10 research outputs found
Reactive Oxygen Metabolites are Closely Associated With the Diagnosis and Prognosis of Coronary Artery Disease
Elevated oxidative DNA damage in patients with coronary artery disease and its association with oxidative stress biomarkers
Evaluation of CD147 gene expression, lipid peroxidation, and antioxidants in cases of acute coronary syndrome in Egyptian population
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Abstract Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as statins for hypercholesterolemia or beta-blockers for hypertension, the elderly appear to present a greater likelihood of suffering non-related side effects such as increased risk of developing new onset type 2 diabetes (NODM). In some cases, lower efficacy in the elderly have also been reported. Alternative forms of treatment have been sought to address these issues, and there has been a growing interest in looking at herbal remedies or plant-based natural compounds. Oxidative stress and inflammation are implicated in the manifestation of ageing-related cardiovascular disease. Thus, it is natural that a compound that possesses both antioxidative and anti-inflammatory bioactivities would be considered. This review article examines the potential of tocotrienols, a class of Vitamin E compounds with proven superior antioxidative and anti-inflammatory activity compared to tocopherols (the other class of Vitamin E compounds), in ameliorating ageing-related cardiovascular diseases and its associated morbidities. In particular, the potential of tocotrienols in improving inflammaging, dyslipidemia and mitochondrial dysfunction in ageing-related cardiovascular diseases are discussed
A review of canine babesiosis: the European perspective
Canine babesiosis is a significant tick-borne disease caused by various species of the protozoan genus Babesia. Although it occurs worldwide, data relating to European infections have now been collected for many years. These data have boosted the publication record and increased our working knowledge of these protozoan parasites. Both the large and small forms of Babesia species (B. canis, B. vogeli, B. gibsoni, and B. microti-like isolates also referred to as "B. vulpes" and "Theileria annae") infect dogs in Europe, and their geographical distribution, transmission, clinical signs, treatment, and prognosis vary widely for each species. The goal of this review is to provide veterinary practitioners with practical guidelines for the diagnosis, treatment and prevention of babesiosis in European dogs. Our hope is that these guidelines will answer the most frequently asked questions posed by veterinary practitioners
Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
A stacked record of relative geomagnetic paleointensity for the past 270 kyr from the western continental rise of the Antarctic Peninsula
Paleomagnetic and rock magnetic investigations were carried out on four gravity cores recovered from the western continental rise
of the Antarctic Peninsula during the SEDANO II cruise of RV OGS-Explora. The studied cores, each about 6.5 m-long, were
collected at a depth of 3700–4100 m below the sea level, on the distal gentle side of sediment Drift 7, and consist of very fine-grained
sediments spanning through various glacial–interglacial cycles. Detailed analysis of the paleomagnetic and rock magnetic data
allowed to reconstruct relative paleointensity (RPI) records (NRM20 mT/ARM20 mT) for each core.We established a refined age model
for the studied sequences by correlating individual SEDANO RPI curves to the global RPI stack SINT-800 [Y. Guyodo, J.-P. Valet,
Global changes in intensity of the Earth's magnetic field during the past 800 kyr, Nature 399 (1999) 249–252]. The individual
normalized SEDANO RPI records are in mutual close agreement; they were thus merged in a RPI stacking curve spanning the last
270 kyr and showing a low standard deviation. This study also points out that RPI records may provide a viable tool to date otherwise
difficult-to-date sedimentary sequences, such as those deposited along peri-Antarctic margins. The new RPI chronology indicates that
the sampled sedimentary sequence is younger than previously thought and allows a new high-resolution correlation to oxygen isotope
stages. Furthermore, we recognized variations in the rock magnetic parameters that appear to be climatically-driven, with changes in
the relative proportion of two magnetic mineral populations with distinct coercivities. Rock magnetic and lithological trends observed
in the SEDANO cores indicate that during the climatic cycles of the Late Pleistocene this sector of the peri-Antarctic margin was
subjected to subtle, yet identifiable, environmental changes, confirming a relatively higher instability of theWest Antarctic ice sheet
with respect to the East Antarctic counterpart