62 research outputs found
Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic. Results from the MIMIC Study (A Multi-centre cohort study evaluating the role of Inflammatory Markers in patients presenting with acute ureteric Colic)
- Author
- Abboudi H
- Abdaal AC
- Abdelmoteleb H
- Abu Yousif M
- Acher P
- Adams R
- Ager M
- Ahmed I
- Ajayi L
- Akintimehin A
- Akman J
- Al Hayek S
- Al-Dhahir W
- Al-Qassim Z
- Al-Shakhshir S
- Alberto M
- Arya M
- Assaf N
- Ayres B
- Badgery H
- Bateman K
- Bdesha A
- Bedi N
- Begum R
- Belal M
- Biyani CS
- Bolton D
- Bultitude M
- Burge F
- Bycroft J
- Cameron F
- Campbell A
- Cannon A
- Carrie A
- Cashman S
- Chappell B
- Chin AOL
- Chow K
- Christidis D
- Clements J
- Coode-Bate J
- Cronbach P
- Cumberbatch M
- Curry D
- Dasgupta R
- Demirel S
- Derbyshire L
- Din W
- Docherty E
- Edison E
- Eldred-Evans D
- Ellis G
- Erotocritou P
- Evans S
- Foley R
- Frymann R
- Gallagher M
- Gao C
- Gowardhan B
- Graham J
- Graham S
- Gray S
- Grice P
- Gupta S
- Hamad S
- Hann GA
- Hussain Z
- Ibrahim H
- Irving S
- Ivin N
- Jaffer A
- Jalil R
- Kashora F
- Kasivisvanathan V
- Kavia R
- Kerr L
- Khadouri S
- Khan A
- Khan M
- Khan S
- Koschel S
- Kozan AA
- Kum F
- Kynaston H
- Laird A
- Lamb B
- Lavan L
- Lawrentschuk N
- Lee JCM
- Lee S
- Liew M
- Mackenzie K
- Malki M
- Manning T
- Manson-Bahr D
- Mason H
- Matanhelia M
- Maw J
- Mbuvi J
- Mc Cauley N
- Mc Kay AC
- McGrath S
- Mcilhenny C
- Miakhil I
- Miller M
- Mirza AB
- Morrison-Jones V
- Morrow J
- Mosey R
- Murtagh K
- Nambiar A
- Natarajan M
- Nehikhare Y
- Ness D
- Ng A
- Ngweso S
- Nkwam N
- Nyandoro M
- Nzenza T
- O'Brien J
- O'Brien J
- O'Rourke J
- Olaniyi P
- Olivier J
- Osman B
- Oyekan A
- Pang K
- Pankhania R
- Parwaiz I
- Parys B
- Patterson J
- Peacock A
- Pearce I
- Peters M
- Phipps S
- Pickard R
- Premakumar Y
- Probert JL
- Quinlan D
- Ratan H
- Reid K
- Rezacova M
- Rezvani S
- Rodger F
- Rogers A
- Ross D
- Rowbotham C
- Rujancich P
- Ruljancich P
- Sadien I
- Sakthivel A
- Saleemi A
- Samsudin A
- Sandhu S
- Seaward L
- Shah TT
- Sharma A
- Sharma S
- Shergill I
- Shetty A
- Shingles C
- Simmons L
- Simpson R
- Simson N
- Singh H
- Smith D
- Smith D
- Sriprasad S
- Stammeijer R
- Steen C
- Stewart H
- Stonier T
- Suraparaj L
- Swallow D
- Symes A
- Symes R
- Tailor K
- Tait C
- Tam JP
- Tay J
- Tay LJ
- Tregunna R
- Tudor E
- Udovicich C
- Umez-Eronini N
- van Rossum PSN
- Van Son MJ
- Wang L
- Ward A
- Weeratunga G
- Withington J
- Wong C
- Wozniak S
- Yassaie O
- Young M
- Publication venue
- 'Wiley'
- Publication date
- 22/08/2019
- Field of study
Objectives
There is conflicting data on the role of white blood cell count (WBC) and other inflammatory markers in spontaneous stone passage in patients with acute ureteric colic. The aim of the study was to assess the relationship of WBC and other routinely collected inflammatory and clinical markers including stone size, stone position and Medically Expulsive Therapy use (MET) with spontaneous stone passage (SSP) in a large contemporary cohort of patients with acute ureteric colic.
Subjects and Methods
Multi‐centre retrospective cohort study coordinated by the British Urology Researchers in Surgical Training (BURST) Research Collaborative at 71 secondary care hospitals across 4 countries (United Kingdom, Republic of Ireland, Australia and New Zealand). 4170 patients presented with acute ureteric colic and a computer tomography confirmed single ureteric stone. Our primary outcome measure was SSP as defined by the absence of need for intervention to assist stone passage. Multivariable mixed effects logistic regression was used to explore the relationship between key patient factors and SSP.
Results
2518 patients were discharged with conservative management and had further follow up with a SSP rate of 74% (n = 1874/2518). Sepsis after discharge with conservative management was reported in 0.6% (n = 16/2518). On multivariable analysis neither WBC, Neutrophils or CRP were seen to predict SSP, with an adjusted OR of 0.97 [95% CI 0.91 to 1.04, p = 0.38], 1.06 [95% CI 0.99 to 1.13, p = 0.1] and 1.00 [95% CI 0.99 to 1.00, p = 0.17], respectively. Medical expulsive therapy (MET) also did not predict SSP [adjusted OR 1.11 [95% CI 0.76 to 1.61]). However, stone size and stone position were significant predictors. SSP for stones 7mm. For stones in the upper ureter the SSP rate was 52% [95% CI 48 to 56], middle ureter was 70% [95% CI 64 to 76], and lower ureter was 83% [95% CI 81 to 85].
Conclusion
In contrast to the previously published literature, we found that in patients with acute ureteric colic who are discharged with initial conservative management, neither WBC, Neutrophil count or CRP help determine the likelihood of spontaneous stone passage. We also found no overall benefit from the use of MET. Stone size and position are important predictors and our findings represent the most comprehensive stone passage rates for each mm increase in stone size from a large contemporary cohort adjusting for key potential confounders. We anticipate that these data will aid clinicians managing patients with acute ureteric colic and help guide management decisions and the need for intervention
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
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- Aguilar-Jimenez J
- Aguilera M
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- Al-Obaedi O
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- Alamoudi U
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- Yaseen T
- Yaseen TM
- Yavuz MA
- Yee J
- Yeo LS
- Yeung ENW
- Yong CO
- Youssef D
- Youssef H
- Youssif JH
- Zachariades D-C
- Zakir M
- Zalabia MF
- Zamarin K
- Zani A
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zhang Z
- Zheng F
- Zidan H
- Zidan M
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- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskiene R
- Zimmermann EF
- Zuber M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Aali Amirali
- Abbas Qamar
- Abbasi Behzad
- Abbasi-Kangevari Mohsen
- Abbasi-Kangevari Zeinab
- Abbastabar Hedayat
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed Abdelwahab
- Abdoli Gholamreza
- Abdulkader Rizwan Suliankatchi
- Abdulkadir Hanan Abdulkadir
- Abedi Aidin
- Abegaz Kedir Hussein
- Abidi Hassan
- Aboagye Richard Gyan
- Abolhassani Hassan
- Absalan Abdorrahim
- Abtew Yonas Derso
- Abu-Gharbieh Eman
- Achappa Basavaprabhu
- Acheson Alistair R
- Acuna Juan Manuel
- Addison Daniel
- Addo Isaac Yeboah
- Adegboye Oyelola A
- Adesina Miracle Ayomikun
- Adnan Mohammad
- Adnani Qorinah Estiningtyas Sakilah
- Advani Shailesh M
- Afrin Sumia
- Afzal Muhammad Sohail
- Aggarwal Manik
- Ahinkorah Bright Opoku
- Ahmad Araz Ramazan
- Ahmad Rizwan
- Ahmad Sajjad
- Ahmad Sohail
- Ahmadi Sepideh
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Aiman Wajeeha
- Ajami Marjan
- Akalu Gizachew Taddesse
- Akbarzadeh-Khiavi Mostafa
- Aklilu Addis
- Akonde Maxwell
- Akunna Chisom Joyqueenet
- Al-Hanawi Mohammed Khaled
- Al-Maweri Sadeq Ali Ali
- Al-Raddadi Rajaa M
- Al-Rifai Rami H Hani
- Al-Sabah Salman Khalifah
- Al-Tammemi Ala'a B
- Alahdab Fares
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Alessy Saleh Ali
- Algammal Abdelazeem M
- Alhassan Robert Kaba
- Ali Adel Hajj
- Ali Beriwan Abdulqadir
- Ali Hiwa Abubaker
- Ali Liaqat
- Ali Syed Shujait
- Alimohamadi Yousef
- Alipour Vahid
- Aljunid Syed Mohamed
- Alkhayyat Motasem
- Almustanyir Sami
- Alonso Nivaldo
- Alqalyoobi Shehabaldin
- Altawalah Haya
- Alvis-Guzman Nelson
- Amare Firehiwot
- Ameyaw Edward Kwabena
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amusa Ganiyu Adeniyi
- Ancuceanu Robert
- Anderson Jason A
- Animut Yaregal Animut
- Anoushiravani Amir
- Anoushirvani Ali Arash
- Ansari-Moghaddam Alireza
- Ansha Mustafa Geleto
- Antony Benny
- Antwi Maxwell Hubert
- Anwar Sumadi Lukman
- Anwer Razique
- Anyasodor Anayochukwu Edward
- Arab-Zozani Morteza
- Arabloo Jalal
- Aremu Olatunde
- Argaw Ayele Mamo
- Ariffin Hany
- Aripov Timur
- Arshad Muhammad
- Artaman Al
- Arulappan Judie
- Aruleba Raphael Taiwo
- Aryannejad Armin
- Asaad Malke
- Asemahagn Mulusew A
- Asemi Zatollah
- Asghari-Jafarabadi Mohammad
- Ashraf Tahira
- Assadi Reza
- Athar Mohammad
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Attia Sameh
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Avval Atlas Haddadi
- Awedew Atalel Fentahun
- Awoke Mamaru Ayenew
- Awoke Tewachew
- Ayana Tegegn Mulatu
- Ayen Solomon Shitu
- Azadi Davood
- Azadnajafabad Sina
- Azami-Aghdash Saber
- Azanaw Melkalem Mamuye
- Azangou-Khyavy Mohammadreza
- Azizi Hosein
- Azzam Ahmed YY
- Babajani Amirhesam
- Badar Muhammad
- Badiye Ashish D
- Baghcheghi Nayereh
- Bagheri Nader
- Bagherieh Sara
- Bahadory Saeed
- Baig Atif Amin
- Bain Luchuo Engelbert
- Baker Jennifer L
- Bakhtiari Ahad
- Bakshi Ravleen Kaur
- Banach Maciej
- Banerjee Indrajit
- Bardhan Mainak
- Barone-Adesi Francesco
- Barra Fabio
- Barrow Amadou
- Bashir Nasir Z
- Bashiri Azadeh
- Basu Saurav
- Batiha Abdul-Monim Mohammad
- Begum Aeysha
- Bekele Alehegn Bekele
- Belay Alemayehu Sayih
- Belete Melaku Ashagrie
- Belgaumi Uzma Iqbal
- Bell Arielle Wilder
- Belo Luis
- Benzian Habib
- Berhie Alemshet Yirga
- Bermudez Amiel Nazer C
- Bernabe Eduardo
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhandari Bharti Bhandari
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhattacharyya Krittika
- Bhojaraja Vijayalakshmi S
- Bhuyan Soumitra S
- Bibi Sadia
- Bicer Burcu Kucuk
- Bilchut Awraris Hailu
- Bintoro Bagas Suryo
- Biondi Antonio
- Birega Mesfin Geremaw Birega
- Birhan Habitu Eshetu
- Bjørge Tone
- Blyuss Oleg
- Bodicha Belay Boda Abule
- Bohan Phillip M Kemp
- Bolla Srinivasa Rao
- Boloor Archith
- Bosetti Cristina
- Braithwaite Dejana
- Brauer Michael
- Brenner Hermann
- Briko Andrey Nikolaevich
- Briko Nikolay Ivanovich
- Buchanan Christina Maree
- Bulamu Norma B
- Bustamante-Teixeira Maria Teresa
- Butt Muhammad Hammad
- Butt Nadeem Shafique
- Butt Zahid A
- Cao Chao
- Cao Yin
- Carreras Giulia
- Carvalho Márcia
- Cembranel Francieli
- Cerin Ester
- Chakraborty Promit Ananyo
- Chandrasekar Viveksandeep Thoguluva
- Charalampous Periklis
- Chattu Vijay Kumar
- Chimed-Ochir Odgerel
- Chirinos-Caceres Jesus Lorenzo
- Cho Daniel Youngwhan
- Cho William CS
- Christopher Devasahayam J
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Cohen Aaron J
- Collaborators GBD 2019 Cancer Risk Factors
- Compton Kelly
- Conde Joao
- Cortés Sandra
- Costa Vera Marisa
- Cruz-Martins Natália
- Culbreth Garland T
- Cámera Luis Alberto
- Dadras Omid
- Dagnaw Fentaw Teshome
- Dahlawi Saad MA
- Dai Xiaochen
- Dandona Lalit
- Dandona Rakhi
- Daneshpajouhnejad Parnaz
- Danielewicz Anna
- Dao An Thi Minh
- Darwesh Aso Mohammad
- Das Saswati
- Davitoiu Dragos Virgil
- De la Hoz Fernando Pio
- Debela Sisay Abebe
- Dehghan Azizallah
- Dehkordi Javad Javad Aminian
- Demisse Biniyam
- Demisse Fitsum Wolde
- Denova-Gutiérrez Edgar
- Derakhshani Afshin
- Dereje Diriba
- Deribe Kalkidan Solomon
- Desai Rupak
- Desalegn Markos Desalegn
- Desideri Lorenzo Ferro
- Dessalegn Fikadu Nugusu
- Dessalegni Samuel Abebe A
- Dessie Gashaw
- Desta Abebaw Alemayehu
- Dewan Syed Masudur Rahman
- Dharmaratne Samath Dhamminda
- Dhimal Meghnath
- Dianatinasab Mostafa
- Diao Nancy
- Diaz Daniel
- Digesa Lankamo Ena
- Dixit Shilpi Gupta
- Doaei Saeid
- Doan Linh Phuong
- Doku Paul Narh
- Dongarwar Deepa
- dos Santos Florentino Luciano Caetano
- dos Santos Wendel Mombaque
- Driscoll Tim Robert
- Dsouza Haneil Larson
- Durojaiye Oyewole Christopher
- Edalati Sareh
- Eghbalian Fatemeh
- Ehsani-Chimeh Elham
- Eini Ebrahim
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- Ekwueme Donatus U
- El-Huneidi Waseem
- Elbahnasawy Mostafa Ahmed
- Elbarazi Iffat
- Elghazaly Hesham
- Elhadi Muhammed
- Emamian Mohammad Hassan
- Enyew Daniel Berhanie
- Erkhembayar Ryenchindorj
- Eshetu Tegegne
- Eshrati Babak
- Eskandarieh Sharareh
- Esmaeili Elham Davtalab
- Espinosa-Montero Juan
- Etaee Farshid
- Etemadimanesh Azin
- Eyayu Tahir
- Ezeonwumelu Ifeanyi Jude
- Ezzikouri Sayeh
- Fagbamigbe Adeniyi Francis
- Fahimi Saman
- Fakhradiyev Ildar Ravisovich
- Faraon Emerito Jose A
- Fares Jawad
- Farmany Abbas
- Farooque Umar
- Farrokhpour Hossein
- Fasanmi Abidemi Omolara
- Fatehizadeh Ali
- Fatima Wafa
- Fattahi Hamed
- Fekadu Ginenus
- Feleke Berhanu Elfu
- Ferrari Allegra Allegra
- Ferrero Simone
- Filip Irina
- Fischer Florian
- Fonseca Mariana Gaspar
- Force Lisa M
- Foroumadi Roham
- Foroutan Masoud
- Fukumoto Takeshi
- Gaal Peter Andras
- Gad Mohamed M
- Gadanya Muktar A
- Gaipov Abduzhappar
- Galehdar Nasrin
- Gallus Silvano
- Garg Tushar
- Gebremariam Yosef Haile
- Gebremeskel Teferi Gebru
- Gebremichael Mathewos Alemu
- Geda Yohannes Fikadu
- Gela Yibeltal Yismaw
- Gemeda Belete Negese Belete
- Getachew Melaku
- Getachew Motuma Erena
- Ghaffari Kazem
- Ghafourifard Mansour
- Ghamari Seyyed-Hadi
- Ghassemi Fariba
- Ghimire Ajnish
- Ghith Nermin
- Gholamalizadeh Maryam
- Ghozy Sherief
- Gilani Syed Amir
- Gill Paramjit Singh
- Ginindza Themba G
- Gizaw Abraham Tamirat T
- Glasbey James C
- Godos Justyna
- Goel Amit
- Golechha Mahaveer
- Goleij Pouya
- Golinelli Davide
- Golitaleb Mohamad
- Gorini Giuseppe
- Goulart Bárbara Niegia Garcia
- Grosso Giuseppe
- Guadie Habtamu Alganeh
- Gubari Mohammed Ibrahim Mohialdeen
- Gudayu Temesgen Worku
- Guerra Maximiliano Ribeiro
- Gunawardane Damitha Asanga
- Gupta Bhawna
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Gurara Mekdes Kondale
- Guta Alemu
- Habibzadeh Parham
- Hafezi-Nejad Nima
- Haj-Mirzaian Arvin
- Halboub Esam S
- Halimi Aram
- Halwani Rabih
- Hamad Hanadi Al
- Hamadeh Randah R
- Hameed Sajid
- Hamidi Samer
- Hanif Asif
- Hariri Sanam
- Harlianto Netanja I
- Haro Josep Maria
- Hartono Risky Kusuma
- Hasaballah Ahmed I
- Hasan SM Mahmudul
- Hasani Hamidreza
- Hashemi Seyedeh Melika
- Hassan Abbas M
- Hassanipour Soheil
- Hay Simon I
- Hayat Khezar
- Heidari Golnaz
- Heidari Mohammad
- Heidarymeybodi Zahra
- Henrikson Hannah Jacqueline
- Herrera-Serna Brenda Yuliana
- Herteliu Claudiu
- Hezam Kamal
- Hiraike Yuta
- Hlongwa Mbuzeleni Mbuzeleni
- Holla Ramesh
- Holm Marianne
- Horita Nobuyuki
- Hoseini Mohammad
- Hossain Mahbub
- Hossain Mohammad Bellal Hossain
- Hosseini Mohammad-Salar
- Hosseinzadeh Ali
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Huang Junjie
- Hugo Fernando N
- Humayun Ayesha
- Hussain Salman
- Hussein Nawfal R
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Iftikhar Pulwasha Maria
- Ikuta Kevin S
- Ilesanmi Olayinka Stephen
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- Wickramasinghe Nuwan Darshana
- Woldemariam Melat
- Woldu Berhanu
- Xiao Hong
- Xu Rixing
- Xu Suowen
- Xu Xiaoyue
- Yadav Lalit
- Yang Lin
- Yazdanpanah Fereshteh
- Yeshaw Yigizie
- Yismaw Yazachew
- Yonemoto Naohiro
- Younis Mustafa Z
- Yousefi Zabihollah
- Yousefian Fatemeh
- Yu Chuanhua
- Yu Yong
- Yunusa Ismaeel
- Zahir Mazyar
- Zaki Nazar
- Zaman Burhan Abdullah
- Zangiabadian Moein
- Zare Fariba
- Zare Iman
- Zareshahrabadi Zahra
- Zarrintan Armin
- Zastrozhin Mikhail Sergeevich
- Zeineddine Mohammad A
- Zhang Dongyu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhou Linghui
- Zodpey Sanjay
- Zoladl Mohammad
- Šekerija Mario
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe
The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
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- Humayun A
- Hussain S
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- Hwang B-F
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- Iftikhar PM
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- Isfahani HM
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- Islam RM
- Islami F
- Ismail NE
- Isola G
- Iwagami M
- Jabbari SHY
- Jafari AA
- Jaiswal A
- Jakovljevic M
- Jalili M
- Jalilian S
- Jamshidi E
- Jang S-I
- Jani CT
- Jarisson M
- Javaheri T
- Jayarajah UU
- Jayaram S
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- Jemal B
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- Jindal HA
- John-Akinola YO
- Jonas JB
- Jonasson JM
- Joo T
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- Kabir A
- Kacimi SEO
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- Kahe F
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- Kalankesh LR
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- Kamal VK
- Kamangar F
- Kamath A
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- Kandaswamy E
- Kandel H
- Kandel SN
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- Kanno GG
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- Karch A
- Karimi A
- Kashani HRK
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- Katoto PDMC
- Kauppila JH
- Kaur H
- Kebede AG
- Keikavoosi-Arani L
- Kejela GG
- Keramati M
- Keykhaei M
- Khajuria H
- Khan A
- Khan AAK
- Khan EA
- Khan G
- Khan MN
- Khanali J
- Khaneghah AM
- Khatab K
- Khatatbeh MM
- Khatib MN
- Khayamzadeh M
- Khezeli M
- Khodadost M
- Kim MS
- Kim YJ
- Kisa A
- Kisa S
- Klugar M
- Klugarova J
- Kocarnik JM
- Kolahi A-A
- Kolkhir P
- Kompani F
- Koul PA
- Koyanagi A
- Krishan K
- Krishnamoorthy Y
- Kugbey N
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- Kumar A
- Kumar GA
- Kumar N
- Kurmi OP
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- Leigh J
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- Liu J
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- Lohiya A
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- Lunevicius R
- Madadizadeh F
- Mafi AR
- Magdeldin S
- Mahesh PA
- Mahjoub S
- Mahmoodpoor A
- Mahmoudi M
- Mahmoudimanesh M
- Mahumud RA
- Majeed A
- Majidpoor J
- Makki A
- Makris KC
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- Malekzadeh R
- Malik AA
- Malleshappa SS
- Mallhi TH
- Mallya SD
- Mamun MA
- Manda AL
- Manjula S
- Mansour-Ghanaei F
- Mansouri B
- Mansournia MA
- Mantovani LG
- Martini S
- Martorell M
- Masoudi S
- Masoumi SZ
- Matei CN
- Mathews E
- Mathur MR
- Mathur V
- McKee M
- Meena JK
- Mehmood K
- Mehrotra R
- Melese A
- Mendoza W
- Menezes RG
- Mengesha SD
- Mensah LG
- Mentis A-FA
- Mera-Mamian AYM
- Meretoja TJ
- Merid MW
- Merin LJ
- Mersha AG
- Meselu BT
- Meshkat M
- Mestrovic T
- Miazgowski T
- Michalek IM
- Mijena GFW
- Miller TR
- Mir SA
- Mirinezhad SK
- Mirmoeeni S
- Mirza-Aghazadeh-Attari M
- Mirzaei H
- Mirzaei HR
- Misganaw AS
- Misra S
- Mohammadi E
- Mohammadi M
- Mohammadian-Hafshejani A
- Mohammadpourhodki R
- Mohammed A
- Mohammed S
- Mohan S
- Mohseni M
- Moka N
- Mokdad AH
- Molassiotis A
- Molla MD
- Molokhia M
- Momenzadeh K
- Momtazmanesh S
- Monasta L
- Mons U
- Montazeri F
- Montero A
- Moosavi MA
- Moradi A
- Moradi Y
- Moraga P
- Morawska L
- Morrison SD
- Morze J
- Mosapour A
- Mostafavi E
- Mousavi SM
- Mpundu-Kaambwa C
- Mubarik S
- Mulita F
- Munblit D
- Munro SB
- Murillo-Zamora E
- Murray CJL
- Musa J
- Nabhan AF
- Nagarajan AJ
- Nagaraju SP
- Nagel G
- Naghipour M
- Naimzada MD
- Nair TS
- Naqvi AA
- Narayana AI
- Nasab EM
- Nassereldine H
- Natto ZS
- Navashenaq JG
- Nayak BP
- Ndejjo R
- Nduaguba SO
- Negash WW
- Nejadghaderi SA
- Nejati K
- Nguyen HVN
- Niazi RK
- Noor NM
- Noori M
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- Nour MG
- Nouraei H
- Nowroozi A
- Null MMWA
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- Nzoputam CI
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- Oancea B
- Odukoya OO
- Oghenetega OB
- Ogunsakin RE
- Oguntade AS
- Oh I-H
- Okati-Aliabad H
- Okekunle AP
- Olagunju AT
- Olagunju TO
- Olakunde BO
- Olufadewa II
- Omer E
- Omonisi AEE
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- Onwujekwe OE
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- Padubidri JR
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- Pana A
- Pandey A
- Pant S
- Pardhan S
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- Park S
- Patel J
- Pati S
- Paudel R
- Paudel U
- Paun M
- Penberthy L
- Peng M
- Pereira J
- Pereira RB
- Perna S
- Perumalsamy N
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- Pezzani R
- Piccinelli C
- Pillay JD
- Piracha ZZ
- Pischon T
- Postma MJ
- Pourshams A
- Pourtaheri N
- Prashant A
- Qadir MMF
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- Rabiee M
- Rabiee N
- Rad EM
- Radfar A
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- Rafiee A
- Rafiei A
- Raheem N
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- Rahman M
- Rahman MA
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- Rahmani S
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- Rajai N
- Rajesh A
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- Ranabhat K
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- Rao SJ
- Rashedi S
- Rashid TA
- Rashidi A
- Rashidi M-M
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- Rawaf DL
- Rawaf S
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- Rehman IU
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- Saberzadeh-Ardestani B
- Sabour S
- Saddik B
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- Saeed U
- Safaei M
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- Sahebazzamani M
- Sahebkar A
- Sahoo H
- Sajid MR
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- Salimzadeh H
- Samodra YL
- Samy AM
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- Sankararaman S
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- Santric-Milicevic MM
- Saqib MAN
- Sarabi MM
- Sarveazad A
- Sarvi F
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- Satpathy M
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- Schneider IJC
- Schwarzinger M
- Senthilkumaran S
- Sepanlou SG
- Seylani A
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- Sha F
- Shafaat O
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- Shahabi S
- Shahid I
- Shahrbaf MA
- Shahsavari HR
- Shaikh MA
- Shaka MF
- Shaker E
- Shannawaz M
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- Sharifi A
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- Sharma P
- Shashamo BB
- Sheikh A
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- Silva DAS
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- Silvestris N
- Simegn W
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- Sinke AH
- Siraj MS
- Sitas F
- Siwal SS
- Skryabin VY
- Skryabina AA
- Socea B
- Soeberg MJ
- Sofi-Mahmudi A
- Solomon Y
- Soltani RDC
- Soltani-Zangbar MS
- Song S
- Song Y
- Soodejani MT
- Sorensen RJD
- Soshnikov S
- Sotoudeh H
- Sowe A
- Sufiyan MB
- Suk R
- Suleman M
- Sultana S
- Sur D
- Swamy SN
- Syed ZQ
- Szacska M
- Tabaeian SP
- Tabares-Seisdedos R
- Tabari MAK
- Tabatabaei SM
- Tabuchi T
- Tadbiri H
- Tahbaz SV
- Taheri E
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- Takahashi K
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- Tat NY
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- Tekalegn Y
- Tesfay FH
- Thapar R
- Thavamani A
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- Thomas NK
- Ticoalu JHV
- Tiyuri A
- Tollosa DN
- Topor-Madry R
- Toroudi HP
- Touvier M
- Tovani-Palone MR
- Traini E
- Tran KB
- Tran MTN
- Tripathy JP
- Ukke GG
- Ullah I
- Ullah S
- Unnikrishnan B
- Vacante M
- Vaezi M
- Valdez PR
- Vardavas C
- Varniab ZS
- Varthya SB
- Vaziri S
- Velazquez DZ
- Veroux M
- Villeneuve PJ
- Violante FS
- Vladimirov SK
- Vlassov V
- Vo B
- Vos T
- Vu LG
- Wadood AW
- Waheed Y
- Walde MT
- Wamai RG
- Wang C
- Wang F
- Wang N
- Wang Y
- Ward P
- Waris A
- Westerman R
- Wickramasinghe ND
- Woldemariam M
- Woldu B
- Xiao H
- Xu R
- Xu S
- Xu X
- Yadav L
- Yang L
- Yazdanpanah F
- Yeshaw Y
- Yismaw Y
- Yonemoto N
- Younis MZ
- Yousefi Z
- Yousefian F
- Yu C
- Yu Y
- Yunusa I
- Zahir M
- Zaki N
- Zaman BA
- Zangiabadian M
- Zare F
- Zare I
- Zareshahrabadi Z
- Zarrintan A
- Zastrozhin MS
- Zeineddine MA
- Zhang D
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhou L
- Zodpey S
- Zoladl M
- Publication venue
- Publication date
- 20/08/2022
- Field of study
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Ala Moein
- Aladelusi Timothy Olukunle
- Alalalmeh Samer O
- Alam Khurshid
- Alam Manjurul
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldridge Robert W
- Alemi Sharifullah
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
- Alimi Rasoul
- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
- Almahmeed Wael
- Almazan Joseph Uy
- Almidani Omar
- Alomari Mahmoud A
- Alonso Nivaldo
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Altaf Awais
- Altirkawi Khalid A
- Alvi Farrukh Jawad
- Alwafi Hassan
- Aly Hany
- Alzoubi Karem H
- Amare Azmeraw T
- Ameyaw Edward Kwabena
- Amhare Abebe Feyissa
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Aminian Dehkordi Javad
- Amiri Sohrab
- Amu Hubert
- Amugsi Dickson A
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angappan Dhanalakshmi
- Anil Abhishek
- Anjum Afifa
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Iyadunni Adesola
- Anwar Sumadi Lukman
- Anyasodor Anayochukwu Edward
- Appiah Seth Christopher Yaw
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Araújo Ana Margarida
- Aravkin Aleksandr Y
- Aremu Abdulfatai
- Ariffin Hany
- Aripov Timur
- Armocida Benedetta
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Arulappan Judie
- Aruleba Idowu Thomas
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asgary Saeed
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayele Getnet Melaku
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azhar Gulrez Shah
- Aziz Shahkaar
- Azzam Ahmed Y
- Babashahi Mina
- Babu Abraham Samuel
- Badar Muhammad
- Badawi Alaa
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bah Sulaiman
- Bahadorikhalili Saeed
- Bai Jianjun
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balogun Saliu A
- Baltatu Ovidiu Constantin
- Bam Kiran
- Banach Maciej
- Bandyopadhyay Soham
- Banik Biswajit
- Banik Palash Chandra
- Bansal Hansi
- Barati Shirin
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barr Ronald D
- Barrero Lope H
- Basharat Zarrin
- Bashir Asma'u I J
- Bashiru Hameed Akande
- Baskaran Pritish
- Basnyat Buddha
- Bassat Quique
- Basso João Diogo
- Basu Saurav
- Batra Kavita
- Batra Ravi
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Beaney Thomas
- Bedi Neeraj
- Begum Tahmina
- Behboudi Emad
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Belgaumi Uzma Iqbal
- Bell Michelle L
- Bello Aminu K
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bendak Salaheddine
- Bennett Derrick A
- Bensenor Isabela M
- Benzian Habib
- Berezvai Zombor
- Berman Adam E
- Bermudez Amiel Nazer C
- Bettencourt Paulo J G
- Beyene Habtamu B
- Beyene Kebede A
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhalla Ashish
- Bhandari Dinesh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhardwaj Prarthna V
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Binmadi Nada
- Bintoro Bagas Suryo
- Biondi Antonio
- Bisignano Catherine
- Bisulli Francesca
- Biswas Atanu
- Biswas Raaj Kishore
- Bitaraf Saeid
- Bjørge Tone
- Bleyer Archie
- Boampong Mary Sefa
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bolarinwa Obasanjo Afolabi
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
- Bora Kaustubh
- Borodo Safiya Bala
- Borschmann Rohan
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boudalia Sofiane
- Boyko Edward J
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Brenner Hermann
- Britton Gabrielle
- Browne Annie J
- Brunoni Andre R
- Bulamu Norma B
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- Olufadewa Isaac Iyinoluwa
- Olusanya Bolajoko Olubukunola
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- Thangaraju Pugazhenthan
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- Xiao Hong
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- Xu Xiaoyue
- Yadav Lalit
- Yaghoubi Sajad
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Ye Pengpeng
- Yesera Gesila Endashaw
- Yesodharan Renjulal
- Yesuf Subah Abderehim
- Yiğit Arzu
- Yiğit Vahit
- Yip Paul
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zandi Milad
- Zandieh Ghazal G Z
- Zanghì Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
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- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Global economic burden of unmet surgical need for appendicitis
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
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- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
- Author
- Aawsaj Y.
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- Publication venue
- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
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- Abdulaziz H
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- Abdulhakeem EM
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- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
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- Abem OE
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- Aboarab A
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- Aboelmagd O
- Aboelsoud MR
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- Aboul-Naga MS
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- Abouzaid A
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- Ademuyiwa AO
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- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
- Cabala Chiong JA
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
- Cameron B
- Camilleri GM
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
- Capleton P
- Carabott K
- Careta MC
- Carlucci M
- Carmela Lapitan M
- Carmona JM
- Carpio J
- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
- Cocker DM
- Cocorullo G
- Cohen DM
- Cohen F
- Cole S
- Coletta D
- Coletti M
- Colombani J-F
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Corro-Diaz Gonzalez S
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz DH
- Cruz H
- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
- D'aguzan N
- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish AKZ
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
- Davies R
- Davor A
- Dawnay G
- Dawood K
- Dawoud H
- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Franciscis S
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
- Garcia Torres CP
- Garcia-Florez L
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
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