124 research outputs found
The chemokine CXCL13 in acute neuroborreliosis
- Author
- Publication venue
- 'BMJ'
- Publication date
- 03/12/2009
- Field of study
Objective Recent studies have suggested an important role of the B cell chemoattractant CXCL13 in acute neuroborreliosis (NB). Our aim was to confirm the diagnostic role of CXCL13 and to evaluate its relevance as a therapy response and disease activity marker in NB. Methods CXCL13 was measured in cerebrospinal fluid (CSF) and serum of patients with NB (n = 28), systemic borreliosis (SB, n = 9), Guillaine-Barre syndrome (GBS, n = 11), Bell's palsy (BP, n = 19), other cranial nerve palsies (CNP, n = 5), cephalgia (C, n = 20), bacterial CNS infections (B-CNS-I, n = 16) and viral CNS infections (V-CNS-I, n = 18). For follow-up studies, serial sample pairs were evaluated from 25 patients with NB (n = 56), 11 with B-CNS-I (n = 25) and 14 with V-CNS-I (n = 36). Results CSF-CXCL13 was significantly elevated in NB compared with other neurological diseases (p<0.001). Using receiver operating characteristic analysis, 337 ng/g was determined as a cut-off with a sensitivity of 96.4% and a specificity of 96.9%. Of all the parameters investigated, CSF CXCL13 showed the fastest response to antibiotic therapy, decreasing significantly (p = 0.008) within 1 week. In untreated patients, CSF CXCL13 was elevated in patients with a short duration of disease. Borrelia burgdorferi antibody index showed no significant (p = 0.356) change over follow-up. Conclusions The study confirms the relevance of CXCL13 as a diagnostic biomarker of NB and suggests that CSF CXCL13 in NB is linked to duration of disease and could be a marker of disease activity and response to antibiotic therapy
The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>The chemokine CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. Whether it influences B cell trafficking during acute infection, is largely unclear. In previous studies, we showed that (I) CXCL13 levels are markedly increased in the B cell-rich cerebrospinal fluid (CSF) of patients with acute Lyme neuroborreliosis (LNB), and (II) CXCL13 is released by monocytes upon recognition of borrelial outer surface proteins by Toll-like receptor 2. Here, we assessed the role of CXCL13 - in comparison to other chemokines - in the recruitment of B cells to the CSF of patients with acute LNB.</p> <p>Methods</p> <p>Measurement of chemokines was done by ELISA. B cells were isolated from whole blood using magnetic cell separation (MACS). For migration experiments, a modified Boyden chamber assay was used and the migrated B cells were further analysed by FACS. The migration was inhibited either by preincubation of the CSF samples with neutralizing antibodies, heating to 60°C, removal of proteins >3 kDa, or by pre-treatment of the B cells with pertussis toxin. The principal statistical tests used were one-way analysis of variance and Bonferroni test (chemokine measurements) as well as paired Student's t-test (migration experiments).</p> <p>Results</p> <p>Measurements of chemokine levels revealed an increase in three of the four known major B cell chemoattractants CXCL13, CCL19 and CXCL12 in LNB CSF. The CXCL13 CSF:serum ratio, as a measure of the chemotactic gradient, was substantially higher than that of CCL19 and CXCL12. Moreover, the chemotactic activity of LNB CSF was reduced up to 56% after preincubation with a neutralizing CXCL13 antibody, while combined preincubation with antibodies against CXCL13, CCL19, and CXCL12 did not lead to further reduction. Since treatment with pertussis toxin, heating to 60°C, and removal of proteins >3 kDa abrogated the chemotactic activity, further not yet identified chemokines seem to be involved in B cell recruitment to LNB CSF.</p> <p>Conclusion</p> <p>Combined, our study suggests a key role of CXCL13 in B cell migration to sites of infection as shown here for the CSF of LNB patients.</p
Left ventricular support adjustment to aortic valve opening with analysis of exercise capacity
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Background
LVAD speed adjustment according to a functioning aortic valve has hypothetic advantages but could lead to submaximal support. The consequences of an open aortic valve policy on exercise capacity and hemodynamics have not yet been investigated systematically.
Methods
Ambulatory patients under LVAD support (INCOR®, Berlin Heart, mean support time 465 ± 257 days, average flow 4.0 ± 0.3 L/min) adjusted to maintain a near normal aortic valve function underwent maximal cardiopulmonary exercise testing (CPET) and right heart catheterization (RHC) at rest and during constant work rate exercise (20 Watt).
Results
Although patients (n = 8, mean age 45 ± 13 years) were in NYHA class 2, maximum work-load and peak oxygen uptake on CPET were markedly reduced with 69 ± 13 Watts (35% predicted) and 12 ± 2 mL/min/kg (38% predicted), respectively. All patients showed a typical cardiac limitation pattern and severe ventilatory inefficiency with a slope of ventilation to carbon dioxide output of 42 ± 12. On RHC, patients showed an exercise-induced increase of mean pulmonary artery pressure (from 16 ± 2.4 to 27 ± 2.8 mmHg, p < 0.001), pulmonary artery wedge pressure (from 9 ± 3.3 to 17 ± 5.3 mmHg, p = 0.01), and cardiac output (from 4.7 ± 0.5 to 6.2 ± 1.0 L/min, p = 0.008) with a corresponding slight increase of pulmonary vascular resistance (from 117 ± 35.4 to 125 ± 35.1 dyn*sec*cm−5, p = 0.58) and a decrease of mixed venous oxygen saturation (from 58 ± 6 to 32 ± 9%, p < 0.001).
Conclusion
An open aortic valve strategy leads to impaired exercise capacity and hemodynamics, which is not reflected by NYHA-class. Unknown compensatory mechanisms can be suspected. Further studies comparing higher vs. lower support are needed for optimization of LVAD adjustment strategies
Experimental study of pedestrian flow through a bottleneck
- Author
- Anna Grünebohm
- Blue V J
- Daamen W
- Dijkstra J
- Fahy R F
- Galea E
- Halcrow Paxport
- Hoogendoorn S P
- IMO Correspondence Group
- Kerner B S Klenov S L
- Kerridge J
- Ketchell N
- Kisko T M
- Klüpfel H
- Kretz T
- Legion International Limited
- Michael Schreckenberg
- Nei M
- Nishinari K
- Ohi N
- Popkov V
- Predtetschenski W M Milinski A I
- Rupprecht T
- Savannah Simulations AG
- Sreenivasan S Cohen R López E Toroczkai Z Stanley H E
- Still G K
- Sugiyama Y
- Syohei Yamamoto S Hieida S Tadaki S
- Thompson P A
- Tobias Kretz
- Publication venue
- 'IOP Publishing'
- Publication date
- 11/10/2006
- Field of study
In this work the results of a bottleneck experiment with pedestrians are
presented in the form of total times, fluxes, specific fluxes, and time gaps. A
main aim was to find the dependence of these values from the bottleneck width.
The results show a linear decline of the specific flux with increasing width as
long as only one person at a time can pass, and a constant value for larger
bottleneck widths. Differences between small (one person at a time) and wide
bottlenecks (two persons at a time) were also found in the distribution of time
gaps.Comment: accepted for publication in J. Stat. Mec
Acute mountain sickness.
- Author
- Alan H. Beggs
- Alan P. Knutsen
- Albert C. Ludolph
- Albert H. Gennip
- Albert H. Gennip
- Alessandra Baumer
- Alessia Diana
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander Leaf
- Alfried Kohlschütter
- Amrik Sahota
- Andrea Cignarella
- Andromachi Scaradavou
- André B. P. Kuilenburg
- André B. P. Kuilenburg
- Andy Wessels
- Anna Sarkozy
- Arndt Hartmann
- Atilla Şenaylı
- Avi Fischer
- Birgit Haack
- Björn Stork
- Bruno Dallapiccola
- Bruno Marino
- Carl Borrebaeck
- Carsten A. Wagner
- Christian Zietz
- Christie P. Thomas
- Christie P. Thomas
- Christopher K. Zarins
- Christos C. Zouboulis
- Colin A. Johnson
- Cord Sunderkötter
- Cord Sunderkötter
- Damian C. Melles∗
- Dan Donoghue
- Daniel Batlle
- Daniel Batlle
- Daniel Batlle
- Daniela Eser
- Darryl C. Zeldin
- Davendra Mehta
- David A. Lomas
- Deepak Kamat
- Deirdre Ward
- Dorothée Nashan
- Du Toit Loots
- Ehteshamudin Syed
- Eleanor M. Summerhill
- Engin Sezer
- Essi Viding
- F. Dennis McCool
- Federico Fracassi
- Filip Vanhoenacker
- Friedhelm Beyersdorf
- Gema Ariceta
- Gema Ariceta
- Georg Kojda
- Georges Berghe
- Gerd Hasenfuss
- Gordon Dent
- Guido Adler
- H. Anne Simmonds
- Hans H. Goebel
- Haran Burri
- Helmut Hintner
- Henrik Larsson
- Herbert L. Bonkovsky
- Holger S. Willenberg
- Holger S. Willenberg
- Hubert Scharnagl
- Hugo Ten Cate
- Jaak Jaeken
- Jacob I. Sznajder
- James K. Stoller
- James M. Powers
- James M. Powers
- Jay A. Tischfield
- Jeno Sebes
- Jens J. Kaden
- Jens Mogensen
- Jens Seiler
- John-John B. Schnog
- Jonathan M. Kalman
- Jorge Frank
- Karel Frasch
- Karina Yazdanbakhsh
- Kirsty Kiezebrink
- Klaus-Peter Lesch
- Konrad Beyreuther
- Kumarasamy Thangaraj
- Kurt C. Roberts-Thomson
- Lee A. Denson
- Lucia K. Ma
- M. Cristina Digilio
- Malin Lindstedt
- Manish Suneja
- Manish Suneja
- Manish Thapar
- Marc Zimmermann
- Mark Berneburg
- Mark G. Buckley
- Markus Böhm
- Markus Böhm
- Markus Jäger
- Markus Pfister
- Martin Rotter
- Martina Bienova
- Matthias Siepe
- Matthias Wenning
- Mayumi Endo
- Meinhard Schiller
- Michael Emberger
- Michael L. H. Ma
- Michael L. H. Ma
- Michael L. H. Ma
- Michael L. H. Ma
- Michael M. Hoffmann
- Michael S. Hershfield
- Michael Stürzl
- Michala Bezdekova
- Michelle M. Estrella
- Mohamed G. Atta
- Moosa Mohammadi
- Murat Bas
- Mónica Guevara
- Nada Kanaan
- Nigel G. Laing
- Nilufar Mohebbi
- Norbert Frey
- Norbert Gattermann
- Omar A. Ibrahimi
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Pavel Fencl
- Pere Ginès
- Peter Klein
- Raffi Bekeredjian
- Rainer Rupprecht
- Ralf Paus
- Randolf Brehler
- Randolf Brehler
- Renata Kucerova
- Rita L. McGill
- Robert Dalla Pozza
- Roberto Manfredi
- Rodolfo Paoletti
- Ruth Danzeisen
- S. Marie
- Sebastian Wesselborg
- Sehsuvar Ertürk
- Sim Kutlay
- Singh Rajender
- Siobhan D. Ma
- Sishir Mathur
- Srijita Sen-Chowdhry
- Stefan Kins
- Stefan R. Bornstein
- Stefan R. Bornstein
- Stephen T. Holgate
- Steven Mumm
- Susanna Mac
- Susanne Kohl
- Sven Schinner
- Svetlana Brychtova
- Sylvia Stöckler-Ipsiroglu
- Thomas A. Luger
- Thomas A. Luger
- Thomas Bourgeron
- Thomas Frieling
- Thomas Hawranek
- Thomas Klockgether
- Thomas Klockgether
- Thomas Klockgether
- Thomas Schwarz
- Thomas Schwarz
- Tim McQuinn
- Tobias W. Fischer
- Tomas Brychta
- Victor E. A. Gerdes
- Volker Liebe
- William J. McKenna
- Wim Hul
- Winfried März
- Winfried März
- Wolfgang Dietmaier
- Wolfgang Schillinger
- Yun Zhao
- Zdenek Kolar
- Zhirong Yao
- Publication venue
- Publication date
- 01/05/2001
- Field of study
Acute mountain sickness (AMS) is a clinical syndrome occurring in otherwise healthy normal individuals who ascend rapidly to high altitude. Symptoms develop over a period ofa few hours or days. The usual symptoms include headache, anorexia, nausea, vomiting, lethargy, unsteadiness of gait, undue dyspnoea on moderate exertion and interrupted sleep. AMS is unrelated to physical fitness, sex or age except that young children over two years of age are unduly susceptible. One of the striking features ofAMS is the wide variation in individual susceptibility which is to some extent consistent. Some subjects never experience symptoms at any altitude while others have repeated attacks on ascending to quite modest altitudes. Rapid ascent to altitudes of 2500 to 3000m will produce symptoms in some subjects while after ascent over 23 days to 5000m most subjects will be affected, some to a marked degree. In general, the more rapid the ascent, the higher the altitude reached and the greater the physical exertion involved, the more severe AMS will be. Ifthe subjects stay at the altitude reached there is a tendency for acclimatization to occur and symptoms to remit over 1-7 days
Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asilar Ece
- Asin Ivan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian Tobias
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Basegmez Suzan
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behnamian Hadi
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W.
- Bellan Riccardo
- Bellato Marco
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berruti Gaia Maria
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Boimska Bozena
- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Bortoletto Daniela
- Borzou Ahmad
- Bose Suvadeep
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G.
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Brito Lucas
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brodski Michael
- Brom Jean-Marie
- Brona Grzegorz
- Brondolin Erica
- Brooke James John
- Brown Robert M.
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Burns Douglas
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Buttignol Michael
- Butz Erik
- Bylsma Ben
- Byszuk Adrian
- Bäni Lukas
- Böser Christian
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calamba Aristotle
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Calpas Betty
- Calvelli Valerio
- Calvert Brian
- Calvo Enrique
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Cappello Gigi
- Caputo Claudio
- Carlin Roberto
- Carlsmith Duncan
- Carlson Benjamin
- Carnes Andrew
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Casimiro Linares Edgar
- Castaldi Rino
- Castaneda Hernandez Alfredo
- Castello Roberto
- Castilla-Valdez Heriberto
- Castiñeiras De Saa Juan Ramon
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Celik Ali
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chamizo Llatas Maria
- Chang Paoti
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Shubhanshu
- Chauhan Sushil
- Chaves Jorge
- Chawla Ridhi
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Po-Hsun
- Chen Yi
- Chen Zhenyu
- Cheng Tongguang
- Cherepanov Vladimir
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chistov Ruslan
- Chlebana Frank
- Cho Sungwoong
- Choi Minkyoo
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Somnath
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Cieri Davide
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cirkovic Predrag
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clarke Christopher
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
- Cockerill David J. A.
- Cocoros Alice
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cornelis Tom
- Corpe Louie
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costanza Francesco
- Coubez Xavier
- Couderc Fabrice
- Coughlan John A.
- Courbon Benoit
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cristella Leonardo
- Crucy Shannon
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Curras Esteban
- Curry David
- Cussans David
- Custódio Analu
- Cutts David
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- D'imperio Giulia
- Dabrowski Anne
- Daci Nadir
- Dahmes Bryan
- Dalchenko Mykhailo
- Dall'Osso Martino
- Dallavalle Gaetano-Marco
- Damarseckin Serdal
- Damgov Jordan
- Danilov Mikhail
- Daponte Vincenzo
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Dauncey Paul
- David Tinoco Mendes Andre
- Davies Gavin
- Davignon Olivier
- de Barbaro Pawel
- De Boer Wim
- De Bruyn Isabelle
- De Castro Manzano Pablo
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- De Souza Santos Angelo
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wit Adinda
- De Wolf Eddi A.
- Degano Alessandro
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G.
- Delcourt Martin
- Delgado Peris Antonio
- Delgado Andrea
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Dellacasa Giulio
- Demaria Natale
- Demina Regina
- Demiragli Zeynep
- Demiroglu Zuhal Seyma
- Denegri Daniel
- Depasse Pierre
- Derdzinski Mark
- Dermenev Alexander
- Deroover Kevin
- Descroix Alexis
- Dev Nabarun
- Devetak Damir
- Dewanjee Ram Krishna
- Dey Sourav
- Di Francesco Agostino
- Di Guida Salvatore
- Di Marco Emanuele
- Di Matteo Leonardo
- Di Mattia Alessandro
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dishaw Adam
- Dissertori Günther
- Dittmann Jay
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- Weiler Thomas
- Weinberg Marc
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- Wendland Lauri
- Weng Yao
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- Wetzel James
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- Wickramage Nadeesha
- Wilbur Scott
- Williams Thomas
- Williamson Shawn
- Wimpenny Stephen
- Winer Brian L.
- Wissing Christoph
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- Wolf Roger
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- Wöhrmann Clemens
- Würthwein Frank
- Xia Fan
- Xiao Meng
- Xie Si
- Xie Wei
- Xin Yongjie
- Xu Lingshan
- Xu Qiao
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Mingming
- Yang Yong
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagozdzinska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Jinzhong
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukov Valery
- Zhukova Victoria
- Zolkapli Zukhaimira
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV
Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asin Ivan
- Askew Andrew
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Awad Adel
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behnamian Hadi
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berruti Gaia Maria
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
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- Bitioukov Sergei
- Blekman Freya
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- Bloch Philippe
- Bloom Kenneth
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- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Borzou Ahmad
- Bose Suvadeep
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Brito Lucas
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brom Jean-Marie
- Brona Grzegorz
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
- Bunichev Viacheslav
- Bunin Pavel
- Bunkowski Karol
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- Wissing Christoph
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- Xiao Meng
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- Xie Wei
- Xin Yongjie
- Xu Lingshan
- Xu Qiao
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Mingming
- Yang Yong
- Yang Yu Chul
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Jinzhong
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zolkapli Zukhaimira
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Search for anomalous couplings in boosted WW/WZ -> l nu q(q)over-bar production in proton-proton collisions at root s=8TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akbiyik Melike
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amin Nick
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
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- Northup Michael
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- Smith Dominic
- Smith Geoffrey
- Smith John
- Smith Nicholas
- Smith Vincent J
- Smith Wesley H
- Snigirev Alexander
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- Tonelli Manganote Edmilson José
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- Wickramage Nadeesha
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- Williams Thomas
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- Wimpenny Stephen
- Winer Brian L
- Winn Dave
- Wissing Christoph
- Wittich Peter
- Wolf Matthias
- Wolf Roger
- Wolfe Evan
- Wood Darien
- Wood John
- Woodard Anna
- Woods Nathaniel
- Wright Douglas
- Wright Jack
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- Wu Zhenbin
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Wöhrmann Clemens
- Würthwein Frank
- Xia Fan
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- Yagil Avraham
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- Yazgan Efe
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- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
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- You Can
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- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zykunov Vladimir
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Peer reviewe
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
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- Alford C
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- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
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- Amundson A
- Andersen K
- Andersen M
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- Anderson G
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- Andersson H
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- Andresen D
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- Appel Kf
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Complement C1q and C3 Are Critical for the Innate Immune Response to Streptococcus pneumoniae
- Author
- Publication venue
- 'The American Association of Immunologists'
- Publication date
- Field of study
- …