Young accreted globular clusters in the outer halo of M31

We report on Gemini/GMOS observations of two newly discovered globular clusters in the outskirts of M31. These objects, PAndAS-7 and PAndAS-8, lie at a galactocentric radius of ~87 kpc and are projected, with separation ~19 kpc, onto a field halo substructure known as the South-West Cloud. We measure radial velocities for the two clusters which confirm that they are almost certainly physically associated with this feature. Colour-magnitude diagrams reveal strikingly short, exclusively red horizontal branches in both PA-7 and PA-8; both also have photometric [Fe/H] = -1.35 +/- 0.15. At this metallicity, the morphology of the horizontal branch is maximally sensitive to age, and we use the distinctive configurations seen in PA-7 and PA-8 to demonstrate that both objects are very likely to be at least 2 Gyr younger than the oldest Milky Way globular clusters. Our observations provide strong evidence for young globular clusters being accreted into the remote outer regions of M31 in a manner entirely consistent with the established picture for the Milky Way, and add credence to the idea that similar processes play a central role in determining the composition of globular cluster systems in large spiral galaxies in general.Comment: 14 pages, 8 figures, accepted for publication in MNRA

Intimal Surface Suture Line (End-Product) Assessment of End-to-Side Microvascular Anastomosis.

Microsurgery simulation courses increasingly use assessment methodologies to evaluate the quality of microvascular anastomosis and to provide constructive feedback in competency-based training. Assessment tools evaluating the "journey" of skill acquisition in anastomosis have evolved, including global rating scores, hand motion analysis, and evaluation of the final outcome, that is, "end-product" assessment. Anastomotic patency is the gold standard end-product in clinical microvascular surgery, and in vivo end-to-side anastomosis, which can be confirmed using the Acland-test. Microsurgery simulation training is moving to include nonliving models, where possible, according to the principles of the replacement, reduction, and refinement of the use of animals in research. While a standardized end-product assessment tool for nonliving end-to-end anastomosis exists, there is no similar tool for end-to-side anastomosis. Intimal surface suture line assessment is an error list-based tool, which involves exposing the intimal surface of a vessel and analysis of the quality of suture placement. Errors in end-to side anastomosis were classified according to the potential clinical significance (high, medium, or low) perceived by the senior authors. Intimal surface suture line assessment provides constructive feedback during microsurgery training, helping to minimize technical errors, which are likely to impact on the final outcome in a clinical environment. Intimal surface suture line assessment lends itself to nonliving simulation training courses as an end-product self-assessment tool, especially during the early learning curve, to demonstrate progression. It has intraoperative relevance by assessment of the intimal surface suture line as the final sutures are placed in an end-to-side anastomosis to provide objective feedback to trainees in relation to likely physiological anastomotic outcome

Newly-Discovered Globular Clusters in NGC 147 and NGC 185 from PAndAS

Using data from the Pan-Andromeda Archaeological Survey (PAndAS), we have discovered four new globular clusters (GCs) associated with the M31 dwarf elliptical (dE) satellites NGC 147 and NGC 185. Three of these are associated with NGC 147 and one with NGC 185. All lie beyond the main optical boundaries of the galaxies and are the most remote clusters yet known in these systems. Radial velocities derived from low resolution spectra are used to argue that the GCs are bound to the dwarfs and are not part of the M31 halo population. Combining PAndAS with UKIRT/WFCAM data, we present the first homogeneous optical and near-IR photometry for the entire GC systems of these dEs. Colour-colour plots and published colour-metallicity relations are employed to constrain GC ages and metallicities. It is demonstrated that the clusters are in general metal poor ([Fe/H] < -1.25 dex), while the ages are more difficult to constrain. The mean (V-I)$_0$ colours of the two GC systems are very similar to those of the GC systems of dEs in the Virgo and Fornax clusters, as well as the extended halo GC population in M31. The new clusters bring the GC specific frequency (S_N) to ~9 in NGC 147 and ~5 in NGC 185, consistent with values found for dEs of similar luminosity residing in a range of environments.Comment: 14 pages, 6 figures, 6 tables, accepted for publication in MNRA

Major Substructure in the M31 Outer Halo: the South-West Cloud

We undertake the first detailed analysis of the stellar population and spatial properties of a diffuse substructure in the outer halo of M31. The South-West Cloud lies at a projected distance of ~100 kpc from the centre of M31, and extends for at least ~50 kpc in projection. We use Pan-Andromeda Archaeological Survey photometry of red giant branch stars to determine a distance to the South-West Cloud of 793 +/- 45 kpc. The metallicity of the cloud is found to be [Fe/H] = -1.3 +/- 0.1. This is consistent with the coincident globular clusters PAndAS-7 and PAndAS-8, which have metallicities determined using an independent technique of [Fe/H] = -1.35 +/- 0.15. We measure a brightness for the Cloud of M_V = -12.1 mag; this is ~75 per cent of the luminosity implied by the luminosity-metallicity relation. Under the assumption that the South-West Cloud is the visible remnant of an accreted dwarf satellite, this suggests that the progenitor object was amongst M31's brightest dwarf galaxies prior to disruption.Comment: 13 pages, 9 figures, accepted for publication in MNRA

The outer halo globular cluster system of M31 - II. Kinematics

We present a detailed kinematic analysis of the outer halo globular cluster (GC) system of M31. Our basis for this is a set of new spectroscopic observations for 78 clusters lying at projected distances between Rproj ~20-140 kpc from the M31 centre. These are largely drawn from the recent PAndAS globular cluster catalogue; 63 of our targets have no previous velocity data. Via a Bayesian maximum likelihood analysis we find that GCs with Rproj > 30 kpc exhibit coherent rotation around the minor optical axis of M31, in the same direction as more centrally- located GCs, but with a smaller amplitude of 86+/-17 km s-1. There is also evidence that the velocity dispersion of the outer halo GC system decreases as a function of projected distance from the M31 centre, and that this relation can be well described by a power law of index ~ -0.5. The velocity dispersion profile of the outer halo GCs is quite similar to that of the halo stars, at least out to the radius up to which there is available information on the stellar kinematics. We detect and discuss various velocity correlations amongst subgroups of GCs that lie on stellar debris streams in the M31 halo. Many of these subgroups are dynamically cold, exhibiting internal velocity dispersions consistent with zero. Simple Monte Carlo experiments imply that such configurations are unlikely to form by chance, adding weight to the notion that a significant fraction of the outer halo GCs in M31 have been accreted alongside their parent dwarf galaxies. We also estimate the M31 mass within 200 kpc via the Tracer Mass Estimator, finding (1.2 - 1.6) +/- 0.2 10^{12}M_sun. This quantity is subject to additional systematic effects due to various limitations of the data, and assumptions built in into the TME. Finally, we discuss our results in the context of formation scenarios for the M31 halo.Comment: 24 pages, 12 figures, 7 tables; Accepted for publication in MNRA

The merger that led to the formation of the Milky Way's inner stellar halo and thick disk

The assembly process of our Galaxy can be retrieved using the motions and chemistry of individual stars. Chemo-dynamical studies of the nearby halo have long hinted at the presence of multiple components such as streams, clumps, duality and correlations between the stars' chemical abundances and orbital parameters. More recently, the analysis of two large stellar surveys have revealed the presence of a well-populated chemical elemental abundance sequence, of two distinct sequences in the colour-magnitude diagram, and of a prominent slightly retrograde kinematic structure all in the nearby halo, which may trace an important accretion event experienced by the Galaxy. Here report an analysis of the kinematics, chemistry, age and spatial distribution of stars in a relatively large volume around the Sun that are mainly linked to two major Galactic components, the thick disk and the stellar halo. We demonstrate that the inner halo is dominated by debris from an object which at infall was slightly more massive than the Small Magellanic Cloud, and which we refer to as Gaia-Enceladus. The stars originating in Gaia-Enceladus cover nearly the full sky, their motions reveal the presence of streams and slightly retrograde and elongated trajectories. Hundreds of RR Lyrae stars and thirteen globular clusters following a consistent age-metallicity relation can be associated to Gaia-Enceladus on the basis of their orbits. With an estimated 4:1 mass-ratio, the merger with Gaia-Enceladus must have led to the dynamical heating of the precursor of the Galactic thick disk and therefore contributed to the formation of this component approximately 10 Gyr ago. These findings are in line with simulations of galaxy formation, which predict that the inner stellar halo should be dominated by debris from just a few massive progenitors.Comment: 19 pages, 8 figures. Published in Nature in the issue of Nov. 1st, 2018. This is the authors' version before final edit

Oral leukoplakia manifests differently in smokers and non-smokers

Oral leukoplakias (OL) are potentially malignant lesions that are typically white in color. Smoking is considered a risk factor for developing OL, and dysplastic lesions are more prone to malignant transformation. The aim of this study was to describe the clinical features observed in dysplastic and non-dysplastic OL in both smokers and nonsmokers. A total of 315 cases of OL were retrieved and separated into either dysplastic or non-dysplastic lesions, and these cases were further categorized as originating in either smokers or non-smokers. Frequencies of the type of OL lesion, with respect to whether the patients smoked, were established. The results demonstrated that 131 cases of OL were dysplastic (74 smokers and 57 non-smokers), and 184 were non-dysplastic (96 smokers and 88 non-smokers). For OL cases in smokers for which information about alcohol consumption was also available (84 cases), the results revealed no significant difference in the amount of dysplastic and non-dysplastic lesions. Dysplastic lesions were more frequent in male smokers and in non-smoking females. The median age of smokers with cases of OL was significantly lower than in non-smokers; the lowest median ages were observed for female smokers with dysplastic OL. The most frequent anatomical sites of dysplastic lesions were the floor of the mouth in smokers and the tongue in non-smokers. Dysplastic lesions in smokers were significantly smaller than non-dysplastic lesions in non-smokers. Being a male smoker, being female, being younger, and having smaller lesions were associated with dysplastic features in OL. These clinical data may be important for predicting OL malignant transformation

<i>Gaia</i> Data Release 1. Summary of the astrometric, photometric, and survey properties

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims. A summary of Gaia DR1 is presented along with illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. Methods. The raw data collected by Gaia during the first 14 months of the mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC) and turned into an astrometric and photometric catalogue. Results. Gaia DR1 consists of three components: a primary astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the HIPPARCOS and Tycho-2 catalogues – a realisation of the Tycho-Gaia Astrometric Solution (TGAS) – and a secondary astrometric data set containing the positions for an additional 1.1 billion sources. The second component is the photometric data set, consisting of mean G-band magnitudes for all sources. The G-band light curves and the characteristics of ∼3000 Cepheid and RR-Lyrae stars, observed at high cadence around the south ecliptic pole, form the third component. For the primary astrometric data set the typical uncertainty is about 0.3 mas for the positions and parallaxes, and about 1 mas yr−1 for the proper motions. A systematic component of ∼0.3 mas should be added to the parallax uncertainties. For the subset of ∼94 000 HIPPARCOS stars in the primary data set, the proper motions are much more precise at about 0.06 mas yr−1. For the secondary astrometric data set, the typical uncertainty of the positions is ∼10 mas. The median uncertainties on the mean G-band magnitudes range from the mmag level to ∼0.03 mag over the magnitude range 5 to 20.7. Conclusions. Gaia DR1 is an important milestone ahead of the next Gaia data release, which will feature five-parameter astrometry for all sources. Extensive validation shows that Gaia DR1 represents a major advance in the mapping of the heavens and the availability of basic stellar data that underpin observational astrophysics. Nevertheless, the very preliminary nature of this first Gaia data release does lead to a number of important limitations to the data quality which should be carefully considered before drawing conclusions from the data