Dissecting the roles and clinical potential of YY1 in the tumor microenvironment

Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a vital dual biological role in cancer as an oncogene or a tumor suppressor during tumorigenesis and tumor progression. The tumor microenvironment (TME) is identified as the “soil” of tumor that has a critical role in both tumor growth and metastasis. Many studies have found that YY1 is closely related to the remodeling and regulation of the TME. Herein, we reviewed the expression pattern of YY1 in tumors and summarized the function and mechanism of YY1 in regulating tumor angiogenesis, immune and metabolism. In addition, we discussed the potential value of YY1 in tumor diagnosis and treatment and provided a novel molecular strategy for the clinical diagnosis and treatment of tumors

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Multiple-objective Risk-Sensitive Control and its Small Noise Limit

This paper is concerned with a (minimizing) multiple-objective risk-sensitive control problem. Asymptotic analysis leads to the introduction of a new class of two-player, zero-sum, deterministic differential games. The distinguishing feature of this class of games is that the cost functional is multiple-objective in nature, being composed of the risk-neutral integral costs associated with the original risk-sensitive problem. More precisely, the opposing player in such a game seeks to maximize the most 'vulnerable' member of a given set of cost functionals while the original controller seeks to minimize the worst 'damage' that the opponent can do over this set. It is then shown that the problem of finding an efficient risk-sensitive controller is equivalent, asymptotically, to solving this differential game. Surprisingly, this differential game is proved to be independent of the weights on the different objectives in the original multiple-objective risk-sensitive problem. As a by-product, our results generalize the existing results for the single-objective risk-sensitive control problem to a substantially larger class of nonlinear systems, including those with control-dependent diffusion terms