722 research outputs found
Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expression Levels
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2012
- Field of study
BACKGROUND:
Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous deletions that involve relevant pathogenic genes and other genes whose role remains unknown.
METHODOLOGY:
Single-nucleotide polymorphism (SNP)-arrays were used to determine the frequency of recurrent amplicons and homozygous deletions in GBM (n = 46), and to evaluate the impact of copy number alterations (CNA) on mRNA levels of the genes involved.
PRINCIPAL FINDINGS:
Recurrent amplicons were detected for chromosomes 7 (50%), 12 (22%), 1 (11%), 4 (9%), 11 (4%), and 17 (4%), whereas homozygous deletions involved chromosomes 9p21 (52%) and 10q (22%). Most genes that displayed a high correlation between DNA CNA and mRNA levels were coded in the amplified chromosomes. For some amplicons the impact of DNA CNA on mRNA expression was restricted to a single gene (e.g., EGFR at 7p11.2), while for others it involved multiple genes (e.g., 11 and 5 genes at 12q14.1-q15 and 4q12, respectively). Despite homozygous del(9p21) and del(10q23.31) included multiple genes, association between these DNA CNA and RNA expression was restricted to the MTAP gene.
CONCLUSIONS:
Overall, our results showed a high frequency of amplicons and homozygous deletions in GBM with variable impact on the expression of the genes involved, and they contributed to the identification of other potentially relevant genes
Ultrasound imaging in an experimental model of fatty liver disease and cirrhosis in rats
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Discrepancies between Aedes aegypti identification in the field and in the laboratory after collection with a sticky trap
- Author
- Allan Kardec Ribeiro Galardo
- Arthur Weiss da Silva Lima
- Chadee DD
- Claudia Torres Codeço
- Clements AN
- Consoli RAGB
- Denise Valle
- Facchinelli L
- FĂĄvaro AE
- Giovanini Evelim Coelho
- Ima Aparecida Braga
- José Bento Pereira Lima
- Legendre P
- Maciel-de-Freitas R
- Nildimar Alves HonĂłrio
- Powell JR
- Rafael Maciel-de-Freitas
- Resende MC
- Resende MC
- Resende MC
- Santos EMM
- Service MW
- Simone Costa AraĂșjo
- Williams CR
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
As condiçÔes de vida e saĂșde de pessoas acima de 50 anos com deficiĂȘncia e seus cuidadores em um municĂpio paulista
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
- Field of study
The molecular detection of different Leishmania species within sand flies from a cutaneous and visceral leishmaniasis sympatric area in Southeastern Brazil
- Author
- Andrade Filho JD
- Andrade Filho JD
- Antero Silva Ribeiro de Andrade
- Aransay AM
- Arias JR
- Carvalho ALM
- Carvalho GM
- Carvalho GML
- Cortes S
- de Andrade AS
- de Andrade HM
- de Bruijn MH
- de Pita-Pereira D
- de Pita-Pereira D
- Degrave W
- Galati EAB
- José Dilermando Andrade Filho
- Kato H
- Killick-Kendrick R
- Lainson R
- Lara Saraiva
- Lins RM
- Luz E
- Marcondes CB
- Maria Norma Melo
- Michalsky EM
- Naiff RD
- Oliveira EMD
- Oliveira FS
- Paiva BR
- Perez JE
- Perruolo G
- Pugedo H
- Resende MC
- Rocha L de S
- RodrĂguez N
- Saraiva L
- Saraiva L
- Savani ES
- Soraia de Oliveira Silva
- Souza CM
- Souza GD
- Volpini AC
- Wallace FG
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2010
- Field of study
Over the last 20 years, there has been an increase in the number of leishmaniasis cases in Brazil. Belo Horizonte (BH) is one of the most highly populated Brazilian cities that is affected by visceral leishmaniasis (VL). The health services in BH are coordinated by a central nucleus that is subdivided into nine sanitary districts. Historically, the highest level of human VL cases was found in the northeast sanitary district (NSD). The objective of our study was to detect Leishmania infection in the phlebotomine sand flies collected in the NSD by dissection and molecular approaches. Following the occurrence of human VL cases in 2005, entomological captures were performed from July 2006-June 2007. Out of the 245 sand flies dissected, only three Lutzomyia longipalpis spp contained flagellates. The female sand flies were grouped into 120 pools according to date, collection site and species, with approximately 10 individual sand flies in each pool. Subsquently, the DNA was extracted and Leishmania spp and other parasites were detected and identified by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorfism. Leishmania infantum was present in at least 19% of the Lu. longipalpis collected, in 3.8% of the Nyssomiya whitmani collected, in 33.3% of the Evandromiya termitophila collected and in 14.3% of the Nyssomiya intermedia collected. When the females of the cortelezzii complex were compared with each other, 3.2% of the females were infected with Leishmania braziliensis, whereas 3.2% of the females were infected with trypanosomatids
Optimization of genomic selection training populations with a genetic algorithm
- Author
- AC Atkinson
- AE Hoerl
- CR Henderson
- D Gianola
- D Habier
- DE Goldberg
- Deniz Akdemir
- F Phocas
- F Pukelsheim
- G de Los Campos
- HP Piepho
- I Misztal
- J Crossa
- JB Endelman
- Jean-Luc Jannink
- JH Holland
- JM Hickey
- JO Ogutu
- Julio I Sanchez
- K Zhao
- L Pronzato
- LD Davis
- MC Romay
- MF Resende
- N Heslot
- P VanRaden
- R Rincent
- S Atwell
- V Wimmer
- VB Melas
- VS Windhausen
- VV Fedorov
- WM Muir
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Saberes e pråticas de mulheres idosas na prevenção do cùncer cérvico-uterino
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro GuimarĂŁes da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
- Becker S
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
- Bellagamba L
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez Garcia JA
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Berghaus F
- Berglund E
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- Bernat P
- Bernhard R
- Bernius C
- Bernlochner FU
- Berry T
- Bertella C
- Bertin A
- Bertolucci F
- Besana MI
- Besjes GJ
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
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- Bingul A
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- Biscarat C
- Bittner B
- Black CW
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- Blair RE
- Blanchard JB
- Blazek T
- Bloch I
- Blocker C
- Blocki J
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
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- Bogdanchikov A
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- Borisov A
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- Bortfeldt J
- Bortolotto V
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- Boscherini D
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- Bouchami J
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- Bracinik J
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- Brau JE
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- Brazzale SF
- Brelier B
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- Brooijmans G
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- Bruckman de Renstrom PA
- Bruncko D
- Bruneliere R
- Brunet S
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- Bryngemark L
- Buanes T
- Buat Q
- Bucci F
- Buchanan J
- Buchholz P
- Buckingham RM
- Buckley AG
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- Budagov IA
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- Bundock AC
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- Buran T
- Burckhart H
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- Butterworth JM
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- BĂŒscher V
- Cabrera UrbĂĄn S
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- Cavaliere V
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- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
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- Cerutti F
- Cetin SA
- Chafaq A
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- Chalupkova I
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- Chapleau B
- Chapman JD
- Chapman JW
- Charlton DG
- Chavda V
- Chavez Barajas CA
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
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- Cheplakov A
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
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- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
- Chizhov MV
- Choudalakis G
- Chouridou S
- Chow BK
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciocio A
- Cirilli M
- Cirkovic P
- Citron ZH
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- Ciubancan M
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- Clark PJ
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- Cleland W
- Clemens JC
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- Compostella G
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- Coniavitis E
- Conidi MC
- Consonni SM
- Consorti V
- Constantinescu S
- Conta C
- Conti G
- Conventi F
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
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- Cornelissen T
- Corradi M
- Corriveau F
- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
- Costanzo D
- Cottin G
- Courneyea L
- Cowan G
- Cox BE
- Cranmer K
- Crescioli F
- Cristinziani M
- Crosetti G
- Crépé-Renaudin S
- Cuciuc CM
- Cuenca Almenar C
- Cuhadar Donszelmann T
- Cummings J
- Curatolo M
- Curtis CJ
- Cuthbert C
- Cwetanski P
- Czirr H
- Czodrowski P
- Czyczula Z
- CÎté D
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dallaire F
- Dallapiccola C
- Dam M
- Damiani DS
- Danielsson HO
- Dao V
- Darbo G
- Darlea GL
- Dassoulas JA
- Davey W
- Davidek T
- Davidson N
- Davidson R
- Davies E
- Davies M
- Davignon O
- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Daya-Ishmukhametova RK
- de Asmundis R
- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De La Taille C
- De la Torre H
- De Lorenzi F
- De Nooij L
- De Pedis D
- De Salvo A
- De Sanctis U
- De Santo A
- De Vivie De Regie JB
- De Zorzi G
- De K
- Dearnaley WJ
- Debbe R
- Debenedetti C
- Dechenaux B
- Dedovich DV
- Degenhardt J
- Del Peso J
- Del Prete T
- Delemontex T
- Deliyergiyev M
- Dell'acqua A
- Dell'asta L
- Della Pietra M
- Della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
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- Dervan P
- Desch K
- Deviveiros PO
- Dewhurst A
- Dewilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
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- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
- Diaz MA
- Diehl EB
- Dietrich J
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- Diglio S
- Dindar Yagci K
- Dingfelder J
- Dinut F
- Dionisi C
- Dita P
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- Djama F
- Djobava T
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- Do Valle Wemans A
- Doan TK
- Dobbs M
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- Dodd J
- Doglioni C
- Doherty T
- Dohmae T
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- Duda D
- Dudarev A
- Dudziak F
- Duerdoth IP
- Duflot L
- Dufour MA
- Duguid L
- Dunford M
- Duran Yildiz H
- Duxfield R
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- DĂŒhrssen M
- DĂŒren M
- Ebenstein WL
- Ebke J
- Eckweiler S
- Edson W
- Edwards CA
- Edwards NC
- Ehrenfeld W
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- Eisenhandler E
- Ekelof T
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- Ellert M
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- Ellinghaus F
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- Elmsheuser J
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- Espinal Curull X
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- Fleck I
- Fleischmann P
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- Flores Castillo LR
- Florez Bustos AC
- Flowerdew MJ
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- Fortin D
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- Franchini M
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- Franz S
- Fraternali M
- Fratina S
- French ST
- Friedrich C
- Friedrich F
- Froidevaux D
- Frost JA
- Fukunaga C
- Fullana Torregrosa E
- Fulsom BG
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- Gabaldon C
- Gabizon O
- Gadatsch S
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- Gadomski S
- Gagliardi G
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- Galea C
- Galhardo B
- Gallas EJ
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- Gan KK
- Gandrajula RP
- Gao YS
- Gaponenko A
- Garay Walls FM
- Garberson F
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- GarcĂa Navarro JE
- GarcĂa C
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- Garonne V
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- Gazis EN
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- Gellerstedt K
- Gemme C
- Gemmell A
- Genest MH
- Gentile S
- George M
- George S
- Gerbaudo D
- Gerlach P
- Gershon A
- Geweniger C
- Ghazlane H
- Ghodbane N
- Giacobbe B
- Giagu S
- Giangiobbe V
- Gianotti F
- Gibbard B
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- Gibson SM
- Gilchriese M
- Gillam TP
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- Gingrich DM
- Ginzburg J
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- Giordani MP
- Giordano R
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- Zaidan R
- Zaitsev AM
- Zambito S
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- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- ZeniĆĄ T
- Zerwas D
- Zevi Della Porta G
- Zhang D
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- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
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- Zinonos Z
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- Zmouchko VV
- Zobernig G
- Zoccoli A
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- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
Search for high-mass resonances decaying to dilepton final states in pp collisions at sâ=7 TeV with the ATLAS detector
- Author
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- Abajyan T
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- Abdallah J
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- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
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- Yanush S
- Yao L
- Yao Y
- Yasu Y
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- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
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- Yu J
- Yu J
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral ZâČ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/Îł bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fbâ1 in the e + e â channel and 5.0 fbâ1 in the ÎŒ + ÎŒ âchannel. A Z âČ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal ZâČ Models
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
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- Yamanaka T
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- Yamazaki Y
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- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Smit GVY
- Ye J
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
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- Youssef S
- Yu D
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
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- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
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- Zhemchugov A
- Zhong J
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- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
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- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fbâ1 of sâ=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan ÎČ < 40
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