Development of voluntary behaviour of senior preschool children using gamification in physical education lessons

The article examines the issue of voluntary behaviour as a process aimed at personality development that contributes to the formation of skills necessary for learning at school. Voluntary behaviour manifests itself in various aspects of a child’s life, including play activity. Playing children learn to regulate their behaviour. Games with rules acquire a special role, using game rules children have to act purposefully and overcome difficulties in solving a game task. The study of the level of voluntary behaviour development in senior preschool children was carried out using diagnostic techniques. The results of the study showed that at the beginning of the research the pre-schoolers had low indicators of voluntary behaviour. Therefore, a complex of outdoor games with rules was selected for voluntary behaviour development in senior pre-schoolers since they contain a number accompanying conditions that increase voluntary behaviour

Wound healing and hyper-hydration - a counter intuitive model

Winters seminal work in the 1960s relating to providing an optimal level of moisture to aid wound healing (granulation and re-epithelialisation) has been the single most effective advance in wound care over many decades. As such the development of advanced wound dressings that manage the fluidic wound environment have provided significant benefits in terms of healing to both patient and clinician. Although moist wound healing provides the guiding management principle confusion may arise between what is deemed to be an adequate level of tissue hydration and the risk of developing maceration. In addition, the counter-intuitive model ‘hyper-hydration’ of tissue appears to frustrate the moist wound healing approach and advocate a course of intervention whereby tissue is hydrated beyond what is a normally acceptable therapeutic level. This paper discusses tissue hydration, the cause and effect of maceration and distinguishes these from hyper-hydration of tissue. The rationale is to provide the clinician with a knowledge base that allows optimisation of treatment and outcomes and explains the reasoning behind wound healing using hyper-hydration

Lake surface temperature [in “State of the Climate in 2017”]

Observed lake surface water temperature anomalies in 2017 are placed in the context of the recent warming observed in global surface air temperature by collating long-term in situ lake surface temperature observations from some of the world’s best-studied lakes and a satellite-derived global lake surface water temperature dataset. The period 1996–2015, 20 years for which satellite-derived lake temperatures are available, is used as the base period for all lake temperature anomaly calculations

Role of biomarkers of myocardial injury and inflammation in predicting ischemia-reperfusion injury in patients with ST-segment elevation acute coronary syndrome undergoing endovascular revascularization

Aim. To evaluate the informative value of biomarkers (cardiac troponin l (cTnl), high-sensitivity C-reactive protein (hsCRP), N-terminal pro-brain natriuretic peptide (NTproBNP), stimulating growth factor (ST2)) as laboratory markers of myocardial ischemia-reperfusion injury in patients with ST-segment elevation acute coronary syndrome (STEACS) undergoing endovascular revascularization.Material and methods. The study included 115 patients with STEACS who underwent endovascular myocardial revascularization. To identify the informative value of biomarkers, the levels of cTnl, NTproBNP, hsCRP, sST2 were analyzed at baseline, as well as after reperfusion therapy on the 2nd (cTnl) and 5th (sST2, hsCRP, NTproBNP) days. Contrast-enhanced cardiac magnetic resonance imaging was performed 5 days after endovascular intervention.Results. Microvascular obstruction was detected in 54 patients (47%), of which 24 (44%) patients had a combination of microvascular obstruction and myocardial hemorrhage. ln 61 cases (53%), no microvascular damage was registered. lt was found that with an increase in the threshold initial NTproBNP levels >590 pg/ml, the odds ratio (OR) of myocardial reperfusion injury was 12,2 (95% confidence interval (CI), 4,81-30,92, p<0,001). In addition, we analyzed biomarker levels in the early period after myocardial infarction, at which threshold values of reperfusion injury parameters were established as follows: for cTnI >8,1 ng/ml, OR=7,17 (95% CI, 3,11-16,53, p=0,001); for hsCRP >14 mg/L, OR=12,71 (95% CI, 5,03-32,08, p=0,001); for NTproBNP >334 pg/ml, OR=11,8 (95% CI, 4,88-28,59, p=0,001); for sST2 >41 ng/ml, OR=7,17 (95% CI, 3,11-16,53, p=0,001). According to multivariate analysis, predictors of microvascular injury were the initial NTproBNP values, as well as the cTnI, hsCRP, and sST2 values in the early postinfarction period (sensitivity — 89,5%, specificity — 83,3%).Conclusion. Thus, the initial NTproBNP, as well as cTnI, hsCRP, sST2 values after percutaneous coronary intervention are more informative for assessing the risk of microvascular damage

ИССЛЕДОВАНИЕ ВЛИЯНИЯ ПАССИВИРУЮЩИХ СЛОЕВ НА ЕМКОСТНЫЕ ХАРАКТЕРИСТИКИ ГЕТЕРОСТРУКТУР AlGaN/GaN

AlGaN/GaN heterostructures grown by MOCVD method on sapphire and silicon substrates were test subjects. The capacity− voltage characteristic measurements have been run in 200Hz — 1MHz frequency range at planar disposition of mercury and second probe on the sample surface. The shape of typical C−V curves for the heterostructures with the upper undoped i−AlGaN and i−GaN layers at thickness 15—25 A have been analyzed. The appearance of a typical peak on the C−V curves at changing from depletion region to accumulation region has been registered for some structures with thickness of i−GaN layer 50A at low frequencies (f < 50—200 kHz). The height of this peak increased with reduction of frequency. It has been found experimentally that frequency at which the peak is registered can depend on the dislocation density in heterostructures. Possible explanation of the peak formation and band diagram modifications in these structures under an applied electric field have been presented. We show that using a Si3N4 passivation layer results in the formation of additional positive charge.Исследованы гетероструктуры AlGaN/ GaN, выращенные методом МOCVD на сапфировых и кремниевых подложках. Проведены измерения вольт−фарадных характеристик при планарном расположении ртутного зонда и второго электрода на поверхности образцов в диапазоне частот от 200 Гц до 1 МГц. Проанализирован вид типичных С—V−характеристик для гетероструктур с верхними нелегированными слоями i−AlGaN и i−GaN при толщине верхних слоев 1,5—2,5 нм. В ходе исследований при работе на низких частотах (f < 50÷200 кГц) для ряда структур с толщиной слоя i−GaN 5,0 нм при переходе из области обе- днения в область обогащения зафиксировано появление на С—V− кривых характерного пика. Высота этого пика увеличивалась с уменьшением частоты. Экспериментально показано, что частота, при которой фиксировали этот пик, может зависеть от плотности дислокаций в гетероструктурах. Дано возможное объяснение причин появления пиков с учетом модификации зонной диаграммы таких структур при наложении внешних электрических полей. Показано, что использование пассивирующего слоя Si3N4 приводит к возникновению дополнительного положительного заряда в барьерном слое

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Rasd1 Modulates the Coactivator Function of NonO in the Cyclic AMP Pathway

All living organisms exhibit autonomous daily physiological and behavioural rhythms to help them synchronize with the environment. Entrainment of circadian rhythm is achieved via activation of cyclic AMP (cAMP) and mitogen-activated protein kinase signaling pathways. NonO (p54nrb) is a multifunctional protein involved in transcriptional activation of the cAMP pathway and is involved in circadian rhythm control. Rasd1 is a monomeric G protein implicated to play a pivotal role in potentiating both photic and nonphotic responses of the circadian rhythm. In this study, we have identified and validated NonO as an interacting partner of Rasd1 via affinity pulldown, co-immunoprecipitation and indirect immunofluorescence studies. The GTP-hydrolysis activity of Rasd1 is required for the functional interaction. Functional interaction of Rasd1-NonO in the cAMP pathway was investigated via reporter gene assays, chromatin immunoprecipitation and gene knockdown. We showed that Rasd1 and NonO interact at the CRE-site of specific target genes. These findings reveal a novel mechanism by which the coregulator activity of NonO can be modulated

Global patterns and drivers of ecosystem functioning in rivers and riparian zones

River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth's biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented "next-generation biomonitoring" by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.peerReviewe