"They Would Not Take Me There" People, Places, and Stories from Champlain's Travels in Canada 1603-1616

This is the publisher's version, also available electronically from http://www.cartographicperspectives.org/index.php/journal/article/view/96.No abstract is available for this item

Current Concepts and Trends in Human-Automation Interaction

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.The purpose of this panel was to provide a general overview and discussion of some of the most current and controversial concepts and trends in human-automation interaction. The panel was composed of eight researchers and practitioners. The panelists are well-known experts in the area and offered differing views on a variety of different human-automation topics. The range of concepts and trends discussed in this panel include: general taxonomies regarding stages and levels of automation and function allocation, individualized adaptive automation, automation-induced complacency, economic rationality and the use of automation, the potential utility of false alarms, the influence of different types of false alarms on trust and reliance, and a system-wide theory of trust in multiple automated aids

Thoroughbred Racehorse Welfare through the Lens of ‘Social License to Operate—With an Emphasis on a U.S. Perspective

This review addresses the question of whether Thoroughbred horse racing is sustainable in the context of current social values. A recently acknowledged framework, known as ‘Social License to Operate’ (SLO), provides us with a lens through which to view and assess racehorse welfare. In multiple surveys of the general public, the horse owning public, and university students, the primary topics of concern regarding Thoroughbred racing show considerable concordance: concern about catastrophic injuries—particularly as related to track surfaces, concern over the racing of two-year-olds, whip use by jockeys, drug/medication policies, and aftercare opportunities for retired Thoroughbred racehorses. Legitimacy of an industry, consent from industry stakeholders, and trust between the community players, are all essential to have and maintain SLO. In the current era of 24/7 global media access, and the proliferation of social media providing an interactive platform for all interested parties, a dramatic change has occurred in commentary related to racehorse welfare concerns. The situation at Santa Anita (California, USA) from late December 2018 through mid-November 2019 demonstrated just how tenuous the SLO for horse racing is. This article will provide a brief review of what ‘Social License to Operate’ is, along with a brief literature review of five of the areas of primary concern voiced by stakeholders

Untangling multi-species fisheries data with species distribution models

Long-term trends in fisheries catch are useful to monitor effects of fishing on wild populations. However, fisheries catch data are often aggregated in multi-species complexes, complicating assessments of individual species. Non-target species are often grouped together in this way, but this becomes problematic when increasingly common shifts toward targeting incidental species demand closer management focus at the species level. Species distribution models (SDMs) offer an under-utilised tool to allocate aggregated catch data among species for individual assessments. Here, we present a case study of two shovel-nosed lobsters (Thenus spp.), previously caught incidentally and recorded together in logbook records, to illustrate the design and use of catch allocation SDMs to untangle multi-species data for stock assessments of individual species. We demonstrate how catch allocation SDMs reveal previously masked species-specific catch trends from aggregated data and can identify shifts in fishing behaviour, e.g., changes in target species. Finally, we review key assumptions and limitations of this approach that may arise when applied across a broad geographic or taxonomic scope. Our aim is to provide a template to assist researchers and managers seeking to assess stocks of individual species using aggregated multi-species data

Why crises happen: nonstationary macroeconomics

A Real Business Cycle model of the UK is developed to account for the behaviour of UK nonstationary macro data. The model is tested by the method of indirect inference, bootstrapping the errors to generate 95% confidence limits for a VECM representation of the data; we find the model can explain the behaviour of main variables (GDP, real exchange rate, real interest rate) but not that of detailed GDP components. We use the model to explain how ‘crisis’ and ‘euphoria’ are endemic in capitalist behaviour due to nonstationarity; and we draw some policy lessons

Conserved Regulation of MAP Kinase Expression by PUF RNA-Binding Proteins

Mitogen-activated protein kinase (MAPK) and PUF (for Pumilio and FBF [fem-3 binding factor]) RNA-binding proteins control many cellular processes critical for animal development and tissue homeostasis. In the present work, we report that PUF proteins act directly on MAPK/ERK-encoding mRNAs to downregulate their expression in both the Caenorhabditis elegans germline and human embryonic stem cells. In C. elegans, FBF/PUF binds regulatory elements in the mpk-1 3′ untranslated region (3′ UTR) and coprecipitates with mpk-1 mRNA; moreover, mpk-1 expression increases dramatically in FBF mutants. In human embryonic stem cells, PUM2/PUF binds 3′UTR elements in both Erk2 and p38α mRNAs, and PUM2 represses reporter constructs carrying either Erk2 or p38α 3′ UTRs. Therefore, the PUF control of MAPK expression is conserved. Its biological function was explored in nematodes, where FBF promotes the self-renewal of germline stem cells, and MPK-1 promotes oocyte maturation and germ cell apoptosis. We found that FBF acts redundantly with LIP-1, the C. elegans homolog of MAPK phosphatase (MKP), to restrict MAPK activity and prevent apoptosis. In mammals, activated MAPK can promote apoptosis of cancer cells and restrict stem cell self-renewal, and MKP is upregulated in cancer cells. We propose that the dual negative regulation of MAPK by both PUF repression and MKP inhibition may be a conserved mechanism that influences both stem cell maintenance and tumor progression

User-interfaces layout optimization using eye-tracking, mouse movements and genetic algorithms

[EN] Establishing the best layout configuration for software-generated interfaces and control panels is a complex problem when they include many controls and indicators. Several methods have been developed for arranging the interface elements; however, the results are usually conceptual designs that must be manually adjusted to obtain layouts valid for real situations. Based on these considerations, in this work we propose a new automatized procedure to obtain optimal layouts for software-based interfaces. Eye-tracking and mouse-tracking data collected during the use of the interface is used to obtain the best configuration for its elements. The solutions are generated using a slicing-trees based genetic algorithm. This algorithm is able to obtain really applicable configurations that respect the geometrical restrictions of elements in the interface. Results show that this procedure increases effectiveness, efficiency and satisfaction of the users when they interact with the obtained interfaces.This work was supported by the Programa estatal de investigacion, desarrollo e innovacion orientada a los retos de la sociedad of the Government of Spain under Grant DPI 2016-79042-R.Diego-Mas, JA.; Garzon Leal, D.; Poveda Bautista, R.; Alcaide Marzal, J. (2019). User-interfaces layout optimization using eye-tracking, mouse movements and genetic algorithms. Applied Ergonomics. 78:197-209. https://doi.org/10.1016/j.apergo.2019.03.004S1972097

Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life

Background Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model. Methods Pregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age. Results Maternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels. Conclusions Maternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma

Simplicity in Visual Representation: A Semiotic Approach

Simplicity, as an ideal in the design of visual representations, has not received systematic attention. High-level guidelines are too general, and low-level guidelines too ad hoc, too numerous, and too often incompatible, to serve in a particular design situation. This paper reviews notions of visual simplicity in the literature within the analytical framework provided by Charles Morris' communication model, specifically, his trichotomy of communication levels—the syntactic, the semantic, and the pragmatic. Simplicity is ultimate ly shown to entail the adjudication of incompatibilities both within, and between, levels.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68281/2/10.1177_105065198700100103.pd

X-ray emission from the Sombrero galaxy: discrete sources

We present a study of discrete X-ray sources in and around the bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival Chandra observations with a total exposure of ~200 ks. With a detection limit of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30 kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray binaries (LMXBs). We quantify the differential luminosity functions (LFs) for both the detected GC and field LMXBs, whose power-low indices (~1.1 for the GC-LF and ~1.6 for field-LF) are consistent with previous studies for elliptical galaxies. With precise sky positions of the GCs without a detected X-ray source, we further quantify, through a fluctuation analysis, the GC LF at fainter luminosities down to 1E35 erg/s. The derived index rules out a faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent findings in several elliptical galaxies and the bulge of M31. On the other hand, the 2-6 keV unresolved emission places a tight constraint on the field LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101 sources in the halo of Sombrero. The presence of these sources cannot be interpreted as galactic LMXBs whose spatial distribution empirically follows the starlight. Their number is also higher than the expected number of cosmic AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray surveys. We suggest that either the cosmic X-ray background is unusually high in the direction of Sombrero, or a distinct population of X-ray sources is present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres