Search for Fractional Charges in Water

Results are presented from a search for fractional charges in water from a variety of natural sources. About 30 000 water drops have been measured, comprising 51 μg of water and dissolved materials. No evidence for fractional charge was seen

Aadh2p: an Arxula adeninivorans alcohol dehydrogenase involved in the first step of the 1-butanol degradation pathway

Additional file 3: Figures S3. Key compounds of the ß-oxidation - microarray studies. The SBGN style metabolic network depicts reversible (double headed arrow) and irreversible (single headed arrow) reactions catalyzed by the corresponding enzymes (rectangular square). Enzymes are enriched with color-coded fold change values of time resolved expression data of the respective genes. The colors represent upregulation (blue) and downregulation (red) of genes in cells shifted to medium containing 1-butanol as the carbon source compared to cells grown with glucose. Metabolites or enzymes occurring multiple times in the metabolic network are decorated with a clone marker (e.g. CoA) (produced using VANTED [2, 3])

Spatial correlation structures of wind speed and irradiance in Europe as modelled in regional climate models and the ERA5 reanalysis

Objective & Background For comprehensive energy systems analysis considering high shares of weather-dependent renewables, the spatiotemporal characteristics of meteorological input data (in particular, wind speed and irradiance) are of considerable interest. Studies aiming to evaluate the potential effects of future climate change rely on model-based projections of these variables. In order to reach as high a spatiotemporal resolution as possible, global climate models (GCM) can be used as drivers for regional climate models (RCM). In doing so, global climate effects are considered on large scales, while the higher resolution computations are limited to the domain of interest. Here, we analyse such regional climate model outputs as well as reanalysis data with regards to their suitability in energy systems analysis, using spatial correlation structures of the wind and solar resource anomalies. Method Based on 10 years of historical experiments of EURO-CORDEX regional climate model output and ERA5 reanalyses, we compute climate anomalies of both wind speed and irradiance for each point in space and time by subtracting the multi-year mean of each point from the instantaneous values at that point. In doing so, we largely remove effects of seasonal and diurnal cycles, especially in the case of irradiance. From each of these wind speed and irradiance anomaly fields, we sample distinct two-dimensional correlation structures (i.e., maps of the correlation coefficient between each pixel’s time series and a reference pixel’s series). Increasing the number of reference pixels hence increases the number of spatial correlation structures available in the analysis. We finally estimate the degree of similarity between the spatial correlation structures of each EURO-CORDEX member and its corresponding ERA5 counterpart using the coefficient of pattern correlation (i.e., the correlation coefficient of the mapped spatial correlation structures in vector form). Principal Findings Kernel density estimates and box-plot statistics of all available pattern correlations show that the wind speed anomaly spatial correlation structures tend to be better represented than their irradiance counterparts. Between different driving global models, the performance is relatively similar for wind speed anomaly correlation structures, while solar irradiance anomaly structures can be associated with a few unusually low pattern correlations for some global models. In terms of regional climate models, these cases of low pattern correlation values are largely associated with the SMHI-RCA4 regional model during the summer. Discussion This initial comparison of CORDEX model output and ERA5 reanalysis based on correlation structures in wind speed and solar irradiance anomalies allows to help in the selection of global and regional models when compiling an ensemble for use in energy systems analysis. In this context, the spatial correlation structures of wind speed need less attention when selecting model outputs, while the irradiance anomaly projections of the regional climate model SMHI-RCA4 should be handled with caution. Increasing the number of reference points used in the spatial correlation structure calculations may lead to further insights regarding potential regional differences in CORDEX model performances

Search for Fractional Charges Produced in Heavy-Ion Collisions at 1.9 GeV/nucleon

An experiment was performed to capture fractionally charged particles produced in heavy-ion collisions and to concentrate them in samples suitable for analysis by various techniques. Two of the samples so produced have been searched, with use of an automated version of Millikan\u27s oil-drop apparatus. The beam was 56Fe at 1.9 GeV/nucleon, incident on a lead target. Less than one fractional charge per 1.0× 104 Fe-Pb collisions was found to be produced, and, with further assumptions, less than one per 2.0× 106 collisions

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Effect of surgical experience and spine subspecialty on the reliability of the {AO} Spine Upper Cervical Injury Classification System

OBJECTIVE The objective of this paper was to determine the interobserver reliability and intraobserver reproducibility of the AO Spine Upper Cervical Injury Classification System based on surgeon experience (< 5 years, 5–10 years, 10–20 years, and > 20 years) and surgical subspecialty (orthopedic spine surgery, neurosurgery, and "other" surgery). METHODS A total of 11,601 assessments of upper cervical spine injuries were evaluated based on the AO Spine Upper Cervical Injury Classification System. Reliability and reproducibility scores were obtained twice, with a 3-week time interval. Descriptive statistics were utilized to examine the percentage of accurately classified injuries, and Pearson’s chi-square or Fisher’s exact test was used to screen for potentially relevant differences between study participants. Kappa coefficients (κ) determined the interobserver reliability and intraobserver reproducibility. RESULTS The intraobserver reproducibility was substantial for surgeon experience level (< 5 years: 0.74 vs 5–10 years: 0.69 vs 10–20 years: 0.69 vs > 20 years: 0.70) and surgical subspecialty (orthopedic spine: 0.71 vs neurosurgery: 0.69 vs other: 0.68). Furthermore, the interobserver reliability was substantial for all surgical experience groups on assessment 1 (< 5 years: 0.67 vs 5–10 years: 0.62 vs 10–20 years: 0.61 vs > 20 years: 0.62), and only surgeons with > 20 years of experience did not have substantial reliability on assessment 2 (< 5 years: 0.62 vs 5–10 years: 0.61 vs 10–20 years: 0.61 vs > 20 years: 0.59). Orthopedic spine surgeons and neurosurgeons had substantial intraobserver reproducibility on both assessment 1 (0.64 vs 0.63) and assessment 2 (0.62 vs 0.63), while other surgeons had moderate reliability on assessment 1 (0.43) and fair reliability on assessment 2 (0.36). CONCLUSIONS The international reliability and reproducibility scores for the AO Spine Upper Cervical Injury Classification System demonstrated substantial intraobserver reproducibility and interobserver reliability regardless of surgical experience and spine subspecialty. These results support the global application of this classification system

Search for Gravitational Waves Associated with Fast Radio Bursts Detected by CHIME/FRB During the LIGO--Virgo Observing Run O3a

We search for gravitational-wave transients associated with fast radio bursts (FRBs) detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project (CHIME/FRB), during the first part of the third observing run of Advanced LIGO and Advanced Virgo (1 April 2019 15:00 UTC-1 Oct 2019 15:00 UTC). Triggers from 22 FRBs were analyzed with a search that targets compact binary coalescences with at least one neutron star component. A targeted search for generic gravitational-wave transients was conducted on 40 FRBs. We find no significant evidence for a gravitational-wave association in either search. Given the large uncertainties in the distances of the FRBs inferred from the dispersion measures in our sample, however, this does not conclusively exclude any progenitor models that include emission of a gravitational wave of the types searched for from any of these FRB events. We report $90\%$ confidence lower bounds on the distance to each FRB for a range of gravitational-wave progenitor models. By combining the inferred maximum distance information for each FRB with the sensitivity of the gravitational-wave searches, we set upper limits on the energy emitted through gravitational waves for a range of emission scenarios. We find values of order $10^{51}$-$10^{57}$ erg for a range of different emission models with central gravitational wave frequencies in the range 70-3560 Hz. Finally, we also found no significant coincident detection of gravitational waves with the repeater, FRB 20200120E, which is the closest known extragalactic FRB

Measurement of cross sections and leptonic forward-backward asymmetries at the Z pole and determination of electroweak parameters

We report on the measurement of the leptonic and hadronic cross sections and leptonic forward-backward asymmetries at the Z peak with the L3 detector at LEP. The total luminosity of 40.8 pb −1 collected in the years 1990, 1991 and 1992 corresponds to 1.09·10 6 hadronic and 0.98·10 5 leptonic Z decays observed. These data allow us to determine the electroweak parameters. From the cross sections we derive the properties of the Z boson: assuming lepton universality. We obtain an invisible width of Γ inv =496.5±7.9 MeV which, in the Standard Model, corresponds to a number of light neutrino species of N v =2.981±0.050.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47894/1/10052_2005_Article_BF01574160.pd