Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome.

Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients

Influence of trace metal release from volcanic ash on growth of Thalassiosira pseudonana and Emiliania huxleyi

Recent studies demonstrate that volcanic ash has the potential to increase phytoplankton biomass in the open ocean. However, besides fertilizing trace metals such as Fe, volcanic ash contains a variety of potentially toxic metals such as Cd, Cu, Pb, and Zn. Especially in coastal regions closer to the volcanic eruption, where ash depositions can be very high, toxic effects are possible. Here we present the first results of laboratory experiments, showing that trace metal release from different volcanic materials can have both fertilizing and toxic effects on marine phytoplankton in natural coastal seawater. The diatom Thalassiosira pseudonana generally showed higher growth rates in seawater that was in short contact with volcanic ash compared to the controls without ash addition. In contrast to that, the addition of volcanic ash had either no effect or significantly decreased the growth rate of the coccolithophoride Emiliania huxleyi. It was not possible to attribute the effects to single trace metals, however, our results suggest that Mn plays an important role in regulating the antagonistic and synergistic effects of the different trace metals. This study shows that volcanic ash can lead to changes in the phytoplankton species composition in the high fall-out area of the surface ocean. Highlights: ► We tested the effect of volcanic ash on growth of T. pseudonana and E. huxleyi ► Volcanic ash increased growth of T. pseudonana but not of E. huxleyi ► Mn seems important to regulate the effects of different trace metals from the ash ► Volcanic eruptions have the potential to change phytoplankton community structure

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change : UNEP Environmental Effects Assessment Panel, Update 2020

This assessment by the Environmental Effects Assessment Panel (EEAP) of the United Nations Environment Programme (UNEP) provides the latest scientific update since our most recent comprehensive assessment (Photochemical and Photobiological Sciences, 2019, 18, 595-828). The interactive effects between the stratospheric ozone layer, solar ultraviolet (UV) radiation, and climate change are presented within the framework of the Montreal Protocol and the United Nations Sustainable Development Goals. We address how these global environmental changes affect the atmosphere and air quality; human health; terrestrial and aquatic ecosystems; biogeochemical cycles; and materials used in outdoor construction, solar energy technologies, and fabrics. In many cases, there is a growing influence from changes in seasonality and extreme events due to climate change. Additionally, we assess the transmission and environmental effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the COVID-19 pandemic, in the context of linkages with solar UV radiation and the Montreal Protocol.Peer reviewe

Scientists’ Warning to Humanity: Rapid degradation of the world\u27s large lakes

Large lakes of the world are habitats for diverse species, including endemic taxa, and are valuable resources that provide humanity with many ecosystem services. They are also sentinels of global and local change, and recent studies in limnology and paleolimnology have demonstrated disturbing evidence of their collective degradation in terms of depletion of resources (water and food), rapid warming and loss of ice, destruction of habitats and ecosystems, loss of species, and accelerating pollution. Large lakes are particularly exposed to anthropogenic and climatic stressors. The Second Warning to Humanity provides a framework to assess the dangers now threatening the world\u27s large lake ecosystems and to evaluate pathways of sustainable development that are more respectful of their ongoing provision of services. Here we review current and emerging threats to the large lakes of the world, including iconic examples of lake management failures and successes, from which we identify priorities and approaches for future conservation efforts. The review underscores the extent of lake resource degradation, which is a result of cumulative perturbation through time by long-term human impacts combined with other emerging stressors. Decades of degradation of large lakes have resulted in major challenges for restoration and management and a legacy of ecological and economic costs for future generations. Large lakes will require more intense conservation efforts in a warmer, increasingly populated world to achieve sustainable, high-quality waters. This Warning to Humanity is also an opportunity to highlight the value of a long-term lake observatory network to monitor and report on environmental changes in large lake ecosystems

Environmental effects of ozone depletion, UV radiation and interactions with climate change : UNEP Environmental Effects Assessment Panel, update 2017

Peer reviewe