The role of women in the fur trade society of the Canadian west 1700-1850.

PhDThis thesis traces the evolution of the role played by Indian, mixed-blood and white women in the development of fur trade society in western Canada from about 1700 to 1850. The importance of the role played by women in the fur trade has been generally overlooked by historians of the subject but such a study provides many insights into the complex interaction which took place between European and Indian as a result of this enterprise. The men of both the Hudson's Bay and North West Companies formed liaisons with women from the various tribes of western Canada. In the English company, these unions were formed in spite of official rulings to the contrary, whereas the Canadian company actively encouraged unions between its servants and Indian women. Such alliances served to cement trade ties. Indian women performed a variety of important economic tasks vital to the functioning of the fur trade besides fulfilling the role of wife and mother left void by the absence of white women. Eventually, however, the Indian wife was to become a source of friction rather than an effective liaison between Indian and white, and by the early nineteenth century, her place was being taken by a growing number of mixed-blood women. The very child of the fur trade, the mixed-blood woman's dual heritage gave her the ideal qualifications for a fur trader's wife. It is significant that marriages contracted A la façon du pays during this period showed a marked tendency to become permanent unions. After the union of the two companies in 1821, however, the position of native women in fur trade society was threatened by two outside forces--the missionaries and white women. While the missionaries' attack on fur trade morality was to lead to a good deal of cultural dislocation, the coming of white women presented a potent threat to the prominence of mixed-blood women in fur trade society. The resulting development of social and racial tension between these two groups of women was to erupt in a divisive scandal in Red River in 1850, which symbolized the increasing ascendancy of white women in western Canadian societ

“Women in Between”: Indian Women in Fur Trade Society in Western Canada

Cet article examine, à partir d'une perspective féminine, le rôle de l'Indienne dans la société de la traite des fourrures des Pays de l'Ouest. La situation unique de la femme indienne en présence de deux groupes mâles distincts, les Indiens et les Européens, lui permettait souvent d'agir comme intermédiaire entre les deux groupes. L'auteur évalue jusqu'à quel point elles en ont profité pour accroître leur influence et améliorer leur situation et jusqu'à quel point elles pouvaient apprécier les avantages matériaux que lui apportait cette situation. Elle conclut en supputant les raisons qui ont pu amener la fin de cette influence

An analysis of speed related UK accidents using a human functional failure methodology

Accidents involving either illegal or inappropriate speeding play a part in a large proportion of accidents involving cars. The types of typical failure generating scenarios found in car accidents where illegal speeding or inappropriate speeding is contributory are compared using the detailed human functional failure methodology developed in the European TRACE project (TRaffic Accident Causation in Europe), funded by the European Commission. Using on-scene cases from the UK ‘On The Spot’ database (funded by the UK Department for Transport and Highways Agency), a sample of cases where speed is contributory have been analysed. An overview of speeding cases from the 4,000 in-depth cases available in the dataset is also presented. The results highlight not only the differences between inappropriate and illegal speeding cases, but also the differences in the functional failures experienced by both the ‘at fault’ and ‘not at fault’ road users in both types of speed-related accidents. The results form a unique base of knowledge for future work on the human-related issues associated with speeding of both types, for all crash participants. Also considered is how new technologies can address speeding accidents

Reconsidering accident causation analysis and evaluating the safety benefits of technologies: final results of the TRACE project

The objectives of the EU-funded project TRACE (TRaffic Accident Causation in Europe, 2006-2008) are the up-dating of the etiology of road accidents and the assessment of the safety benefits of promising technology-based solutions. The analyses are based on available, reliable and accessible existing databases (access to which has been greatly facilitated by a number of partners highly experienced in safety analysis, coming from 8 different countries and having access to different kinds of databases, in-depth or regional or national statistics in their own country). Apart from considerable improvements in the methodologies applicable to accident research in the field of human factors, statistics and epidemiology, allowing a better understanding of the crash generating issues, the TRACE project quantified the expected safety benefits for existing and future safety applications. As for existing safety functions or safety packages, the main striking results show that any increment of a passive or active safety function selected in this project produces additional safety benefits. In general, the safety gains are even higher for higher injury severity levels. For example, if all cars were Euro NCAP five stars and fitted with EBA and ESC, compared to four stars without ESC and EBA, injury accidents would be reduced by 47%, all injuries would be mitigated by 68% and severe + fatal injuries by 70%. As for future advanced safety functions, TRACE investigated 19 safety systems. The results show that the greatest additional safety gains potential are expected from intelligent speed adaptation systems, automatic crash notification systems, and collision warning and collision avoidance systems. Their expected benefits (expected reduction in the total number of injured persons if the fleet is 100% equipped) are between 6% and 11%. Safety benefits of other systems are more often below 5%. Some systems have a very low expected safety benefit (around or less than 1%)

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Franchises lost and gained: post-coloniality and the development of women’s rights in Canada

The Canadian constitution is to some extent characterised by its focus on equality, and in particular gender equality. This development of women’s rights in Canada and the greater engagement of women as political actors is often presented as a steady linear process, moving forwards from post-enlightenment modernity. This article seeks to disturb this ‘discourse of the continuous,’ by using an analysis of the pre-confederation history of suffrage in Canada to both refute a simplistic linear view of women’s rights development and to argue for recognition of the Indigenous contribution to the history of women’s rights in Canada. The gain of franchise and suffrage movements in Canada in the late nineteenth and early twentieth century are, rightly, the focus of considerable study (Pauker 2015), This article takes an alternative perspective. Instead, it examines the exercise of earlier franchises in pre-confederation Canada. In particular it analyses why franchise was exercised more widely in Lower Canada and relates this to the context of the removal of franchises from women prior to confederation

A Phylogenetic Analysis of the Globins in Fungi

BACKGROUND: ALL GLOBINS BELONG TO ONE OF THREE FAMILIES: the F (flavohemoglobin) and S (sensor) families that exhibit the canonical 3/3 α-helical fold, and the T (truncated 3/3 fold) globins characterized by a shortened 2/2 α-helical fold. All eukaryote 3/3 hemoglobins are related to the bacterial single domain F globins. It is known that Fungi contain flavohemoglobins and single domain S globins. Our aims are to provide a census of fungal globins and to examine their relationships to bacterial globins. RESULTS: Examination of 165 genomes revealed that globins are present in >90% of Ascomycota and ∼60% of Basidiomycota genomes. The S globins occur in Blastocladiomycota and Chytridiomycota in addition to the phyla that have FHbs. Unexpectedly, group 1 T globins were found in one Blastocladiomycota and one Chytridiomycota genome. Phylogenetic analyses were carried out on the fungal globins, alone and aligned with representative bacterial globins. The Saccharomycetes and Sordariomycetes with two FHbs form two widely divergent clusters separated by the remaining fungal sequences. One of the Saccharomycete groups represents a new subfamily of FHbs, comprising a previously unknown N-terminal and a FHb missing the C-terminal moiety of its reductase domain. The two Saccharomycete groups also form two clusters in the presence of bacterial FHbs; the surrounding bacterial sequences are dominated by Proteobacteria and Bacilli (Firmicutes). The remaining fungal FHbs cluster with Proteobacteria and Actinobacteria. The Sgbs cluster separately from their bacterial counterparts, except for the intercalation of two Planctomycetes and a Proteobacterium between the Fungi incertae sedis and the Blastocladiomycota and Chytridiomycota. CONCLUSION: Our results are compatible with a model of globin evolution put forward earlier, which proposed that eukaryote F, S and T globins originated via horizontal gene transfer of their bacterial counterparts to the eukaryote ancestor, resulting from the endosymbiotic events responsible for the origin of mitochondria and chloroplasts

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Exome Sequencing and the Management of Neurometabolic Disorders

BACKGROUND: Whole-exome sequencing has transformed gene discovery and diagnosis in rare diseases. Translation into disease-modifying treatments is challenging, particularly for intellectual developmental disorder. However, the exception is inborn errors of metabolism, since many of these disorders are responsive to therapy that targets pathophysiological features at the molecular or cellular level. METHODS: To uncover the genetic basis of potentially treatable inborn errors of metabolism, we combined deep clinical phenotyping (the comprehensive characterization of the discrete components of a patient's clinical and biochemical phenotype) with whole-exome sequencing analysis through a semiautomated bioinformatics pipeline in consecutively enrolled patients with intellectual developmental disorder and unexplained metabolic phenotypes. RESULTS: We performed whole-exome sequencing on samples obtained from 47 probands. Of these patients, 6 were excluded, including 1 who withdrew from the study. The remaining 41 probands had been born to predominantly nonconsanguineous parents of European descent. In 37 probands, we identified variants in 2 genes newly implicated in disease, 9 candidate genes, 22 known genes with newly identified phenotypes, and 9 genes with expected phenotypes; in most of the genes, the variants were classified as either pathogenic or probably pathogenic. Complex phenotypes of patients in five families were explained by coexisting monogenic conditions. We obtained a diagnosis in 28 of 41 probands (68%) who were evaluated. A test of a targeted intervention was performed in 18 patients (44%). CONCLUSIONS: Deep phenotyping and whole-exome sequencing in 41 probands with intellectual developmental disorder and unexplained metabolic abnormalities led to a diagnosis in 68%, the identification of 11 candidate genes newly implicated in neurometabolic disease, and a change in treatment beyond genetic counseling in 44%. (Funded by BC Children's Hospital Foundation and others.)