60 research outputs found
The geological cycle of plastics and their use as a stratigraphic indicator of the Anthropocene
The rise of plastics since the mid-20th century, both as a material element of modern life and as a growing environmental pollutant, has been widely described. Their distribution in both the terrestrial and marine realms suggests that they are a key geological indicator of the Anthropocene, as a distinctive stratal component. Most immediately evident in terrestrial deposits, they are clearly becoming widespread in marine sedimentary deposits in both shallow- and deep-water settings. They are abundant and widespread as macroscopic fragments and virtually ubiquitous as microplastic particles; these are dispersed by both physical and biological processes, not least via the food chain and the âfaecal expressâ route from surface to sea floor. Plastics are already widely dispersed in sedimentary deposits, and their amount seems likely to grow several-fold over the next few decades. They will continue to be input into the sedimentary cycle over coming millennia as temporary stores â landfill sites â are eroded. Plastics already enable fine time resolution within Anthropocene deposits via the development of their different types and via the artefacts (âtechnofossilsâ) they are moulded into, and many of these may have long-term preservation potential when buried in strata
Effects of Reducing the Digestible Lysine and Tryptophan to Lysine Ratio on Growth Performance of Grow-Finish Pigs
A total of 1,080 finishing pigs (327 Ă 1050, PIC; initially 71.3 ± 1.91 lb) were used in a 119-d growth trial to evaluate the effects of reducing the dietary SID Lys and SID Trp:Lys ratio on growth performance to find strategies to reduce growth rate of pigs during the grow-finish period. Pigs were allotted by initial BW and randomly assigned to 1 of 4 dietary treatments in a completely randomized block design with 27 pigs per pen and 10 pens per treatment. Dietary treatments were corn-soybean meal-based diets with DDGS. Three dietary regimes were formulated to contain either 100, 90, or 80% of the estimated SID Lys requirement for pigs in this facility, and these diets had a SID Trp:Lys ratio of 19%, with the exception of the last dietary phase formulated to 17% SID Trp:Lys. A fourth regime was formulated to 80% SID Lys with a SID Trp:Lys ratio of 16% (80â16% SID Trp:Lys) throughout all phases.
Overall, from d 0 to 119, ADG and final BW decreased (linear, P \u3c 0.001) and F/G tended to worsen (linear, P = 0.087) as SID Lys decreased from 100 to 80% of the requirement. Pigs fed the diet with 80â16% SID Trp:Lys also had decreased ADG and poorer F/G compared with pigs fed 80% of the SID Lys requirement with high a Trp:Lys ratio.
In conclusion, reducing SID Lys decreased growth performance and final BW of pigs during the grow-finish period. A further reduction in Trp:Lys ratio also decreased ADG and tended to worsen feed efficiency. This resulted in a 25 lb difference in final BW between pigs fed Lys and Trp at the requirement (100%) compared with pigs fed the 80% SID Lys and 16% Trp:Lys ratio. This study provides alternatives to producers to reduce growth rate of finishing pigs
Colonization of the Americas, 'Little Ice Age' climate, and bomb-produced carbon: their role in defining the Anthropocene
A recently published analysis by Lewis and Maslin (Lewis SL and Maslin MA (2015) Defining the Anthropocene. Nature 519: 171â180) has identified two new potential horizons for the HoloceneâAnthropocene boundary: 1610 (associated with European colonization of the Americas), or 1964 (the peak of the excess radiocarbon signal arising from atom bomb tests). We discuss both of these novel suggestions, and consider that there is insufficient stratigraphic basis for the former, whereas placing the latter at the peak of the signal rather than at its inception does not follow normal stratigraphical practice. Wherever the boundary is eventually placed, it should be optimized to reflect stratigraphical evidence with the least possible ambiguity
Transcription errors induce proteotoxic stress and shorten cellular lifespan
Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitored yeast cells that were genetically engineered to display error-prone transcription. We discovered that these cells suffer from a profound loss in proteostasis, which sensitizes them to the expression of genes that are associated with protein-folding diseases in humans; thus, transcription errors represent a new molecular mechanism by which cells can acquire disease. We further found that the error rate of transcription increases as cells age, suggesting that transcription errors affect proteostasis particularly in aging cells. Accordingly, transcription errors accelerate the aggregation of a peptide that is implicated in Alzheimerâs disease, and shorten the lifespan of cells. These experiments reveal a novel, basic biological process that directly affects cellular health and aging
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
A call to action for climate change research on Caribbean dry forests
The final publication is available at Springer via https://doi.org/10.1007/s10113-018-1334-6Tropical dry forest (TDF) is globally one of the most threatened forest types. In the insular Caribbean, limited land area and high population pressure have resulted in the loss of over 60% of TDF, yet local peopleâs reliance on these systems for ecosystem services is high. Given the sensitivity of TDF to shifts in precipitation regimes and the vulnerability of the Caribbean to climate change, this study examined what is currently known about the impacts of climate change on TDF in the region. A systematic review (n =â89) revealed that only two studies addressed the ecological response of TDF to climate change. Compared to the rapidly increasing knowledge of the effects of climate change on other Caribbean systems and on TDF in the wider neotropics, this paucity is alarming given the value of these forests. We stress the need for long-term monitoring of climate change responses of these critical ecosystems, including phenological and hotspot analyses as priorities
AVONET: morphological, ecological and geographical data for all birds
Functional traits offer a rich quantitative framework for developing and testing theories in evolutionary biology, ecology and ecosystem science. However, the potential of functional traits to drive theoretical advances and refine models of global change can only be fully realised when speciesâlevel information is complete. Here we present the AVONET dataset containing comprehensive functional trait data for all birds, including six ecological variables, 11 continuous morphological traits, and information on range size and location. Raw morphological measurements are presented from 90,020 individuals of 11,009 extant bird species sampled from 181 countries. These data are also summarised as species averages in three taxonomic formats, allowing integration with a global phylogeny, geographical range maps, IUCN Red List data and the eBird citizen science database. The AVONET dataset provides the most detailed picture of continuous trait variation for any major radiation of organisms, offering a global template for testing hypotheses and exploring the evolutionary origins, structure and functioning of biodiversity
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Global Boundary Stratotype Section and Point (GSSP) for the Anthropocene Series: Where and how to look for potential candidates
International audienc
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