Representaciones sociales de la infancia escolarizada desde la voz de los niños y niñas de básica primaria de la Institución Educativa Pablo Sexto, Dosquebradas-Risaralda

La presente investigación es de tipo cualitativo. En ella se identifican y analizan las representaciones sociales sobre la infancia escolarizada desde la voz de treinta y ocho niños y niñas de básica primaria de la Institución Educativa Pablo Sexto, en el municipio de Dosquebradas - Risaralda. Dichas representaciones son abordadas desde tres categorías: (a) la relación con los sujetos; (b) los espacios y (c) el saber. Teniendo en cuenta la teoría del “Núcleo Central” de Abric y el enfoque de la sociología de la infancia que busca dar mayor participación a los niños como sujetos activos dentro de los procesos de investigación. Los resultados evidencian que al interior de la escuela los niños y niñas aún se representan desde una visión tradicional, como alumnos que dependen de otro para aprender; no obstante, se constatan cambios en algunas prácticas de la infancia escolarizada en cuanto a sus diferentes interacciones en el espacio institucional. Los resultados del estudio posibilitan la comprensión de la infancia en la escuela y pueden ser usados para orientar acciones como: el ejercicio pedagógico por parte del docente; la intervención de las entidades gubernamentales en cuanto al diseño e implementación de políticas públicas y el trabajo intersectorial entre familia, infancia, escuela y sociedad. Y así promover prácticas educativas que permitan una transformación de la escuela y de la forma como el niño se percibe, construye y actúa en ella

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

IBRORS-MCL study: a Spanish retrospective and observational study of relapsed/refractory mantle-cell lymphoma treated with ibrutinib in routine clinical practice.

This retrospective study evaluated 66 patients diagnosed with relapsed and/or refractory mantle cell lymphoma (R/R MCL) treated with ibrutinib in Spain in routine clinical practice. At diagnosis, patients had a median age of 64.5 years, 63.6% presented with intermediate/high sMIPI (simplified prognostic index for advanced-stage mantle cell lymphoma), 24.5% had the blastoid variant, and 55.6% had a Ki67 > 30%. Patients had received a median of 2 prior lines of therapy (range 1-2; min-max 1-7). Overall response rate was 63.5%, with 38.1% of patients achieving complete response (CR). With a median duration of ibrutinib exposure of 10.7 months (range 5.2-19.6; min-max 0.3-36), the median progression-free survival (PFS) and overall survival (OS) were 20 months [95% confidence interval (CI) 8.8-31.1] and 32 months (95% CI 22.6-41.3), respectively, and were not reached in patients achieving CR. No grade ≥ 3 cardiovascular toxicity or bleeding was reported. This study supports that treatment with ibrutinib leads to high response rates and favorable survival outcomes in patients with R/R MCL

Máster Universitario en Profesorado de Enseñanza Secundaria Obligatoria, Bachillerato, Formación Profesional y Enseñanza de Idiomas (MAES) : Hostelería y Turismo

716 páginasLa educación secundaria ha experimentado cambios notables en los últimos años. La Ley Orgánica 8/2013, de 9 de diciembre, para la mejora de la calidad educativa, supuso una reestructuración de las etapas educativas, sobre todo a partir de la figura del “consejo orientador”, que adelanta la elección entre el itinerario académico y el de formación profesional a los 15 años, introduciendo la Formación Profesional Básica. Asimismo, la Ley Orgánica 3/2022, de 31 de marzo, de ordenación e integración de la Formación Profesional, supone una profunda reorganización de la formación profesional, para contribuir a eliminar el elevado desempleo estructural y dar respuesta a las necesidades del sistema productivo, con la intención de cubrir algunas de sus ofertas de empleo, sobre todo en niveles intermedios de cualificación –vinculados a la formación profesional- y, más en concreto, en aquellas actividades directamente relacionas con la modernización del sistema económico exigida por el cambio tecnológico y la nueva economía verde. Así lo indica el preámbulo de la Ley al señalar que “El escaso desarrollo de las cualificaciones intermedias en la estructura formativa española exige duplicar, con rapidez, el número de personas con formación intermedia para poder responder a las necesidades del sistema productivo”. Por otra parte, los docentes profesionales de la actual sociedad digital deben poseer una serie de conocimientos y destrezas profesionales que les permitan comprender y tratar de superar las dificultades de aprendizaje de su alumnado, diseñar materiales educativos y actividades motivadoras, fomentar la convivencia y la participación del alumnado, utilizar las nuevas tecnologías, el aprendizaje activo y significativo, mejorar el proceso de evaluación, orientar y tutorizar al alumnado, implicarse en el funcionamiento colectivo de los centros educativos, etc. Es en este marco en el que cobra más sentido aún la exigencia de profesionalización docente, que se introdujera ya con el Real Decreto 1393/2007, de 29 de octubre, por el que se establece la ordenación de las enseñanzas universitarias oficiales, en el marco del Espacio Europeo de Educación Superior. Asimismo, con independencia del nivel educativo o la especialidad en que imparte el profesorado, su formación debe ser académica y multidisciplinar. En este contexto es en el que se ha diseñado este Título de Máster de Profesorado en la UNIA, que atiende a la demanda de estudiantes que se orientan profesionalmente hacia la docencia en niveles de Educación Secundaria Profesional, respondiendo a la obligatoriedad de cursar estudios de Máster para ejercer la docencia en estos ámbitos dispuesta en la Ley Orgánica de Educación 2/2006 de 24 de mayo, y según la regulación establecida para estos Másteres en la Orden 3858/2007 de 27 de diciembre, que ahora se refuerza con la Ley Orgánica de Ordenación e Integración de la Formación Profesional en trámite parlamentario

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research

Freeze-out radii extracted from three-pion cumulants in pp, p–Pb and Pb–Pb collisions at the LHC

In high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose-Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplicity collisions, two-pion correlations are substantially altered by background correlations, e.g. mini-jets. Such correlations can be suppressed using three-pion cumulant correlations. We present the first measurements of the size of the system at freeze-out extracted from three-pion cumulant correlations in pp, p-Pb and Pb-Pb collisions at the LHC with ALICE. At similar multiplicity, the invariant radii extracted in p-Pb collisions are found to be 5-15% larger than those in pp, while those in Pb-Pb are 35-55% larger than those in p-Pb. Our measurements disfavor models which incorporate substantially stronger collective expansion in p-Pb as compared to pp collisions at similar multiplicity