La justicia transicional no es una consigna ideológica política

Hay algo fundamental en la situación del país con respecto a la justicia transicional y es que se tiene la concepción errónea de que la justicia transicional es “torcerle el pescuezo” a la justicia. Al contrario, desde otro lado del análisis de la justicia transicional ha habido un inmenso olvido de que esta no es un producto académico, es una reflexión que desde los años 90 Naciones Unidas venía plateándose sobre cuál es el mínimo de obligaciones de un Estado en un proceso de transición. de superación de un conflicto armado interno, de un régimen autocrático etcétera

Mesa redonda // Impacto de la información sobre salud en la relcación médico/paciente y en la salud pública

La información sobre salud se ha multiplicado en los últimos años. El impacto que provoca variará si el destinatario es un paciente o la sociedad en general. La información disponible en los medios de comunicación e Internet está contribuyendo a modificar la tradicional relación médico/paciente, con un cambio de un modelo paternalista a una actitud más participativa por parte del paciente en la toma de decisiones. Sin duda, el incremento en las fuentes de información, a las que acceden profesionales sanitarios y no sanitarios, ha provocado diversas modificaciones también en la salud pública. Este tema es analizado desde cuatro interesantes perspectivas

Rentabilidad y desempeño bursátil en compañías componentes del indice S&P/BVL Perú Select periodo 2018 – 2020

La investigación tuvo como objetivo central determinar el nivel de relación entre la rentabilidad de las compañías componentes del S&P/BVL Perú Select y el desempeño bursátil del índice durante el periodo 2018 – 2020. El eje del estudio fue responder el problema: ¿Cuál es el nivel de relación entre la rentabilidad de las compañías componentes del S&P/BVL Perú Select y el desempeño bursátil del índice durante el mismo periodo? La metodología empleada tuvo un enfoque cuantitativo correspondiente a un alcance correlacional no experimental y de corte longitudinal de carácter aplicada. Para la obtención de los resultados se empleó información financiera de trece compañías que son componentes del índice de estudio la cual se procesó calculando los indicadores ROE Dupont, ROA y el desempeño del índice bursátil; uno de los resultados más significativos es haber determinado que la desviación estándar de las variables es muy pequeña y que los valores parciales de los ROEpromtrim y ROApromtrim son también muy cercanos entre si, de igual modo los resultados de las correlaciones bivariadas (rho spearman) entre las variables con el Índice bursátil permitieron verificar que para ambos indicadores sus p-valor son diferentes mostrando valores 0.05

Reconstruction of Protein Form with X-ray Solution Scattering and a Genetic Algorithm

We have reconstructed, from experimental $2 nm resolution X-ray solution scattering pro®les, the corresponding shapes and sizes of myoglobin, troponin C, spermadhesin PSP-I/PSP-II, chymotrypsinogen A, superoxide dismutase, ovalbumin, tubulin, nitrite reductase, catalase, the structural change of troponin C upon dissociation of the two high af®nity Ca 2 , and the solution model structure of a tandem pair of ®bronectin type III cytoplasmic domains of integrin a6b4 before determination of its crystal structure. To this purpose we have designed a new genetic algorithm which gradually explores a discrete search space and evolves convergent models made of several hundred beads (down to 0.3 nm radius) best ®tting the scattering pro®le upon Debye calculation, without geometrical constraints or penalty for loose beads. This is a procedure of effective numerical transformation of the one-dimensional scattering pro®les into three-dimensional model structures. The number of beads in models is correlated with the protein molecular mass (with one exception). The shape and approximate dimensions of each protein have been retrieved by a set of ten solution models, essentially superimposable with the available crystal structures

Base de datos multicéntrica de hemorragia subaracnoidea espontánea del Grupo de Trabajo de Patología Vascular de la Sociedad Española de Neurocirugía: presentación,criterios de inclusión y desarrollo de una base de datos en internet = Spontaneous Subarachnoid Haemorrhage multicenter database from the Group for the Study of Vascular Pathology of the Spanish Society for Neurosurgery: Presentation, inclusion criteria and development of an internet-based registry

Introducción. La hemorragia subaracnoidea (HSA) continúa siendo una de las enfermedades de interés neuroquirúrgico de más alta morbilidad y mortalidad. Su estudio es clave a la hora de mejorar la atención de estos enfermos en nuestro medio. Con este fin el Grupo de Trabajo de Patología Vascular de la SENEC decidió la creación de una base de datos multicéntrica para su estudio. Material y métodos. Se incluyen en esta base de datos todos los casos de hemorragia subaracnoidea espontánea ingresados en los centros participantes de forma prospectiva desde Noviembre del año 2004 hasta Noviembre del 2007. Se decidieron de forma consensuada los campos a recoger incluyendo edad, antecedentes personales, características clínicas, características radiológicas y del aneurisma, tipo de tratamiento y complicaciones de la enfermedad, evolución según la escala de evolución de Glasgow (GOS) al alta y a los seis meses así como el resultado angiográfico del tratamiento. Todos los campos se recogieron en un formulario rellenable a través de una página web segura. Resultados. En los tres años en los que ha estado activa la base se han recogido un total de 1149 casos de HSA espontánea recogidos por 14 centros participantes. Se ha estimado que es necesario aproximadamente un tiempo de 3.4 minutos para rellenar cada caso. En cuanto a sus características generales la serie es similar a otras series hospitalarias no seleccionadas. La edad media de los enfermos incluidos es de unos 55 años y la relación mujer:hombre 4:3. En cuanto a la gravedad del sagrado inicial un 32% de los enfermos se encontraba en mal grado clínico (WFNS = 4 ó 5). El 5% de los pacientes fallecieron antes de realizarse una angiografía que confirmara el origen aneurismático del sangrado. Se confirmó el origen aneurismático en el 76% de los pacientes mientras que en el 19% no se encontró ninguna lesión vascular responsable del sangrado, siendo clasificados como HSA idiopática. En los pacientes en los que se detectó un aneurisma su tratamiento fue endovascular en el 47% de los casos, quirúrgico en el 39, mixto en el 3% y no recibieron tratamiento de su aneurisma el 11% de los pacientes por fallecimiento precoz. En cuanto a su evolución, la mortalidad global de la serie se sitúa en el 22%. Sólo el 40% de los enfermos con HSA aneurismática presentaron una buena evolución (GOS=5). Conclusiones. La HSA espontánea continúa siendo una enfermedad con alta morbilidad y mortalidad. Esta base de datos puede ser un instrumento para conocer mejor sus características en nuestro medio y mejorar sus resultados, ya que se trata de una serie multicéntrica hospitalaria no seleccionada. Sería pues recomendable que esta base constituyera el germen de un registro nacional de HSA espontánea. Introduction. Subarachnoid haemorrhage is one of the most severe neurosurgical diseases. Its study is crucial for improving the care of these patients in our environment. With this goal the Group for the Study of Neurovascular Pathology of the Spanish Society for Neurosurgery (SENEC) decided to create a multicenter registry for the study of this disease. Materials and methods. In this database we have prospectively included all cases with spontaneous subarachnoid haemorrhage admitted to the participant hospitals from November 2004 to November 2007. The fields to be included in the database were selected by consensus, including age, past medical history, clinical characteristics at admission, radiological characteristics including presence or absence of an aneurysm and its size and location, type and complications of the aneurysm treatment, outcome assessed by the Glasgow Outcome Scale (GOS) at discharge and six months after the bleeding as well as the angiographic result of the aneurysm treatment. All fields were collected by means of an electronic form posted in secure web page. Results. During the three years of study a total of 1149 patients have been included by 14 Hospitals. The time needed to fill in a patient in the registry is approximately 3.4 minutes. This series of patients with spontaneous SAH is similar to other non-selected in-hospital series of SAH. The mean age of the patients is 55 years and there is a 4:3 female to male ratio. In relation to the severity of the bleeding 32% of the patients were in poor clinical grade at admission (WFNS 4 or 5). 5% of the patients died before angiography could be performed. An aneurysm was confirmed as the origin of the bleeding in 76% of the patients (aSAH), while in 19% of the patients no lesion was found in the angiographic studies and were thus classified as idiopathic subarachnoid hemorrhage (ISAH). Of those patients with aSAH, 47% were treated endovascularly, 39% surgically, 3% received a combined treatment and 11% did not receive any treatment for their aneurysm because of early death. Regarding outcome, there is a 22% mortality in the series. Only 40% of the patients with aSAH reached a good outcome at discharge (GOS = 5). Conclusions. Spontaneous SAH continues to be a disease with high morbidity and mortality. This database can be an ideal instrument for improving the knowledge about this disease in our environment and to achieve better results. It would be desirable that this database could in the future be the origin of a national registry of spontaneous SAH

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.<p></p> Methods: Sixty-six non-HLA SNPs showing a P value <10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.<p></p> Conclusion: Our results suggest a role of PPARG gene in the development of SSc

Using a structural and logics systems approach to infer bHLH–DNA binding specificity determinants

Numerous efforts are underway to determine gene regulatory networks that describe physical relationships between transcription factors (TFs) and their target DNA sequences. Members of paralogous TF families typically recognize similar DNA sequences. Knowledge of the molecular determinants of protein–DNA recognition by paralogous TFs is of central importance for understanding how small differences in DNA specificities can dictate target gene selection. Previously, we determined the in vitro DNA binding specificities of 19 Caenorhabditis elegans basic helix-loop-helix (bHLH) dimers using protein binding microarrays. These TFs bind E-box (CANNTG) and E-box-like sequences. Here, we combine these data with logics, bHLH–DNA co-crystal structures and computational modeling to infer which bHLH monomer can interact with which CAN E-box half-site and we identify a critical residue in the protein that dictates this specificity. Validation experiments using mutant bHLH proteins provide support for our inferences. Our study provides insights into the mechanisms of DNA recognition by bHLH dimers as well as a blueprint for system-level studies of the DNA binding determinants of other TF families in different model organisms and humans.National Institute of General Medical Sciences (U.S.) (DK068429)National Institute of General Medical Sciences (U.S.) (HG003985)European Union (PROSPECTS HEALTH-F4-2008-201648

Using protein design algorithms to understand the molecular basis of disease caused by protein–DNA interactions: the Pax6 example

Quite often a single or a combination of protein mutations is linked to specific diseases. However, distinguishing from sequence information which mutations have real effects in the protein’s function is not trivial. Protein design tools are commonly used to explain mutations that affect protein stability, or protein–protein interaction, but not for mutations that could affect protein–DNA binding. Here, we used the protein design algorithm FoldX to model all known missense mutations in the paired box domain of Pax6, a highly conserved transcription factor involved in eye development and in several diseases such as aniridia. The validity of FoldX to deal with protein–DNA interactions was demonstrated by showing that high levels of accuracy can be achieved for mutations affecting these interactions. Also we showed that protein-design algorithms can accurately reproduce experimental DNA-binding logos. We conclude that 88% of the Pax6 mutations can be linked to changes in intrinsic stability (77%) and/or to its capabilities to bind DNA (30%). Our study emphasizes the importance of structure-based analysis to understand the molecular basis of diseases and shows that protein–DNA interactions can be analyzed to the same level of accuracy as protein stability, or protein–protein interactions

PROVABGS: The Probabilistic Stellar Mass Function of the BGS One-Percent Survey

We present the probabilistic stellar mass function (pSMF) of galaxies in the DESI Bright Galaxy Survey (BGS), observed during the One-Percent Survey. The One-Percent Survey was one of DESI's survey validation programs conducted from April to May 2021, before the start of the main survey. It used the same target selection and similar observing strategy as the main survey and successfully observed the spectra and redshifts of 143,017 galaxies in the $r < 19.5$ magnitude-limited BGS Bright sample and 95,499 galaxies in the fainter surface brightness and color selected BGS Faint sample over $z < 0.6$. We derive pSMFs from posteriors of stellar mass, $M_*$, inferred from DESI photometry and spectroscopy using the Hahn et al. (2022a; arXiv:2202.01809) PRObabilistic Value-Added BGS (PROVABGS) Bayesian SED modeling framework. We use a hierarchical population inference framework that statistically and rigorously propagates the $M_*$ uncertainties. Furthermore, we include correction weights that account for the selection effects and incompleteness of the BGS observations. We present the redshift evolution of the pSMF in BGS as well as the pSMFs of star-forming and quiescent galaxies classified using average specific star formation rates from PROVABGS. Overall, the pSMFs show good agreement with previous stellar mass function measurements in the literature. Our pSMFs showcase the potential and statistical power of BGS, which in its main survey will observe >100$\times$ more galaxies. Moreover, we present the statistical framework for subsequent population statistics measurements using BGS, which will characterize the global galaxy population and scaling relations at low redshifts with unprecedented precision.Comment: 25 pages, 12 figures; data used to generate figures is available at https://doi.org/10.5281/zenodo.8018936; submitted to Ap