354 research outputs found
Doping dependence of the superconducting gap in Bi2Sr2CaCu2O{8 + delta}
Bi2Sr2CaCu2O{8 + \delta} crystals with varying hole concentrations (0.12 < p
< 0.23) were studied to investigate the effects of doping on the symmetry and
magnitude of the superconducting gap. Electronic Raman scattering experiments
that sample regions of the Fermi surface near the diagonal (B_{2g}) and
principal axes (B_{1g}) of the Brillouin Zone have been utilized. The frequency
dependence of the Raman response function at low energies is found to be linear
for B_{2g} and cubic for B_{1g} (T< T_c). The latter observations have led us
to conclude that the doping dependence of the superconducting gap is consistent
with d_{x^2-y^2} symmetry, for slightly underdoped and overdoped crystals.
Studies of the pair-breaking peak found in the B_{1g} spectra demonstrate that
the magnitude of the maximum gap decreases monotonically with increasing hole
doping, for p > 0.12. Based on the magnitude of the B_{1g} renormalization, it
is found that the number of quasiparticles participating in pairing increases
monotonically with increased doping. On the other hand, the B_{2g} spectra show
a weak "pair-breaking peak" that follows a parabolic-like dependence on hole
concentration, for 0.12 < p < 0.23.Comment: 9 pages REvTex document including 8 eps figures; new table II;
changes to Fig. 5 and tex
A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression
We describe the characterisation of a variable number tandem repeat (VNTR) domain within intron 1 of the amyotrophic lateral sclerosis (ALS) risk gene CFAP410 (Cilia and flagella associated protein 410) (previously known as C21orf2), providing insight into how this domain could support differential gene expression and thus be a modulator of ALS progression or risk. We demonstrated the VNTR was functional in a reporter gene assay in the HEK293 cell line, exhibiting both the properties of an activator domain and a transcriptional start site, and that the differential expression was directed by distinct repeat number in the VNTR. These properties embedded in the VNTR demonstrated the potential for this VNTR to modulate CFAP410 expression. We extrapolated these findings in silico by utilisation of tagging SNPs for the two most common VNTR alleles to establish a correlation with endogenous gene expression. Consistent with in vitro data, CFAP410 isoform expression was found to be variable in the brain. Furthermore, although the number of matched controls was low, there was evidence for one specific isoform being correlated with lower expression in those with ALS. To address if the genotype of the VNTR was associated with ALS risk, we characterised the variation of the CFAP410 VNTR in ALS cases and matched controls by PCR analysis of the VNTR length, defining eight alleles of the VNTR. No significant difference was observed between cases and controls, we noted, however, the cohort was unlikely to contain sufficient power to enable any firm conclusion to be drawn from this analysis. This data demonstrated that the VNTR domain has the potential to modulate CFAP410 expression as a regulatory element that could play a role in its tissue-specific and stimulus-inducible regulation that could impact the mechanism by which CFAP410 is involved in ALS
Energetics, forces, and quantized conductance in jellium modeled metallic nanowires
Energetics and quantized conductance in jellium modeled nanowires are
investigated using the local density functional based shell correction method,
extending our previous study of uniform in shape wires [C. Yannouleas and U.
Landman, J. Phys. Chem. B 101, 5780 (1997)] to wires containing a variable
shaped constricted region. The energetics of the wire (sodium) as a function of
the length of the volume conserving, adiabatically shaped constriction leads to
formation of self selecting magic wire configurations. The variations in the
energy result in oscillations in the force required to elongate the wire and
are directly correlated with the stepwise variations of the conductance of the
nanowire in units of 2e^2/h. The oscillatory patterns in the energetics and
forces, and the correlated stepwise variation in the conductance are shown,
numerically and through a semiclassical analysis, to be dominated by the
quantized spectrum of the transverse states at the narrowmost part of the
constriction in the wire.Comment: Latex/Revtex, 11 pages with 5 Postscript figure
Hole concentration and phonon renormalization in Ca-doped YBa_2Cu_3O_y (6.76 < y < 7.00)
In order to access the overdoped regime of the YBa_2Cu_3O_y phase diagram, 2%
Ca is substituted for Y in YBa_2Cu_3O_y (y = 7.00,6.93,6.88,6.76). Raman
scattering studies have been carried out on these four single crystals.
Measurements of the superconductivity-induced renormalization in frequency
(Delta \omega) and linewidth (\Delta 2\gamma) of the 340 cm^{-1} B_{1g} phonon
demonstrate that the magnitude of the renormalization is directly related to
the hole concentration (p), and not simply the oxygen content. The changes in
\Delta \omega with p imply that the superconducting gap (\Delta_{max})
decreases monotonically with increasing hole concentration in the overdoped
regime, and \Delta \omega falls to zero in the underdoped regime. The linewidth
renormalization \Delta 2\gamma is negative in the underdoped regime, crossing
over at optimal doping to a positive value in the overdoped state.Comment: 18 pages; 5 figures; submitted to Phys. Rev. B Oct. 24, 2002 (BX8292
The Physics of turbulent and dynamically unstable Herbig-Haro jets
The overall properties of the Herbig-Haro objects such as centerline
velocity, transversal profile of velocity, flow of mass and energy are
explained adopting two models for the turbulent jet. The complex shapes of the
Herbig-Haro objects, such as the arc in HH34 can be explained introducing the
combination of different kinematic effects such as velocity behavior along the
main direction of the jet and the velocity of the star in the interstellar
medium. The behavior of the intensity or brightness of the line of emission is
explored in three different cases : transversal 1D cut, longitudinal 1D cut and
2D map. An analytical explanation for the enhancement in intensity or
brightness such as usually modeled by the bow shock is given by a careful
analysis of the geometrical properties of the torus.Comment: 17 pages, 10 figures. Accepted for publication in Astrophysics &
Spac
Large-amplitude driving of a superconducting artificial atom: Interferometry, cooling, and amplitude spectroscopy
Superconducting persistent-current qubits are quantum-coherent artificial
atoms with multiple, tunable energy levels. In the presence of large-amplitude
harmonic excitation, the qubit state can be driven through one or more of the
constituent energy-level avoided crossings. The resulting
Landau-Zener-Stueckelberg (LZS) transitions mediate a rich array of
quantum-coherent phenomena. We review here three experimental works based on
LZS transitions: Mach-Zehnder-type interferometry between repeated LZS
transitions, microwave-induced cooling, and amplitude spectroscopy. These
experiments exhibit a remarkable agreement with theory, and are extensible to
other solid-state and atomic qubit modalities. We anticipate they will find
application to qubit state-preparation and control methods for quantum
information science and technology.Comment: 13 pages, 5 figure
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies
Measurement of the cross section for isolated-photon plus jet production in pp collisions at âs=13 TeV using the ATLAS detector
The dynamics of isolated-photon production in association with a jet in protonâproton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fbâ1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photonâjet invariant mass and the scattering angle in the photonâjet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements
Measurement of the View the tt production cross-section using eÎŒ events with b-tagged jets in pp collisions at âs = 13 TeV with the ATLAS detector
This paper describes a measurement of the inclusive top quark pair production cross-section (ÏttÂŻ) with a data sample of 3.2 fbâ1 of protonâproton collisions at a centre-of-mass energy of âs = 13 TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electronâmuon pair in the final state. Jets containing b-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two b-tagged jets are counted and used to determine simultaneously ÏttÂŻ and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be:
ÏttÂŻ = 818 ± 8 (stat) ± 27 (syst) ± 19 (lumi) ± 12 (beam) pb,
where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented
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