Reading and Writing Practices with a Potential for Transformation: Collaborative Research in School, Hospital, Community and Working-Class Neighborhood Environments

En este escrito desarrollamos el marco conceptual de un proyecto de investigación colaborativa denominado Prácticas de Lectura y Escritura con Potencial (Trans)Formativo, para lo cual explicamos primero la perspectiva que se asumió al inicio del proyecto y sus transformaciones a lo largo de tres años de trabajo exploratorio. A continuación, analizamos cuatro prácticas (trans)formativas, ubicadas en ámbitos diversos de la Ciudad de Buenos Aires. Hemos identificado estas prácticas porque, tomadas en su conjunto, nos permiten: a) mostrar la noción de potencial transformativo cuando se lo piensa ligado a prácticas de lectura y escritura; b) describir y analizar la centralidad que ocupan el leer y el escribir en espacios, organizaciones e institucionalidades muy diferentes entre sí, pero que tienen en común un potencial para interpelar el orden dado y transformarlo, y c) hacer visible cómo estas prácticas fueron apelando a diversos formatos, soportes, disciplinas y lenguajes, y al hacerlo, reconfiguraron el mismo sentido de leer y escribir. En la sección final subrayamos los alcances de nuestro estudio en tanto los análisis de experiencias singulares nos permiten arribar a conclusiones en relación con el potencial transformativo de la lectura y la escritura. Asimismo, dejamos planteadas algunas limitaciones del estudio realizado e interrogantes para desarrollo futuro.In this paper we develop a conceptual framework for a collaborative research project called Literacy Practices and their Potential for Transformation. We first explain our theoretical and methodological approach, describing how we constructed a relevant framework over three years of exploratory work. We then analyze four different experiences currently being conducted in the City of Buenos Aires, Argentina. We have identified this set of practices because, taken together, they allow us to a) show the notion of a potential for transformation when linked to reading and writing practices, b) to describe and analyze the central role of reading and writing in very different spaces, organizations and institutions with a common potential to question the established order and transform it, and c) to make visible how these practices appealed to different formats, supports, disciplines, and languages, and in doing so reshaped the very meaning of reading and writing. We conclude by underscoring the scope of our study insofar as the analysis of specific experiences leads us to insights on the transformational potential of reading and writing practices, and point out some of the limitations of our study and possible lines of further research.Fil: Heras Monner Sans, Ana Ines. Universidad Nacional de San Martin. Escuela de Humanidades. Laboratorio de Investigacion En Ciencias Humanas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Laboratorio de Investigacion En Ciencias Humanas.; ArgentinaFil: Miano, María Amalia. Universidad Nacional de San Martin. Escuela de Humanidades. Laboratorio de Investigacion En Ciencias Humanas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Laboratorio de Investigacion En Ciencias Humanas.; ArgentinaFil: Moyano, Ana Rosa. Universidad Nacional de San Martín; ArgentinaFil: Ferreira, Mariel Lucía. Universidad Nacional de San Martín. Escuela de Humanidades. Centro de Estudios Desigualdades, Sujetos e Instituciones; ArgentinaFil: Soto, Eliana Verónica. Universidad Nacional de San Martín. Escuela de Humanidades. Centro de Estudios Desigualdades, Sujetos e Instituciones; ArgentinaFil: Cárdenas, Horacio. Universidad Nacional de San Martín; ArgentinaFil: Esposito, Silvina Adriana. Universidad Nacional de San Martín; ArgentinaFil: Del Valle Martínez, Judith. Universidad Nacional de San Martín; ArgentinaFil: Mori, María Inés. Universidad Nacional de San Martín; ArgentinaFil: Galli, María Laura. Universidad Nacional de San Martín; ArgentinaFil: Morana, María Victoria. Universidad Nacional de San Martín; ArgentinaFil: Schneider, Ana Patricia. Universidad Nacional de San Martín; Argentin

Assessment of awake bruxism in undergraduate students, using Ecological Momentary Assessment, through WhatsApp

This study assessed awake bruxism (AB) in undergraduate students using WhatsApp and examined the association of this behavior with quality of life and anxiety. The sample was composed of 36 healthy young adults of both genders, with an average age of 20.74 years. AB behaviors (teeth contact, teeth clenching, teeth grinding and mandible bracing) and relaxed jaw muscles were reported with Ecological Momentary Assessment, through WhatsApp, 15 times a day, for 7 days, between 8:00 am and 7:00 pm. Quality of Life (QoL) and anxiety were assessed using the SF-36 and GAD-7 questionnaires, respectively. The Mann-Whitney U non-parametric, Pearson and Spearman correlation and Pairwise non-parametric multiple comparisons 2- to-2 tests were used. The frequency of AB was 40.7%. The most frequent AB behavior was teeth contact (23.1%). Higher frequency of AB occurred on weekdays (42.3%) compared to the weekend (35.5%) (p<0.05). There was a negative correlation of AB behaviors and mandible bracing with the QoL - emotional aspects domain (p<0.05) and positive correlation of mandible bracing with anxiety (p<0.01). There was no difference between genders for QoL, anxiety and AB behaviors (p>0.05). This study highlights the importance of AB and anxiety control to improve undergraduate students’ quality of life.This study assessed awake bruxism (AB) in undergraduate students using WhatsApp and examined the association of this behavior with quality of life and anxiety. The sample was composed of 36 healthy young adults of both genders, with an average age of 20.74 years. AB behaviors (teeth contact, teeth clenching, teeth grinding and mandible bracing) and relaxed jaw muscles were reported with Ecological Momentary Assessment, through WhatsApp, 15 times a day, for 7 days, between 8:00 am and 7:00 pm. Quality of Life (QoL) and anxiety were assessed using the SF-36 and GAD-7 questionnaires, respectively. The Mann-Whitney U non-parametric, Pearson and Spearman correlation and Pairwise non-parametric multiple comparisons 2- to-2 tests were used. The frequency of AB was 40.7%. The most frequent AB behavior was teeth contact (23.1%). Higher frequency of AB occurred on weekdays (42.3%) compared to the weekend (35.5%) (p<0.05). There was a negative correlation of AB behaviors and mandible bracing with the QoL - emotional aspects domain (p<0.05) and positive correlation of mandible bracing with anxiety (p<0.01). There was no difference between genders for QoL, anxiety and AB behaviors (p>0.05). This study highlights the importance of AB and anxiety control to improve undergraduate students’ quality of life

Cymbopogon winterianus essential oil attenuates bleomycin-induced pulmonary fibrosis in a murine model

The essential oil of Cymbopogon winterianus (EOCW) is a natural product with antioxidant, anti-inflammatory, and antifibrotic properties. We studied the effect of EOCW in the progression of histological changes of pulmonary fibrosis (PF) in a rodent model. The oil was obtained by hydrodistillation and characterized using gas chromatographymass spectrometry. Intratracheal instillation of bleomycin was performed in 30 rats to induce PF, while Sham animals were subjected to instillation of saline solution. The treatment was performed using daily oral administration of distilled water, EOCW at 50, 100, and 200 mg/kg, and deflazacort (DFC). After 28 days, hemogram and bronchoalveolar lavage fluid (BALF), tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were assayed. Histological grading of PF, immunohistochemical expression of -smooth muscle actin (-SMA), and transforming growth factor- (TGF-) were also analyzed. The EOCW major compounds were found to be citronellal, geraniol, and citronellol. EOCW significantly reduced inflammation in BALF, reduced MDA levels, and increased SOD activity. EOCW attenuated histological grading of PF and reduced immunohistochemical expression of -SMA and TGF- in a dose-dependent way, likely due to the reduction of oxidative stress, inflammation, and TGF--induced myofibroblast differentiation.This research was financed by the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). EBS wishes to acknowledge the sponsorship of the project UIDB/04469/2020 (strategic fund) from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and was co-financed by FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersio

PLANETA ARTE: desenhando e compartilhando arte através de um ambiente virtual de aprendizagem

O presente artigo apresenta o Planeta Arte, no que se refere ao contexto envolvido, fundamentação teórica, questões técnicas, pedagógicas e de design. Trata-se de uma funcionalidade do ambiente virtual de aprendizagem PLANETA ROODA, disponívelem http://www.nuted.edu.ufrgs.br/planetarooda, o qual é destinado à Educação Infantil e Anos Iniciais

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Comparison of weather station and climate reanalysis data for modelling temperature-related mortality

Multi-Country Multi-City (MCC) Collaborative Research Network: Barrak Alahmad, Rosana Abrutzky, Paulo Hilario Nascimento Saldiva, Patricia Matus Correa, Nicolás Valdés Orteg, Haidong Kan, Samuel Osorio, Ene Indermitte, Jouni J K Jaakkola, Niilo Ryti, Alexandra Schneider, Veronika Huber, Klea Katsouyanni, Antonis Analitis, Alireza Entezari, Fatemeh Mayvaneh, Paola Michelozzi, Francesca de'Donato, Masahiro Hashizume, Yoonhee Kim, Magali Hurtado Diaz, César De la Cruz Valencia, Ala Overcenco, Danny Houthuijs, Caroline Ameling, Shilpa Rao, Xerxes Seposo, Baltazar Nunes, Iulian-Horia Holobaca, Ho Kim, Whanhee Lee, Carmen Íñiguez, Bertil Forsberg, Christofer Åström, Martina S Ragettli, Yue-Liang Leon Guo, Bing-Yu Chen, Valentina Colistro, Antonella Zanobetti, Joel Schwartz, Tran Ngoc Dang, Do Van DungErratum in: Author Correction: Sci Rep. 2022 May 13;12(1):7960. doi: 10.1038/s41598-022-11769-6. https://www.nature.com/articles/s41598-022-11769-6Epidemiological analyses of health risks associated with non-optimal temperature are traditionally based on ground observations from weather stations that offer limited spatial and temporal coverage. Climate reanalysis represents an alternative option that provide complete spatio-temporal exposure coverage, and yet are to be systematically explored for their suitability in assessing temperature-related health risks at a global scale. Here we provide the first comprehensive analysis over multiple regions to assess the suitability of the most recent generation of reanalysis datasets for health impact assessments and evaluate their comparative performance against traditional station-based data. Our findings show that reanalysis temperature from the last ERA5 products generally compare well to station observations, with similar non-optimal temperature-related risk estimates. However, the analysis offers some indication of lower performance in tropical regions, with a likely underestimation of heat-related excess mortality. Reanalysis data represent a valid alternative source of exposure variables in epidemiological analyses of temperature-related risk.The study was primarily supported by Grants from the European Commission’s Joint Research Centre Seville (Research Contract ID: JRC/SVQ/2020/MVP/1654), Medical Research Council-UK (Grant ID: MR/R013349/1), Natural Environment Research Council UK (Grant ID: NE/R009384/1), European Union’s Horizon 2020 Project Exhaustion (Grant ID: 820655). The following individual Grants also supported this work: J.K and A.U were supported by the Czech Science Foundation, project 20-28560S. A.T was supported by MCIN/AEI/10.13039/501100011033, Grant CEX2018-000794-S. V.H was supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant agreement No 101032087.info:eu-repo/semantics/publishedVersio

Characterization of the SNAG and SLUG Domains of Snail2 in the Repression of E-Cadherin and EMT Induction: Modulation by Serine 4 Phosphorylation

Snail1 and Snail2, two highly related members of the Snail superfamily, are direct transcriptional repressors of E-cadherin and EMT inducers. Previous comparative gene profiling analyses have revealed important differences in the gene expression pattern regulated by Snail1 and Snail2, indicating functional differences between both factors. The molecular mechanism of Snail1-mediated repression has been elucidated to some extent, but very little is presently known on the repression mediated by Snail2. In the present work, we report on the characterization of Snail2 repression of E-cadherin and its regulation by phosphorylation. Both the N-terminal SNAG and the central SLUG domains of Snail2 are required for efficient repression of the E-cadherin promoter. The co-repressor NCoR interacts with Snail2 through the SNAG domain, while CtBP1 is recruited through the SLUG domain. Interestingly, the SNAG domain is absolutely required for EMT induction while the SLUG domain plays a negative modulation of Snail2 mediated EMT. Additionally, we identify here novel in vivo phosphorylation sites at serine 4 and serine 88 of Snail2 and demonstrate the functional implication of serine 4 in the regulation of Snail2-mediated repressor activity of E-cadherin and in Snail2 induction of EMT

a three-stage modelling study

Funding Information: This study was supported by the Australian Research Council (DP210102076) and the Australian National Health and Medical Research Council (APP2000581). YW was supported by the China Scholarship Council (number 202006010044). SL was supported by an Emerging Leader Fellowship of the Australian National Health and Medical Research Council (number APP2009866). QZ was supported by the Program of Qilu Young Scholars of Shandong University, Jinan, China. BW was supported by the China Scholarship Council (number 202006010043). JK and AU were supported by the Czech Science Foundation (project number 20–28560S). NS was supported by the National Institute of Environmental Health Sciences-funded HERCULES Center (P30ES019776). S-CP and YLG were supported by the Ministry of Science and Technology (Taiwan; MOST 109–2621-M-002–021). YH was supported by the Environment Research and Technology Development Fund (JPMEERF15S11412) of the Environmental Restoration and Conservation Agency. MdSZSC and PHNS were supported by the São Paulo Research Foundation (FAPESP). ST was supported by the Science and Technology Commission of Shanghai Municipality (grant number 18411951600). HO and EI were supported by the Estonian Ministry of Education and Research (IUT34–17). JM was supported by a fellowship of Fundação para a Ciência e a Tecnlogia (SFRH/BPD/115112/2016). AG and FS were supported by the Medical Research Council UK (grant ID MR/R013349/1), the Natural Environment Research Council UK (grant ID NE/R009384/1), and the EU's Horizon 2020 project, Exhaustion (grant ID 820655). AS, SR, and FdD were supported by the EU's Horizon 2020 project, Exhaustion (grant ID 820655). VH was supported by the Spanish Ministry of Economy, Industry and Competitiveness (grant ID PCIN-2017–046). AT was supported by MCIN/AEI/10.13039/501100011033 (grant CEX2018-000794-S). YG was supported by the Career Development Fellowship (number APP1163693) and Leader Fellowship (number APP2008813) of the Australian National Health and Medical Research Council. Statistics South Africa kindly provided the mortality data, but had no other role in the study. This Article is published in memory of Simona Fratianni, who helped to contribute the data for Romania. Publisher Copyright: © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Increased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000–19. Methods: In this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000–19. Temperature variability was calculated as the SD of the average of the same and previous days’ minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades. Findings: An increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901–2 357 718) were associated with temperature variability per year, accounting for 3·4% (2·2–4·6) of all deaths. Most of Asia, Australia, and New Zealand were observed to have a higher percentage excess in mortality than the global mean. Globally, the percentage excess in mortality increased by about 4·6% (3·7–5·3) per decade. The largest increase occurred in Australia and New Zealand (7·3%, 95% CI 4·3–10·4), followed by Europe (4·4%, 2·2–5·6) and Africa (3·3, 1·9–4·6). Interpretation: Globally, a substantial mortality burden was associated with temperature variability, showing geographical heterogeneity and a slightly increasing temporal trend. Our findings could assist in raising public awareness and improving the understanding of the health impacts of temperature variability. Funding: Australian Research Council, Australian National Health & Medical Research Council.publishersversionpublishe