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974 research outputs found

Implementación de receta digital en Swiss Medical, Argentina

Author: Castro D.
Curras V.
Del Piano E.
González F.
Novick G.
Quispe Uznayo M.
Publication venue
Publication date: 01/09/2019
Field of study

La prescripción de un fármaco es un acto médico y administrativo. La prescripción electrónica genera menor riesgo de errores de legibilidad en la dispensación, administración de medicamentos, y permitiendo utilizar sistemas de soporte a toma de decisiones. Asimismo, evitan problemas de facturación y posibles fraudes. En marzo de 2016 Swiss Medical y DXC.technology se implementó la Historia Clínica Electrónica, donde se puede acceder al historial del paciente y contar con sistemas de alertas de duplicidad de principio activo y dosis máxima. En agosto de 2018 se inició el proyecto de telemedicina y receta digital, con atención a pacientes pediátricos y adultos afiliados. En la cual se genera la receta por nombre genérico (Ley 25.649), con firma digital (Ley 25.506), enviando la receta y las indicaciones médicas al paciente, para que accedan a cualquier farmacia de la red de Farmalink para adquirir el fármaco prescrito.Sociedad Argentina de Informática e Investigación Operativ

Servicio de Difusión de la Creación Intelectual

GATEKEEPER’s Strategy for the Multinational Large-Scale Piloting of an eHealth Platform: Tutorial on How to Identify Relevant Settings and Use Cases

Author: Androutsos O.
Antonini Alessio
Arana E.
Arredondo M. T.
Barbastro R. A.
Barbe F.
Benitez I. D.
Cabrera-Umpierrez M. F.
Cea G.
Curras P.
Dafoulas G. Epsilon.
de Batlle J.
Fico G.
Folkvord F.
Fullaondo A.
Giuliani F.
Guillen S.
Huang H. -L.
Innominato P. F.
Kardas P.
Lou V. W. Q.
Manios Y.
Matsangidou M.
Mercalli F.
Mokhtari Mounir
Moncusi-Moix A.
Pagliara S. M.
Pecchia L.
Posada J.
Schellong J.
Stieler L.
Torres G.
Votis K.
Publication venue
Publication date: 01/01/2023
Field of study

Background: The World Health Organization’s strategy toward healthy aging fosters person-centered integrated care sustained by eHealth systems. However, there is a need for standardized frameworks or platforms accommodating and interconnecting multiple of these systems while ensuring secure, relevant, fair, trust-based data sharing and use. The H2020 project GATEKEEPER aims to implement and test an open-source, European, standard-based, interoperable, and secure framework serving broad populations of aging citizens with heterogeneous health needs. Objective: We aim to describe the rationale for the selection of an optimal group of settings for the multinational large-scale piloting of the GATEKEEPER platform. Methods: The selection of implementation sites and reference use cases (RUCs) was based on the adoption of a double stratification pyramid reflecting the overall health of target populations and the intensity of proposed interventions; the identification of a principles guiding implementation site selection; and the elaboration of guidelines for RUC selection, ensuring clinical relevance and scientific excellence while covering the whole spectrum of citizen complexities and intervention intensities. Results: Seven European countries were selected, covering Europe’s geographical and socioeconomic heterogeneity: Cyprus, Germany, Greece, Italy, Poland, Spain, and the United Kingdom. These were complemented by the following 3 Asian pilots: Hong Kong, Singapore, and Taiwan. Implementation sites consisted of local ecosystems, including health care organizations and partners from industry, civil society, academia, and government, prioritizing the highly rated European Innovation Partnership on Active and Healthy Aging reference sites. RUCs covered the whole spectrum of chronic diseases, citizen complexities, and intervention intensities while privileging clinical relevance and scientific rigor. These included lifestyle-related early detection and interventions, using artificial intelligence–based digital coaches to promote healthy lifestyle and delay the onset or worsening of chronic diseases in healthy citizens; chronic obstructive pulmonary disease and heart failure decompensations management, proposing integrated care management based on advanced wearable monitoring and machine learning (ML) to predict decompensations; management of glycemic status in diabetes mellitus, based on beat to beat monitoring and short-term ML-based prediction of glycemic dynamics; treatment decision support systems for Parkinson disease, continuously monitoring motor and nonmotor complications to trigger enhanced treatment strategies; primary and secondary stroke prevention, using a coaching app and educational simulations with virtual and augmented reality; management of multimorbid older patients or patients with cancer, exploring novel chronic care models based on digital coaching, and advanced monitoring and ML; high blood pressure management, with ML-based predictions based on different intensities of monitoring through self-managed apps; and COVID-19 management, with integrated management tools limiting physical contact among actors. Conclusions: This paper provides a methodology for selecting adequate settings for the large-scale piloting of eHealth frameworks and exemplifies with the decisions taken in GATEKEEPER the current views of the WHO and European Commission while moving forward toward a European Data Space

Archivio istituzionale della ricerca - Università di Cagliari

Selection of the silicon sensor thickness for the Phase-2 upgrade of the CMS Outer Tracker

Author: Abbaneo D.
Abbas M.
Acosta J. G.
Adam W.
Agram J.-L.
Ahmad A.
Ahmed I.
Albergo S.
Albert A.
Albert E.
Alexander J.
Alhusseini M.
Allard Y.
Almeida J.
Ambrozas M.
Amram O.
Anagnostou G.
Andrea J.
Androsov K.
Anguiano J.
Apparu D.
Ardila L.
Asenov P.
Asilar E.
Assiouras P.
Azzi P.
Azzurri P.
Bacchetta N.
Backhaus M.
Bagliesi G.
Bainbridge R.
Bakshi A.
Baldinelli G.
Balzer M.
Balázs T.
Barbagli G.
Barinoff M.
Bartek R.
Bartz E.
Barvich T.
Basti A.
Batista Lopes J.
Baulieu G.
Bean A.
Beaumont W.
Beccherle R.
Becerril Gonzalez H.
Becker R.
Beghin D.
Bellan R.
Benelli G.
Bergamin G.
Bergauer T.
Berger P.
Berry D. R.
Bertacchi V.
Bertl W.
Bethani A.
Bhardwaj A.
Bhattacharya R.
Bianchi F.
Bianchini L.
Bilei G. M.
Bilin B.
Bisello D.
Bizzaglia S.
Blanchot G.
Blank T.
Blekman F.
Bloch D.
Bloom K.
Blöch D.
Boccali T.
Bonnin C.
Bordlemay Padilla Y.
Borg J.
Bortignon P.
Bosi F.
Botta V.
Boudoul G.
Bourgatte G.
Boyer F.
Brianzi M.
Bright-Thonney S.
Brigljević V.
Brivio F.
Brom J.-M.
Brown C.
Bruno G.
Brzhechko D.
Brücken E.
Burkett K.
Burkle B.
Bury F.
Butler D.
Butz E.
Bösiger K.
Calafiori D. di
Calandri A.
Caminada L.
Canelli F.
Canepa A.
Cannaert E.
Caponetto L.
Caprai M.
Caputo C.
Caratelli A.
Cardwell B.
Cariola P.
Carnesecchi R.
Caselle M.
Cassese A.
Castaldi R.
Ceccarelli R.
Ceresa D.
Chabert E.
Chang P.
Chanon N.
Charles L.
Chawla R.
Checcucci B.
Chen P.-H.
Chen X.
Cheng C.
Cheng T.
Cheng Y.
Chertok M.
Christiansen J.
Ciangottini D.
Ciaranfi R.
Cichy K.
Ciocci M. A.
Ciulli V.
Civinini C.
Claes D. R.
Clement E.
Clerbaux B.
CMS Tracker Collaboration
Coldham K.
Cole J.
Coli S.
Collard C.
Connor P.
Contardo D.
Conway J.
Conway J.
Cooperstein S. B.
Cormier K.
Costa M.
Costa S.
Coubez X.
Coughlan J. A.
Covarelli R.
Cranshaw D.
Creanza D.
Cremaldi L. M.
Cumalat J. P.
Curras Rivera E.
Cussans D.
D\u27Alessandro R.
D\u27Angelo P.
D\u27Hondt J.
Daguin J.
Dangelser E.
Darej D.
Das A.
Das S.
Daskalakis G.
Datta A.
David P.
De Boer W.
De Cosa A.
De Lentdecker G.
De Robertis G.
De Wit A.
Deblaere A.
Deelen N.
Del Burgo R.
Delaere C.
Delcourt M.
Dell\u27Orso R.
Dellacasa G.
Demaria N.
Demina R.
Demiragli Z.
Deng W.
Dené P.
Derylo G.
Detraz S.
Di Croce D.
Di Mattia A.
Di Petrillo K. F.
Dickinson J.
Dierlamm A.
Dinardo M. E.
Dini P.
Dittmer S.
Djambazov L.
Dolen J.
Dominguez A.
Donato S.
Donega M.
Donertas I. S.
Dorfer C.
Dorigo T.
Dragicevic M.
Droll A.
Duarte Campderros J.
Dudek M.
Dulemba J.
Dupasquier T.
Durgut S.
Dutta S.
Dutta V.
Dziwok C.
Eble F.
Ebrahimi A.
Eckerlin G.
Ecklund K. M.
Eckstein D.
Eerola P.
El Morabit K.
Elicabuk U.
Eminizer N.
Emriskova N.
Erdmann W.
Eusebi R.
Evdokimov A.
Evdokimov O.
Faccio F.
Fangmeier C.
Fanò L.
Farnesini L.
Favart L.
Fedi G.
Feld L.
Ferenček D.
Fernandez M.
Ferro F.
Filenius A.
Fiore L.
Fiori F.
Fluegge G.
Focardi E.
Ford W. T.
Francis B.
Frank N.
Freed S.
French T.
Frühwirth R.
Gaioni L.
Galbit G.
Gallo E.
Gandrakotra A.
Garbolino S.
Garcia Alonso A.
Gastler D.
Gennai S.
Gerber C. E.
Gerosa R.
Gershtein Y.
Ghorbani M.
Ghosh A.
Giammanco A.
Giannini L.
Giassi A.
Gingu C.
Glessgen F.
Goerlach U.
Goldstein J.
Golf F.
Gomez G.
Gonzalez Sanchez F. J.
Gonzalez H.
Gouskos L.
Grab C.
Grebenyuk A.
Grimault C.
Grippo M.
Grippo M. T.
Gritsan A.
Gross L.
Grünendahl S.
Guthoff M.
Guzzi L.
Haas C.
Hahn K.
Halkiadakis E.
Hall G.
Hanson G.
Harb A.
Harder K.
Hart A.
Hartmann F.
Haza G.
Hazen E.
Heintz U.
Hemer D.
Hill C. S.
Hindrichs O.
Hinger V.
Hinton N.
Hits D.
Hofman D. J.
Hogan J.
Hogan S.
Hohov D.
Hollos A.
Honma A.
Horisberger R.
Horyn L.
Hou W.-S.
Hugo G.
Husemann U.
Huwiler M.
Iashvili I.
Incandela J.
Ince M.
Ionica M.
Ivanov A.
Jain C.
Jain G.
Jain S.
Janssen X.
Jaramillo Echeverria R.
Jensen F.
Jofrehei A.
Johnson M.
Jones M.
Joo C.
Jung A.
Juodagalvis A.
Kaestli H.-C.
Kalsi A.
Kaplon J.
Kar C.
Karpinski W.
Kazas I.
Kello T.
Kerekes Z.
Khalil S.
Khalilzadeh A.
Khan A.
Kharchilava A.
Kilminster B.
Kilpatrick M.
Klabbers P.
Klein K.
Kleinwort C.
Kloukinas K.
Koppenhöfer R.
Korjenevski S.
Korotkov A.
Koshy A.
Koss N.
Kotlinski D.
Kottelat L.
Koukola D.
Kovacs M.
Krauth M.
Kravchenko I.
Krutelyov S.
Kumar A.
Kumar A.
Kyberd P.
Kyre S.
Kyriacou S.
Kyriakis A.
La Rosa A.
Lampén T.
Langenegger U.
Lantz S.
Lath A.
Latino G.
Lei C. M.
Lelek A.
Lemaitre V.
Lenoir P.
Lenzi P.
Leontsinis S.
Li D.
Li J.
Ligabue F.
Lipinski M.
Lipton R.
Liu H.
Liu M.
Liu Y.
Lizzo M.
Loddo F.
Loos R.
Los S.
Louis D.
Loukas D.
Lowette S.
Lu R.-S.
Lukasik M.
Lumb N.
Lustermann W.
Luukka P.
Macchiolo A.
MacDonald E.
Magazzu G.
Maggi G.
Magherini M.
Mahdavikhorrami M.
Maier R.
Maier S.
Majumder D.
Makarenko I.
Maksimovic P.
Mal P.
Malik S.
Mallows S.
Malvezzi S.
Manca E.
Mandorli G.
Manghisoni M.
Mankel R.
Manolopoulos K.
Mantilla Suarez C.
Mantovani G.
Marchioro A.
Mariani V.
Martikainen L.
Martiradonna S.
Maser H.
Massa M.
Mateos Dominguez I.
Mazzoni E.
McLean C.
Mehner T.
Meier B.
Meinhard M.
Menasce D.
Menichelli M.
Merkel P.
Mersi S.
Meschini M.
Messineo A.
Metzler M.
Meuser D.
Meyer M.
Michelis S.
Migliore E.
Mikuni V.
Millet A.
Mills C.
Mirabito L.
Mishra S.
Missiroli M.
Mitchell T.
Modak A.
Modes J.
Moggi A.
Mohanty R.
Molinatti U.
Mondal K.
Mongelli M.
Monk D.
Monroy J.
Monteil E.
Monteno M.
Moortgat S.
Moroni L.
Morozzi A.
Morsani F.
Morton A.
Moscatelli F.
Moureaux L.
Moya D.
Muhammad S.
Muhl C.
Muller D.
Muller Th.
Murat P.
Mussgiller A.
My S.
Márton K.
Müller-Gosewisch J.-O.
Nachtman J.
Nahn S.
Narain M.
Nash K.
Negro G.
Neufeld M.
Neutelings I.
Nguyen D.
Nibigira E.
Niedziela J.
Nodari B.
Noehte L.
Norberg S.
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Nürnberg A.
Oliveros S.
Ollivier-Henry N.
Onel Y.
Onnela A.
Orfanelli S.
Ortona G.
Osherson M.
Otarid Y.
Pacher L.
Pakulski T.
Palit P.
Palla F.
Palma M. de
Paoletti S.
Papadopoulos A.
Parashar N.
Parker A.
Parolia S.
Passeri D.
Pauls A.
Peck A.
Pedrini D.
Pekkanen J.
Perera L.
Perez Gomez F.
Perez A.
Perloff A.
Pernot J.-F.
Perovic V.
Perries S.
Pesaresi M.
Petagna P.
Piazza Q.
Piccinelli A.
Pierschel G.
Pitzl D.
Placidi P.
Pooth O.
Popov A.
Postema H.
Postiau N.
Potenza R.
Prisciandaro J.
Qu H.
Quach D.
Quinnan M.
Raffaelli F.
Ramirez Sanchez G.
Ramirez Vargas J. E.
Ranjan K.
Rappoccio S.
Ratti L.
Rauch M.
Ravera F.
Re V.
Reichelt O.
Reichert J.
Reichmann M.
Reid I. D.
Reid M.
Reimers A.
Riceputi E.
Riley D.
Rinkevicius A.
Ristic B.
Rivera R.
Rivetti A.
Rizzi A.
Robert F.
Robmann P.
Robutti E.
Roeser U.
Roguljić M.
Rohe T.
Rohlf J.
Rose P.
Roskes J.
Rossi A.
Roy Chowdhury S.
Roy T.
Rude C.
Rudrabhatla S.
Ruini D.
Ruiz Jimeno A.
Ryd A.
Röwert N.
Sagir S.
Saha G.
Saha P.
Sahasransu A. R.
Saizu M. A.
Sander O.
Santocchia A.
Sarkar S.
Sathia B. N.
Saumya S.
Savitskyi M.
Scarfì S.
Schell D.
Schmitz E.
Schnetzer S.
Schröder M.
Schulz J.
Scodellaro L.
Seidita R.
Seif El Nasr-Storey S.
Selvaggi G.
Sguazzoni G.
Sharma V.
Shvetsov I.
Si W.
Siado J.
Siklér F.
Silva Jiménez E.
Silvestris L.
Simonis H. J.
Simpson F.
Sinani M.
Skinnari L.
Smolenski K.
Snyder C.
Solano A.
Song Z.
Spagnolo P.
Spencer E.
Spiegel L.
Spiga D.
Stahl A.
Stanulla J.
Starodumov A.
Steck P.
Steininger H.
Stenson K.
Stever R.
Stone R.
Storchi L.
Streuli S.
Strohman C.
Stylianou N.
Sultan A.
Summers D.
Sung K.
Swain S.
Swartz M.
Szilasi N.
Sörensen J.
Sørensen Bols E.
Tadel M.
Takahashi Y.
Taliercio A.
Tavares Rego R.
Taylor R.
Tedeschi T.
Teklishyn M.
Tenchini R.
Teroerde M.
Thieman J.
Thom J.
Thomas L.
Thomson J.
Tomalin I. R.
Tonelli G.
Tonon N.
Tosi M.
Traversi G.
Tricomi A.
Tropea P.
Troska J.
Tsirou A.
Tuominen E.
Turrioni C.
Tuuva T.
Tuve C.
Uchida K.
Ulmer K. A.
Uniyal R.
Uplegger L.
Usai E.
Vagnerini A.
Vami T.
Van Mechelen P.
Van Putte S.
Van Remortel N.
Vander Donckt M.
Vanlaer P.
Vannerom D.
Vargas Hernandez A. M.
Vasey F.
Velyka A.
Venturi A.
Verdini P. G.
Veszprémi V.
Vichoudis P.
Vila I.
Viliani L.
Viret S.
Virto A. L.
Vischia P.
Vizan Garcia J. M.
Voelker J.
Voirin E.
Wagner S. R.
Wallny R.
Walsh R.
Wang H.
Wang Q.
Wang Q.
Wassmer M.
Weber H. A.
Weber M.
Weddigen A.
Wei K.
Wei W.
Welton T.
Wertz S.
Wilson G.
Wittich P.
Wittig F.
Wlochal M.
Wolf D.
Wong W. Y.
Yagil A.
Yang Y.
Yarar H.
Yi K.
Yohay R.
Yoo J.
Zhang F.
Zhang W.
Ziemons T.
Zografos A.
Zou R.
Zuber A.
Zuolo D.
Šuša T.
Publication venue: Institute of Physics Publishing Ltd
Publication date: 02/12/2021
Field of study

During the operation of the CMS experiment at the High-Luminosity LHC the silicon sensors of the Phase-2 Outer Tracker will be exposed to radiation levels that could potentially deteriorate their performance. Previous studies had determined that planar float zone silicon with n-doped strips on a p-doped substrate was preferred over p-doped strips on an n-doped substrate. The last step in evaluating the optimal design for the mass production of about 200 m

^{2}

of silicon sensors was to compare sensors of baseline thickness (about 300 μm) to thinned sensors (about 240 μm), which promised several benefits at high radiation levels because of the higher electric fields at the same bias voltage. This study provides a direct comparison of these two thicknesses in terms of sensor characteristics as well as charge collection and hit efficiency for fluences up to 1.5 × 10

^{15}

_{eq}

/cm

^{2}

. The measurement results demonstrate that sensors with about 300 μm thickness will ensure excellent tracking performance even at the highest considered fluence levels expected for the Phase-2 Outer Tracker

KITopen

Comparative evaluation of analogue front-end designs for the CMS Inner Tracker at the High Luminosity LHC

Author: Abbaneo D.
Abbas M.
Acosta J. G.
Adam W.
Agram J.-L.
Ahmed I.
Albergo S.
Albert A.
Albert E.
Alexander J.
Alhusseini M.
Allard Y.
Almeida J.
Amram O.
Anagnostou G.
Andrea J.
Androsov K.
Anguiano J.
Apparu D.
Ardila L.
Asenov P.
Asilar E.
Assiouras P.
Azzi P.
Azzurri P.
Bacchetta N.
Backhaus M.
Bagliesi G.
Bainbridge R.
Bakshi A.
Baldinelli G.
Balzer M.
Balázs T.
Barbagli G.
Barinoff M.
Bartek R.
Bartz E.
Barvich T.
Basti A.
Batista Lopes J.
Baulieu G.
Bean A.
Beaumont W.
Beccherle R.
Becerril Gonzalez H.
Becker R.
Beghin D.
Bellan R.
Benecke A.
Benelli G.
Bergamin G.
Bergauer T.
Berger P.
Berry D. R.
Bertacchi V.
Bertl W.
Bethani A.
Bhardwaj A.
Bhattacharya R.
Bianchi F.
Bianchini L.
Bilei G. M.
Bilin B.
Bisello D.
Biskop H.
Bizzaglia S.
Blanchot G.
Blank T.
Blekman F.
Bloch D.
Bloom K.
Blöch D.
Boccali T.
Bonnin C.
Bordlemay Padilla Y.
Borg J.
Bortignon P.
Bosi F.
Boudoul G.
Bourgatte G.
Boyer F.
Brianzi M.
Bright-Thonney S.
Brigljevic V.
Brivio F.
Brom J.-M.
Brown C.
Bruno G.
Brzhechko D.
Brücken E.
Buhmann P.
Burkett K.
Burkle B.
Bury F.
Butler D.
Butz E.
Bösiger K.
Calandri A.
Caminada L.
Canelli F.
Canepa A.
Cannaert E.
Caponetto L.
Caprai M.
Caputo C.
Caratelli A.
Cardwell B.
Cariola P.
Carnesecchi R.
Caselle M.
Cassese A.
Castaldi R.
Ceccarelli R.
Ceresa D.
Chabert E.
Chang P.
Chanon N.
Charles L.
Chawla R.
Checcucci B.
Chen P.-H.
Chen X.
Cheng C.
Cheng T.
Cheng Y.
Chertok M.
Christiansen J.
Ciangottini D.
Ciaranfi R.
Cichy K.
Ciocci M. A.
Ciulli V.
Civinini C.
Claes D. R.
Clement E.
Clerbaux B.
Coldham K.
Cole J.
Coli S.
Collard C.
Connor P.
Contardo D.
Conway J.
Conway J.
Cooperstein S. B.
Cormier K.
Costa M.
Costa S.
Coubez X.
Coughlan J. A.
Covarelli R.
Cranshaw D.
Creanza D.
Cremaldi L. M.
Cumalat J. P.
Curras Rivera E.
Cussans D.
Daguin J.
Dangelser E.
Darej D.
Das A.
Das S.
Daskalakis G.
Datta A.
David P.
De Boer W.
De Lentdecker G.
De Palma M.
De Robertis G.
De Wit A.
Deblaere A.
Deelen N.
Del Burgo R.
Delaere C.
Delcourt M.
Dellacasa G.
Dell’Orso R.
Demaria N.
Demina R.
Demiragli Z.
Deng W.
Dené P.
Derylo G.
Detraz S.
Di Calafiori D.
Di Croce D.
Di Mattia A.
Dickinson J.
Dierlamm A.
Dinardo M. E.
Dini P.
Dittmer S.
Djambazov L.
Dolen J.
Dominguez A.
Donato S.
Donega M.
Donertas I. S.
Dorfer C.
Dorigo T.
Dragicevic M.
Droll A.
Duarte Campderros J.
Dudek M.
Dulemba J.
Dupasquier T.
Durgut S.
Dutta S.
Dutta V.
Dziwok C.
D’Alessandro R.
D’Angelo P.
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Starodumov A.
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Stever R.
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Sung K.
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Wagner S. R.
Wallny R.
Walsh R.
Wang H.
Wang Q.
Wang Q.
Wassmer M.
Weber H. A.
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Wolf D.
Wong W. Y.
Yagil A.
Yang Y.
Yarar H.
Yi K.
Yohay R.
Yoo J.
Zhang F.
Zhang W.
Ziemons T.
Zografos A.
Zoi I.
Zou R.
Zuber A.
Zuolo D.
Šuša T.
Publication venue: Institute of Physics Publishing Ltd
Publication date: 26/01/2022
Field of study

The CMS Inner Tracker, made of silicon pixel modules, will be entirely replaced prior to the start of the High Luminosity LHC period. One of the crucial components of the new Inner Tracker system is the readout chip, being developed by the RD53 Collaboration, and in particular its analogue front-end, which receives the signal from the sensor and digitizes it. Three different analogue front-ends (Synchronous, Linear, and Differential) were designed and implemented in the RD53A demonstrator chip. A dedicated evaluation program was carried out to select the most suitable design to build a radiation tolerant pixel detector able to sustain high particle rates with high efficiency and a small fraction of spurious pixel hits. The test results showed that all three analogue front-ends presented strong points, but also limitations. The Differential front-end demonstrated very low noise, but the threshold tuning became problematic after irradiation. Moreover, a saturation in the preamplifier feedback loop affected the return of the signal to baseline and thus increased the dead time. The Synchronous front-end showed very good timing performance, but also higher noise. For the Linear front-end all of the parameters were within specification, although this design had the largest time walk. This limitation was addressed and mitigated in an improved design. The analysis of the advantages and disadvantages of the three front-ends in the context of the CMS Inner Tracker operation requirements led to the selection of the improved design Linear front-end for integration in the final CMS readout chip

KITopen

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Author: Abdulla A.
Abelake Eugenia
Adeel A.O.A.
Aebi C.
Agapow P.
Agbeko R.
Agyeman P.
Anderson S.
Antonio M.
Arpe V.
Ausserer B.
Baer W.
Barham H.
Barral-Arca Ruth
Barrios X.G.
Bartlett M.
Beckmann R.
Beiroa A.G.
Bellos E.
Bensch J.
Berger C.
Berger T.
Bernhard-Stirnemann S.
Binder A.
Bindl L.
Bittrich H.J.
Boeddha N.P.
Bojang K.
Bokhandi S.
Borghini L.
Brangenberg R.
Breuer H.A.
Breukels M.A.
Brinkman D.M.C.
Brió Sanagustín Sonia
Broede H.
Bruckner R.
Calle I.R.
Carreras Eduardo
Carrol E.D.
Carter S.
Cebey-López M.
Coin L.J.
Cole F.
Contreras J.R.
Cratev L.
Cremer M.
Curras-Tuala M.J.
Davies P.
Davila S.
de Groot R.
de Korte C.C.M.M.
de Vries E.
de Waal W.J.
Deeg K.H.
Deep A.
Dekkers R.
Diab G.
Dilch A.
Dings-Lammertink A.
Doedens R.A.
Donker A.E.
Dousma M.
Driessen G.J.A.
Eitelberger F.
Eleftherohorinou H.
Emonts M.
Evert W.
Faber T.E.
Faust S.
Fedlmaier M.
Fernández R.
Fernández S.S.
Fink C.
Forte M.S.
Fortune P.M.
Frederick H.
Fucik P.
Fusch C.
Förster K.M.
Gabriel Markwart
Galassini R.
García N.
Geishofer G.
Gerrits G.P.J.M.
Gerver J.A.M.
Giannoni E.
González F.Á.
Gormley S.
Grande A.J.
Gribbin A.
Groneck P.
Grube R.
Gruber A.
Gröblacher-Roth H.
Guillén S.
Gómez-Carballa A.
Göpel W.
Görke W.
Hamilton S.
Hammer J.
Hardy K.
Hasters P.
Hauser E.
Hautz J.
Hazelzet J.
Heidema J.
Heininger U.
Heininger U.
Hennenberger A.
Herberg J.
Herrmann J.
Herting E.
Hibberd M.L.
Hofmann T.
Hoggart C.
Homan-van der Veen J.
Hourmat B.
Hudnott P.
Huemer C.
Hüseman D.
Iglesias P.L.
Inwald D.
Jacobs M.A.M.
Jansen N.J.G.
Jennings R.
Johnston J.
Kaforou M.
Kahlert C.
Kalhoff H.
Kasper J.M.
Kawczynski P.
Kebbeh N.
Kenwright R.
Klinge J.
Klobassa D.
Klucovska K.
Knaufer-Schiefer S.
Kneyber M.C.J.
Koch H.
Koch R.
Koopman-Keemink Y.
Kronberger M.
Kuijpers T.W.
Kumlien B.
Kunze W.
Kurnik P.
König M.
Langenhorst V.J.
Lenz K.
Leusink J.
Levin M.
León M.C.L.
Lischka A.
Loranth K.
Loza B.F.
Lozano M.J.
Luigs P.
Lässig W.
Maak B.
Mahler K.
Markart M.
Martin M.
Martinon-Torres F.
Martinón-Torres N.
Mashbat M.
McCorkell J.
McCready S.
Meier P.
Meissl M.
Menikou S.
Merth I.T.
Miedema C.J.
Miething R.
Mingorance Á.N.
Mitter H.
Moreno D.
Moser R.
Mustafa S.
Müller H.
Nadel S.
Navarra H.
Navarro M.
Neeleman C.
Neth O.
Nicolai T.h.
Niederer-Loher A.
Noordzij J.G.
Nossal R.
Nsirim E.
O'Neill L.
Obihara C.C.
Pacheco P.O.
Padilla M.d.C.M.
Pajkrt D.
Paky F.
Palacios A.
Pardo-Seco J.
Patel R.
Patel S.
Pathan N.
Paulus S.
Penzien J.M.
Pernice W.
Peters J.
Peters M.
Pfau E.
Pfurtscheller K.
Philipsen H.L.A.
Pinnock E.
Pischedda S.
Png E.
Pollard A.J.
Poortman G.H.
Posfay-Barbe K.M.
Potgieter S.T.
Potjewijd J.
Power S.
Pérez B.M.
Quietzach J.
Rahman R.
Ramaiah R.
Redondo-Collazo L.
Reiter H.L.
Reiter K.
Relly C.
Reyes S.B.
Rial J.G.
Ridout J.
Rodríguez-Tenreiro C.
Rojo P.
Rosias P.P.R.
Royad C.
Runge K.
Rödl S.
Saidykhan M.
Salas Antonio
Salzer H.R.
Sancho-Shimizu V.
Sanders E.A.M.
Santos A.E.M.
Sarr I.
Schaller G.
Scheibenpflug C.
Schermann P.
Schimmel U.
Schlapbach L.J.
Schmidt A.
Schulz D.
Schwarick J.
Schwarz R.
Schweitzer-Krantz S.
Schürmann R.
Secka F.
Seidenberg J.
Seidler E.
Seitz C.
Sey G.
Sillaber U.
Silva M.d.S.P.
Silveira L.F.
Simic-Schleicher G.
Simma B.
Sitzmann F.C.
Sontheimer D.
Sperl W.
Sprong T.
Standing F.
Stocker M.
Straßer F.
Streif W.
Sánchez F.G.
Sánchez J.M.M.
Ta V.H.
Tato L.M.P.
ten Tussher G.W.
Thakker C.
Thio B.J.
Thomas G.
Thurston S.
Tillmann R.
Torre A.C.
Tramper-Stranders G.A.
Tuffrey C.
Töpke B.
Universitat Autònoma de Barcelona
van de Beek D.
van der Ende A.
van der Flier M.
van der Flier M.
van der Meer H.
van Deuren M.
van Furth A.M.T.
van Kuppevelt A.J.M.
van Overbeek-van Gils A.L.T.
van Wermeskerken A.M.
Varnholt V.
Vega A.
Vergara E.O.
Verwijs W.A.
Vicente L.G.
Vivanco A.
von der Wense A.
Walcher W.
Weigand N.
Weikmann E.
Weiss U.
White D.
White S.
Willis L.
Wocko L.
Wolfs T.F.W.
Wright Victoria
Young Z.
Zenz W.
Zobel G.
Zwiauer K.
Zöhrer B.
Álvarez C.Á.
Publication venue
Publication date: 01/01/2019
Field of study

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes