11 research outputs found

    Functional magnetic resonance imaging (fMRI) item analysis of empathy and theory of mind

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    In contrast to conventional functional magnetic resonance imaging (fMRI) analysis across participants, item analysis allows generalizing the observed neural response patterns from a specific stimulus set to the entire population of stimuli. In the present study, we perform an item analysis on an fMRI paradigm (EmpaToM) that measures the neural correlates of empathy and Theory of Mind (ToM). The task includes a large stimulus set (240 emotional vs. neutral videos to probe empathic responding and 240 ToM or factual reasoning questions to probe ToM), which we tested in two large participant samples (N = 178, N = 130). Both, the empathy-related network comprising anterior insula, anterior cingulate/dorsomedial prefrontal cortex, inferior frontal gyrus, and dorsal temporoparietal junction/supramarginal gyrus (TPJ) and the ToM related network including ventral TPJ, superior temporal gyrus, temporal poles, and anterior and posterior midline regions, were observed across participants and items. Regression analyses confirmed that these activations are predicted by the empathy or ToM condition of the stimuli, but not by low-level features such as video length, number of words, syllables or syntactic complexity. The item analysis also allowed for the selection of the most effective items to create optimized stimulus sets that provide the most stable and reproducible results. Finally, reproducibility was shown in the replication of all analyses in the second participant sample. The data demonstrate (a) the generalizability of empathy and ToM related neural activity and (b) the reproducibility of the EmpaToM task and its applicability in intervention and clinical imaging studies. © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc

    Measurement of the Z boson differential cross section in transverse momentum and rapidity in proton-proton collisions at 8 TeV

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    We present a measurement of the Z boson differential cross section in rapidity and transverse momentum using a data sample of pp collision events at a centre-of-mass energy s=8 TeV, corresponding to an integrated luminosity of 19.7 fb-1. The Z boson is identified via its decay to a pair of muons. The measurement provides a precision test of quantum chromodynamics over a large region of phase space. In addition, due to the small experimental uncertainties in the measurement the data has the potential to constrain the gluon parton distribution function in the kinematic regime important for Higgs boson production via gluon fusion. The results agree with the next-to-next-to-leading-order predictions computed with the fewz program. The results are also compared to the commonly used leading-order MadGraph and next-to-leading-order powheg generators. © 2015 CERN for the benefit of the CMS Collaboration

    Measurement of the Z boson differential cross section in transverse momentum and rapidity in proton-proton collisions at 8 TeV

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    Peer reviewe

    OpenMS: a flexible open-source software platform for mass spectrometry data analysis

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    High-resolution mass spectrometry (MS) has become an important tool in the life sciences, contributing to the diagnosis and understanding of human diseases, elucidating biomolecular structural information and characterizing cellular signaling networks. However, the rapid growth in the volume and complexity of MS data makes transparent, accurate and reproducible analysis difficult. We present OpenMS 2.0 (http://www.openms.de), a robust, open-source, cross-platform software specifically designed for the flexible and reproducible analysis of high-throughput MS data. The extensible OpenMS software implements common mass spectrometric data processing tasks through a well-defined application programming interface in C++ and Python and through standardized open data formats. OpenMS additionally provides a set of 185 tools and ready-made workflows for common mass spectrometric data processing tasks, which enable users to perform complex quantitative mass spectrometric analyses with ease

    Angular coefficients of Z bosons produced in pp collisions at <tex>\sqrt{s}</tex>=8TeVanddecayingto<tex>μ+μ</tex>=8 TeV and decaying to <tex>\mu^{+}\mu^{-}</tex> as a function of transverse momentum and rapidity

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    French reconstruction in a European context

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    Digitised version produced by the EUI Library and made available online in 2020

    Evidence for Transverse Momentum and Pseudorapidity Dependent Event Plane Fluctuations in PbPb and pPb Collisions

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    A systematic study of the factorization of long-range azimuthal two-particle correlations into a product of single-particle anisotropies is presented as a function of pTp_\mathrm{T} and η\eta of both particles, and as a function of the particle multiplicity in PbPb and pPb collisions. The data were taken with the CMS detector for PbPb collisions at sNN\sqrt{s_{\mathrm{NN}}} = 2.76 TeV and pPb collisions at sNN\sqrt{s_{\mathrm{NN}}} = 5.02 TeV, covering a very wide range of multiplicity. Factorization is observed to be broken as a function of both particle pTp_\mathrm{T} and η\eta. When measured with particles of different pTp_\mathrm{T}, the magnitude of the factorization breakdown for the second Fourier harmonic reaches 20% for very central PbPb collisions but decreases rapidly as the multiplicity decreases. The data are consistent with viscous hydrodynamic predictions, which suggest that the effect of factorization breaking is mainly sensitive to the initial-state conditions rather than to the transport properties (e.g., shear viscosity) of the medium. The factorization breakdown is also computed with particles of different η\eta. The effect is found to be weakest for mid-central PbPb events but becomes larger for more central or peripheral PbPb collisions, and also for very high-multiplicity pPb collisions. The η\eta-dependent factorization data provide new insights to the longitudinal evolution of the medium formed in heavy ion collisions

    Measurement of the Z boson differential cross section in transverse momentum and rapidity in proton–proton collisions at 8 TeV

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    Angular coefficients of Z bosons produced in pp collisions at s\sqrt{s} = 8 TeV and decaying to μ+μ\mu^+ \mu^- as a function of transverse momentum and rapidity

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