Erratum: a synonymous variant in GCK gene as a cause of gestational diabetes mellitus (diabetes mellitus. 2019;22(2). Doi: 10.14341/dm9938)

An erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019). Diabetes mellitus. 22(2). doi: 10.14341/DM9938An error was made in the list of authors: Fatima F. Burumkulova was not indicated as author of this article. The correct list of authors: Natalya A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov.The editorial board apologize for this error and state that this does not change the scientific conclusions of the article in any way.The original article has been updated

A synonymous variant in GCK gene as a cause of gestational diabetes mellitus

The diagnosis of MODY as a subtype of gestational diabetes mellitus (GDM) is important for an adequate management during pregnancy and the postnatal period. The present report describes a case of GDM caused by a synonymous с.666C>G р.V222V substitution in the GCK gene. The variant, which was initially ranked as ‘likely benign’, was later proven to be pathogenic by in vitro studies. The с.666C>G substitution led to the use of a new donor splice site and synthesis of the aberrant mRNA with deletion of 16 base pairs. The case illustrates that additional clinical and experimental data may be required for the correct interpretation of sequence variants pathogenicity

CMS physics technical design report : Addendum on high density QCD with heavy ions

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Improving the Method of Rotational Broaching in the Production of Profile Openings on the Lathes of Turning Group

We examined methods of manufacturing profile openings on the metal-cutting machines by the rotational broaching method. Based on the generalized results of analysis of the methods for manufacturing profile openings, we proposed a method of rotational broaching. Bits for drilling machines or screwdrivers are used as the tool. Hardness of the bit is quite high; therefore, making a centering opening in it is difficult. The problem is solved by pressing a transition bushing onto the bit, with a centering opening made in advance. Implementation of the method requires a Morse cone with a welded plate. This allows fixing the rotating centre in a tool carrier. The proposed method makes it possible at minimal financial cost to perform the shaping of profile openings within a wide range of both the shape and nominal dimensions. The method is based on the effect of self-centering and, therefore, does not require preliminary adjustment. Adjusting tool entrance angle is achieved by displacing a transverse support of the lathe and by tool carrier rotation. In addition, in the production of profile opening, its input cone is formed, which provides for easy installation of the wrench to transmit rotational moment without losing load capacity. The studies conducted defined suboptimal values of the input variables that are accepted as rational in the examined technological process of rotational broaching. These are: a tool entrance angle (1.5...2.5 degrees), its supply (0.1...0.3 mm/rev) and the rate of processing (15...25 m/min

Improving the Abrasive Resistance of a Slide Frame in a Mortar Mixer

A method has been proposed for machining the outer and inner conical surfaces of the wrist pin and insert, which represent a sliding friction pair on the mortar mixer frame. The machining implies the application on the conical surface of parts, preliminary prepared through turning, of a wear-resistant material in the form of a hard alloyed nickel-based powder. It is applied with a special burner with a hopper-dispenser filled with powder. The result of mixing a combustible gas (acetylene and oxygen) in the burner with the powder from the hopper is melting.In the course of implementing a given technological process, by using mathematical modeling methods, we have determined the optimal mode parameters (PG10N-01 powder consumption is 33.5 g/min.; oxygen flow rate is 7.0 l/min; acetylene pressure is 0.043 MPa) for the gas-flame surfacing, which ensured maximum effect, that is, the greatest strength of adhesion (45 MPa) for the surfaced coating. The surfaced coating quality was checked by using a pin method for determining the adhesion strength between the new coating and the base on a tensile testing machine.A series of experimental studies into the enhancement of abrasive resistance of a sliding frame, namely a comparison of the surfaced coating with other well-known wear-resistant materials such as steel ShKh15, KhVG, were carried out at a specially designed experimental bench. Its structure is based on a vertically drilling desktop machine adjusted to the conditions of a working process that occurs inside the body of a mortar mixer. These include an abrasive medium, and the radial and axial efforts. To determine the axial load on a frame, we have proposed a structure of the hydraulic device, which includes a pressure gauge, a piston, a sleeve, and a ball. The axial load has been found for the most unfavorable conditions of mixer operation. Its value was implemented at an experimental wear bench. In addition, we have performed a series of experimental studies to determine an optimum angle of the cone at the apex of the wrist pin and insert in a conical slide frame for the minimal wear.Using the proposed technique of a gas-flame surfacing could significantly improve the abrasive and corrosion resistance of a slide frame, thereby prolonging the lifespan of a mortar mixer in general, as well as the overhaul cycle for equipment designed to prepare soluble mixtures used for constructio

Modernization of the Technique for Rotary Shape-formation of Outer Profiled Surfaces

We have proposed a technique for obtaining outer profiled surfaces, which is characterized by affordability and low cost of equipment used. The technique is based on that a regular rotating center is fixed in a lathe's tool holder in a special way. A basic socket head of the required profile is applied as a profile-forming matrix. A tool holder's rotation angle ensures a fracture angle of the rotating center's axis relative to the axis of a workpiece rotation. A value for the fracture angle reaches 1.5°. The end surface edge of the matrix executes a reciprocating motion per every rotation of the lathe chuck along the surface of a workpiece. In this case, the end surface of the matrix and a workpiece are in contact at a single point, going deeper by the magnitude of feed per every rotation of the chuck.Application of a given technique is an alternative to existing technique of rotational shape-formation of outer profiled surfaces, whose implementation requires specialized equipment and specialized cutting tools, the price for which is quite high (UAH 57,000 and UAH 6,000, respectively). In addition, changing the size or shape of the required profile necessitates installing a new cutting tool, replacing which requires additional adjustment.The tests were carried out when manufacturing the twelve-point outer surface the size of S10. An analysis of vibrograms from the shape-formation process has established the most rational variant of equipment for manufacturing profiled outer surfaces. We have manufactured pilot outer profiled surfaces, such as hexagon the size of S10, the TORX surface the size of E14, and others. They confirmed a possibility for successful manufacturing of different profiled outer surfaces using the proposed tooling.Using the proposed technique, which implies low cost and does not require specialized equipment, could significantly expand the scope of application of conjugated surfaces with a profiled shape in mechanical engineerin

The formation of human populations in South and Central Asia

By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.N.P. carried out this work while a fellow at the Radcliffe Institute for Advanced Study at Harvard University. P.M. was supported by a Burroughs Wellcome Fund CASI award. N.N. is supported by a NIGMS (GM007753) fellowship. T.C. and A.D. were supported by the Russian Science Foundation (project 14-50-00036). T.M.S. was supported by the Russian Foundation for Basic Research (grant 18-09-00779) “Anthropological and archaeological aspects of ethnogenesis of the population of the southern part of Western and Central Siberia in the Neolithic and Early Bronze Age.” D.P., S.S., and D.L. were supported by European Research Council ERC-2011-AdG 295733 grant (Langelin). O.M. was supported by a grant from the Ministry of Education and Sciences of the Russian Federation No. 33.1907, 2017/Π4 “Traditional and innovational models of a development of ancient Volga population”. A.E. was supported by a grant from the Ministry of Education and Sciences of the Russian Federation No. 33.5494, 2017/BP “Borderlands of cultural worlds (Southern Urals from Antiquity to Early Modern period).” Radiocarbon dating work supported by the NSF Archaeometry program BCS-1460369 to D.Ken. and B.J.C. and by the NSF Archaeology program BCS-1725067 to D.Ken. K.Th. was supported by NCP fund (MLP0117) of the Council of Scientific and Industrial Research (CSIR), Government of India, New Delhi. N.Bo., A.N., and M.Z. were supported by the Max Planck Society. D.Re. is an Investigator of the Howard Hughes Medical Institute, and his ancient DNA laboratory work was supported by National Science Foundation HOMINID grant BCS-1032255, by National Institutes of Health grant GM100233, by an Allen Discovery Center grant, and by grant 61220 from the John Templeton Foundation

The CMS experiment at the CERN LHC

The Compact Muon Solenoid (CMS) detector is described. The detector operates at the Large Hadron Collider (LHC) at CERN. It was conceived to study proton-proton (and lead-lead) collisions at a centre-of-mass energy of 14 TeV (5.5 TeV nucleon-nucleon) and at luminosities up to 10(34)cm(-2)s(-1) (10(27)cm(-2)s(-1)). At the core of the CMS detector sits a high-magnetic-field and large-bore superconducting solenoid surrounding an all-silicon pixel and strip tracker, a lead-tungstate scintillating-crystals electromagnetic calorimeter, and a brass-scintillator sampling hadron calorimeter. The iron yoke of the flux-return is instrumented with four stations of muon detectors covering most of the 4 pi solid angle. Forward sampling calorimeters extend the pseudo-rapidity coverage to high values (vertical bar eta vertical bar <= 5) assuring very good hermeticity. The overall dimensions of the CMS detector are a length of 21.6 m, a diameter of 14.6 m and a total weight of 12500 t

The CMS experiment at the CERN LHC

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