Dialect Identification Across a Nation-State Border: Perception of Dialectal Variants in Seattle, WA and Vancouver, BC

The Atlas of North America English distinguishes the West from Western Canada on the basis of /æ/ retraction and Canadian Raising (Labov, Ash, and Boberg 2006). Since the Atlas, scholars have provided a more detailed understanding of /æɡ/ raising, /æ/retraction, and Canadian Raising throughout the Western United States and Western Canada (Boberg 2008, Fridland et al. 2016, Presnyakova, Umbal, and Pappas 2017, Roeder, Onosson, and D\u27Arcy 2018). In a production study, Swan (2016) found that Seattle and Vancouver, BC are differentiated primarily by Canadian Raising and pre-nasal raising of /æ/ and show minimal difference with respect to /æɡ/ raising and /æ/ retraction. Seattle and Vancouver speakers also shared different ideologies about their speech: Seattle respondents felt more confident that they could identify a Vancouver talker based on speech than vice versa. The current study builds from these observations to ask how natives of Seattle and Vancouver perceive the similarities and distinctions documented in the production literature. Can listeners differentiate a talker as being from Seattle or Vancouver? What cues are listeners relying on to judge a talker as being from Seattle or Vancouver? Do these perceptual cues align with the production differences between the cities? What does this imply for a dialectology of the West? These questions are addressed using a forced-choice dialect identification task using the variables represented by FAN, PATH, TAG, and DEVOUT. Our analysis considers signal detection theoretic measures to elucidate sensitivity and bias (Macmillan and Creelman 2005). The results suggest that differentiating Seattle and Vancouver talkers is a challenging task for listeners native to these cities. Neither Seattle nor Vancouver listeners show very accurate performance for any of the single-word stimuli or short phrase blocks of the task and are generally not able classify a talker\u27s city of origin based on their speech. The most accurate performance emerges for Seattle listeners classifying talkers saying DEVOUT, which aligns with the production differences between the cities and is likely driven by stereotypes about Canadian English. Listeners from both cities show more own city bias for the phonetic features that are shown to be more similar across the cities (PATH and TAG) than for those shown to be more different in production (FAN and DEVOUT). A closer look at bias reveals that while Seattle listeners perform with slightly more accuracy, they also show more own-city bias. We discussion possible reasons for this pattern and implications for dialectology of the West and Western Canada

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

'Le sport vers le féminisme' : l'engagement du milieu athlétique féminin français au temps de la FSFSF (1917-1936)

Mixed marriages have always had an ambiguous and often problematic relationship with the law. On one hand, mixed marriages have been seen as a key indicator of sociocultural integration into mainstream society. In terms of the law, this perception has been expressed, for example, as privileged access to citizenship status for immigrant family members of citizens. On the other hand, mixed marriages have been seen as a threat to society and social cohesion. In this article, I argue that these contradictory perceptions of mixed relationships have informed the development of citizenship law over time. Building on literature on the regulation of mixed marriages in law, as well as gender and citizenship law, I use the Netherlands as a case study to demonstrate how citizenship law has been used as a tool to prevent certain types of "undesirable" mixed couples and how this approach has informed Dutch citizenship law until today