MFM-Net: Unpaired Shape Completion Network with Multi-stage Feature Matching

Unpaired 3D object completion aims to predict a complete 3D shape from an incomplete input without knowing the correspondence between the complete and incomplete shapes during training. To build the correspondence between two data modalities, previous methods usually apply adversarial training to match the global shape features extracted by the encoder. However, this ignores the correspondence between multi-scaled geometric information embedded in the pyramidal hierarchy of the decoder, which makes previous methods struggle to generate high-quality complete shapes. To address this problem, we propose a novel unpaired shape completion network, named MFM-Net, using multi-stage feature matching, which decomposes the learning of geometric correspondence into multi-stages throughout the hierarchical generation process in the point cloud decoder. Specifically, MFM-Net adopts a dual path architecture to establish multiple feature matching channels in different layers of the decoder, which is then combined with the adversarial learning to merge the distribution of features from complete and incomplete modalities. In addition, a refinement is applied to enhance the details. As a result, MFM-Net makes use of a more comprehensive understanding to establish the geometric correspondence between complete and incomplete shapes in a local-to-global perspective, which enables more detailed geometric inference for generating high-quality complete shapes. We conduct comprehensive experiments on several datasets, and the results show that our method outperforms previous methods of unpaired point cloud completion with a large margin

The prognostic role of circulating CD8+ T cell proliferation in patients with untreated extensive stage small cell lung cancer.

peer reviewed[en] BACKGROUND: Immunosuppression caused by tumorigenesis may promote tumor progress and invasion. Here, we investigated whether the characteristics of circulating T lymphocyte subtypes in patients with extensive small cell lung cancer (ED-SCLC) can be used as an alternative marker of tumor progression. METHODS: This study included 36 newly diagnosed ED-SCLC patients before treatment and the patients were followed up. 22 age and sex-matched healthy volunteers were selected as control. The percentages and proliferation potential of T lymphocyte subpopulations from peripheral blood were measured. RESULTS: CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) were elevated in ED-SCLC patients compared with healthy controls (p = 0.0083). In contrast, the percentages of CD3+ and CD3+CD4+ T cells were significantly lower in SCLC patients (p < 0.001; p = 0.0014). The proliferation (%divided) of CD8+ T cells of SCLC patients was suppressed compared with healthy controls (p = 0.0058), but not of CD4+ T cells (p = 0.1611). Multivariate analyses showed that the %divided of CD8+ T cells is an independent predictor for PFS (HR: 4.342, 95% CI 1.324-14.245; p = 0.015). The percentages of peripheral Tregs and the degree of chemotherapy or radiotherapy induced lymphopenia negatively correlated with the proliferation of CD8+ T cells (p = 0.0225, r = - 0.379; p = 0.0003, r = - 0.464). CONCLUSION: The present study indicates that SCLC patients have impaired immunity in peripheral blood, and the proliferation potential of circulating CD8+ T cells is a significant predicator for PFS

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements