Comparitive Study of Efficacy of Single Dose Antibiotic in Minor, Triple Dose Antibiotic in Major Surgeries Vs Routine Post Operative Antibiotic Theraphy in Clean Minor and Major Surgeries

BACKGROUND: Surgical Site infection is the most common nosocomial infection encountered in post operative surgical wards. The advent of prophylactic antibiotic in surgery has changed the face of surgical site infection and reduced its incidence dramatically. But the use of prophylactic antibiotic in elective surgical cases is still a subject of controversy to surgeons. OBJECTIVES: The objective of the study is 1. To reduce the post-operative wound infection at or around the surgical sites, such surgical site infection will prolong the duration of hospitalization by one week and also costs for the patients. 2. To reduce the prevalence of hospital acquired infection. 3. To reduce the incidence of resistance to antibiotics. 4. To reduce the overall cost effectiveness to the patients. 5. Patients comfort and tolerance. 6. Adverse effect of antibiotics are minimized. METHODOLOGY: The material for the comparative study of prophylactic antibiotics in Minor cases was collected from 100 cases admitted under two groups of 50 each Group A1 was given prophylactic antibiotic prior to sincision and Group A2 was given routine conventional 5 day Post op antibiotics. Material for Major cases was collected from 100 cases admitted under two groups of 50 each Group B1 who received 3 doses of antibiotics, first dose Prior to incision, second dose 8 hours later and third dose 8 hours after the second dosage. Cases other than clean cases were excluded from the study group. Post op wound was inspected for signs of infection and graded according to Southampton scoring. RESULTS: In Minor surgery, two out of 50 patients in group A1 who were given one dose of antibiotic prior to incision were infected and 2 out of 50 patients in Group A2 who received conventional Antibiotic coverage were infected. In Major surgeries, amongst Group B1 who were given three dose of antibiotic coverage three cases out of 50 were infected and in Group B2 who received conventional 5 day Antibiotic, two cases out of 50 patients were infected. CONCLUSION: Based on my study I would like to conclude that it is recommendable to use single dose antibiotic prophylaxis using appropriate antibiotics for all Minor surgeries and three dose of Antibiotics for Major surgeries, as per the study results there is no significant difference in incidence of SSI when compared to the traditional regimes with the added advantage of significant reduction in hospital stay, with its resultant savings in resources. In addition as the use of antibiotics is reduced it further results in increased cost effectiveness and reduces the incidence of complications due to antibiotic overuse

UPPLIED: UAV Path Planning for Inspection through Demonstration

In this paper, a new demonstration-based path-planning framework for the visual inspection of large structures using UAVs is proposed. We introduce UPPLIED: UAV Path PLanning for InspEction through Demonstration, which utilizes a demonstrated trajectory to generate a new trajectory to inspect other structures of the same kind. The demonstrated trajectory can inspect specific regions of the structure and the new trajectory generated by UPPLIED inspects similar regions in the other structure. The proposed method generates inspection points from the demonstrated trajectory and uses standardization to translate those inspection points to inspect the new structure. Finally, the position of these inspection points is optimized to refine their view. Numerous experiments were conducted with various structures and the proposed framework was able to generate inspection trajectories of various kinds for different structures based on the demonstration. The trajectories generated match with the demonstrated trajectory in geometry and at the same time inspect the regions inspected by the demonstration trajectory with minimum deviation. The experimental video of the work can be found at https://youtu.be/YqPx-cLkv04.Comment: Accepted for publication in IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2023), Detroit, Michigan, US

DynaCon: Dynamic Robot Planner with Contextual Awareness via LLMs

Mobile robots often rely on pre-existing maps for effective path planning and navigation. However, when these maps are unavailable, particularly in unfamiliar environments, a different approach become essential. This paper introduces DynaCon, a novel system designed to provide mobile robots with contextual awareness and dynamic adaptability during navigation, eliminating the reliance of traditional maps. DynaCon integrates real-time feedback with an object server, prompt engineering, and navigation modules. By harnessing the capabilities of Large Language Models (LLMs), DynaCon not only understands patterns within given numeric series but also excels at categorizing objects into matched spaces. This facilitates dynamic path planner imbued with contextual awareness. We validated the effectiveness of DynaCon through an experiment where a robot successfully navigated to its goal using reasoning. Source code and experiment videos for this work can be found at: https://sites.google.com/view/dynacon.Comment: Submitted to ICRA 202

Recurrent Pleural and Pericardial Effusions Due to Sarcoidosis

A 54-year-old man presented with fever, shortness of breath, and left-sided pleuritic chest pain. His bilateral pleural effusions and pericardial effusion turned out to be due to sarcoidosi

Monitoring of Multi-Aspect Drought Severity and Socio-Economic Status in the Semi-Arid Regions of Eastern Tamil Nadu, India

A framework was set up to monitor drought in the semi-arid regions of eastern Tamil Nadu, southern India, for the period of 2014–2018 CE with the application of the standardized precipitation index (SPI), the scaled drought-condition index (SDCI), and the standardized water-level index (SWI). The results emphasized that this region had a negative precipitation anomaly and vegetative stress, both of which triggered meteorological and agricultural droughts and caused significant losses in the farming sector. The distributions of extreme and high-level hydrological droughts were at their maximum in 2017 CE. The multi-drought severity index (MDSI), implemented to assess the combined impact and highlighting the gradient of affected areas, illustrated that the eastern region (i.e., Jayankondam block) was the most extremely affected, followed by the northern and southern regions (i.e., T.Palur and Andimadam), which were moderately affected by droughts. The extremely affected eastern region has less of an ability to overcome droughts due to its socio-economic vulnerability, with its greater population and household density leading to the over-exploitation of potential resources. Therefore, the focus of this study is on the monitoring of drought severity in micro-administrative units to suggest an appropriate management plan. Hence, the extreme-drought- prone block (Jayankondam) should be given high priority in monitoring and implementing long-term management practices for its conservation and resilience against the effects of severe droughts

The effect of web advertising visual design on online purchase intention: An examination across gender

With web advertising growing to be a huge industry, it is important to understand the effectiveness of web advertisement. In this study we investigate the effects of web advertising visual design (WAVD) purchasing intention within the framework of an integrated model. Nine hypotheses were developed and tested on a dataset of 316 observations collected via a questionnaire survey. The results of structural equation modeling (SEM) indicate that while web advertising visual cues influence consumers' purchasing intention through advertising attitudes and brand attitudes, they do not have direct effects on purchasing intention. Further results on the moderating role of gender suggest that web advertising visual cues have direct effect on consumers' purchasing intention for male groups but not for female groups. This study contributes to the understanding the role of visual dimensions in forming online purchase intentions

An Adoption Framework for Mobile Augmented Reality Games: The Case of Pokémon Go

Pokémon Go was the first mobile augmented reality (AR) game to reach the top of the download charts of mobile applications. However, little is known about this new generation of mobile online AR games. Existing theories provide limited applicability for user understanding. Against this background, this research provides a comprehensive framework based on uses and gratification theory, technology risk research, and flow theory. The proposed framework aims to explain the drivers of attitudinal and intentional reactions, such as continuance in gaming or willingness to invest money in in-app purchases. A survey among 642 Pokémon Go players provides insights into the psychological drivers of mobile AR games. The results show that hedonic, emotional, and social benefits and social norms drive consumer reactions while physical risks (but not data privacy risks) hinder consumer reactions. However, the importance of these drivers differs depending on the form of user behavior

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease