Thinking outside the gundeck: maritime history, the royal navy, and the outbreak of British civil war, 1625-1642

This is the peer reviewed version of the following article: Thinking outside the gundeck: maritime history, the royal navy and the outbreak of British civil war, 1625–1642, Historical Research, vol. 87 no. 236 (2014), pp. 251-274, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/1468-2281.12049/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.Maritime history seems to be suffering an identity crisis, rising in popularity but unsure of its place within historical scholarship and divided in approach. Seafarers, as a consequence, have remained marginal within mainstream history. This article argues that only by integrating the study of maritime topics into wider historical debates can maritime history overcome these doubts, taking as a case study the role of seafarers and the navy in British politics during 1625−42. First examining previous interpretations offered by scholars, largely based on a conception of seafarers as politically and socially isolated from developments ashore, the article then reassesses the available evidence for popular political activity within the maritime community. It argues that seafarers were deeply involved in the political and religious divisions that drove Britain into civil war in 1642; and, more broadly, that scholars should recognize the importance of both local and global approaches to maritime history – that they should think outside the gundeck.Arts and Humanities Research Council (AHRC

Excitonic and lattice contributions to the charge density wave in 1T-TiSe2 revealed by a phonon bottleneck

Understanding collective electronic states such as superconductivity and charge density waves is pivotal for fundamental science and applications. The layered transition metal dichalcogenide 1T-TiSe2 hosts a unique charge density wave (CDW) phase transition whose origins are still not fully understood. Here, we present ultrafast time- and angle-resolved photoemission spectroscopy (TR-ARPES) measurements complemented by time-resolved reflectivity (TRR) which allows us to establish the contribution of excitonic and electron-phonon interactions to the CDW. We monitor the energy shift of the valence band (VB) and coupling to coherent phonons as a function of laser fluence. The VB shift, directly related to the CDW gap closure, exhibits a markedly slower recovery dynamics at fluences above Fth = 60 microJ cm-2. This observation coincides with a shift in the relative weight of coherently coupled phonons to higher frequency modes in time-resolved reflectivity (TRR), suggesting a phonon bottleneck. Using a rate equation model, the emergence of a high-fluence bottleneck is attributed to an abrupt reduction in coupled phonon damping and an increase in exciton dissociation rate linked to the loss of CDW superlattice phonons. Thus, our work establishes the important role of both excitonic and phononic interactions in the CDW phase transition and the advantage of combining complementary femtosecond techniques to understand the complex interactions in quantum materials.Comment: 11 pages, 4 figure

Episodic river flooding events revealed by palynological assemblages in Jurassic deposits of the Brent Group, North Sea

Spore and pollen (sporomorph) assemblages from Middle Jurassic marine deposits of the Brent Group in the northern North Sea are investigated to assess temporal and spatial variations in vegetation and depositional processes. Four wells were sampled for palynology from the Penguins Cluster and the Don North East fields through the Rannoch Formation shoreface succession. Hyperpycnite deposits occur throughout, but are concentrated within the lower part of the section. These are expressed by sand-prone beds displaying waxing and waning current motifs, normally graded muddy beds and structureless mudstones. Hyperpycnal/hypopycnal deposits resulting from episodic river flooding represent important sedimentary features as they may be preserved below fair weather wave base in more offshore settings and potentially be the only record of the former presence of a nearby river mouth. The hyperpycnites typically contain abundant Botryoccocus spp., Amorphous Organic Matter (AOM) and hinterland sporomorph taxa with relatively few marine components compared to associated marine shoreface facies. Variations in palynofacies assemblages and Botryococcus spp. abundances indicate frequent river mouth avulsion. Ordination of samples using non-metric multidimensional scaling (NMDS) indicates that shoreface samples of the sampled wells are relatively distinct, but hyperpycnite samples are highly similar regardless of their sampled well. This suggests that depositional processes and spore/pollen sources (i.e. catchment zones) were similar among hyperpycnite events across different wells. Abundant bisaccate pollen, Botryococcus spp. and AOM within interpreted hyperpycnites suggest sediment mixing along the fluvial drainage path during flooding events. The terrestrial signature of hyperpycnite sporomorph assemblages demonstrates that underflows remained coherent as they descended the shoreface profile with little turbulent mixing with ambient marine waters. Sporomorph assemblages display few large changes through time suggesting vegetation on the adjacent coastal plain was relatively static through the studied interval

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations

Purpose To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics. Patients and Methods One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS). Results There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO. Conclusion Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit

Lineage specification and heterogeneity of T follicular helper cells

T follicular helper (Tfh) cells were originally described as a non-polarized CD4(+) T cell subset with follicular homing capacity and a potent ability to induce antibody production from B cells. However, a number of studies published in the past year have revealed a degree of heterogeneity within the germinal center CD4(+) T cell population, which suggests additional complexity. The overzealous activities of Tfh cells, or inappropriate expression of certain cytokines, represent new pathways for the development of autoimmune diseases. This review focuses on current progress in unraveling the biology of Tfh cells in health and disease, and understanding the relationship of Tfh cells to other CD4(+) T cell lineages