A eficiência da suplementação de vitamina c na prevenção e combate do estresse oxidativo em tabagistas

Smoking is responsible for causing adverse effects on tissues through oxidative damage. The consumption of vitamin C inhibits oxidative damage in molecules by intercepting free radicals generated by cellular metabolism or by exogenous sources. Objectives: To verify the efficiency of vitamin supplementation in combating oxidative stress in smokers. Data source: Meta-analysis of studies identified through research in the databases Pubmed, Europa PMC, Web of Science and Scielo until 2021.Data synthesis: 306 articles were identified, of which 4 characteristics are relevant to the objectives of this study. Results: The intervention with vitamin C supplementation did not alter the oxidative stress caused by smoking (MD 2.45, 95% CI -1.51; 6.40; p=0.23; I2 = 92%). Conclusions: Based on the results found, we can conclude that vitamin C supplementation is not an efficient strategy to combat the oxidative stress caused by smoking.O tabagismo é responsável por ocasionar efeitos adversos sobre os tecidos por meio do dano oxidativo. Por outro lado, o consumo de vitamina C se apresenta como um antioxidante o qual poderia inibir os danos oxidativos nas moléculas através da interceptação dos radicais livres gerados pelo metabolismo celular ou por fontes exógenas. Objetivo: Analisar a eficiência da suplementação da vitamina C no combate ao estresse oxidativo em tabagistas. Fonte de dados: Metánalise de estudos identificados por meio de pesquisa nas bases de dados Pubmed, Europe PMC, Web of Science e Scielo até 2021.Síntese de dados: Foram identificados 306 artigos dos quais 4 mostraram-se relevantes aos objetivos deste estudo. Resultados: Os estudos levantados demonstraram que a intervenção com suplementação de vitamina C não alterou o estresse oxidativo provocado pelo tabagismo (MD 2,45, 95% IC -1,51; 6,40; p=0.23; I2 = 92%). Conclusão: A partir dos resultados encontrados podemos concluir que a suplementação de vitamina C não se apresenta como estratégia eficiente para o combate ao estresse oxidativo provocado pelo tabagismo

Fatores de risco cardiovasculares em pacientes com fibromialgia

Objetivo: Verificar os fatores de risco cardiovasculares em pacientes com fibromialgia (FM). Métodos: O estudo foi composto por 40 mulheres diagnosticadas com FM e encaminhadas para o setor de Reabilitação Física do Hospital de Clínicas de Uberlândia. Foi aplicado um questionário do American College of Sports Medicine contendo perguntas sobre histórico familiar; tabagismo; hipertensão; dislipidemia; glicose de jejum alterada; obesidade; sedentarismo e etilismo. Resultados: O sedentarismo teve prevalência de 92,5%, hereditariedade 52,5%, obesidade 50%, hipertensão arterial 45%, dislipidemia 37,5%, tabagismo 25%, etilismo 8% e diabetes 7,5%. Além disso, 60% da amostra apresentou três ou mais fatores de risco, 30% apresentou 2 fatores e 10% apresentou apenas um fator de risco. Conclusão: Pacientes com FM apresentam vários fatores de risco cardiovasculares, desse modo, deve-se orientar tais pacientes à mudança do estilo de vida, a fim de reduzir tais fatores e consequentemente eventos cardíacos futuros, e proporciona melhora do quadro de dor

Avaliação das capacidades físicas de atletas de categoria de base do Mancha E. C. da cidade de Araguari-MG durante uma temporada

O objetivo desse estudo foi avaliar as capacidades físicas de atletas de categoria de base do Mancha E. C. da cidade de Araguari-MG durante uma temporada. Foram incluídos atletas do sexo masculino com idade de 16 e 17 anos que foram submetidos a três avaliações no início, meio e final da temporada. Os atletas foram submetidos as avaliações de capacidade aeróbica, teste de agilidade, potência de membros superiores, potência de membros inferiores, flexibilidade, resistência de membros superiores, resistência abdominal e mobilidade de tornozelo. O teste de análise de variância de uma entrada com posthoc de Bonferroni foi utilizado para analisar as diferenças significativas entre os momentos da temporada (pré vs meio vs final) tendo nível de significância quando p<0,05. Foi encontrado que todos os resultados encontrados no meio e final da temporada foram significativamente melhores comparados à pré-temporada (p<0,001). Além disso, observa-se que os valores de teste de agilidade (p=0,03), salto vertical (p<0,001), e flexibilidade (p=0,02) apresentaram diferença significativa entre o final da temporada e meio da temporada. Conclui-se que houve melhora das capacidades físicas de atletas de categoria de base durante uma temporada de treinamento físico

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe

Measurement of the Splitting Function in &ITpp &ITand Pb-Pb Collisions at root&ITsNN&IT=5.02 TeV

Data from heavy ion collisions suggest that the evolution of a parton shower is modified by interactions with the color charges in the dense partonic medium created in these collisions, but it is not known where in the shower evolution the modifications occur. The momentum ratio of the two leading partons, resolved as subjets, provides information about the parton shower evolution. This substructure observable, known as the splitting function, reflects the process of a parton splitting into two other partons and has been measured for jets with transverse momentum between 140 and 500 GeV, in pp and PbPb collisions at a center-of-mass energy of 5.02 TeV per nucleon pair. In central PbPb collisions, the splitting function indicates a more unbalanced momentum ratio, compared to peripheral PbPb and pp collisions.. The measurements are compared to various predictions from event generators and analytical calculations.Peer reviewe

Electroweak production of two jets in association with a Z boson in proton-proton collisions root s =13 TeV

A measurement of the electroweak (EW) production of two jets in association with a Z boson in proton-proton collisions at root s = 13 TeV is presented, based on data recorded in 2016 by the CMS experiment at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lljj final state with l including electrons and muons, and the jets j corresponding to the quarks produced in the hard interaction. The measured cross section in a kinematic region defined by invariant masses m(ll) > 50 GeV, m(jj) > 120 GeV, and transverse momenta P-Tj > 25 GeV is sigma(EW) (lljj) = 534 +/- 20 (stat) fb (syst) fb, in agreement with leading-order standard model predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. No evidence is found and limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are -2.6 <cwww/Lambda(2) <2.6 TeV-2 and -8.4 <cw/Lambda(2) <10.1 TeV-2. The additional jet activity of events in a signal-enriched region is also studied, and the measurements are in agreement with predictions.Peer reviewe