Determination of blue water footprint in forages crops from irrigation disctrict 017, Comarca Lagunera, Mexico

El objetivo de este trabajo fue la determinación de la huella hídrica azul en los cultivos forrajeros del DR-017 Comarca Lagunera, México. Mediante el uso de indicadores de productividad y eficiencia se desarrollaron modelos matemáticos que permitieron estimar la huella hídrica azul de los cultivos. Los resultados muestran que los forrajes ocuparon 45% de la superficie total agrícola, empleando 94,7% del agua subterránea, generando 33% del Valor Bruto de la Producción agrícola. Los índices de productividad física fueron en promedio 252 L kg-1 (sorgo forrajero 181 L kg-1, avena forrajera 413 L kg- 1, alfalfa L kg-1). El ingreso por m3 empleado fue de US$0,04 m-3 en promedio (maíz forrajero US$ 0,07 m-3, alfalfa US$0,05 m-3). El indicador de eficiencia social mostró que en promedio se generaron 0,048 empleos hm-3 (0,037empleos hm-3 en alfalfa y 0,076 empleos hm-3 en rye grass). Finalmente bajo las mismas condiciones de cultivo, así como de mercado, la cantidad mínima que se requiere producir para tener una operación viable (punto de equilibrio) en promedio fue 39,02 t ha-1. En conclusión, la producción de maíz y sorgo forrajero en la región resultó altamente eficiente y productiva en comparación con los demás cultivos forrajeros lo que se tradujo en una menor huella hídrica azul.The aim of this work was the determination of the blue water footprint in forage crops from DR-017 “Comarca Lagunera", México. By means of productivity and efficiency mathematical models were used to estimate the blue water footprint of forages crops. The results show that forages occupied 45of groundwater, generating 33rates were on average 252 L kg-1 (forage sorghum 181 L kg-1, forage oats 413 L kg-1 alfalfa L kg- 1). Income per m3 was US$ 0.04 m-3 on average (US$0.94 m-3 in forage maize, US$ 0.05 m-3 alfalfa forage). The social efficiency indicator showed in average 0.048 jobs per hectometer (0.037 jobs hm-3 in alfalfa and 0.076 jobs hm-3 in rye grass). Finally, under the same crop y market conditions the minimum amount for a viable operation (break-even point) was 39.02 t ha-1. In conclusion, the production of corn and sorghum forage in the region was highly efficient and productive compared to other forage crops which resulted in lower blue water footprint.Fil: Ríos Flores, José Luis. Universidad Autónoma Chapingo (México)Fil: Torres Moreno, Miriam. México. Secretaría de Agricultura, Ganadería, Desarrollo Rural, Pesca y AlimentaciónFil: Castro Franco, Rafael. Universidad Autónoma Chapingo (México)Fil: Torres Moreno, Marco Antonio. Universidad Autónoma Chapingo (México)Fil: Ruiz Torres, José. Universidad Autónoma Chapingo (México

Determinación de la huella hídrica azul en los cultivos forrajeros del DR-017, Comarca Lagunera, México

The aim of this work was the determination of the blue water footprint in forage crops from DR-017 "Comarca Lagunera", México. By means of productivity and efficiency mathematical models were used to estimate the blue water footprint of forages crops. The results show that forages occupied 45% of the total agricultural area using 94,7% of groundwater, generating 33% of the Gross Value Production. Physical productivity rates were on average 252 L kg-1 (forage sorghum 181 L kg-1, forage oats 413 L kg-1 alfalfa L kg- 1). Income per m3 was US$0.04 m-3 on average (US$ 0.94 m-3 in forage maize, US 0.05 m-3 alfalfa forage). The social efficiency indicator showed in average 0.048 jobs per hectometer (0.037 jobs hm-3 in alfalfa and 0.076 jobs hm-3 in rye grass). Finally, under the same crop y market conditions the minimum amount for a viable operation (break-even point) was 39.02 t ha-1. In conclusion, the production of corn and sorghum forage in the region was highly efficient and productive compared to other forage crops which resulted in lower blue water footprint.    El objetivo de este trabajo fue la determinación de la huella hídrica azul en los cultivos forrajeros del DR-017 Comarca Lagunera, México. Mediante el uso de indicadores de productividad y eficiencia se desarrollaron modelos matemáticos que permitieron estimar la huella hídrica azul de los cultivos. Los resultados muestran que los forrajes ocuparon 45% de la superficie total agrícola, empleando 94,7% del agua subterránea, generando 33% del Valor Bruto de la Producción agrícola. Los índices de productividad física fueron en promedio 252 L kg-1 (sorgo forrajero 181 L kg-1, avena forrajera 413 L kg- 1, alfalfa L kg-1). El ingreso por m3 empleado fue de US 0,04 m-3 en promedio (maíz forrajero US$0,07 m-3, alfalfa US$ 0,05 m-3). El indicador de eficiencia social mostró que en promedio se generaron 0,048 empleos hm-3 (0,037empleos hm-3 en alfalfa y 0,076 empleos hm-3 en rye grass). Finalmente bajo las mismas condiciones de cultivo, así como de mercado, la cantidad mínima que se requiere producir para tener una operación viable (punto de equilibrio) en promedio fue 39,02 t ha-1. En conclusión, la producción de maíz y sorgo forrajero en la región resultó altamente eficiente y productiva en comparación con los demás cultivos forrajeros lo que se tradujo en una menor huella hídrica azul

App de tráfico y navegación para ciclistas “Bike Ride”

Este trabajo de investigación muestra el plan de negocios para Bike Ride , una app de tráfico y navegación para ciclistas, proyecto que busca satisfacer la evolución del transporte en la sociedad, los riesgos, aglomeraciones que puede implicar movilizarse en un autobús después de la pandemia del coronavirus o simplemente evitar las horas punta y el tráfico de manejar un auto en la capital. El modelo de negocio ofrece un aplicativo óptimo con previsualización de rutas de ciclovías al momento de redactar una dirección o nombre de algún negocio, el cual le brinda alternativas de desplazamiento al usuario ciclista para que pueda trasladarse por el trayecto que más prefiera. En el análisis del entorno sobresale la creación de la ley promueve y regula el uso de la bicicleta como medio de transporte sostenible. En el análisis interno detalla que las fortalezas son ser una propuesta innovadora con un servicio que facilita la búsqueda de lugares interconectando las principales ciclovías y avenidas para llegar de una manera rápida y segura a sus destinos. La investigación de mercado arrojo que arrojó que el perfil de los usuarios son hombres y mujeres entre 18 y 55 años pertenecientes a Lima Metropolitana. del nivel socioeconómico B y C, que utilizan su smartphone para poder desplazarse a diferentes lugares a través de un aplicativo de navegación. El plan de marketing contempla una estrategia diferenciación y de penetración de mercado, así como una estrategia comunicacional. El plan operativo detalla estándares para el funcionamiento del proyecto en cuanto al servicio, calidad. Además, plasma el Layout del local según las normas vigentes. El proyecto cuenta con un plan financiero viable ya que los tiempos de recuperación se encuentran en 1.47 años además de poseer una TIR de 110%. Estos indicaron hacen atractiva la inversión y puesta en operación del proyecto.This research work shows the business plan for Bike Ride, a traffic and navigation app for cyclists, a project that seeks to satisfy the evolution of transport in society, the risks, agglomerations that may involve moving on a bus after the pandemic of the coronavirus or simply avoiding rush hours and traffic to drive a car in the capital. The business model offers an optimal application with a preview of bicycle routes when writing an address or name of a business, which provides alternative routes for cyclists so that they can travel on the route they prefer. In the analysis of the environment, the creation of the law that promotes and regulates the use of bicycles as a sustainable means of transport stands out. In the internal analysis, it details that the strengths are to be an innovative proposal with a service that facilitates the search for places by interconnecting the main bicycle lanes and avenues to reach their destinations quickly and safely. The market research showed that the profile of the users are men and women between 18 and 55 years old belonging to Metropolitan Lima. from socioeconomic level B and C, who use their smartphone to be able to move to different places through a navigation application. The marketing plan includes a differentiation and market penetration strategy, as well as a communication strategy. The operational plan details standards for the operation of the project in terms of service, quality. In addition, it reflects the Layout of the premises according to current regulations. The project has a viable financial plan since the recovery times are in 1.47 years in addition to having a return rate of 110%. These indicated make the investment and start-up of the project attractive.Trabajo de investigació

Immunophenotype and Transcriptome Profile of Patients With Multiple Sclerosis Treated With Fingolimod: Setting Up a Model for Prediction of Response in a 2-Year Translational Study

BackgroundFingolimod is a functional sphingosine-1-phosphate antagonist approved for the treatment of multiple sclerosis (MS). Fingolimod affects lymphocyte subpopulations and regulates gene expression in the lymphocyte transcriptome. Translational studies are necessary to identify cellular and molecular biomarkers that might be used to predict the clinical response to the drug. In MS patients, we aimed to clarify the differential effects of fingolimod on T, B, and natural killer (NK) cell subsets and to identify differentially expressed genes in responders and non-responders (NRs) to treatment.Materials and methodsSamples were obtained from relapsing–remitting multiple sclerosis patients before and 6 months after starting fingolimod. Forty-eight lymphocyte subpopulations were measured by flow cytometry based on surface and intracellular marker analysis. Transcriptome sequencing by next-generation technologies was used to define the gene expression profiling in lymphocytes at the same time points. NEDA-3 (no evidence of disease activity) and NEDA-4 scores were measured for all patients at 1 and 2 years after beginning fingolimod treatment to investigate an association with cellular and molecular characteristics.ResultsFingolimod affects practically all lymphocyte subpopulations and exerts a strong effect on genetic transcription switching toward an anti-inflammatory and antioxidant response. Fingolimod induces a differential effect in lymphocyte subpopulations after 6 months of treatment in responder and NR patients. Patients who achieved a good response to the drug compared to NR patients exhibited higher percentages of NK bright cells and plasmablasts, higher levels of FOXP3, glucose phosphate isomerase, lower levels of FCRL1, and lower Expanded Disability Status Scale at baseline. The combination of these possible markers enabled us to build a probabilistic linear model to predict the clinical response to fingolimod.ConclusionMS patients responsive to fingolimod exhibit a recognizable distribution of lymphocyte subpopulations and a different pretreatment gene expression signature that might be useful as a biomarker

Totally ecofriendly synthesis of silver nanoparticles from aqueous dissolutions of polysaccharides

In this contribution, a totally ecofriendly synthesis of silver nanoparticles from aqueous dissolution of polysaccharides is reported. The synthesis of nanoparticles was performed using aqueous dissolutions of silver nitrate (AgNO3) and carboxymethyl-cellulose (CMC) as both reducing and stabilization agent and using different AgNO3 : CMC weight ratios. Resultant yellowish to reddish dispersions were characterized by means of transmission electron microscopy and their related techniques, such as bright field and Z-contrast imaging and electron diffraction, as well as ultraviolet-visible and infrared spectroscopic techniques. The experimental evidence suggests that the morphology and particle size distribution of the silver nanoparticles depend on the AgNO3 : CMC weight ratio. This feature seems to be related to the stabilization given by the CMC matrix, which, according to our experimental findings, is steric in nature. Regarding such experimental evidence, a synthesis mechanism in which CMC acts as stabilizer and reducing agent is proposed

Natural transmission of dengue virus by aedes albopictus at Monterrey, Northeastern Mexico

Dengue cases occur frequently at Nuevo Leon, Mexico, where Aedes aegypti (L.) and Ae. albopictus (Skuse) are present. Ae. albopictus is considered the second vector of dengue. Because it bites humans outdoors during the day, the mosquito plays an important role in transmission of dengue virus (DENV). However, no previous studies at Nuevo Leon indicated the role of the mosquito outdoors. To assess Ae. albopictus for dengue virus, mosquitoes were collected from April to October 2010 at five localities at Guadalupe and Santiago, Nuevo Leon, (Northeast) Mexico, by using two methods: engine backpack aspirator and ovitraps. In total, 1,836 Ae. albopictus and 833 Ae. aegypti mosquitoes were collected by ovitrap and engine backpack aspirator methods. Groups of mosquitoes were processed by RT-PCR. Examination for DENV infection of mosquitoes showed one positive group of four female Ae. albopictus from an ovitrap. This research provided information that showed transovarial transmission of dengue virus in Ae. albopictus occurred naturally, maintaining endemic levels of disease at a study site

Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems

Automated antimicrobial susceptibility testing devices are widely implemented in clinical microbiology laboratories in Spain, mainly using EUCAST (European Committee on Antimicrobial Susceptibility Testing) breakpoints. In 2007, a group of experts published recommendations for including antimicrobial agents and selecting concentrations in these systems. Under the patronage of the Spanish Antibiogram Committee (Comité Español del Antibiograma, COESANT) and the Study Group on Mechanisms of Action and Resistance to Antimicrobial Agents (GEMARA) from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), and aligned with the Spanish National Plan against Antimicrobial Resistance (PRAN), a group of experts have updated this document. The main modifications from the previous version comprise the inclusion of new antimicrobial agents, adaptation of the ranges of concentrations to cover the EUCAST breakpoints and epidemiological cut-off values (ECOFFs), and the inference of new resistance mechanisms. This proposal should be considered by different manufacturers and users when designing new panels or cards. In addition, recommendations for selective reporting are also included. With this approach, the implementation of EUCAST breakpoints will be easier, increasing the quality of antimicrobial susceptibility testing data and their microbiological interpretation. It will also benefit epidemiological surveillance studies as well as the clinical use of antimicrobials aligned with antimicrobial stewardship programs.Los sistemas automáticos utilizados en el estudio de la sensibilidad a los antimicrobianos están introducidos en la mayoría de los laboratorios de Microbiología Clínica en España, utilizando principalmente los puntos de corte del European Committee on Antimicrobial Susceptibility Testing (EUCAST). En 2007, un grupo de expertos publicó unas recomendaciones para incluir antimicrobianos y seleccionar concentraciones en estos sistemas. Bajo el auspicio del Comité Español del Antibiograma (COESANT) y del Grupo de Estudio de los Mecanismos de Acción y Resistencia a los Antimicrobianos (GEMARA) de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) y alineado con el Plan Nacional frente a la Resistencia a los Antibióticos (PRAN), un grupo de expertos ha actualizado dicho documento. Las principales modificaciones realizadas sobre la versión anterior comprenden la inclusión de nuevos agentes antimicrobianos, la adaptación de los rangos de concentraciones para cubrir los puntos de corte clínicos y los puntos de corte epidemiológicos (ECOFF) definidos por el EUCAST, y para la inferencia de nuevos mecanismos de resistencia. Esta propuesta debería ser considerada por los diferentes fabricantes y los usuarios cuando se diseñen nuevos paneles o tarjetas. Además, se incluyen recomendaciones para realizar informes selectivos. Con este enfoque, la implementación de los puntos de corte del EUCAST será más fácil, aumentando la calidad de los datos del antibiograma y su interpretación microbiológica. También será de utilidad para los estudios de vigilancia epidemiológica, así como para el uso clínico de los antimicrobianos, de acuerdo con los programas de optimización de uso de antimicrobianos (PROA)

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Marejadas rurales y luchas por la vida, vol. iv: permanencias, resistencias y luchas por la vida

Volumen 4. Permanencias, resistencias y luchas por la vida, coordinado por: Elisabeth A. Mager Hois, Miguel Ángel Paz Frayre y Carla Zamora Lomelí, integra 15 capítulos y está dividido en tres secciones, la primera denominada Permanencia, contiene 5 capítulos que intentan establecer como eje común la lucha continua en las comunidades campesinas para continuar con la vida rural. La segunda, Identidad y resistencia, está compuesta por 4 capítulos que reflexionan sobre varios procesos de resistencia de la vida rural ante los cambios globales e internos en su propio proceso de vida, otros trabajos intentan encontrar aquellos elementos que generan y mantienen alguna forma de identidad, y la tercera sección, Lucha por la vida, contiene 6 trabajos que demuestran todas aquellas posibilidades que existen en el medio rural para sostenerse y mantenerse, generando diferentes formas y estrategias que los une en la continua lucha por vivir con pocas pretensiones y con difíciles perspectivas pero siempre encontrando alternativas.ASOCIACIÓN MEXICANA DE ESTUDIOS RURALES, INSTITUTO DE CIENCIAS AGROPECUARIAS Y RURALES (ICAR), UNIVERSIDAD DE GUADALAJARA, FACULTAD DE ESTUDIOS SUPERIORES ACATLÁN-UNAM, ECOSUR, CUCOSTA SUR GRANA, EL COLEGIO DE MICHOACÁN A.C., UNIVERSIDAD MICHOACANA DE SAN NICOLAS HIDALG

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group