
- Burnier Michel
- Cabrera Claudia P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chang I-Shou
- Chasman Daniel I.
- Chen Yii-Der I.
- Cheng Ching-Yu
- Chines Peter S.
- Chung Ren-Hua
- Collins Francis S.
- Connell John M.
- Cooper Richard S.
- Dallongeville Jean
- Danesh John
- De Faire Ulf
- Dedoussis George
- Delgado Graciela
- Deloukas Panos
- Dominiczak Anna F.
- Doney Alex S. F.
- Donnelly Louise A.
- Drenos Fotios
- Döring Angela
- Edkins Sarah
- Ehret Georg B.
- Eicher John D.
- Elliott Paul
- Elosua Roberto
- Enroth Stefan
- Erdmann Jeanette
- Eriksson Niclas
- Eriksson Per
- Esko Tonu
- Evangelou Evangelos
- Evans Alun
- Fall Tove
- Farrall Martin
- Fava Cristiano
- Felix Janine F.
- Ferreira Teresa
- Ferrières Jean
- Ferrucci Luigi
- Folkersen Lasse
- Fornage Myriam
- Forrester Terrence
- Franceschini Nora
- Franco Oscar H.
- Franco-Cereceda Anders
- Franke Lude
- Franks Paul W.
- Fraser Ross M.
- Froguel Philippe
- Ganesh Santhi K.
- Gao He
- Gertow Karl
- Gianfagna Francesco
- Gierman Hinco J.
- Gigante Bruna
- Giulianini Franco
- Goel Anuj
- Goodall Alison H.
- Goodarzi Mark O.
- Gorski Mathias
- Groves Christopher J.
- Gräßler Jürgen
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf
- Hallmans Göran
- Hamsten Anders
- Hartikainen Anna-Liisa
- Hassinen Maija
- Havulinna Aki S.
- Hayward Caroline
- Hercberg Serge
- Herzig Karl-Heinz
- Hicks Andrew A.
- Hingorani Aroon D.
- Hirschhorn Joel N.
- Hofman Albert
- Holmen Jostein
- Holmen Oddgeir Lingaas
- Hottenga Jouke-Jan
- Hovingh G. Kees
- Howard Phil
- Hsiung Chao A.
- Hughes Maria F.
- Hunt Steven C.
- Hveem Kristian
- Ikram M Arfan
- Illig Thomas
- Ingelsson Erik
- Iribarren Carlos
- Jackson Anne U.
- Jansen Rick
- Jarvelin Marjo-Riitta
- Jensen Richard A.
- Joehanes Roby
- Johnson Andrew D.
- Johnson Toby
- Kaakinen Marika
- Kang Hyun Min
- Kanoni Stavroula
- Kathiresan Sekar
- Keating Brendan J.
- Khaw Kay-Tee
- Kim Eric
- Kim Stuart K.
- Kim Young Jin
- Kim Yun Kyoung
- Kivimaki Mika
- Kleber Marcus E.
- Klopp Norman
- Kolovou Genovefa
- Komulainen Pirjo
- Kooner Jaspal S.
- Kosova Gulum
- Krauss Ronald M.
- Kristiansson Kati
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuulasmaa Kari
- Kuusisto Johanna
- Kvaløy Kirsti
- Kähönen Mika
- Laakso Markku
- Lakatta Edward G.
- Lakka Timo A.
- Langenberg Claudia
- Lataniotis Lazaros
- Lee I-Te
- Lee Jong-Young
- Lee Nanette R.
- Lee Wen-Jane
- Lehtimäki Terho
- Levy Daniel
- Li Xiaohui
- Liang Kae-Woei
- Lin Honghuang
- Lin Li
- Lind Lars
- Lindström Jaana
- Lobbens Stéphane
- Loos Ruth J. F.
- Luan Jian'An
- Lyytikäinen Leo-Pekka
- Mach François
- Magnusson Patrik K.
- Markus Hugh S.
- Marouli Eirini
- McCarthy Mark I.
- McKenzie Colin A.
- Meirelles Osorio
- Melander Olle
- Meneton Pierre
- Menni Cristina
- Metspalu Andres
- Mijatovic Vladan
- Mohlke Karen L.
- Moilanen Leena
- Montasser May E.
- Morris Andrew D.
- Morris Andrew P.
- Morrison Alanna C.
- Mulas Antonella
- Munroe Patricia B.
- Männistö Satu
- März Winfried
- Müller Gabriele
- Müller-Nurasyid Martina
- Nagaraja Ramaiah
- Narisu Narisu
- Newton-Cheh Christopher
- Nikus Kjell
- Njølstad Inger
- Nolte Ilja M.
- O'Donnell Christopher J.
- O'Reilly Paul F.
- Ong Ken K.
- Paccaud Fred
- Palmas Walter
- Palmer Cameron D.
- Palmer Colin N. A.
- Parsa Afshin
- Pedersen Nancy L.
- Penninx Brenda W.
- Perola Markus
- Pers Tune H.
- Peters Annette
- Petersen Ann-Kristin
- Pihur Vasyl
- Poulter Neil
- Pramstaller Peter P.
- Psaty Bruce M.
- Quertermous Thomas
- Rallidis Loukianos S.
- Rao Dabeeru C.
- Rasheed Asif
- Rauramaa Rainer
- Rayner N William
- Renström Frida
- Rettig Rainer
- Rice Kenneth M.
- Ridker Paul M.
- Roberts Robert
- Rose Lynda M.
- Rossouw Jacques
- Rotter Jerome I.
- Saleheen Danish
- Salfati Elias L.
- Salomaa Veikko
- Saltevo Juha
- Samani Nilesh J.
- Sanna Serena
- Saramies Jouko
- Schmidt Ellen M.
- Schunkert Heribert
- Schwarz Peter E. H.
- Sebert Sylvain
- Sever Peter
- Shah Sonia
- Sheu Wayne H.-H.
- Shin Young-Ah
- Shungin Dmitry
- Sim Xueling
- Smit Johannes H.
- Smith Albert V.
- Smith Andrew J. P.
- Snieder Harold
- Sosa Maria X.
- Spector Tim D.
- Stanton Alice V.
- Stančáková Alena
- Stefansson Kari
- Stirrups Kathleen E.
- Strawbridge Rona J.
- Stringham Heather M.
- Sundstrom Johan
- Swift Amy J.
- Syvänen Ann-Christine
- Tai E-Shyong
- Tanaka Toshiko
- Tarasov Kirill V.
- Taylor Kent D.
- Tayo Bamidele O.
- Teumer Alexander
- Theusch Elizabeth
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tobin Martin D.
- Tremoli Elena
- Tuomilehto Jaakko
- Uitterlinden Andre G.
- Uusitupa Matti
- Vaez Ahmad
- Vaidya Dhananjay
- Van Duijn Cornelia M.
- Van Iperen Erik P. A.
- Vasan Ramachandran S.
- Verwoert Germaine C.
- Virtamo Jarmo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Wagner Aline
- Wain Louise V.
- Wareham Nicholas J.
- Warren Helen
- Watkins Hugh
- Weder Alan B.
- Westra Harm-Jan
- Wichmann H-Erich
- Wilks Rainford
- Willer Cristen J.
- Wilsgaard Tom
- Wilson James F.
- Witkowska Kate
- Wong Andrew
- Wong Tien Y.
- Wu Ying
- Yang Tsun-Po
- Yao Jie
- Yengo Loic
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zhu Xiaofeng
- Publication venue
- Publication date
- 01/01/2016
- Field of study
To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation
Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial
- Author
- Abaci Adnan
- Abaci Adnan
- Abhaichand Rajpal
- Abhaichand Rajpal
- Adams Kirkwood
- Adams Kirkwood
- Akin Mustafa
- Akin Mustafa
- Alvarenga Pablo
- Alvarenga Pablo
- Apro Dezso
- Apro Dezso
- Arneja Jaspal
- Arneja Jaspal
- Aron Wilma
- Aron Wilma
- Babcak Marian
- Babcak Marian
- Babilonia Noe A.
- Babilonia Noe A.
- Badak Ozer
- Badak Ozer
- Banker Darshan
- Banker Darshan
- Barbiero Mario
- Barbiero Mario
- Barnard Denise
- Barnard Denise
- Baschiera Fabio
- Bassan Roberto
- Bassan Roberto
- Behrens Steffen
- Behrens Steffen
- Belohlavek Jan
- Belohlavek Jan
- Bergin James
- Bergin James
- Berkovich Olga
- Berkovich Olga
- Berkowski Piotr
- Berkowski Piotr
- Bharani Anil
- Bharani Anil
- Blumberg Eduardo Salmon
- Blumberg Eduardo Salmon
- Boccanelli Alessandro
- Boccanelli Alessandro
- Bodanese Luiz
- Bodanese Luiz
- Boldueva Svetlana
- Boldueva Svetlana
- Borghi Claudio
- Borghi Claudio
- Boyarkin Mikhail
- Boyarkin Mikhail
- Brabec Tomas
- Brabec Tomas
- Branzi Angelo
- Branzi Angelo
- Braun-Dullaeus Ruediger
- Braun-Dullaeus Ruediger
- Brottman Michael
- Brottman Michael
- Brown Christopher
- Brown Christopher
- Brunotte Richard
- Brunotte Richard
- Bueno Manuel Gomez
- Bueno Manuel Gomez
- Burnham Kenneth
- Burnham Kenneth
- Böhm Michael
- Cabrera Jose Angel
- Cabrera Jose Angel
- Callister Tracy
- Callister Tracy
- Canesin Manoel
- Canesin Manoel
- Cangemi Dott Francesco
- Cangemi Dott Francesco
- Castagnino Jorge
- Castagnino Jorge
- Cavallini Claudio
- Cavallini Claudio
- Chang Kuan-Cheng
- Chang Kuan-Cheng
- Cherng Wen-Jin
- Cherng Wen-Jin
- Chockalingam Kulasekaran
- Chockalingam Kulasekaran
- Chung Eugene
- Chung Eugene
- Cizinsky Stella
- Cizinsky Stella
- Cohen Ariel
- Cohen Ariel
- Comin Josep
- Comin Josep
- Costard-Jaeckle Angelika
- Costard-Jaeckle Angelika
- Cotes Carlos
- Cotes Carlos
- Dan Gheorghe
- Dan Gheorghe
- De Keulenaer Gilles
- De Keulenaer Gilles
- De Lorenzi Ettore
- De Lorenzi Ettore
- de Sa Esteban Lopez
- de Sa Esteban Lopez
- De Santis Fernando
- De Santis Fernando
- De Servi Stefano
- De Servi Stefano
- Dendale Paul
- Dendale Paul
- Di Biase Matteo
- Di Biase Matteo
- Di Somma Salvatore
- Di Somma Salvatore
- Diez Mirta
- Diez Mirta
- Dizeo Claudio
- Dizeo Claudio
- Dluzniewski Miroslaw
- Dluzniewski Miroslaw
- Dorobantu Maria
- Dorobantu Maria
- Dragulescu Stefan
- Dragulescu Stefan
- Duengen Hans-Dirk
- Duengen Hans-Dirk
- Dunlap Stephanie
- Dunlap Stephanie
- Dzielinska Zofia
- Dzielinska Zofia
- Ebelt Henning
- Ebelt Henning
- Ebinc Haksun
- Ebinc Haksun
- Echeverria Luis
- Echeverria Luis
- Eisen Howard
- Eisen Howard
- Ershova Olga
- Ershova Olga
- Felix Stephan
- Felix Stephan
- Fernandez Alberto
- Fernandez Alberto
- Ferrolino Arthur M.
- Ferrolino Arthur M.
- Figulla Hans-Reiner
- Figulla Hans-Reiner
- Fischer Sven
- Fischer Sven
- Floresta Agata
- Floresta Agata
- Florez Noel
- Florez Noel
- Fomin Igor
- Fomin Igor
- Fonarow Gregg C.
- Freire Ramon Bover
- Freire Ramon Bover
- French William
- French William
- Fulmer James
- Fulmer James
- Gadkari Milind
- Gadkari Milind
- Galinier Michel
- Galinier Michel
- Garcia Magali
- Garcia Magali
- Geiss Ernst
- Geiss Ernst
- Gheorghiade Mihai
- Giannetti Nadia
- Giannetti Nadia
- Gimpelewicz Claudio R.
- Goette Andreas
- Goette Andreas
- Goloschekin Boris
- Goloschekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Gonzalez Juanatey Jose Ramon
- Gonzalez Juanatey Jose Ramon
- Gordeev Ivan
- Gordeev Ivan
- Gordienko Alexander
- Gordienko Alexander
- Gosse Philippe
- Gosse Philippe
- Graf Kristof
- Graf Kristof
- Graham Susan
- Graham Susan
- Greco Dott Cosimo
- Greco Dott Cosimo
- Greco Oswaldo
- Greco Oswaldo
- Greene Stephen J.
- Gregor Pavel
- Gregor Pavel
- Guerrero Rodolfo Ahuad
- Guerrero Rodolfo Ahuad
- Gunawardena D.R.
- Gunawardena D.R.
- Gupta Vishal
- Gupta Vishal
- Habet Kalim
- Habet Kalim
- Haddad Haissam
- Haddad Haissam
- Hagerman Inger
- Hagerman Inger
- Hamann Frank
- Hamann Frank
- Hambrecht Rainer
- Hambrecht Rainer
- Hasbani Eduardo
- Hasbani Eduardo
- Hazelrigg Monica
- Hazelrigg Monica
- Heilman Karl
- Heilman Karl
- Heitzer Thomas
- Heitzer Thomas
- Hengstenberg Christian
- Hengstenberg Christian
- Henry Philippe
- Henry Philippe
- Herczeg Bela
- Herczeg Bela
- Hiremath Jagdish
- Hiremath Jagdish
- Hoffmann Stefan
- Hoffmann Stefan
- Hojerova Silvia
- Hojerova Silvia
- Hominal Miguel
- Hominal Miguel
- Hoppe Uta
- Hoppe Uta
- Hradec Jaromir
- Hradec Jaromir
- Hua Tsushung A.
- Hutyra Martin
- Hutyra Martin
- Huynh Thao
- Huynh Thao
- Ibañez Julio
- Ibañez Julio
- Isnard Richard
- Isnard Richard
- Izzo Joseph L.
- Izzo Joseph L.
- Jankowski Piotr
- Jankowski Piotr
- Jansky Petr
- Jansky Petr
- Jaramillo Mónica
- Jaramillo Mónica
- Joseph Susan
- Joseph Susan
- Jourdain Patrick
- Jourdain Patrick
- Juneman Elizabeth
- Juneman Elizabeth
- Kaeaeb Stefan
- Kaeaeb Stefan
- Karpov Yurii
- Karpov Yurii
- Kasperova Viera
- Kasperova Viera
- Katz Amos
- Katz Amos
- Katz Richard
- Katz Richard
- Keren Andre
- Keren Andre
- Kettner Jiri
- Kettner Jiri
- Khan Aziz
- Khan Aziz
- Kislyak Oxana
- Kislyak Oxana
- Kisters Klaus
- Kisters Klaus
- Klapholz Marc
- Klapholz Marc
- Kleinrok Andrzej
- Kleinrok Andrzej
- Knebel Fabian
- Knebel Fabian
- Kornacewicz-Jac Zdzislawa
- Kornacewicz-Jac Zdzislawa
- Kostenko Victor
- Kostenko Victor
- Kovar Frantisek
- Kovar Frantisek
- Krauze-Wielicka Magdalena
- Krauze-Wielicka Magdalena
- Kruells-Muench Juergen
- Kruells-Muench Juergen
- Kuchmin Alexey
- Kuchmin Alexey
- Kumbla Makund
- Kumbla Makund
- Kuo Chi-Tai
- Kuo Chi-Tai
- Kuo Jen-Yuan
- Kuo Jen-Yuan
- Kycina Peter
- Kycina Peter
- Lai Wen-Ter
- Lai Wen-Ter
- Lama Manuel Geraldia
- Lama Manuel Geraldia
- Le Tan Ju
- Le Tan Ju
- Lembo Giuseppe
- Lembo Giuseppe
- Lesogor Anastasia
- Leutermann-Oei Marie-Louise
- Leutermann-Oei Marie-Louise
- Lewis Basil
- Lewis Basil
- Lewis Eldrin F.
- Lippolis Nicholas
- Lippolis Nicholas
- Livarek Bernard
- Livarek Bernard
- Lopez Alejandro
- Lopez Alejandro
- Lopez Mónica
- Lopez Mónica
- Lueders Stephan
- Lueders Stephan
- Luna Alejandra
- Luna Alejandra
- Lundbye Justin
- Lundbye Justin
- Lupkovics Geza
- Lupkovics Geza
- Luquez Hugo
- Luquez Hugo
- Maggioni Aldo P.
- Mahajan Vijay
- Mahajan Vijay
- Maniyal Vijayakukmar
- Maniyal Vijayakukmar
- Manlutac Benjamin
- Manlutac Benjamin
- Marechal Patrick
- Marechal Patrick
- Marino Roberto Luis
- Marino Roberto Luis
- Marmor Alon
- Marmor Alon
- Marquez Lilia Lobo
- Marquez Lilia Lobo
- Martsevich Sergey
- Martsevich Sergey
- Masini Dott Franco
- Masini Dott Franco
- Mathur Atul
- Mathur Atul
- Matoltsy Andras
- Matoltsy Andras
- Mazurek Walentyna
- Mazurek Walentyna
- Mendoza Fernan
- Mendoza Fernan
- Metra Marco
- Metra Marco
- Meymandi Sheba
- Meymandi Sheba
- Milesi Rodolfo
- Milesi Rodolfo
- Militaru Constantin
- Militaru Constantin
- Miriuka Santiago
- Miriuka Santiago
- Mitrovic Veselin
- Mitrovic Veselin
- Mody Freny
- Mody Freny
- Moe Gordon
- Moe Gordon
- Moiseev Valentin
- Moiseev Valentin
- Monhart Zdenek
- Monhart Zdenek
- Mortara Andrea
- Mortara Andrea
- Murali Srinivas
- Murali Srinivas
- Muth Gerhard
- Muth Gerhard
- Najjar Samer
- Najjar Samer
- Nanjappa Manjunath
- Nanjappa Manjunath
- Neuder Yannick
- Neuder Yannick
- Neuenschwande Fernando
- Neuenschwande Fernando
- Nienaber Christoph
- Nienaber Christoph
- Nikolaidis Lazaros
- Nikolaidis Lazaros
- Novikova Nina
- Novikova Nina
- Nowalany-Kozie Ewa
- Nowalany-Kozie Ewa
- Nyman Kai
- Nyman Kai
- Olbrich Hans-Georg
- Olbrich Hans-Georg
- Oliveira Mucio
- Oliveira Mucio
- Omary Muhamad
- Omary Muhamad
- Ong Hean Yee
- Ong Hean Yee
- Oren Ron
- Oren Ron
- Orlikova Olga
- Orlikova Olga
- Pajari Risto
- Pajari Risto
- Pajes Giuseppe
- Pajes Giuseppe
- Pakhomova Inna
- Pakhomova Inna
- Palinkas Attila
- Palinkas Attila
- Parish David
- Parish David
- Patki Nitin
- Patki Nitin
- Peberdy Mary Ann
- Peberdy Mary Ann
- Percoco Dott Giovanni
- Percoco Dott Giovanni
- Perlman Richard
- Perlman Richard
- Perna Eduardo
- Perna Eduardo
- Peterka Martin
- Peterka Martin
- Peura Jennifer
- Peura Jennifer
- Phillips Roland
- Phillips Roland
- Picard François
- Picard François
- Pietilä Mikko
- Pietilä Mikko
- Pinna Jorge Garcia
- Pinna Jorge Garcia
- Piovaccari Giancarlo
- Piovaccari Giancarlo
- Pirelli Salvatore
- Pirelli Salvatore
- Poliacik Pavol
- Poliacik Pavol
- Poy Carlos
- Poy Carlos
- Premchand Rajendra
- Premchand Rajendra
- Prondzinsky Roland
- Prondzinsky Roland
- Quintero Adalberto
- Quintero Adalberto
- Ramos Silvina
- Ramos Silvina
- Ravikishore A.G.
- Ravikishore A.G.
- Reddy P. Naveen
- Reddy P. Naveen
- Reichert Petr
- Reichert Petr
- Reis Gilmar
- Reis Gilmar
- Remppis Bjoern
- Remppis Bjoern
- Roehnisch Jens-Uwe
- Roehnisch Jens-Uwe
- Romanowski Witold
- Romanowski Witold
- Rosocha Stefan
- Rosocha Stefan
- Rossol Siegbert
- Rossol Siegbert
- Rotter Achim
- Rotter Achim
- Santini Alberto
- Santini Alberto
- Santosh M.J.
- Santosh M.J.
- Saraiva Jose
- Saraiva Jose
- Schaufelberger Maria
- Schaufelberger Maria
- Schellong Sebastian
- Schellong Sebastian
- Schwinger Robert
- Schwinger Robert
- Schygiel Pablo
- Schygiel Pablo
- Selles Manuel Martinez
- Selles Manuel Martinez
- Severi Silvia
- Severi Silvia
- Sheppard Richard
- Sheppard Richard
- Shochat Michael
- Shochat Michael
- Shogenov Zaur
- Shogenov Zaur
- Shvarts Yury
- Shvarts Yury
- Simanenkov Vladimir
- Simanenkov Vladimir
- Sirotiakova Jana
- Sirotiakova Jana
- Sitnikova Maria
- Sitnikova Maria
- Skalina Ivan
- Skalina Ivan
- Smolders Walter
- Smolders Walter
- Solar Miroslav
- Solar Miroslav
- Solomon Scott D.
- Soriano FranciscoRidocci
- Soriano FranciscoRidocci
- Sosa Carlos
- Sosa Carlos
- Spinar Jindrich
- Spinar Jindrich
- Stancak Branislav
- Stancak Branislav
- Stawowy Philipp
- Stawowy Philipp
- Stewart Robert
- Stewart Robert
- Striekwold Harry
- Striekwold Harry
- Sussex Bruce
- Sussex Bruce
- Szachniewicz Joanna
- Szachniewicz Joanna
- Szelemej Roman
- Szelemej Roman
- Szentivanyi Miroslav
- Szentivanyi Miroslav
- Tebbe Ulrich
- Tebbe Ulrich
- Tereschenko Sergey
- Tereschenko Sergey
- Tomcsanyi Janos
- Tomcsanyi Janos
- Torres Adriana
- Torres Adriana
- Toth Kalman
- Toth Kalman
- Toth Peter
- Toth Peter
- Tranquilino Francisco P.
- Tranquilino Francisco P.
- Tyrenko Vadim
- Tyrenko Vadim
- Tyurina Tatiana
- Tyurina Tatiana
- Ullman Bengt
- Ullman Bengt
- Ural Dilek
- Ural Dilek
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhaecke Johan
- Vanhaecke Johan
- Vassanelli Corrado
- Vassanelli Corrado
- Vertes Andras
- Vertes Andras
- Vervoort Geert
- Vervoort Geert
- Vicho Raul
- Vicho Raul
- Vico Marisa
- Vico Marisa
- Viecca Maurizio
- Viecca Maurizio
- Vintila Marius
- Vintila Marius
- Visconti Luigi Oltrona
- Visconti Luigi Oltrona
- Vishnevsky Alexandr
- Vishnevsky Alexandr
- Vita Nestor
- Vita Nestor
- Vladoianu Mircea
- Vladoianu Mircea
- Volpe Massimo
- Volpe Massimo
- von Scheidt Wolfgang
- von Scheidt Wolfgang
- Vrolix Mathias
- Vrolix Mathias
- Werner Dierk
- Werner Dierk
- Werner Nikos
- Werner Nikos
- Wexler Dov
- Wexler Dov
- Wierzchowiecki Jerzy
- Wierzchowiecki Jerzy
- Williams Celeste
- Williams Celeste
- Winterton John
- Winterton John
- Wong Raymond
- Wong Raymond
- Wysokinski Andrzej
- Wysokinski Andrzej
- Yigit Zerrin
- Yigit Zerrin
- Yilmaz Mehmet
- Yilmaz Mehmet
- Yokusoglu Mehmet
- Yokusoglu Mehmet
- Yu Wen-Chung
- Yu Wen-Chung
- Zacà Valerio
- Zacà Valerio
- Zadionchenko Vladimir
- Zadionchenko Vladimir
- Zamolyi Karoly
- Zamolyi Karoly
- Zannad Faiez
- Zolty Ronald
- Zolty Ronald
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D
The trans-ancestral genomic architecture of glycemic traits
- Author
- Abecasis Gonçalo
- Adair Linda
- Aguilar-Salinas Carlos Alberto
- Ahluwalia Tarunveer
- Alarcón-Riquelme Marta
- Amin Najaf
- An Ping
- Anasanti Mila
- Appel Emil
- Arzumanyan Zorayr
- Astrup Arne
- Aviles-Santa Larissa
- Bakker Stephan
- Baldassarre Damiano
- Barroso Inês
- Becker Diane
- Beekman Marian
- Beilin Lawrence
- Bergman Richard
- Bergmann Sven
- Bertoni Alain
- Bielak Lawrence
- Bisgaard Hans
- Black Corri
- Blüher Matthias
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori
- Boomsma D.
- Bornstein Stefan
- Bottinger Erwin
- Boutin Thibaud
- Bowden Donald
- Brody Jennifer
- Buchanan Thomas
- Burtt Noël
- Böhm Bernhard
- Bønnelykke Klaus
- Cabrera Claudia
- Cade Brian
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Canouil Mickaël
- Caulfield Mark
- Chai Jin Fang
- Chai Xiaoran
- Chambers John
- Chan Kei Hang Katie
- Chang Li-Ching
- Chang Yi Cheng
- Chasman Daniel
- Chen Brian
- Chen Chien-Hsiun
- Chen Ji
- Chen Yii-Der Ida
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Chiu Yen-Feng
- Chu Audrey
- Claringbould Annique
- Collins Francis
- Corbin Laura
- Correa Adolfo
- Cucca Francesco
- de Geus Eco
- de Geus Eco
- de Haan Hugoline
- de Haan Hugoline
- de Silva H. Janaka
- de Silva H. Janaka
- Dedoussis George
- Dehghan Abbas
- Delgado Graciela
- Demirkan Ayse
- Du Shufa
- Duan Qing
- Dupuis Josée
- Eiriksdottir Gudny
- Elmståhl Sölve
- Engmann Jorgen
- Evans Michele
- Farmaki Aliki Eleni
- Fatumo Segun
- Ferrannini Ele
- Ferrucci Luigi
- Florez Jose
- Franks Paul
- Frayling Timothy
- Froguel Philippe
- Frånberg Mattias
- Fuchsberger Christian
- Gao Yutang
- Gayán Javier
- Gigante Bruna
- Giulianini Franco
- Gjesing Anette
- Gloyn Anna
- Goel Anuj
- Gong Jung Ho
- Goodarzi Mark
- Gordon-Larsen Penny
- Grallert Harald
- Grarup Niels
- Grimsgaard Sameline
- Groop Leif
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Hai Yang
- Hamsten Anders
- Han Sohee
- Hansen Torben
- Hartman Catharina
- Hartwig Fernando
- Hayward Caroline
- He Jing
- Heckbert Susan
- Heianza Yoriko
- Heikkinen Jani
- Herder Christian
- Hicks Andrew
- Hong Jaeyoung
- Horikoshi Momoko
- Horta Bernardo
- Hottenga Jouke-Jan
- Hsieh Chang-Hsun
- Hsueh Willa
- Huang Tao
- Huang Wei
- Huerta-Chagoya Alicia
- Huo Shaofeng
- Hwang Mi Yeong
- Ichihara Sahoko
- Igase Michiya
- Ikram M. Arfan
- Ingelsson Erik
- James Pankow
- Jarvelin Marjo-Ritta
- Jensen Richard
- Johnson W. Craig
- Jonas Jost
- Joshi Peter
- Jukema J. Wouter
- Jørgensen Marit
- Kaakinen Marika
- Kaleebu Pontiano
- Kalyani Rita
- Kandeel Fouad
- Kaplan Robert
- Kardia Sharon
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Keinanen-Kiukaanniemi Sirkka
- Kentistou Katherine
- Khor Chiea Chuen
- Kiess Wieland
- Kim Bong-Jo
- Kim Young Jin
- Kivimaki Mika
- Kleber Marcus
- Koistinen Heikki
- Kolcic Ivana
- Kooner Ishminder
- Kooner Jaspal
- Kovacs Peter
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuulasmaa Teemu
- Kuusisto Johanna
- Körner Antje
- Laakso Markku
- Lai Shuiqing
- Lakka Timo
- Lam Kelvin
- Lange Leslie
- Langefeld Carl
- Langenberg Claudia
- Launer Lenore
- Lauzon Marie
- Lawlor Deborah
- Leander Karin
- Lee Nanette
- Lemaitre Rozenn
- Leong Aaron
- Li Honglan
- Li Huaixing
- Li Man
- Li-Gao Ruifang
- Ligthart Symen
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia
- Lindström Jaana
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Simin
- Loh Marie
- Long Jirong
- Loos Ruth
- Lorenzo Carlos
- Louie Tin
- Luan Jian’an
- Lyssenko Valeriya
- Läll Kristi
- Magnusson Patrik
- Mahajan Anubha
- Mangino Massimo
- Marenne Gaëlle
- Marzi Carola
- Matsubara Tatsuaki
- Matsuda Fumihiko
- Mccarthy Mark
- Meigs James
- Metspalu Andres
- Mingrone Geltrude
- Mohlke Karen
- Montasser May
- Mooijaart Simon
- Mook-Kanamori Dennis
- Moon Sanghoon
- Moreno-Macias Hortensia
- Mori Trevor
- Morris Andrew
- Munroe Patricia
- Mägi Reedik
- März Winfried
- Nabika Toru
- Nadkarni Girish
- Nadler Jerry
- Nag Abhishek
- Nakatochi Masahiro
- Ndungu Anne
- Nelis Mari
- Nelson Sarah
- Neville Matt
- Njølstad Inger
- Noce Damia
- Nolte Ilja
- Noordam Raymond
- Norris Jill
- North Kari
- Ohyagi Yasumasa
- Oldehinkel Albertine
- Ong Ken
- O’connell Jeffrey
- Padmanabhan Sandosh
- Palmer Colin
- Palmer Nicholette
- Parker Stephen
- Pedersen Oluf
- Pennell Craig
- Peters Annette
- Peyser Patricia
- Pistis Giorgio
- Polasek Ozren
- Porteous David
- Pramstaller Peter
- Preuss Michael
- Prokopenko Inga
- Province Michael
- Psaty Bruce
- Qi Lu
- Qi Qibin
- Raffel Leslie
- Raffield Laura
- Rasmussen-Torvik Laura
- Raulerson Chelsea
- Rauramaa Rainer
- Raven Dennis
- Ray Debashree
- Redline Susan
- Reilly Dermot
- Reiner Alex
- Rich Stephen
- Ridker Paul
- Rivideneira Fernando
- Robertson Neil
- Rohde Rebecca
- Roll Kathryn
- Rosendaal Frits
- Rotter Jerome
- Rudan Igor
- Rueedi Rico
- Ryan Kathleen
- Rybin Denis
- Saaristo Timo
- Sabanayagam Charumathi
- Sandhu Manjinder
- Sandow Kevin
- Sanna Serena
- Saramies Jouko
- Sattar Naveed
- Saxena Richa
- Schneiderman Neil
- Schraut Katharina
- Schurmann Claudia
- Schwarz Peter
- Schürmann Annette
- Scott Laura
- Scott Robert
- Selvin Elizabeth
- Sennblad Bengt
- Setoh Kazuya
- Sever Peter
- Shi Jinxiu
- Shu Xiao-Ou
- Sim Xueling
- Slagboom P. Eline
- Small Kerrin
- Smith Albert
- Smith Blair
- Snieder Harold
- Sofer Tamar
- Southam Lorraine
- Sparsø Thomas
- Spector Tim
- Spracklen Cassandra
- Stanton Alice
- Steves Claire
- Stewart Isobel
- Strawbridge Rona
- Stringham Heather
- Stumvoll Michael
- Sun Liang
- Sørensen Thorkild
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tan Jingyi
- Taylor Kent
- Teslovich Tanya
- Thuesen Betina
- Timmers Paul
- Timpson Nicholas
- Tremoli Elena
- Trompet Stella
- Tsai Michael
- Tuomilehto Jaakko
- Tusie Teresa
- Tönjes Anke
- Uitterlinden Andre
- Uusitupa Matti
- van Dam Rob
- van Dam Rob
- van den Akker Erik
- van den Akker Erik
- van der Harst Pim
- van der Harst Pim
- van der Most Peter
- van der Most Peter
- van Duijn Cornelia
- van Duijn Cornelia
- van Heemst Diana
- van Heemst Diana
- van Hylckama Vlieg Astrid
- van Hylckama Vlieg Astrid
- van Vliet-Ostaptchouk Jana
- van Willems van Dijk Ko
- Vangipurapu Jagadish
- Varshney Arushi
- Verweij Niek
- Vestergaard Henrik
- Vitart Veronique
- Vogel Mandy
- Vollenweider Peter
- Vrijkotte Tanja
- Waage Johannes
- Wagenknecht Lynne
- Walker Mark
- Wang Carol
- Wang Chaolong
- Wang Heming
- Wang Nan
- Wang Tao
- Wang Ya
- Wang Yujie
- Wareham Nick
- Warren Helen
- Watanabe Richard
- Watkins Hugh
- Wei Wen
- Wen Wanqing
- Wheeler Eleanor
- Wickremasinghe Ananda
- Willems van Dijk Ko
- Willems Sara
- Willemsen Gonneke
- Wilsgaard Tom
- Wilson James
- Wong Andrew
- Wong Tien-Yin
- Wood Andrew
- Wu Jer-Yuarn
- Wu Peitao
- Wu Ying
- Xiang Anny
- Xie Tian
- Yanek Lisa
- Yao Jie
- Yengo Loïc
- Yokota Mitsuhiro
- Zafarmand Mohammad Hadi
- Zeggini Eleftheria
- Zemunik Tatijana
- Zhang Weihua
- Zhang Xiaoshuai
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zonderman Alan
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe
Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adzic Petar
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
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- Hatakeyama Kenichi
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- Hoepfner Kerstin
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- Juodagalvis Andrius
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- Woods Nathaniel
- Wright Douglas
- Wright Jack
- Wu Zhenbin
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Wöhrmann Clemens
- Würthwein Frank
- Xia Fan
- Xiao Meng
- Xie Si
- Xie Wei
- Xin Yongjie
- Xu Lingshan
- Xu Qiao
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Mingming
- Yang Unki
- Yang Yong
- Yang Yu Chul
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Sunan Kalijaga State Islamic University
- Publication date
- 01/01/2012
- Field of study
Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis
Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akin Ilina Vasileva
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Ian
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barth Christian
- Bartosik Nazar
- Basegmez Suzan
- Battilana Carlo
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Beernaert Kelly
- Behnamian Hadi
- Behr Joerg
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F.
- Benucci Leonardo
- Benussi Luigi
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- Beranek Sarah
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- Berger Joram
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- Bernet Colin
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- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
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- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhowmik Sandeep
- Bialkowska Helena
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- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breto Guillermo
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- Brigliadori Luca
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- Choudhary Brajesh C.
- Choudhury Somnath
- Christopher Grant
- Chu Jennifer
- Chwalek Thorsten
- Ciangottini Diego
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- Cihangir Selcuk
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- Claes Daniel R.
- Clare Robert
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- de Barbaro Pawel
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- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Degano Alessandro
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Del Rocio Vargas Trevino Andrea
- Delaere Christophe
- Delannoy Andrés G.
- Delgado Peris Antonio
- Dell'Orso Roberto
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- Kaplan Steven
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- Velkovska Julia
- Venditti Rosamaria
- Venturi Andrea
- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
- Vergili Mehmet
- Vernieri Caterina
- Verwilligen Piet
- Verzetti Mauro
- Veszpremi Viktor
- Vesztergombi Gyorgy
- Veverka Jan
- Vidal Marono Miguel
- Vidal Richard
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- Vilela Pereira Antonio
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
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- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Volpe Roberta
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Walker Matthew
- Wallny Rainer
- Walsh Roberval
- Waltenberger Wolfgang
- Wang Dayong
- Wang Fuqiang
- Wang Jian
- Wang Quan
- Wang Ren-Jie
- Wang Zheng
- Wardle Nicholas
- Wayand Stefan
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Weiler Thomas
- Weinberg Marc
- Welke Charles
- Wendland Lauri
- Weng Yao
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Wickramage Nadeesha
- Wilbur Scott
- Wilken Rachel
- Wilkinson Richard
- Williams Thomas
- Wimpenny Stephen
- Winer Brian L.
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wolf Matthias
- Wolf Roger
- Wolfe Homer
- Wollny Heiner
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Woodard Anna
- Woods Nathaniel
- Worm Steven
- Wright Douglas
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xiao Meng
- Xie Si
- Xie Wei
- Xu Lingshan
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- York Andrew
- You Can
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zvada Marian
- Publication venue
- American Meteorological Society
- Publication date
- 01/08/2011
- Field of study
The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
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- Abington E
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- Abozyed MAF
- Abudeeb H
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- Adel A
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- Zerihun AB
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
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