32 research outputs found
Increasing access to integrated ESKD care as part of Universal Health Coverage
- Author
- Abraham Georgi
- Abu Alfa Ali K
- Aljubori Harith M
- Alrukhaimi Mona N
- Andreoli Sharon P
- Ashuntantang Gloria
- Bello Aminu K
- Bellorin-Font Ezequiel
- Bernieh Bassam
- Blake Peter G
- Brown Edwina
- Brown Mark
- Bunnag Sakarn
- Caskey Fergus J
- Chan Tak Mao
- Chen Yuqing
- Claure-Del Granado Rolando
- Claus Stefaan
- Collins Allan
- Coppo Rosanna
- Couchoud Cecile
- Cueto-Manzano Alfonso
- Cullis Brett
- Davies Simon J
- Donner Jo-Ann
- Douthat Walter
- Dreyer Gavin
- Eiam-Ong Somchai
- Eke Felicia U
- Feehally John
- Finkelstein Fredric O
- Garcia Garcia Guillermo
- Ghnaimat Mohammad A
- Harden Paul
- Harris David CH
- Hassan Mohamed H
- Hemmelgarn Brenda
- Hou Fan Fan
- Ibhais Fuad M
- Jager Kitty
- Jha Vivekanand
- Johnson David W
- Kalantar-Zadeh Kamyar
- Kazancioglu Rumeyza T
- Leong Bak
- Levin Adeera
- Levin Nathan W
- Liew Adrian
- Luyckx Valerie A
- Martin Dominique E.
- McCulloch Mignon I
- McKnight Marla
- Moosa Mohammed Rafique
- Morton Rachael L
- Muller Elmi
- Murtagh Fliss EM
- Naicker Saraladevi
- Nangaku Masaomi
- Niang Abdou
- O'Connell Philip J
- Obrador Gregorio T
- Okpechi Ikechi G
- Ossareh Shahrzad
- Pecoits Filho Roberto
- Perl Jeffrey
- Rahman Muhibur
- Rashid Harun Ur
- Richards Marie
- Rondeau Eric
- Sahay Manisha
- Saleh Abdulkarim
- Schneditz Daniel
- Shah Kamal D
- Sola Laura
- Swanepoel Charles
- Tadesse Yewondwassesn
- Tchokhonelidze Irma
- Tesar Vladimir
- Tonelli Marcello
- Trask Michele
- Tungsanga Kriang
- Twahir Ahmed
- Vachharajani Tushar
- Van Biesen Wim
- Varghese Cherian
- Walker Rachael C
- Walker Robert
- Were Anthony JO
- Yang Chih-Wei
- Yao Qiang
- Yeates Karen
- Yu Xueqing
- Zakharova Elena
- Zemchenkov Alexander
- Zhao Ming-Hui
- Zuniga Carlos
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on integrated ESKD care, including 92 individuals from around the globe with diverse expertise and professional backgrounds. The attendees were from 41 countries, including 16 participants from 11 low- and lower-middle–income countries. The purpose was to develop a strategic plan to improve worldwide access to integrated ESKD care, by identifying and prioritizing key activities across 8 themes: (i) estimates of ESKD burden and treatment coverage, (ii) advocacy, (iii) education and training/workforce, (iv) financing/funding models, (v) ethics, (vi) dialysis, (vii) transplantation, and (viii) conservative care. Action plans with prioritized lists of goals, activities, and key deliverables, and an overarching performance framework were developed for each theme. Examples of these key deliverables include improved data availability, integration of core registry measures and analysis to inform development of health care policy; a framework for advocacy; improved and continued stakeholder engagement; improved workforce training; equitable, efficient, and cost-effective funding models; greater understanding and greater application of ethical principles in practice and policy; definition and application of standards for safe and sustainable dialysis treatment and a set of measurable quality parameters; and integration of dialysis, transplantation, and comprehensive conservative care as ESKD treatment options within the context of overall health priorities. Intended users of the action plans include clinicians, patients and their families, scientists, industry partners, government decision makers, and advocacy organizations. Implementation of this integrated and comprehensive plan is intended to improve quality and access to care and thereby reduce serious health-related suffering of adults and children affected by ESKD worldwide
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions
- Author
- Altay Servet
- Ameratunga S.
- Amouyel Philippe
- Aoki N.
- Aribas Elif
- Arndt Volker
- Aspelund Thor
- Assmann Gerd
- Atkins Robert
- Azizi Fereidoun
- Bakker Stephan Jl
- Balkau Beverley
- Barr Elizabeth L. M.
- Bell Steven
- Ben-Shlomo Yoav
- Ben-Shlomo Yoav
- Ben-Shlomo Yoav
- Berkman Lisa
- Beulens Joline W.
- Bjorkelund Cecilia
- Blaha Michael J.
- Blazer Dan G.
- Bolton Thomas
- Bonita Ruth
- Bonnet Fabrice
- Boonkert Prasit
- Brenner Beaglehole Hermann
- Brenner Hermann
- Broadhurst R.
- Brunner Eric J.
- Buring Julie
- Buring Julie
- Can Gunay
- Casas J. P.
- Casiglia Edoardo
- Casiglia Edoardo
- Chamnan Parinya
- Chen L. Q.
- Chen Z. M.
- Chew S. K.
- Choi Yeun-Hyang
- Choudhury S. R.
- Chowdhury Rajiv
- Christensen H.
- Claessen Heiner
- Coady Sean
- Cohort Finrisk
- Cook Nancy
- Cooney Marie Therese
- Costa Rui Bebiano Da Providencia E.
- Couper David
- Crespo Carlos J.
- Crespo Carlos J.
- Cushman Mary
- D'Agostino Ralph B.
- Dagenais Gilles R.
- Daimon Makoto
- Dale Caroline
- Dallongeville Jean
- Danaei Goodarz
- Danesh John
- Daniels Lori B.
- Davidson Karina W.
- De Bacquer Dirk
- de Boer Ian H.
- DeFilippis Andrew Paul
- Despres Jean-Pierre
- Di Angelantonio Emanuele
- Di Angelantonio Emanuele
- Diabetes Australian
- Dobson A.
- Donfrancesco Chiara
- Dorr Marcus
- Duan X. F.
- Elders Petra J. M.
- Engstrom Gunnar
- Ezzati Majid
- Fang X.
- Fang X. H.
- Fang Xianghua
- Ferrieres Jean
- Feskens Edith
- Ford Ian
- Frikke-Schmidt Ruth
- Fuh J. L.
- Fumeron Frederic
- Gallacher John
- Gansevoort Ron T.
- Gaziano Thomas Andrew
- Geleijnse Johanna M.
- Giampaoli Simona
- Giampaoli Simona
- Giedraitis Vilmantas
- Giles G. G.
- Gillum Richard F.
- Graham Ian
- Grandits Greg
- Grimsgaard Sameline
- Grobbee Diederick E.
- Gu D. F.
- Gu D. F.
- Gudmundsson Elias Freyr
- Gudnason Vilmundur
- Guo Qi
- Guralnik Jack
- Hadaegh Farzad
- Hange Dominique
- Harald Kennet
- Harst Pim van der
- Hashimoto T.
- Hata J.
- Hata Jun
- He Y.
- Heng D.
- Heshmatollah Alis
- Hillige Johannes L.
- Hirakawa Y.
- Hirakawa Yoichiro
- Ho S. C.
- Hobbs M.
- Holleczek Bernd
- Hong Z.
- Horibe H.
- Howard Barbara
- Hozawa A.
- Huang M. S.
- Hughes K.
- Humphries Steve
- Humphries Steve
- Hunt Kelly J.
- Huxley R.
- Ibanez Alejandro Marin
- Ikram M. Arfan
- Ikram M. Kamran
- Imai Y.
- Imai Y.
- Imano Hironori
- Ingelsson Martin
- Ishizaki Masao
- Iso Hiroyasu
- Iso Hiroyasu
- Iso Hiroyasu
- Jackson R.
- Jackson Rod
- Jamrozik K.
- Jamrozik K.
- Jee S. H.
- Jensen Gorm B.
- Jiang C. Q.
- Jousilahti Pekka
- Juan Survey I.
- Jukema J. Wouter
- Kagaya M.
- Kaptoge Stephen
- Kauhanen Jussi
- Kavousi Maryam
- Kayama Takamasa
- Kengne Andre Pascal
- Khalili Davood
- Khan Taskeen
- Khaw Kay-Tee
- Kiechl Stefan
- Kim H. C.
- Kim I. S.
- Kirkland Susan
- Kita Y.
- Kita Y.
- Kiyama Masahiko
- Kiyama Masahiko
- Knuiman M. W.
- Knuiman M. W.
- Knuiman Matthew
- Koenig Wolfgang
- Kromhout Daan
- Krumholz Harlan M.
- Kuller Lewis H.
- Kyowa Ikawa
- Lam T. H.
- Lam T. H.
- Lam T. H.
- Lam T. H.
- Laughlin Gail
- Laughlin Gail A.
- Lee J.
- Li S. C.
- Li Y. H.
- Li Z. Z.
- Li Z. Z.
- Lissner Lauren
- Liu Jing
- Liu L. S.
- Luszcz Mary
- MacMahon S.
- MacMahon S.
- Maegawa H.
- Mahavanakul Weera
- Massaro Joseph J.
- Mathiesen Ellisiv
- Matsushita Kunihiro
- Matsutani Y.
- McEvoy Linda K.
- McLachlan Stela
- Meade Tom W.
- Mehlig Kirsten
- Melander Olle
- Mendis Shanthi
- Moitry Marie
- Moons Karel G. M.
- Nakachi K.
- Nakamura M.
- Nambi Vijay
- Nauck Matthias
- Nietert Paul J.
- Nietert Paul J.
- Nilsson Peter M.
- Ninomiya T.
- Ninomiya Toshiharu
- Nordestgaard Borge G.
- Norman P.
- Norton R.
- Norton R.
- O'Donnell Christopher
- Ohkubo T.
- Oizumi Toshihide
- Okayama A.
- Onuma Oyere
- Packard Chris
- Palmieri Luigi
- Palmieri Luigi
- Pan W. H.
- Pan W. H.
- Panico Salvatore
- Patel Anushka
- Pencina Michael
- Pennells Lisa
- Perel Pablo
- Poppe Katrina
- Price Jackie F.
- Psaty Bruce M.
- Ramachandran Vasan
- Ridker Paul M.
- Riley Leanne
- Robertson Michele
- Rodgers A.
- Rodriguez Beatriz
- Rodriguez Beatriz
- Rosengren Annika
- Rosengren Annika
- Roth Gregory
- Rothenbacher Dietrich
- Roussel Ronan
- Rueda-Ochoa Oscar L.
- Rungger Gregorio
- Rutters Femke
- Saitoh S.
- Saitoh S.
- Sakata K.
- Sakurai Masaru
- Salomaa Veikko
- Salomaa Veikko
- Salonen Jukka T.
- Sato Shinichi
- Savin Stefan
- Schnohr Peter
- Schottker Ben
- Schwartz Joseph E.
- Shan G. L.
- Shara Nawar
- Shaw Jonathan E.
- Shimamoto K.
- Shimbo Daichi
- Shin Hee-Choon
- Shipley Martin
- Simons Judith
- Simons Leon A.
- Sofat Reecha
- Sofianopoulou Eleni
- Sritara P.
- Stevens Gretchen
- Stott David J.
- Study Bruneck
- Study Whitehall Ii
- Suh I.
- Suh I.
- Sundstrom Johan
- Susa Shinji
- Sutherland Susan E.
- Tamakoshi Workers A.
- Tanaka Shibata H.
- Tang Z.
- Thorsson Bolli
- Tikhonoff Valerie
- Tolonen Hanna
- Town Aito
- Town Shigaraki
- Tracy Russell
- Tuomainen Tomi-Pekka
- Ueshima H.
- Ueshima H.
- Ueshima H.
- Ueshima H.
- Ueshima Hirotsugu
- van der Schouw Yvonne T.
- Vanuzzo Diego
- Varghese Cherian
- Vartiainen Erkki
- Virtanen Jyrki
- Volzke Henry
- Wallace Robert B.
- Wang Miao
- Wareham Nicholas J.
- Wettana Benjawan
- Whincup Peter H.
- Whitlock G.
- Whitlock G.
- Wilhelmsen Lars
- Willeit Johann
- Willeit Peter
- Wilsgaard Tom
- Woo J.
- Wood Angela
- Wood David
- Woodward M.
- Woodward Mark
- Woodward Mark
- Wu X. G.
- Wu Z. L.
- Wu Z. S.
- Wu Z. S.
- Xie J. X.
- Yamagishi Kazumasa
- Yang Q. D.
- Yao C. H.
- Yao S. X.
- Yoshida Daigo
- Young Robin
- Yu X. H.
- Zadehvakili Azita
- Zhang H. Y.
- Zhang H. Y.
- Zhang H. Y.
- Zhang Xingguang
- Zhang Yan
- Zhang Ying
- Zhao Dong
- Zhou B.
- Zhou B. F.
- Zhou J.
- Zimmet Paul Z.
- Publication venue
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived 10-year risk prediction models for fatal and non-fatal cardiovascular disease (ie, myocardial infarction and stroke) using individual participant data from the Emerging Risk Factors Collaboration. Models included information on age, smoking status, systolic blood pressure, history of diabetes, and total cholesterol. For derivation, we included participants aged 40-80 years without a known baseline history of cardiovascular disease, who were followed up until the first myocardial infarction, fatal coronary heart disease, or stroke event. We recalibrated models using age-specific and sex-specific incidences and risk factor values available from 21 global regions. For external validation, we analysed individual participant data from studies distinct from those used in model derivation. We illustrated models by analysing data on a further 123 743 individuals from surveys in 79 countries collected with the WHO STEPwise Approach to Surveillance. FINDINGS: Our risk model derivation involved 376 177 individuals from 85 cohorts, and 19 333 incident cardiovascular events recorded during 10 years of follow-up. The derived risk prediction models discriminated well in external validation cohorts (19 cohorts, 1 096 061 individuals, 25 950 cardiovascular disease events), with Harrell's C indices ranging from 0·685 (95% CI 0·629-0·741) to 0·833 (0·783-0·882). For a given risk factor profile, we found substantial variation across global regions in the estimated 10-year predicted risk. For example, estimated cardiovascular disease risk for a 60-year-old male smoker without diabetes and with systolic blood pressure of 140 mm Hg and total cholesterol of 5 mmol/L ranged from 11% in Andean Latin America to 30% in central Asia. When applied to data from 79 countries (mostly low-income and middle-income countries), the proportion of individuals aged 40-64 years estimated to be at greater than 20% risk ranged from less than 1% in Uganda to more than 16% in Egypt. INTERPRETATION: We have derived, calibrated, and validated new WHO risk prediction models to estimate cardiovascular disease risk in 21 Global Burden of Disease regions. The widespread use of these models could enhance the accuracy, practicability, and sustainability of efforts to reduce the burden of cardiovascular disease worldwide. FUNDING: World Health Organization, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence, UK Medical Research Council, and National Institute for Health Research
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
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- Openshaw Peter J M
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- Porteous David J
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- S Turney
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- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
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- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
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- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
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- T Samakomva
- T Smith
- T Smith
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- T Varghes
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- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
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- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani O.
- Abbas A.
- Abbas F.
- Abbas M.
- Abbasi S.
- Abbass H.
- Abbott A.
- Abdallah N.
- Abdelaziz A.
- Abdelfattah M.
- Abdelqader B.
- Abdo D.
- Abdul Rasheed A.
- Abdul B.
- Abdul-Kadir R.
- Abdul-Raheem R.
- Abdulakeem A.
- Abdulle A.
- Abdulmumeen A.
- Abdulshukkoor N.
- Abdusamad K.
- Abed El Khaleq Y.
- Abedalla M.
- Abeer Ul Amna A.U.A.
- Abernethy K.
- Abo-Leyah H.
- Aboaba A.
- Abou-Haggar A.
- Abouibrahim M.
- Abraham M.
- Abraham T.
- Abraheem A.
- Abrams J.
- Abu H.-J.
- Abu-Arafeh A.
- Abubacker S.M.
- Abung A.
- Aceampong Y.
- Achara A.
- Acharya D.
- Acheampong S.
- Acheson J.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 29/05/2021
- Field of study
Background:
Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.
Findings:
Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79).
Interpretation:
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abani O.
- Abbas A.
- Abbas F.
- Abbas M.
- Abbasi S.
- Abbass H.
- Abbott A.
- Abdallah N.
- Abdelaziz A.
- Abdelfattah M.
- Abdelqader B.
- Abdul Rasheed A.
- Abdul B.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Background:
In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings:
Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001).
Interpretation:
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
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- Afolabi D.
- Afrasiabi Z.
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- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
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- Alaamery M.
- Alahmadey Z.Z.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D.
- Bata Iqbal
- Batieha Anwar M.
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benchekor Sounnia Mediene
- Benet Mikhail
- Bennett James E.
- Bennett James E.
- Benson Lowell S.
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bettiol Heloisa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bhargava Santosh K.
- Bia Daniel
- Biasch Katia
- Bikbov Mukharram M.
- Bista Bihungum
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Bjorkelund Cecilia
- Bloch Katia V.
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
- Boggia Jose G.
- Boissonnet Carlos P.
- Bojesen Stig E.
- Boker Lital Keinan
- Bonet Gorbea Mariano
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Boyer Christopher B.
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Jürgen
- Brenner Hermann
- Brewster Lizzy M.
- Briceno Yajaira
- Brito Miguel
- Bruno Graziella
- Bueno Gloria
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cabrera de Leon Antonio
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cameron Christine
- Can Gunay
- Candido Ana Paula C.
- Capanzana Mario V.
- Capkova Nadezda
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carrillo-Larco Rodrigo M.
- Carvalho Joana
- Casanueva Felipe F.
- Censi Laura
- Cervantes-Loaiza Marvin
- Chadjigeorgiou Charalambos A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nish
- Chee Miao Li
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chien Kuo-Liong
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
- Cifkova Renata
- Cinteza Eliza
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Concin Hans
- Cooper Cyrus
- Coppinger Tara C.
- Cordeiro da Silva Bruna Goncalves
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J.
- Cowell Chris
- Craig Cora L.
- Crampin Amelia C.
- Crujeiras Ana B.
- Cruz Juan J.
- Csilla Semanova
- Cui Liufu
- Cureau Felipe V.
- Cuschieri Sarah
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Damasceno Albertino
- Danaei Goodarz
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Moura Silva Caroline Ramos
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Smedt Delphine
- de Wit Tobias F. Rinke
- Deepa Mohan
- Deev Alexander D.
- DeGennaro Vincent Jr
- Dekkaki Imane Cherkaoui
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Demarest Stefaan
- Dennison Elaine
- Deschamps Valerie
- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T.
- Dika Zivka
- Dinc Gonul Horasan
- Djalalinia Shirin
- Do Ha T. P.
- Dobson Annette J.
- Doering Angela
- Doerr Marcus
- Donfrancesco Chiara
- Donoso Silvana P.
- Dorobantu Maria
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A.
- Duboz Priscilla
- Duda Rosemary B.
- Dulskiene Virginija
- Dushpanova Anar
- Dzakula Aleksandar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Eftekhar Ebrahim
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elisa Zapata Maria
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T.
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G.
- Escobedo-de la Pena Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A.
- Fall Caroline H.
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix Stephan B.
- Felix-Redondo Francisco J.
- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M.
- Ferreccio Catterina
- Ferreira Haroldo S.
- Ferrer Eldridge
- Ferrieres Jean
- Figueiro Thamara Hubler
- Fink Gunther
- Fischer Krista
- Foo Leng Huat
- Forsner Maria
- Fouad Heba M.
- Francis Damian K.
- Franco Maria do Carmo
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furer Ariel
- Furusawa Takuro
- Gaciong Zbigniew
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garcia Pablo
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gazzinelli Andrea
- Gehring Ulrike
- Geleijnse Johanna M.
- George Ronnie
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Ghimire Anup
- Gialluisi Alessandro
- Giampaoli Simona
- Gieger Christian
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Glavic Mihalea Marinovic
- Goldberg Marcel
- Goldsmith Rebecca A.
- Gomes Barros Mauro Virgilio
- Gomez Luis F.
- Gomula Aleksandra
- Goncalves Helen
- Goncalves Mauer
- Gonzalez Angel R.
- Gonzalez-Chica David A.
- Gonzalez-Gross Marcela
- Gonzalez-Rivas Juan P.
- Gonzalez-Villalpando Clicerio
- Gonzalez-Villalpando Maria-Elena
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregg Edward W.
- Gregor Ronald D.
- Grodzicki Tomasz
- Grosso Giuseppe
- Gruden Gabriella
- Gu Dongfeng
- Guan Ong Peng
- Gudmundsson Elias F.
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc J.
- Gupta Prakash C.
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Ha Seongjun
- Hadaegh Farzad
- Haghshenas Rosa
- Hakimi Hamid
- Halkjaer Jytte
- Hambleton Ian R.
- Hamzeh Behrooz
- Hange Dominique
- Hanif Abu A. M.
- Hantunen Sari
- Hao Jie
- Hardman Carla Meneses
- Hashemi-Shahri Seyed Mohammad
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J.
- He Jiang
- He Jiang
- He Yuna
- Heier Margit
- Hendriks Marleen Elisabeth
- Henrique Rafael dos Santos
- Henriques Ana
- Herrala Sauli
- Heshmat Ramin
- Hill Allan G.
- Ho Sai Yin
- Ho Suzanne C.
- Hoang Van Minh Hoang Van Minh
- Hobbs Michael
- Holdsworth Michelle
- Homayounfar Reza
- Horimoto Andrea R. V. R.
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huiart Laetitia
- Huisman Martijn
- Husseini Abdullatif S.
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G.
- Ibrahim Mohsen M.
- Ikeda Nayu
- Ikeda Nayu
- Ikram M. Arfan
- Iotova Violeta
- Irazola Vilma E.
- Ishida Takafumi
- Isiguzo Godsent C.
- Islam Muhammad
- Islam Sheikh Mohammed Shariful
- Iurilli Maria L. C.
- Iwasaki Masanori
- Jackson Rod T.
- Jacobs Jeremy M.
- Jaddou Hashem Y.
- Jafar Tazeen
- James Kenneth
- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
- Jerome Charles Sossa
- Jha Anjani Kumar
- Jiang Chao Qiang
- Jimenez Ramon O.
- Joeckel Karl-Heinz
- Joffres Michel
- Johansson Mattias
- Jokelainen Jari J.
- Jonas Jost B.
- Jorgensen Torben
- Jose Tormo Maria
- Joshi Pradeep
- Joukar Farahnaz
- Jozwiak Jacek
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Kaaks Rudolf
- Kafatos Anthony
- Kajantie Eero O.
- Kalmatayeva Zhanna
- Kalpourtzi Natasa
- Kalter-Leibovici Ofra
- Kampmann Freja B.
- Kannan Srinivasan
- Karaglani Eva
- Karhus Line L.
- Karki Khem B.
- Katibeh Marzieh
- Katz Joanne
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
- Kazakbaeva Gyulli M.
- Keil Ulrich
- Keinanen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kemper Han C. G.
- Kengne Andre P.
- Kengne Andre P.
- Keramati Maryam
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khang Young-Ho
- Khanh Le Nguyen Bao Khanh Le Nguyen Bao
- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Dong Wook
- Kim Hyeon Chang
- Kim Hyeon Chang
- Kim Jeongseon
- Klakk Heidi
- Klimek Magdalena
- Klumbiene Jurate
- Knoflach Michael
- Kolle Elin
- Kolsteren Patrick
- Kontto Jukka P.
- Korpelainen Raija
- Korrovits Paul
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kowlessur Sudhir
- Koziel Slawomir
- Kratenova Jana
- Kriaucioniene Vilma
- Kristensen Peter Lund
- Krokstad Steiner
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kujala Urho M.
- Kulaga Zbigniew
- Kumar R. Krishna
- Kumar Rachakulla Hari
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kutsenko Vladimir
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laxmaiah Avula
- Laxmaiah Avula
- Le Coroller Gwenaelle
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lehmann Nils
- Lehtimaki Terho
- Lele Elysee Claude Bika
- Lemogoum Daniel
- Levitt Naomi S.
- Lhoste Victor P. F.
- Li Yanping
- Lilly Christa L.
- Lim Wei-Yen
- Lima-Costa M. Fernanda
- Lin Hsien-Ho
- Lin Hsien-Ho
- Lin Xu
- Lin Yi-Ting
- Lind Lars
- Lingam Vijaya
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Lo Wei-Cheng
- Loit Helle-Mai
- Lopez Tania
- Lopez-Garcia Esther
- Lotufo Paulo A.
- Lovrencic Iva Lukacevic
- Lozano Jose Eugenio
- Lukrafka Janice L.
- Luksiene Dalia
- Lundqvist Annamari
- Lundqvist Robert
- Lunet Nuno
- Lustigova Michala
- Luszczki Edyta
- Ma Guansheng
- Ma Jun
- Machado-Coelho George L. L.
- Machado-Rodrigues Aristides M.
- Macia Enguerran
- Macieira Luisa M.
- Madar Ahmed A.
- Maggi Stefania
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- Magriplis Emmanuella
- Mahasampath Gowri
- Maire Bernard
- Majer Marjeta
- Makdisse Marcia
- Malekzadeh Fatemeh
- Malekzadeh Reza
- Malhotra Rahul
- Mallikharjuna Kodavanti
- Malyutina Sofia K.
- Maniego Lynell V.
- Manios Yannis
- Mann Jim I.
- Mansour-Ghanaei Fariborz
- Manzato Enzo
- Marcil Anie
- Margozzini Maira Paula
- Margozzini Paula
- Marild Staffan B.
- Marques Larissa Pruner
- Marques-Vidal Pedro
- Marrugat Jaume
- Martorell Reynaldo
- Mascarenhas Luis P.
- Matasin Marija
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- Matijasevich Alicia
- Matlosz Piotr
- Matsha Tandi E.
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- Mbanya Jean Claude N.
- Mc Donald Posso Anselmo J.
- McFarlane Shelly R.
- McGarvey Stephen T.
- McLachlan Stela
- McLean Rachael M.
- McLean Scott B.
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- Medzioniene Jurate
- Mehdipour Parinaz
- Mehlig Kirsten
- Mehrparvar Amir Houshang
- Meirhaeghe Aline
- Meisinger Christa
- Mendoza Montano Carlos
- Menezes Ana Maria B.
- Menon Geetha R.
- Mereke Alibek
- Meshram Indrapal I.
- Metspalu Andres
- Meyer Haakon E.
- Mi Jie
- Michels Nathalie
- Mikkel Kairit
- Milanovic Sanja Music
- Milkowska Karolina
- Miller Jody C.
- Minderico Claudia S.
- Mini G. K.
- Miranda J. Jaime
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- Mirjalili Mohammad Reza
- Mirrakhimov Erkin
- Misigoj-Durakovic Marjeta
- Modesti Pietro A.
- Moghaddam Sahar Saeedi
- Mohajer Bahram
- Mohamed Mostafa K.
- Mohamed Shukri F.
- Mohammad Kazem
- Mohammadi Mohammad Reza
- Mohammadi Zahra
- Mohammadifard Noushin
- Mohammadpourhodki Reza
- Mohamud Wan Nazaimoon Wan
- Mohan Viswanathan
- Mohanna Salim
- Mohebbi Iraj
- Mohebi Farnam
- Moitry Marie
- Mollehave Line T.
- Molnar Denes
- Momenan Amirabbas
- Mondo Charles K.
- Monterrubio-Flores Eric
- Monyeki Kotsedi Daniel K.
- Moon Jin Soo
- Moosazadeh Mahmood
- Moreira Leila B.
- Morejon Alain
- Moreno Luis A.
- Morgan Karen
- Moschonis George
- Mossakowska Malgorzata
- Mostafa Aya
- Mostafavi Seyed-Ali
- Mota Jorge
- Motlagh Mohammad Esmaeel
- Motta Jorge
- Mridha Malay K.
- Msyamboza Kelias P.
- Mu Thet Thet
- Muhihi Alfa J.
- Muiesan Maria L.
- Muller-Nurasyid Martina
- Murphy Neil
- Mursu Jaakko
- Musa Kamarul Imran
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- Mustafa Norlaila
- Nabipour Iraj
- Naderimagham Shohreh
- Nagel Gabriele
- Naidu Balkish M.
- Najafi Farid
- Nakamura Harunobu
- Namesna Jana
- Nang Ei Ei K.
- Nangia Vinay B.
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- Ndiaye Ndeye Coumba
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- Neuhauser Hannelore
- Neuhauser Hannelore K.
- Nguyen Chung T.
- Nguyen Nguyen D.
- Nguyen Quang V.
- Nieto-Martinez Ramfis E.
- Niiranen Teemu J.
- Nikitin Yury P.
- Ninomiya Toshiharu
- Nishtar Sania
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- Norat Teresa
- Nordendahl Maria
- Nordestgaard Borge G.
- Noto Davide
- Nowak-Szczepanska Natalia
- Nunes Baltazar
- O'Neill Terence W.
- O'Reilly Dermot
- Ochimana Caleb
- Oda Eiji
- Odili Augustine N.
- Oh Kyungwon
- Ohara Kumiko
- Ohtsuka Ryutaro
- Olie Valerie
- Olinto Maria Teresa A.
- Oliveira Isabel O.
- Omar Mohd Azahadi
- Onat Altan
- Ong Sok King
- Ono Lariane M.
- Ordunez Pedro
- Ornelas Rui
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- Owusu-Dabo Ellis
- Paccaud Fred Michel
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- Padez Cristina
- Pahomova Elena
- Pajak Andrzej
- Palli Domenico
- Palmieri Luigi
- Pan Wen-Harn
- Panda-Jonas Songhomitra
- Panza Francesco
- Paoli Mariela
- Papandreou Dimitrios
- Park Soon-Woo
- Park Suyeon
- Parnell Winsome R.
- Parsaeian Mahboubeh
- Pasquet Patrick
- Patel Nikhil D.
- Pavlyshyn Halyna
- Pecin Ivan
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- Peer Nasheeta
- Peixoto Sergio Viana
- Peltonen Markku
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- Peres Marco A.
- Peters Annette
- Petkeviciene Janina
- Peykari Niloofar
- Pichardo Rafael N.
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pitakaka Freda
- Piwonska Aleksandra
- Pizarro Andreia N.
- Plans-Rubio Pedro
- Polasek Ozren
- Porta Miquel
- Poudyal Anil
- Pourfarzi Farhad
- Pourshams Akram
- Poustchi Hossein
- Pradeepa Rajendra
- Price Alison J.
- Price Jacqueline F.
- Providencia Rui
- Puhakka Soile E.
- Puiu Maria
- Punab Margus
- Qasrawi Radwan F.
- Qorbani Mostafa
- Quang Ngoc Nguyen Quang Ngoc Nguyen
- Queiroz Daniel
- Radic Ivana
- Radisauskas Ricardas
- Rahim Hanan F. Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Raitakari Olli
- Raj Manu
- Rakhimova Ellina M.
- Ramachandran Ambady
- Ramos Elisabete
- Rampal Lekhraj
- Rampal Sanjay
- Rangel Reina Daniel A.
- Rao Sudha Ramachandra
- Rarra Vayia
- Rech Cassiano Ricardo
- Redon Josep
- Reganit Paul Ferdinand M.
- Regecova Valeria
- Revilla Luis
- Rezaianzadeh Abbas
- Ribeiro Robespierre
- Riboli Elio
- Richter Adrian
- Rigo Fernando
- Riley Leanne M.
- Ritti-Dias Raphael M.
- Robitaille Cynthia
- Rodriguez-Artalejo Fernando
- Rodriguez-Villamizar Laura A.
- Roggenbuck Ulla
- Rojas-Martinez Rosalba
- Romaguera Dora
- Romeo Elisabetta L.
- Rosengren Annika
- Roy Joel G. R.
- Rubinstein Adolfo
- Ruidavets Jean-Bernard
- Ruiz-Castell Maria
- Rusakova Iuliia A.
- Russo Paola
- Rutkowski Marcin
- Sabanayagam Charumathi
- Sabbaghi Hamideh
- Sachdev Harshpal S.
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saidi Olfa
- Sakarya Sibel
- Saki Nader
- Salanave Benoit
- Salazar Martinez Eduardo
- Salmeron Diego
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Sanchez-Abanto Jose
- Sandra Ruiz-Betancourt Blanca
- Sans Susana
- Santos Silva Diego Augusto
- Santos Diana A.
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- Saum Kai-Uwe
- Savin Stefan
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- Schaan Beatriz D.
- Schargrodsky Herman
- Schipf Sabine
- Schmidt Carsten O.
- Schnohr Peter
- Schoettker Ben
- Schramm Sara
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- Schutte Aletta E.
- Sebert Sylvain
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- Servais Jennifer
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- Shamshirgaran Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
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- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shirani Majid
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Simon Mary
- Simons Judith
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- Singleton Rosie K.
- Sjostrom Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobngwi Eugene
- Soderberg Stefan
- Soemantri Agustinus
- Sofat Reecha
- Solfrizzi Vincenzo
- Solomon Bethlehem
- Somi Mohammad Hossein
- Son Thai Pham Son Thai Pham
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K.
- Sorensen Thorkild I. A.
- Sorgjerd Elin P.
- Soric Maroje
- Soumare Aicha
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Staessen Jan A.
- Starc Gregor
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D.
- Stergiou George S.
- Stessman Jochanan
- Stevens Gretchen A.
- Stieber Jutta
- Stocks Tanja
- Stoeckl Doris
- Stokwiszewski Jakub
- Stronks Karien
- Strufaldi Maria Wany
- Suka Machi
- Sun Chien-An
- Sundstrom Johan
- Sundstrom Johan
- Sung Yn-Tz
- Suriyawongpaisal Paibul
- Sy Rody G.
- Syddall Holly E.
- Sylva Rene Charles
- Szklo Moyses
- Tai E. Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H.
- Timmermans Erik J.
- Tjandrarini Dwi H.
- Tjonneland Anne
- Toft Ulla
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topor-Madry Roman
- Tornaritis Michael J.
- Torrent Maties
- Torres-Collado Laura
- Touloumi Giota
- Traissac Pierre
- Tran Quoc Bao Tran Quoc Bao
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M.
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu M. T.
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M.
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T.
- Van Herck Koen
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- van Zutphen Elisabeth M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K.
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren W. M. Monique
- Verstraeten Roosmarijn
- Victora Cesar G.
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Walton Janette
- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. FUNDING: WHO
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D.
- Bata Iqbal
- Batieha Anwar M.
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benchekor Sounnia Mediene
- Benet Mikhail
- Bennett James E.
- Bennett James E.
- Benson Lowell S.
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bettiol Heloisa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bhargava Santosh K.
- Bia Daniel
- Biasch Katia
- Bikbov Mukharram M.
- Bista Bihungum
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Bjorkelund Cecilia
- Bloch Katia V.
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
- Boggia Jose G.
- Boissonnet Carlos P.
- Bojesen Stig E.
- Boker Lital Keinan
- Bonet Gorbea Mariano
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Boyer Christopher B.
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M.
- Briceno Yajaira
- Brito Miguel
- Bruno Graziella
- Bueno Gloria
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cabrera de Leon Antonio
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cameron Christine
- Can Gunay
- Candido Ana Paula C.
- Capanzana Mario V.
- Capkova Nadezda
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carrillo-Larco Rodrigo M.
- Carvalho Joana
- Casanueva Felipe F.
- Censi Laura
- Cervantes-Loaiza Marvin
- Chadjigeorgiou Charalambos A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nish
- Chee Miao Li
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chien Kuo-Liong
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
- Cifkova Renata
- Cinteza Eliza
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Collaboration NCD Risk Factor
- Concin Hans
- Cooper Cyrus
- Coppinger Tara C.
- Cordeiro da Silva Bruna Goncalves
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J.
- Cowell Chris
- Craig Cora L.
- Crampin Amelia C.
- Crujeiras Ana B.
- Cruz Juan J.
- Csilla Semanova
- Cui Liufu
- Cureau Felipe V.
- Cuschieri Sarah
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Damasceno Albertino
- Danaei Goodarz
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Moura Silva Caroline Ramos
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Smedt Delphine
- de Wit Tobias F. Rinke
- Deepa Mohan
- Deev Alexander D.
- DeGennaro Vincent Jr
- Dekkaki Imane Cherkaoui
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Demarest Stefaan
- Dennison Elaine
- Deschamps Valerie
- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T.
- Dika Zivka
- Dinc Gonul Horasan
- Djalalinia Shirin
- Do Ha T. P.
- Dobson Annette J.
- Doering Angela
- Doerr Marcus
- Donfrancesco Chiara
- Donoso Silvana P.
- Dorobantu Maria
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A.
- Duboz Priscilla
- Duda Rosemary B.
- Dulskiene Virginija
- Dushpanova Anar
- Dzakula Aleksandar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Eftekhar Ebrahim
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elisa Zapata Maria
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T.
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G.
- Escobedo-de la Pena Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A.
- Fall Caroline H.
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix Stephan B.
- Felix-Redondo Francisco J.
- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M.
- Ferreccio Catterina
- Ferreira Haroldo S.
- Ferrer Eldridge
- Ferrieres Jean
- Figueiro Thamara Hubler
- Fink Gunther
- Fischer Krista
- Foo Leng Huat
- Forsner Maria
- Fouad Heba M.
- Francis Damian K.
- Franco Maria do Carmo
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furer Ariel
- Furusawa Takuro
- Gaciong Zbigniew
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garcia Pablo
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gazzinelli Andrea
- Gehring Ulrike
- Geleijnse Johanna M.
- George Ronnie
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Ghimire Anup
- Gialluisi Alessandro
- Giampaoli Simona
- Gieger Christian
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Glavic Mihalea Marinovic
- Goldberg Marcel
- Goldsmith Rebecca A.
- Gomes Barros Mauro Virgilio
- Gomez Luis F.
- Gomula Aleksandra
- Goncalves Helen
- Goncalves Mauer
- Gonzalez Angel R.
- Gonzalez-Chica David A.
- Gonzalez-Gross Marcela
- Gonzalez-Rivas Juan P.
- Gonzalez-Villalpando Clicerio
- Gonzalez-Villalpando Maria-Elena
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregg Edward W.
- Gregor Ronald D.
- Grodzicki Tomasz
- Grosso Giuseppe
- Gruden Gabriella
- Gu Dongfeng
- Guan Ong Peng
- Gudmundsson Elias F.
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc J.
- Gupta Prakash C.
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Ha Seongjun
- Hadaegh Farzad
- Haghshenas Rosa
- Hakimi Hamid
- Halkjaer Jytte
- Hambleton Ian R.
- Hamzeh Behrooz
- Hange Dominique
- Hanif Abu A. M.
- Hantunen Sari
- Hao Jie
- Hardman Carla Meneses
- Hashemi-Shahri Seyed Mohammad
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J.
- He Jiang
- He Jiang
- He Yuna
- Heier Margit
- Hendriks Marleen Elisabeth
- Henrique Rafael dos Santos
- Henriques Ana
- Herrala Sauli
- Heshmat Ramin
- Hill Allan G.
- Ho Sai Yin
- Ho Suzanne C.
- Hobbs Michael
- Holdsworth Michelle
- Homayounfar Reza
- Horimoto Andrea R. V. R.
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huiart Laetitia
- Huisman Martijn
- Husseini Abdullatif S.
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G.
- Ibrahim Mohsen M.
- Ikeda Nayu
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- Ikram M. Arfan
- Iotova Violeta
- Irazola Vilma E.
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- Islam Muhammad
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- Jackson Rod T.
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- Jafar Tazeen
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- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
- Jerome Charles Sossa
- Jha Anjani Kumar
- Jiang Chao Qiang
- Jimenez Ramon O.
- Joeckel Karl-Heinz
- Joffres Michel
- Johansson Mattias
- Jokelainen Jari J.
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- Jorgensen Torben
- Jose Tormo Maria
- Joshi Pradeep
- Joukar Farahnaz
- Jozwiak Jacek
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Kaaks Rudolf
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- Kalmatayeva Zhanna
- Kalpourtzi Natasa
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- Kampmann Freja B.
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- Katibeh Marzieh
- Katz Joanne
- Kauhanen Jussi
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- Keinanen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kemper Han C. G.
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- Keramati Maryam
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
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- Khalili Davood
- Khang Young-Ho
- Khang Young-Ho
- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Dong Wook
- Kim Hyeon Chang
- Kim Hyeon Chang
- Kim Jeongseon
- Klakk Heidi
- Klimek Magdalena
- Klumbiene Jurate
- Knoflach Michael
- Kolle Elin
- Kolsteren Patrick
- Kontto Jukka P.
- Korpelainen Raija
- Korrovits Paul
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kowlessur Sudhir
- Koziel Slawomir
- Kratenova Jana
- Kriaucioniene Vilma
- Kristensen Peter Lund
- Krokstad Steiner
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kujala Urho M.
- Kulaga Zbigniew
- Kumar R. Krishna
- Kumar Rachakulla Hari
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kutsenko Vladimir
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laxmaiah Avula
- Laxmaiah Avula
- Le Coroller Gwenaelle
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lehmann Nils
- Lehtimaki Terho
- Lele Elysee Claude Bika
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- Viswanathan Bharathi
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- Voutilainen Ari
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- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/01/2021
- Field of study
Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. Copyright (C) 2021 World Health Organization; licensee Elsevier
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D.
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- Batieha Anwar M.
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- Beaglehole Robert
- Bebakar Wan Mohamad Wan
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- Damasceno Albertino
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- Dankner Rachel
- Dantoft Thomas M.
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
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- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Smedt Delphine
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- Deepa Mohan
- Deev Alexander D.
- DeGennaro Vincent Jr
- Dekkaki Imane Cherkaoui
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Demarest Stefaan
- Dennison Elaine
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- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T.
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- Doering Angela
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- Polasek Ozren
- Porta Miquel
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- Puiu Maria
- Punab Margus
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- Qorbani Mostafa
- Quang Ngoc Nguyen Quang Ngoc Nguyen
- Queiroz Daniel
- Radic Ivana
- Radisauskas Ricardas
- Rahim Hanan F. Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Raitakari Olli
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- Ramos Elisabete
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- Regecova Valeria
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- Romaguera Dora
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- Safi Sare
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- Verschuren W. M. Monique
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- Victora Cesar G.
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
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- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Walton Janette
- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
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- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background
Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.
Methods
We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age.
Findings
The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran.
Interpretation
Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings