Extended scaling relations for planar lattice models

It is widely believed that the critical properties of several planar lattice models, like the Eight Vertex or the Ashkin-Teller models, are well described by an effective Quantum Field Theory obtained as formal scaling limit. On the basis of this assumption several extended scaling relations among their indices were conjectured. We prove the validity of some of them, among which the ones by Kadanoff, [K], and by Luther and Peschel, [LP].Comment: 32 pages, 7 fi

A comparison of rolling averages versus discrete time epochs for assessing the worst-case scenario locomotor demands of professional soccer match-play.

OBJECTIVES: To compare fixed epochs (FIXED) and rolling averages (ROLL) for quantifying worst-case scenario ('peak') running demands during professional soccer match-play, whilst assessing contextual influences. DESIGN: Descriptive, observational. METHODS: Twenty-five outfield players from an English Championship soccer club wore 10-Hz microelectromechanical systems during 28 matches. Relative total and high-speed (>5.5ms-1) distances were averaged over fixed and rolling 60-s to 600-s epochs. Linear mixed models compared FIXED versus ROLL and assessed the influence of epoch length, playing position, starting status, match result, location, formation, and time-of-day. RESULTS: Irrespective of playing position or epoch duration, FIXED underestimated ROLL for total (∼7-10%) and high-speed (∼12-25%) distance. In ROLL, worst-case scenario relative total and high-speed distances reduced from 190.1±20.4mmin-1 and 59.5±23.0mmin-1 in the 60-s epoch, to 120.9±13.1mmin-1 and 14.2±6.5mmin-1 in the 600-s epoch, respectively. Worst-case scenario total distance was higher for midfielders (∼9-16mmin-1) and defenders (∼3-10mmin-1) compared with attackers. In general, starters experienced higher worst-case scenario total distance than substitutes (∼3.6-8.5mmin-1), but lower worst-case scenario high-speed running over 300-s (∼3mmin-1). Greater worst-case scenario total and high-speed distances were elicited during wins (∼7.3-11.2mmin-1 and ∼2.7-7.9mmin-1, respectively) and losses (∼2.7-5.7mmin-1 and ∼1.4-2.2mmin-1, respectively) versus draws, whilst time-of-day and playing formation influenced worst-case scenario high-speed distances only. CONCLUSIONS: These data indicate an underestimation of worst-case scenario running demands in FIXED versus ROLL over 60-s to 600-s epochs while highlighting situational influences. Such information facilitates training specificity by enabling sessions to be targeted at the most demanding periods of competition

The physical demands of professional soccer goalkeepers throughout a week-long competitive microcycle and transiently throughout match-play.

The physical demands of English Premier League soccer goalkeepers were quantified during training and match-play in a two-part study. Goalkeeper-specific micromechanical electrical systems (MEMS) devices, profiled training and match-day activities throughout one competitive week (n=8; part A). Changes in MEMS-derived outputs were also profiled throughout match-play (100 matches; n=8, 18±14 observations per goalkeeper; part B). In part A, goalkeeping-training elicited the most dives (51±11) versus all activities (all p≤0.030) except shooting-training (p=0.069). Small-sided games elicited the fewest (5±3) dives (all p≤0.012). High-speed distance covered in match (103±72 m) was similar to goalkeeping-training (p=0.484), while exceeding shooting-training, small-sided games, pre-match shooting, and pre-match warm-up (all p=0.012). Most changes of direction (34±12) and explosive efforts (70±18) occurred during goalkeeping-training, with values exceeding match (both p=0.012). In part B, between-half reductions in total distance, but increased high-speed changes of direction and explosive efforts, occurred (both p≤0.05). Excluding the number of high jumps, all variables differed from 0-15-min during at least one match epoch, with more dives (1.3±1.4 vs 1.0±1.1) and explosive efforts (2.5±2.4 vs 2.0±1.8) performed between 75-90-min versus 0-15-min (all p<0.05). These data highlight the differing physical demands of various activities performed by professional soccer goalkeepers throughout a competitive week

A match-day analysis of the movement profiles of substitutes from a professional soccer club before and after pitch-entry.

Whilst the movement demands of players completing a whole soccer match have been well-documented, comparable information relating to substitutes is sparse. Therefore, this study profiled the match-day physical activities performed by soccer substitutes, focusing separately on the pre and post pitch-entry periods. Seventeen English Championship soccer players were monitored using 10 Hz Micromechanical Electrical Systems (MEMS) devices during 13 matches in which they participated as substitutes (35 observations). Twenty physical variables were examined and data were organised by bouts of warm-up activity (pre pitch-entry), and five min epochs of match-play (post pitch-entry). Linear mixed modelling assessed the influence of time (i.e., 'bout' and 'epoch'), playing position, and match scoreline. Substitutes performed 3±1 rewarm-up bouts∙player-1∙match-1. Compared to the initial warm-up, each rewarm-up was shorter (-19.7 to -22.9 min) and elicited less distance (-606 to -741 m), whilst relative total distances were higher (+26 to +69 m∙min-1). Relative total (+13.4 m∙min-1) and high-speed (+0.4 m∙min-1) distances covered during rewarm-ups increased (p <0.001) with proximity to pitch-entry. Players covered more (+3.2 m; p = 0.047) high-speed distance per rewarm-up when the assessed team was losing compared with when winning at the time of pitch-entry. For 10 out of 20 variables measured after pitch-entry, values reduced from 0-5 min thereafter, and substitutes covered greater (p ˂0.05) total (+67 to +93 m) and high-speed (+14 to +33 m) distances during the first five min of match-play versus all subsequent epochs. Midfielders covered more distance (+41 m) per five min epoch than both attackers (p ˂0.001) and defenders (p = 0.016). Acknowledging the limitations of a solely movement data approach and the potential influence of other match-specific factors, such findings provide novel insights into the match-day demands faced by substitute soccer players. Future research opportunities exist to better understand the match-day practices of this population

Assessing the whole-match and worst-case scenario locomotor demands of international women's rugby union match-play.

OBJECTIVES: To profile the distances covered during international women's rugby union match-play and assess the duration-specific worst-case scenario locomotor demands over 60-s to 600-s epochs, whilst comparing the values determined by fixed epoch (FIXED) versus rolling average (ROLL) methods of worst-case scenario estimation and assessing positional influences. DESIGN: Descriptive, observational. METHODS: Twenty-nine international women's rugby union players wore 10Hz microelectromechanical systems during eight international matches (110 observations). Total, and per-half, distances were recorded, whilst relative total and high-speed (>4.4ms-1) distances were averaged using FIXED and ROLL methods over 60-600-s. Linear mixed models compared distances covered between match halves, assessed FIXED versus ROLL, and examined the influence of playing position. RESULTS: Players covered ∼5.8kmmatch-1, with reduced distances in the second- versus first-half (p<0.001). For worst-case scenario total (∼8-25%) and high-speed (∼10-26%) distance, FIXED underestimated ROLL. In ROLL, worst-case scenario relative total and high-speed distances reduced from ∼144-161mmin-1 and ∼30-69mmin-1 over 60-s, to ∼8089mmin-1 and ∼516mmin-1 in the 600-s epoch, respectively. Forwards performed less high-speed running over all epochs and covered less total distance during epochs of 60-s, 180-s, 420-s and 480-s, compared with backs. Front row players typically returned the lowest locomotor demands. CONCLUSIONS: This is the first study reporting the positional and worst-case scenario demands of international women's rugby union, and indicates an underestimation in FIXED versus ROLL over 60-s to 600-s epochs. Knowledge of the most demanding periods of women's rugby union match-play facilitates training specificity by enabling sessions to be tailored to such demands

Cosmological parameter estimation and the inflationary cosmology

We consider approaches to cosmological parameter estimation in the inflationary cosmology, focussing on the required accuracy of the initial power spectra. Parametrizing the spectra, for example by power-laws, is well suited to testing the inflationary paradigm but will only correctly estimate cosmological parameters if the parametrization is sufficiently accurate, and we investigate conditions under which this is achieved both for present data and for upcoming satellite data. If inflation is favoured, reliable estimation of its physical parameters requires an alternative approach adopting its detailed predictions. For slow-roll inflation, we investigate the accuracy of the predicted spectra at first and second order in the slow-roll expansion (presenting the complete second-order corrections for the tensors for the first time). We find that within the presently-allowed parameter space, there are regions where it will be necessary to include second-order corrections to reach the accuracy requirements of MAP and Planck satellite data. We end by proposing a data analysis pipeline appropriate for testing inflation and for cosmological parameter estimation from high-precision data.Comment: 15 pages RevTeX file with figures incorporated. Slow-roll inflation module for use with the CAMB program can be found at http://astronomy.cpes.susx.ac.uk/~sleach/inflation/ This version corrects a typo in the definition of z_S (after Eq.1) and supersedes the journal versio

Toward a 21st-century health care system: Recommendations for health care reform

The coverage, cost, and quality problems of the U.S. health care system are evident. Sustainable health care reform must go beyond financing expanded access to care to substantially changing the organization and delivery of care. The FRESH-Thinking Project (www.fresh-thinking.org) held a series of workshops during which physicians, health policy experts, health insurance executives, business leaders, hospital administrators, economists, and others who represent diverse perspectives came together. This group agreed that the following 8 recommendations are fundamental to successful reform: 1. Replace the current fee-for-service payment system with a payment system that encourages and rewards innovation in the efficient delivery of quality care. The new payment system should invest in the development of outcome measures to guide payment. 2. Establish a securely funded, independent agency to sponsor and evaluate research on the comparative effectiveness of drugs, devices, and other medical interventions. 3. Simplify and rationalize federal and state laws and regulations to facilitate organizational innovation, support care coordination, and streamline financial and administrative functions. 4. Develop a health information technology infrastructure with national standards of interoperability to promote data exchange. 5. Create a national health database with the participation of all payers, delivery systems, and others who own health care data. Agree on methods to make de-identified information from this database on clinical interventions, patient outcomes, and costs available to researchers. 6. Identify revenue sources, including a cap on the tax exclusion of employer-based health insurance, to subsidize health care coverage with the goal of insuring all Americans. 7. Create state or regional insurance exchanges to pool risk, so that Americans without access to employer-based or other group insurance could obtain a standard benefits package through these exchanges. Employers should also be allowed to participate in these exchanges for their employees' coverage. 8. Create a health coverage board with broad stakeholder representation to determine and periodically update the affordable standard benefit package available through state or regional insurance exchanges

A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial

Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher drug deposition in the lung compared with the existing formulations. We aimed to test the efficacy and safety of inhaled PA101 in patients with IPF and chronic cough and, to explore the antitussive mechanism of PA101, patients with chronic idiopathic cough (CIC) were also studied. Methods This pilot, proof-of-concept study consisted of a randomised, double-blind, placebo-controlled trial in patients with IPF and chronic cough and a parallel study of similar design in patients with CIC. Participants with IPF and chronic cough recruited from seven centres in the UK and the Netherlands were randomly assigned (1:1, using a computer-generated randomisation schedule) by site staff to receive PA101 (40 mg) or matching placebo three times a day via oral inhalation for 2 weeks, followed by a 2 week washout, and then crossed over to the other arm. Study participants, investigators, study staff, and the sponsor were masked to group assignment until all participants had completed the study. The primary efficacy endpoint was change from baseline in objective daytime cough frequency (from 24 h acoustic recording, Leicester Cough Monitor). The primary efficacy analysis included all participants who received at least one dose of study drug and had at least one post-baseline efficacy measurement. Safety analysis included all those who took at least one dose of study drug. In the second cohort, participants with CIC were randomly assigned in a study across four centres with similar design and endpoints. The study was registered with ClinicalTrials.gov (NCT02412020) and the EU Clinical Trials Register (EudraCT Number 2014-004025-40) and both cohorts are closed to new participants. Findings Between Feb 13, 2015, and Feb 2, 2016, 24 participants with IPF were randomly assigned to treatment groups. 28 participants with CIC were enrolled during the same period and 27 received study treatment. In patients with IPF, PA101 reduced daytime cough frequency by 31·1% at day 14 compared with placebo; daytime cough frequency decreased from a mean 55 (SD 55) coughs per h at baseline to 39 (29) coughs per h at day 14 following treatment with PA101, versus 51 (37) coughs per h at baseline to 52 (40) cough per h following placebo treatment (ratio of least-squares [LS] means 0·67, 95% CI 0·48–0·94, p=0·0241). By contrast, no treatment benefit for PA101 was observed in the CIC cohort; mean reduction of daytime cough frequency at day 14 for PA101 adjusted for placebo was 6·2% (ratio of LS means 1·27, 0·78–2·06, p=0·31). PA101 was well tolerated in both cohorts. The incidence of adverse events was similar between PA101 and placebo treatments, most adverse events were mild in severity, and no severe adverse events or serious adverse events were reported. Interpretation This study suggests that the mechanism of cough in IPF might be disease specific. Inhaled PA101 could be a treatment option for chronic cough in patients with IPF and warrants further investigation