ロリクリン欠損が末梢免疫に与える影響

科学研究費助成事業 研究成果報告書：研究活動スタート支援2016-2017課題番号 : 16H0666

Constraining temperature at depth of the Kakkonda geothermal field, Japan, using Bayesian rock-physics modelling of resistivity: Implications to the deep hydrothermal system

Temperature-at-depth estimation is important for assessing supercritical geothermal resources. Bayesian rock-physics modelling of electrical resistivity is effective for estimating temperatures at depth. In this study, we improved a previously proposed Bayesian framework and demonstrated its effectiveness by estimating subsurface temperatures in the Kakkonda geothermal field, Japan. The proposed framework allows the estimation of either effective porosities or salinities in addition to temperatures; further, we were able to constrain the possible states of the crustal fluid at depth based on the estimates. The estimated 3D temperature structure was consistent with available deep temperature logs. Furthermore, the estimated results suggest the existence of a magmatic-hydrothermal system at depth in the field

Constraining temperature at depth of the Kakkonda geothermal field, Japan, using Bayesian rock-physics modelling of resistivity: Implications to the deep hydrothermal system

Temperature-at-depth estimation is important for assessing supercritical geothermal resources. Bayesian rock-physics modelling of electrical resistivity is effective for estimating temperatures at depth. In this study, we improved a previously proposed Bayesian framework and demonstrated its effectiveness by estimating subsurface temperatures in the Kakkonda geothermal field, Japan. The proposed framework allows the estimation of either effective porosities or salinities in addition to temperatures; further, we were able to constrain the possible states of the crustal fluid at depth based on the estimates. The estimated 3D temperature structure was consistent with available deep temperature logs. Furthermore, the estimated results suggest the existence of a magmatic-hydrothermal system at depth in the field

Cutaneous Angiosarcoma: The Possibility of New Treatment Options Especially for Patients with Large Primary Tumor

The most widely accepted treatment for cutaneous angiosarcoma (CAS) is wide local excision and postoperative radiation to decrease the risk of recurrence. Positive surgical margins and large tumors (T2, >5 cm) are known to be associated with poor prognosis. Moreover, T2 tumors are known to be associated with positive surgical margins. According to previous reports, the majority of CAS patients in Japan had T2 tumors, whereas less than half of the patients in the studies from western countries did so. Consequently, the reported 5-year overall survival of Japanese CAS patients without distant metastasis was only 9%, lower than that for stage-IV melanoma. For patients with T2 tumors, management of subclinical metastasis should be considered when planning the initial treatment. Several attempts to control subclinical metastasis have been reported, such as using adjuvant/neoadjuvant chemotherapy in addition to conventional surgery plus radiation. Unfortunately, those attempts did not show any clinical benefit. Besides surgery, new chemotherapeutic approaches for advanced CAS have been introduced in the past couple of decades, such as paclitaxel and docetaxel. We proposed the use of chemoradiotherapy (CRT) using taxanes instead of surgery plus radiation for patients with T2 tumors without distant metastasis and showed a high response ratio with prolonged survival. However, this prolonged survival was seen only in patients who received maintenance chemotherapy after CRT, indicating that continuous chemotherapy is mandatory to control subclinical residual tumors. With the recent development of targeted drugs for cancer, many potential drugs for CAS are now available. Given that CAS expresses a high level of vascular endothelial growth factor (VEGF) receptor, drugs that target VEGF signaling pathways such as anti-VEGF monoclonal antibody and tyrosine kinase inhibitors are also promising, and several successful treatments have been reported. Besides targeted drugs, several new cytotoxic anticancer drugs such as eribulin or trabectedin have also been shown to be effective for advanced sarcoma. However, most of the clinical trials did not include a sufficient number of CAS patients. Therefore, clinical trials focusing only on CAS should be performed to evaluate the effectiveness of these new drugs

Reconstruction using a vertical “sagging cheek” advancement flap for defects following full-thickness excision of non-melanoma skin cancer in the elderly: a case series

Non-melanoma skin cancer (NMSC) has become a major health concern, particularly with the growing aging population in society. The number of surgically treated squamous cell carcinomas (SCC) is comparable to that of basal cell carcinomas (BCCs) [1]. The preauricular area is a common primary site for SCCs in close association with chronic ultraviolet damage [2]. Although primary closure is a better solution in almost all circumstances, relatively large facial defects often pose a problem, especially [...

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements