728 research outputs found
Clinical and surgical assistance in prostate cancer during the COVID-19 Pandemic: Implementation of assistance protocols
Purpose: Propose an approach of prostate cancer (PCa) patients during COVID-19 pandemic. Material and Methods: We conducted a review of current literature related to surgical and clinical management of patients during COVID-19 crisis paying special attention to oncological ones and especially those suffering from PCa. Based on these publications and current urological guidelines, a manual to manage PCa patients is suggested. Results: Patients suffering from cancer are likely to develop serious complications from COVID-19 disease together with an increased risk of postoperative morbidity and mortality. Therefore, the management of oncological patients should be taken into special consideration and most of the treatments postponed. In case the procedure is not deferrable, it should be adapted to the current situation. While the shortest radiotherapy (RT) regimens should be applied, surgical procedures must undergo the following recommendations proposed by main surgical associations. PCa prognosis is generally favourable and therefore one can safely delay most of the biopsies up to 6 months without interfering with survival outcomes in the vast majority of cases. In the same way, most of the localised PCa patients are suitable for active surveillance (AS) or hormonal therapy until local definitive treatment could be reconsidered. In metastatic as well as castration resistant PCa stages, adding androgen receptor targeted agents (abiraterone, apalutamide, darolutamide or enzalutamide) to androgen-deprivation therapy (ADT) could be considered in high risk patients. On the contrary, chemotherapy, immunotherapy and Radium-223 must be avoided with regard to the consequence of hematologic toxicity and risk of COVID-19 infection because of immunodepression. Conclusions: Most of the biopsies should be delayed while AS is advised in those patients with low risk PCa. ADT allows us to defer definitive local treatment in many cases of intermediate and high risk PCa. In regard to metastatic and castration resistant PCa, combination therapies with abiraterone, apalutamide, darolutamide or enzalutamide could be considered. Chemotherapy, Radium-223 and immunotherapy are discouraged
Spatial distribution of the most abundant sea urchin populations on the southeast coast of SĂŁo Paulo (Brazil)
Se investigĂł la variaciĂłn espacial en la abundancia de Echinometra lucunter, Lytechinus variegatus y Arbacia lixula con respecto a cuatro escalas espaciales (105, 104, 103 y 102 m) y dos profundidades (0â3 y 3â8 m), a lo largo de 100 km del litoral de SĂŁo Paulo (agosto a octubre de 1996). Echinometra lucunter fue la especie mĂĄs abundante, prefiriendo los fondos mĂĄs someros bajo el efecto del oleaje. Se identificĂł un gradiente en su abundancia, aumentando en direcciĂłn del suroeste al noreste. Arbacia lixula mostrĂł el mismo gradiente, pero con una mayor abundancia en el sector mĂĄs profundo. Ambas especies mostraron diferencias significativas a una escala espacial de centenares de metros y E. lucunter tambiĂ©n a una escala de kilĂłmetros. Lytechinus variegatus mostrĂł un patrĂłn en mosaico, siendo abundante en ciertos sitios. Las variaciones en la calidad del agua y en la heterogeneidad natural del hĂĄbitat podrĂan explicar de forma conjunta la distribuciĂłn espacial de estas poblaciones.The spatial variability of Echinometra lucunter, Lytechinus variegatus and Arbacia lixula was studied in relation to four spatial scales (105, 104, 103 and 102 m) and two depths (0â3 and 3â8 m), along 100 km of the SĂŁo Paulo coastline (August to October 1996). Echinometra lucunter was the most abundant species, with preference for shallow substrates subject to wave action. An abundance gradient was identified, increasing from southwest to northeast. Arbacia lixula showed the same pattern of spatial variation, but was more abundant in the deeper areas. Both species showed significant differences on a spatial scale of hundreds of meters, and E. lucunter also on a scale of kilometers. Lytechinus variegates presented a patchy distribution, being more abundant at certain sites. Variations in the water quality and natural heterogeneity of the habitat may explain the spatial distribution of these populations.El presente trabajo ha sido realizado gracias a dos becas INTERCAMPUS (1996â1997) concedidas por el Gobierno Español (Ministerio de Asuntos Exteriores) a PSJ para su estancia en el Laboratorio de EcotoxicologĂa (Brasil)
Sunspots: from small-scale inhomogeneities towards a global theory
The penumbra of a sunspot is a fascinating phenomenon featuring complex
velocity and magnetic fields. It challenges both our understanding of radiative
magneto-convection and our means to measure and derive the actual geometry of
the magnetic and velocity fields. In this contribution we attempt to summarize
the present state-of-the-art from an observational and a theoretical
perspective.Comment: Accepted for publication in Space Science Review
Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children
Transmission risk is greatest when mother and offspring both have low CCL3L or CCL4L gene doses. The impact on HIV-AIDS susceptibility of the chemokine gene-rich locus on 17q12 is dependent on the balance between the doses of genes
conferring protective (CCL3La and CCL4La) versus detrimental (CCL4Lb) effects. Hence, the combinatorial genomic content of distinct genes within a copy number variable region may determine disease susceptibility
Endothelial colony forming cells as an autologous model to study endothelial dysfunction in patients with a bicuspid aortic valve
Bicuspid aortic valve (BAV), the most common congenital heart defect, is associated with an increased prevalence of aortic dilation, aortic rupture and aortic valve calcification. Endothelial cells (ECs) play a major role in vessel wall integrity. Little is known regarding EC function in BAV patients due to lack of patient derive
Specific heat and magnetic order in LaMnO_{3+\delta}
Magnetic and specific-heat measurements are performed in three different
samples of LaMnO_{3+\delta}, with \delta=0.11, 0.15 and 0.26, presenting
important disorder effects, such as carrier localization, due to high amounts
of La and Mn vacancies. For the samples with \delta =0.11 and 0.15, magnetic
measurements show signatures of a two-step transition: as the temperature is
lowered, the system enters a ferromagnetic phase followed by a disorder-induced
cluster-glass state. Spin-wave-like contributions and an unexpected large
linear term are observed in the specific heat as a function of temperature. In
the sample with the highest vacancy content, \delta=0.26, the disorder is
sufficient to suppress even short-range ferromagnetic order and yield a
spin-glass-like state.Comment: RevTeX 2-col, 8 pages, 5 ps figures included, submitted to PR
Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS
We present the results of a search for new, heavy particles that decay at a
significant distance from their production point into a final state containing
charged hadrons in association with a high-momentum muon. The search is
conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV
and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS
detector operating at the Large Hadron Collider. Production of such particles
is expected in various scenarios of physics beyond the standard model. We
observe no signal and place limits on the production cross-section of
supersymmetric particles in an R-parity-violating scenario as a function of the
neutralino lifetime. Limits are presented for different squark and neutralino
masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final
version to appear in Physics Letters
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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