Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Neue Aufgabenkultur für digitale Kartenarbeit im Schulunterricht mittels mobiler Geräte

Das gesellschaftliche Leben wird immer digitaler, demzufolge auch die alltägliche Lebenswelt von Lernenden. Um mit digitalen Medien angemessen, zielorientiert und reflektiert umgehen zu können, sind entsprechende Kompetenzen gefordert. Im Fachbereich der Geografie, insbesondere in der Fähigkeit der räumlichen Orientierung, besitzen digitale Orientierungsmittel einen zentralen Stellenwert und deshalb wird dessen Einsatz im Unterricht auch in der Ausbildung von Lehrpersonen fachdidaktisch gefördert. Digitale Karten ermöglichen eine Ersatzbegegnung mit dem Lehrgegenstand oder finden beim ausserschulischem Lernen Einsatz, sie motivieren zur Erschliessung der Lerninhalte und sie bieten eine Diskussionsgrundlage. Des Weiteren unterstützen sie kooperative und handlungsorientierte Lernformen, nebst möglichen Individualisierungen und Differenzierungen in heterogenen Klassenverbänden. Gedruckte Atlanten werden schon seit geraumer Zeit im Schulkontext erfolgreich eingesetzt, insofern sind zu traditionellen Papierkarten passende Frage- und Problemstellungen, methodische Vorgehensweisen und konstruierte Aufgabenstellungen ausreichend didaktisch fundiert. Nun steht aber mit dem Wechsel des Mediums von der analogen zur digitalen Welt ein Neudenken der Aufgabenkultur zur Förderung und Forderung der räumlichen Orientierungskompetenz an. Die praktische Kartenarbeit, welche die drei Teilkompetenzen Karten «anfertigen», «auswerten» und «bewerten» gleichermassen berücksichtigen soll, verändert sich wesentlich durch Einsatz digitaler Lehrmittel. In diesem Vortrag wird veranschaulicht, wie Karten aus der Druckausgabe des Schweizer Weltatlas durch eine mobile App für Tablets mit vielfältigen digitalen Darstellungen und Funktionalitäten aufgewertet werden können

Augmenting printed school atlases with thematic 3D maps

Digitalization in schools requires a rethinking of teaching materials and methods in all subjects. This upheaval also concerns traditional print media, like school atlases used in geography classes. In this work, we examine the cartographic technological feasibility of extending a printed school atlas with digital content by augmented reality (AR). While previous research rather focused on topographic three-dimensional (3D) maps, our prototypical application for Android tablets complements map sheets of the Swiss World Atlas with thematically related data. We follow a natural marker approach using the AR engine Vuforia and the game engine Unity. We compare two workflows to insert geo-data, being correctly aligned with the map images, into the game engine. Next, the imported data are transformed into partly animated 3D visualizations, such as a dot distribution map, curved lines, pie chart billboards, stacked cuboids, extruded bars, and polygons. Additionally, we implemented legends, elements for temporal and thematic navigation, a screen capture function, and a touch-based feature query for the user interface. We evaluated our prototype in a usability experiment, which showed that secondary school students are as effective, interested, and sustainable with printed as with augmented maps when solving geographic tasks.ISSN:2414-408

Augmenting Printed School Atlases with Thematic 3D Maps

Digitalization in schools requires a rethinking of teaching materials and methods in all subjects. This upheaval also concerns traditional print media, like school atlases used in geography classes. In this work, we examine the cartographic technological feasibility of extending a printed school atlas with digital content by augmented reality (AR). While previous research rather focused on topographic three-dimensional (3D) maps, our prototypical application for Android tablets complements map sheets of the Swiss World Atlas with thematically related data. We follow a natural marker approach using the AR engine Vuforia and the game engine Unity. We compare two workflows to insert geo-data, being correctly aligned with the map images, into the game engine. Next, the imported data are transformed into partly animated 3D visualizations, such as a dot distribution map, curved lines, pie chart billboards, stacked cuboids, extruded bars, and polygons. Additionally, we implemented legends, elements for temporal and thematic navigation, a screen capture function, and a touch-based feature query for the user interface. We evaluated our prototype in a usability experiment, which showed that secondary school students are as effective, interested, and sustainable with printed as with augmented maps when solving geographic tasks

FXYD7 is a brain-specific regulator of Na,K-ATPase α1–β isozymes

Recently, corticosteroid hormone-induced factor (CHIF) and the γ-subunit, two members of the FXYD family of small proteins, have been identified as regulators of renal Na,K-ATPase. In this study, we have investigated the tissue distribution and the structural and functional properties of FXYD7, another family member which has not yet been characterized. Expressed exclusively in the brain, FXYD7 is a type I membrane protein bearing N-terminal, post-translationally added modifications on threonine residues, most probably O-glycosylations that are important for protein stabilization. Expressed in Xenopus oocytes, FXYD7 can interact with Na,K-ATPase α1–β1, α2–β1 and α3–β1 but not with α–β2 isozymes, whereas, in brain, it is only associated with α1–β isozymes. FXYD7 decreases the apparent K(+) affinity of α1–β1 and α2–β1, but not of α3–β1 isozymes. These data suggest that FXYD7 is a novel, tissue- and isoform-specific Na,K-ATPase regulator which could play an important role in neuronal excitability

Search for narrow resonances using the dijet mass spectrum in pp collisions at s√=8 TeV

Results are presented of a search for the production of new particles decaying to pairs of partons (quarks, antiquarks, or gluons), in the dijet mass spectrum in proton-proton collisions at s√=8  TeV. The data sample corresponds to an integrated luminosity of 4.0  fb−1, collected with the CMS detector at the LHC in 2012. No significant evidence for narrow resonance production is observed. Upper limits are set at the 95% confidence level on the production cross section of hypothetical new particles decaying to quark-quark, quark-gluon, or gluon-gluon final states. These limits are then translated into lower limits on the masses of new resonances in specific scenarios of physics beyond the standard model. The limits reach up to 4.8 TeV, depending on the model, and extend previous exclusions from similar searches performed at lower collision energies. For the first time mass limits are set for the Randall–Sundrum graviton model in the dijet channel

Measurement of the charge ratio of atmospheric muons with the CMS detector

We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/ c to 1 TeV/ c . The surface flux ratio is measured to be 1.2766±0.0032(stat.)±0.0032(syst.) , independent of the muon momentum, below 100 GeV/ c . This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments.We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/c to 1 TeV/c. The surface flux ratio is measured to be 1.2766 \pm 0.0032(stat.) \pm 0.0032 (syst.), independent of the muon momentum, below 100 GeV/c. This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments