34 research outputs found
Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death
- Author
- A Eilers
- A Nishiyama
- A Wyttenbach
- B Conradt
- CG Besirli
- D Lindholm
- DG Breckenridge
- DP Martin
- E Junn
- E Towers
- EA Lipscomb
- EV Maytin
- Francesca Menghi
- GK Smyth
- GV Putcha
- GV Putcha
- H Puthalakath
- H Zinszner
- I Lassot
- J Gilley
- J Ham
- J Nordberg
- J Whitfield
- J Whitfield
- J Whitfield
- J Yuan
- JL Franklin
- Jonathan Ham
- K Imaizumi
- K Mayumi-Matsuda
- K Virdee
- K Wartiovaara
- KJ Livak
- KM Wright
- KZ Guyton
- M Deshmukh
- M Kristiansen
- M Mota
- M Palmada
- Mark Kristiansen
- MD Jacobson
- MI Smith
- Mike Hubank
- MJ Prieto-Alamo
- N Ohoka
- N Schreiber-Agus
- O Delpuech
- R Hughes
- R Hughes
- RA Kirkland
- Rosie Hughes
- RR Buss
- RS Freeman
- RV Rao
- RW Oppenheim
- S Desagher
- S Estus
- S Kojima
- S Schlisio
- SJ Neame
- SN Edwards
- T Bishop
- T Gotoh
- TC Harding
- TL Deckwerth
- W Huang da
- WB Jacobs
- X Jiang
- Z Galehdar
- Z Xu
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Developing sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis after NGF withdrawal. This process requires de novo gene expression but only a small number of genes induced by NGF deprivation have been identified so far, either by a candidate gene approach or in mRNA differential display experiments. This is partly because it is difficult to obtain large numbers of sympathetic neurons for in vitro studies. Here, we describe for the first time, how advances in gene microarray technology have allowed us to investigate the expression of all known genes in sympathetic neurons cultured in the presence and absence of NGF
Lipids modulate the conformational dynamics of a secondary multidrug transporter
- Author
- A Laganowsky
- AG Lee
- AG Lee
- AJ Driessen
- Albert Konijnenberg
- AM Powl
- AM Powl
- Aurélie Roth
- B Bibal
- B Gbaguidi
- B Webb
- C Bechara
- C Hunte
- C Koshy
- C Lange
- C Pliotas
- CA Shintre
- CC Chen
- Chloé Martens
- Cédric Govaerts
- D Jiang
- DP Claxton
- EF Pettersen
- EG Bligh
- F Lanucara
- F Sobott
- Frank Sobott
- FX Contreras
- G Fernandez-Ballester
- G Heijne
- G Jeschke
- G Jeschke
- G Jeschke
- G Khelashvili
- G Khelashvili
- GW Kaatz
- H Bolhuis
- H Nury
- H Vitrac
- Hassane S Mchaourab
- I Mierau
- IG Denisov
- IT Paulsen
- JD Thompson
- JF Ellena
- JJ Ruprecht
- JN Sachs
- K Adamberg
- L Guan
- M Kates
- M Masureel
- M Pannier
- M Putman
- M Putman
- M Putman
- M Putman
- M Zhou
- MA Hanson
- Matthieu Masureel
- MF Lensink
- MM Gottesman
- N Fluman
- P Hakizimana
- P Mazurkiewicz
- P Zou
- PJ Hamilton
- PR Steed
- R Dawaliby
- R Phillips
- RA Stein
- Richard A Stein
- Rosie Dawaliby
- RS Cantor
- S Brandon
- S Dang
- S Mishra
- S Pöyry
- S Schuldiner
- SJ Singer
- Smriti Mishra
- SS Pao
- T Boldog
- TA Schaedler
- TH Bayburt
- TH Haines
- TH Haines
- W Dowhan
- Y Yin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Direct interactions with lipids have emerged as key determinants of the folding, structure and function of membrane proteins, but an understanding of how lipids modulate protein dynamics is still lacking. Here, we systematically explored the effects of lipids on the conformational dynamics of the proton-powered multidrug transporter LmrP from Lactococcus lactis, using the pattern of distances between spin-label pairs previously shown to report on alternating access of the protein. We uncovered, at the molecular level, how the lipid headgroups shape the conformational-energy landscape of the transporter. The model emerging from our data suggests a direct interaction between lipid headgroups and a conserved motif of charged residues that control the conformational equilibrium through an interplay of electrostatic interactions within the protein. Together, our data lay the foundation for a comprehensive model of secondary multidrug transport in lipid bilayers
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
- Author
- Allison Sarah
- Anderson Matthew
- Asghari Ray
- Ashworth Alan
- Bailey Peter
- Bailey Peter J.
- Bailey Peter J.
- Bailey Ulla-maja
- Bailey Ulla-maja
- Bajrami Ilirjana
- Balkwill Frances
- Ballal Mo
- Barbour Andrew P.
- Barry Simon T.
- Bassi Claudio
- Beer Phillip
- Beghelli Stefania
- Beilin Maria
- Beraldi Dario
- Biankin Andrew V.
- Biankin Andrew V.
- Biankin Andrew V.
- Biankin Andrew V.
- Biankin Andrew V.
- Biobank Victorian Cancer
- Brancato Mary-anne L.
- Brooke-smith Mark E.
- Brough Rachel
- Brunton Holly
- Brunton Holly
- Bruxner Tim
- Caligiuri Giuseppina
- Caligiuri Giuseppina
- Cameron Euan
- Candido Juliana
- Chai Ming
- Chang David K.
- Chang David K.
- Chang David K.
- Chang David K.
- Chang David K.
- Chantrill Lorraine A.
- Chen John
- Chiang Amy
- Chin Venessa T.
- Chou Angela
- Christ Angelika
- Christophi Christopher
- Cloonan Nicole
- Clouston Andrew D.
- Cooke Susanna L.
- Cooke Susanna L.
- Cooper Caroline L.
- Corbo Vincenzo
- Cosman Peter H.
- Cowley Mark J.
- Crawford Howard C.
- Crawford Michael
- Cunningham Richard
- Cunningham Richard
- Daly Roger J.
- Das Amitabha
- Deboer Bastiaan
- Debrencini Tamara
- Dipietro Renee
- Dray Eloise
- Dreyer Stephan
- Dreyer Stephan B.
- Duthie Fraser
- Duthie Fraser
- Dziubinski Michele L.
- Epari Krishna P.
- Eshleman James R.
- Evers Lisa
- Evers Lisa
- Fawcett Jonathan W.
- Feeney Kynan
- Fink J. Lynn
- Fletcher David R.
- Forest Cindy
- Frame Margaret C.
- Froeling Fieke E.m.
- Gallagher James
- Galluzzo Zachary
- Gill Anthony J.
- Giry-laterriere Marc
- Gongora Milena
- Graham Janet S.
- Graham Janet S.
- Grimmond Sean M.
- Grimmond Sean M.
- Grimwood Paul
- Grützmann Robert
- Gulati Aditi
- Guminski Alex
- Hair Jane
- Harliwong Ivon
- Hatzifotis Michael
- Hodgin Mary
- Hodgkinson Peter
- Holmes Oliver
- Hruban Ralph H.
- Humphris Jeremy L.
- Iacobuzio-donahue Christine A.
- Idrisoglu Senel
- Ismail Kasim
- James Virginia
- Jamieson Nigel B.
- Jamieson Nigel B.
- Jamieson Nigel B.
- Jamieson Nigel B.
- Johns Amber
- Johns Amber L.
- Jones Marc
- Jones Marc D.
- Jones Marc D.
- Jones Marc D.
- Joseph David
- Kassahn Karin S.
- Kazakoff Stephen
- Kelly Shane
- Kench James G.
- Krisnan Keerthana
- Lam Vincent W.
- Lampraki Eirini-maria
- Lampraki Eirini-maria
- Lawlor Rita T.
- Laycock Andrew
- Lee Hong Ching
- Leonard Conrad
- Lord Chris
- Maitra Anirban
- Manning Suzanne
- Marshall John
- Martin Patrick
- Martin Sancha
- Martyn-smith Mona
- Mawson Amanda
- Mcdade Brian
- Mcelroy Daniel
- Mcgregor Grant A.
- Mckay Colin J.
- Mckay Colin J.
- Mcleod Duncan
- Mead R. Scott
- Merrett Neil D.
- Miller David K.
- Moran-jones Kim
- Morgan Richard A.
- Morton Jennifer P.
- Mountain Angela
- Mukhedkar Sanjay
- Mukhopadhyay Debabrata
- Musgrove Elizabeth A.
- Musgrove Elizabeth A.
- Musgrove Elizabeth A.
- Musgrove Elizabeth A.
- Nagaraj Shivashankar
- Nagrial Adnan M.
- Newell Felicity
- Nguyen Nan Q.
- Nikfarjam Mehrdad
- Nones Katia
- Nourbakhsh Ehsan
- Nourse Craig
- Nourse Craig
- Nourse Craig
- Nourse Craig
- Oien Karin
- O’connnor Chelsie
- O’rourke Thomas J.
- Pajic Marina
- Pajic Marina
- Papangelis Virginia
- Paris Clara
- Patch Ann-marie
- Paulus-hock Viola
- Paulus-hock Viola
- Pavey Darren
- Pavlakis Nick
- Pearson John V.
- Petersen Gloria M.
- Pettit Jessica
- Pettitt Stephan
- Pilarsky Christian
- Pinese Mark
- Pinho Andreia V.
- Pleass Henry C.
- Plenker Dennis
- Quek Kelly
- Quinn Michael
- Rahib Lola
- Rahib Lola
- Ramsay Donna
- Rebus Selma
- Rebus Selma
- Richardson Arthur
- Rooman Ilse
- Rowe Sarah J.
- Ruszkiewicz Andrew R.
- Samra Jaswinder S.
- Sandroussi Charbel
- Sansom Owen J.
- Scardoni Maria
- Scarlett Christopher J.
- Scarpa Aldo
- Schulick Richard D.
- Serrels Bryan
- Serrels Bryan
- Simeone Diane M.
- Simpson Skye H.
- Slater Kellee
- Song Sarah
- Spry Nigel A.
- Steinmann Angela
- Sutherland Robert L.
- Tan Chuan P.
- Tang Henry
- Tao Jiang
- Taylor Darrin
- Tempero Margaret A.
- Tesson Mathias
- Texler Michael
- Thomas Michelle T.
- Toon Christopher
- Tuveson David A.
- Upstill-goddard Rosie
- Upstill-goddard Rosie
- Waddell Nick
- Waddell Nicola
- Wani Shivangi
- Watson Clare
- Westwood Paul
- Williams Nicola
- Wilson Peter J.
- Wolfgang Christopher L.
- Wong Rachel
- Wood David
- Wood Scott
- Worthley Chris
- Wright Derek W.
- Wright Derek W.
- Wu Jianmin
- Xu Christina
- Yeung Shinn
- Zeps Nikolajs
- Publication venue
- 'Elsevier BV'
- Publication date
- 08/10/2020
- Field of study
Background and aims:
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC.
Methods:
We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids.
Results:
Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, co-segregates with response to platinum (P < 0.001) and PARP inhibitor therapy (P < 0.001) in vitro and in vivo. We generated a novel signature of replication stress with which predicts response to ATR (P < 0.018) and WEE1 inhibitor (P < 0.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P < 0.001) but not associated with DDR deficiency.
Conclusions:
Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR proficient PC, and post-platinum therapy
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- Mérida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson Siân M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
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- Sutherland Grant R.
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- Trani Lee
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- Wright Rita A.
- Wu Chungen
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- Wu Xiaojing
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- Wycoff-Montenegro Melissa
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- Xi Yingying
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- Yada Tetsushi
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- Yakub Syed
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- Zeng Yixin
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
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- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
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- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D.
- Bata Iqbal
- Batieha Anwar M.
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benchekor Sounnia Mediene
- Benet Mikhail
- Bennett James E.
- Bennett James E.
- Benson Lowell S.
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bettiol Heloisa
- Bezerra Jorge
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- Bhargava Santosh K.
- Bia Daniel
- Biasch Katia
- Bikbov Mukharram M.
- Bista Bihungum
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Bjorkelund Cecilia
- Bloch Katia V.
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
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- Boissonnet Carlos P.
- Bojesen Stig E.
- Boker Lital Keinan
- Bonet Gorbea Mariano
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Boyer Christopher B.
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Jürgen
- Brenner Hermann
- Brewster Lizzy M.
- Briceno Yajaira
- Brito Miguel
- Bruno Graziella
- Bueno Gloria
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cabrera de Leon Antonio
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cameron Christine
- Can Gunay
- Candido Ana Paula C.
- Capanzana Mario V.
- Capkova Nadezda
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carrillo-Larco Rodrigo M.
- Carvalho Joana
- Casanueva Felipe F.
- Censi Laura
- Cervantes-Loaiza Marvin
- Chadjigeorgiou Charalambos A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nish
- Chee Miao Li
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chien Kuo-Liong
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
- Cifkova Renata
- Cinteza Eliza
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Concin Hans
- Cooper Cyrus
- Coppinger Tara C.
- Cordeiro da Silva Bruna Goncalves
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J.
- Cowell Chris
- Craig Cora L.
- Crampin Amelia C.
- Crujeiras Ana B.
- Cruz Juan J.
- Csilla Semanova
- Cui Liufu
- Cureau Felipe V.
- Cuschieri Sarah
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Damasceno Albertino
- Danaei Goodarz
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Moura Silva Caroline Ramos
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Smedt Delphine
- de Wit Tobias F. Rinke
- Deepa Mohan
- Deev Alexander D.
- DeGennaro Vincent Jr
- Dekkaki Imane Cherkaoui
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Demarest Stefaan
- Dennison Elaine
- Deschamps Valerie
- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T.
- Dika Zivka
- Dinc Gonul Horasan
- Djalalinia Shirin
- Do Ha T. P.
- Dobson Annette J.
- Doering Angela
- Doerr Marcus
- Donfrancesco Chiara
- Donoso Silvana P.
- Dorobantu Maria
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A.
- Duboz Priscilla
- Duda Rosemary B.
- Dulskiene Virginija
- Dushpanova Anar
- Dzakula Aleksandar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Eftekhar Ebrahim
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elisa Zapata Maria
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T.
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G.
- Escobedo-de la Pena Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A.
- Fall Caroline H.
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix Stephan B.
- Felix-Redondo Francisco J.
- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M.
- Ferreccio Catterina
- Ferreira Haroldo S.
- Ferrer Eldridge
- Ferrieres Jean
- Figueiro Thamara Hubler
- Fink Gunther
- Fischer Krista
- Foo Leng Huat
- Forsner Maria
- Fouad Heba M.
- Francis Damian K.
- Franco Maria do Carmo
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furer Ariel
- Furusawa Takuro
- Gaciong Zbigniew
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garcia Pablo
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gazzinelli Andrea
- Gehring Ulrike
- Geleijnse Johanna M.
- George Ronnie
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Ghimire Anup
- Gialluisi Alessandro
- Giampaoli Simona
- Gieger Christian
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Glavic Mihalea Marinovic
- Goldberg Marcel
- Goldsmith Rebecca A.
- Gomes Barros Mauro Virgilio
- Gomez Luis F.
- Gomula Aleksandra
- Goncalves Helen
- Goncalves Mauer
- Gonzalez Angel R.
- Gonzalez-Chica David A.
- Gonzalez-Gross Marcela
- Gonzalez-Rivas Juan P.
- Gonzalez-Villalpando Clicerio
- Gonzalez-Villalpando Maria-Elena
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregg Edward W.
- Gregor Ronald D.
- Grodzicki Tomasz
- Grosso Giuseppe
- Gruden Gabriella
- Gu Dongfeng
- Guan Ong Peng
- Gudmundsson Elias F.
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L.
- Gulliford Martin C.
- Gunnlaugsdottir Johanna
- Gunter Marc J.
- Gupta Prakash C.
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Ha Seongjun
- Hadaegh Farzad
- Haghshenas Rosa
- Hakimi Hamid
- Halkjaer Jytte
- Hambleton Ian R.
- Hamzeh Behrooz
- Hange Dominique
- Hanif Abu A. M.
- Hantunen Sari
- Hao Jie
- Hardman Carla Meneses
- Hashemi-Shahri Seyed Mohammad
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J.
- He Jiang
- He Jiang
- He Yuna
- Heier Margit
- Hendriks Marleen Elisabeth
- Henrique Rafael dos Santos
- Henriques Ana
- Herrala Sauli
- Heshmat Ramin
- Hill Allan G.
- Ho Sai Yin
- Ho Suzanne C.
- Hoang Van Minh Hoang Van Minh
- Hobbs Michael
- Holdsworth Michelle
- Homayounfar Reza
- Horimoto Andrea R. V. R.
- Hormiga Claudia M.
- Horta Bernardo L.
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huiart Laetitia
- Huisman Martijn
- Husseini Abdullatif S.
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G.
- Ibrahim Mohsen M.
- Ikeda Nayu
- Ikeda Nayu
- Ikram M. Arfan
- Iotova Violeta
- Irazola Vilma E.
- Ishida Takafumi
- Isiguzo Godsent C.
- Islam Muhammad
- Islam Sheikh Mohammed Shariful
- Iurilli Maria L. C.
- Iwasaki Masanori
- Jackson Rod T.
- Jacobs Jeremy M.
- Jaddou Hashem Y.
- Jafar Tazeen
- James Kenneth
- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
- Jerome Charles Sossa
- Jha Anjani Kumar
- Jiang Chao Qiang
- Jimenez Ramon O.
- Joeckel Karl-Heinz
- Joffres Michel
- Johansson Mattias
- Jokelainen Jari J.
- Jonas Jost B.
- Jorgensen Torben
- Jose Tormo Maria
- Joshi Pradeep
- Joukar Farahnaz
- Jozwiak Jacek
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Kaaks Rudolf
- Kafatos Anthony
- Kajantie Eero O.
- Kalmatayeva Zhanna
- Kalpourtzi Natasa
- Kalter-Leibovici Ofra
- Kampmann Freja B.
- Kannan Srinivasan
- Karaglani Eva
- Karhus Line L.
- Karki Khem B.
- Katibeh Marzieh
- Katz Joanne
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
- Kazakbaeva Gyulli M.
- Keil Ulrich
- Keinanen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kemper Han C. G.
- Kengne Andre P.
- Kengne Andre P.
- Keramati Maryam
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khang Young-Ho
- Khanh Le Nguyen Bao Khanh Le Nguyen Bao
- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Dong Wook
- Kim Hyeon Chang
- Kim Hyeon Chang
- Kim Jeongseon
- Klakk Heidi
- Klimek Magdalena
- Klumbiene Jurate
- Knoflach Michael
- Kolle Elin
- Kolsteren Patrick
- Kontto Jukka P.
- Korpelainen Raija
- Korrovits Paul
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kowlessur Sudhir
- Koziel Slawomir
- Kratenova Jana
- Kriaucioniene Vilma
- Kristensen Peter Lund
- Krokstad Steiner
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kujala Urho M.
- Kulaga Zbigniew
- Kumar R. Krishna
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- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kutsenko Vladimir
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laxmaiah Avula
- Laxmaiah Avula
- Le Coroller Gwenaelle
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lehmann Nils
- Lehtimaki Terho
- Lele Elysee Claude Bika
- Lemogoum Daniel
- Levitt Naomi S.
- Lhoste Victor P. F.
- Li Yanping
- Lilly Christa L.
- Lim Wei-Yen
- Lima-Costa M. Fernanda
- Lin Hsien-Ho
- Lin Hsien-Ho
- Lin Xu
- Lin Yi-Ting
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- Quang Ngoc Nguyen Quang Ngoc Nguyen
- Queiroz Daniel
- Radic Ivana
- Radisauskas Ricardas
- Rahim Hanan F. Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Raitakari Olli
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- Rampal Lekhraj
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- Safi Sare
- Safiri Saeid
- Saidi Olfa
- Sakarya Sibel
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- Salanave Benoit
- Salazar Martinez Eduardo
- Salmeron Diego
- Salomaa Veikko
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- Schoettker Ben
- Schramm Sara
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- Shamshirgaran Morteza
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- Sharafkhah Maryam
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- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shirani Majid
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- Shrestha Namuna
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- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Simon Mary
- Simons Judith
- Simons Leon A.
- Singleton Rosie K.
- Sjostrom Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobngwi Eugene
- Soderberg Stefan
- Soemantri Agustinus
- Sofat Reecha
- Solfrizzi Vincenzo
- Solomon Bethlehem
- Somi Mohammad Hossein
- Son Thai Pham Son Thai Pham
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K.
- Sorensen Thorkild I. A.
- Sorgjerd Elin P.
- Soric Maroje
- Soumare Aicha
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Staessen Jan A.
- Starc Gregor
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D.
- Stergiou George S.
- Stessman Jochanan
- Stevens Gretchen A.
- Stieber Jutta
- Stocks Tanja
- Stoeckl Doris
- Stokwiszewski Jakub
- Stronks Karien
- Strufaldi Maria Wany
- Suka Machi
- Sun Chien-An
- Sundstrom Johan
- Sundstrom Johan
- Sung Yn-Tz
- Suriyawongpaisal Paibul
- Sy Rody G.
- Syddall Holly E.
- Sylva Rene Charles
- Szklo Moyses
- Tai E. Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H.
- Timmermans Erik J.
- Tjandrarini Dwi H.
- Tjonneland Anne
- Toft Ulla
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topor-Madry Roman
- Tornaritis Michael J.
- Torrent Maties
- Torres-Collado Laura
- Touloumi Giota
- Traissac Pierre
- Tran Quoc Bao Tran Quoc Bao
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M.
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu M. T.
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M.
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T.
- Van Herck Koen
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- van Zutphen Elisabeth M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K.
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren W. M. Monique
- Verstraeten Roosmarijn
- Victora Cesar G.
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Walton Janette
- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. FUNDING: WHO
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinovic Maja
- Bandosz Piotr
- Banegas Jose R.
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Baran Joanna
- Barbagallo Carlo M.
- Barcelo Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio J. D.
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D.
- Bata Iqbal
- Batieha Anwar M.
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benchekor Sounnia Mediene
- Benet Mikhail
- Bennett James E.
- Bennett James E.
- Benson Lowell S.
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bettiol Heloisa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bhargava Santosh K.
- Bia Daniel
- Biasch Katia
- Bikbov Mukharram M.
- Bista Bihungum
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Bjorkelund Cecilia
- Bloch Katia V.
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
- Boggia Jose G.
- Boissonnet Carlos P.
- Bojesen Stig E.
- Boker Lital Keinan
- Bonet Gorbea Mariano
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Boyer Christopher B.
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M.
- Briceno Yajaira
- Brito Miguel
- Bruno Graziella
- Bueno Gloria
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cabrera de Leon Antonio
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cameron Christine
- Can Gunay
- Candido Ana Paula C.
- Capanzana Mario V.
- Capkova Nadezda
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carrillo-Larco Rodrigo M.
- Carvalho Joana
- Casanueva Felipe F.
- Censi Laura
- Cervantes-Loaiza Marvin
- Chadjigeorgiou Charalambos A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nish
- Chee Miao Li
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chien Kuo-Liong
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G.
- Chudek Jerzy
- Cifkova Renata
- Cifkova Renata
- Cinteza Eliza
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Collaboration NCD Risk Factor
- Concin Hans
- Cooper Cyrus
- Coppinger Tara C.
- Cordeiro da Silva Bruna Goncalves
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J.
- Cowell Chris
- Craig Cora L.
- Crampin Amelia C.
- Crujeiras Ana B.
- Cruz Juan J.
- Csilla Semanova
- Cui Liufu
- Cureau Felipe V.
- Cuschieri Sarah
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Damasceno Albertino
- Danaei Goodarz
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M.
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Moura Silva Caroline Ramos
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Smedt Delphine
- de Wit Tobias F. Rinke
- Deepa Mohan
- Deev Alexander D.
- DeGennaro Vincent Jr
- Dekkaki Imane Cherkaoui
- del Cristo Rodriguez-Perez Maria
- Delisle Helene
- Demarest Stefaan
- Dennison Elaine
- Deschamps Valerie
- Dhimal Meghnath
- Di Castelnuovo Augusto F.
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T.
- Dika Zivka
- Dinc Gonul Horasan
- Djalalinia Shirin
- Do Ha T. P.
- Dobson Annette J.
- Doering Angela
- Doerr Marcus
- Donfrancesco Chiara
- Donoso Silvana P.
- Dorobantu Maria
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A.
- Duboz Priscilla
- Duda Rosemary B.
- Dulskiene Virginija
- Dushpanova Anar
- Dzakula Aleksandar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Eftekhar Ebrahim
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elisa Zapata Maria
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T.
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G.
- Escobedo-de la Pena Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A.
- Fall Caroline H.
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix Stephan B.
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- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M.
- Ferreccio Catterina
- Ferreira Haroldo S.
- Ferrer Eldridge
- Ferrieres Jean
- Figueiro Thamara Hubler
- Fink Gunther
- Fischer Krista
- Foo Leng Huat
- Forsner Maria
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- Francis Damian K.
- Franco Maria do Carmo
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furer Ariel
- Furusawa Takuro
- Gaciong Zbigniew
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garcia Pablo
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
- Gazzinelli Andrea
- Gehring Ulrike
- Geleijnse Johanna M.
- George Ronnie
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Ghimire Anup
- Gialluisi Alessandro
- Giampaoli Simona
- Gieger Christian
- Gill Tiffany K.
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Glavic Mihalea Marinovic
- Goldberg Marcel
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- Gomez Luis F.
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- Goncalves Helen
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- Gonzalez Angel R.
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- Gonzalez-Villalpando Clicerio
- Gonzalez-Villalpando Maria-Elena
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- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregg Edward W.
- Gregor Ronald D.
- Grodzicki Tomasz
- Grosso Giuseppe
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- Gutierrez Laura
- Gutzwiller Felix
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- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huiart Laetitia
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- Huybrechts Inge
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- Iacoviello Licia
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- Janszky Imre
- Janus Edward
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
- Jerome Charles Sossa
- Jha Anjani Kumar
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- Jozwiak Jacek
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Kaaks Rudolf
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- Kalmatayeva Zhanna
- Kalpourtzi Natasa
- Kalter-Leibovici Ofra
- Kampmann Freja B.
- Kannan Srinivasan
- Karaglani Eva
- Karhus Line L.
- Karki Khem B.
- Katibeh Marzieh
- Katz Joanne
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
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- Keil Ulrich
- Keinanen-Kiukaanniemi Sirkka
- Kelishadi Roya
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- Keramati Maryam
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khang Young-Ho
- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Dong Wook
- Kim Hyeon Chang
- Kim Hyeon Chang
- Kim Jeongseon
- Klakk Heidi
- Klimek Magdalena
- Klumbiene Jurate
- Knoflach Michael
- Kolle Elin
- Kolsteren Patrick
- Kontto Jukka P.
- Korpelainen Raija
- Korrovits Paul
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kowlessur Sudhir
- Koziel Slawomir
- Kratenova Jana
- Kriaucioniene Vilma
- Kristensen Peter Lund
- Krokstad Steiner
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kujala Urho M.
- Kulaga Zbigniew
- Kumar R. Krishna
- Kumar Rachakulla Hari
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kutsenko Vladimir
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laxmaiah Avula
- Laxmaiah Avula
- Le Coroller Gwenaelle
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lehmann Nils
- Lehtimaki Terho
- Lele Elysee Claude Bika
- Lemogoum Daniel
- Levitt Naomi S.
- Lhoste Victor P. F.
- Li Yanping
- Lilly Christa L.
- Lim Wei-Yen
- Lima-Costa M. Fernanda
- Lin Hsien-Ho
- Lin Hsien-Ho
- Lin Xu
- Lin Yi-Ting
- Lind Lars
- Lingam Vijaya
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Lo Wei-Cheng
- Loit Helle-Mai
- Lopez Tania
- Lopez-Garcia Esther
- Lotufo Paulo A.
- Lovrencic Iva Lukacevic
- Lozano Jose Eugenio
- Lukrafka Janice L.
- Luksiene Dalia
- Lundqvist Annamari
- Lundqvist Robert
- Lunet Nuno
- Lustigova Michala
- Luszczki Edyta
- Ma Guansheng
- Ma Jun
- Machado-Coelho George L. L.
- Machado-Rodrigues Aristides M.
- Macia Enguerran
- Macieira Luisa M.
- Madar Ahmed A.
- Maggi Stefania
- Magliano Dianna J.
- Magriplis Emmanuella
- Mahasampath Gowri
- Maire Bernard
- Majer Marjeta
- Makdisse Marcia
- Malekzadeh Fatemeh
- Malekzadeh Reza
- Malhotra Rahul
- Mallikharjuna Kodavanti
- Malyutina Sofia K.
- Maniego Lynell V.
- Manios Yannis
- Mann Jim I.
- Mansour-Ghanaei Fariborz
- Manzato Enzo
- Marcil Anie
- Margozzini Maira Paula
- Margozzini Paula
- Marild Staffan B.
- Marques Larissa Pruner
- Marques-Vidal Pedro
- Marrugat Jaume
- Martorell Reynaldo
- Mascarenhas Luis P.
- Matasin Marija
- Mathiesen Ellisiv B.
- Mathur Prashant
- Matijasevich Alicia
- Matlosz Piotr
- Matsha Tandi E.
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- McFarlane Shelly R.
- McGarvey Stephen T.
- McLachlan Stela
- McLean Rachael M.
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- McNulty Breige A.
- Medzioniene Jurate
- Mehdipour Parinaz
- Mehlig Kirsten
- Mehrparvar Amir Houshang
- Meirhaeghe Aline
- Meisinger Christa
- Mendoza Montano Carlos
- Menezes Ana Maria B.
- Menon Geetha R.
- Mereke Alibek
- Meshram Indrapal I.
- Metspalu Andres
- Meyer Haakon E.
- Mi Jie
- Michels Nathalie
- Mikkel Kairit
- Milanovic Sanja Music
- Milkowska Karolina
- Miller Jody C.
- Minderico Claudia S.
- Minh Hoang Van
- Mini G. K.
- Miranda J. Jaime
- Miranda J. Jaime
- Mirjalili Mohammad Reza
- Mirrakhimov Erkin
- Misigoj-Durakovic Marjeta
- Modesti Pietro A.
- Moghaddam Sahar Saeedi
- Mohajer Bahram
- Mohamed Mostafa K.
- Mohamed Shukri F.
- Mohammad Kazem
- Mohammadi Mohammad Reza
- Mohammadi Zahra
- Mohammadifard Noushin
- Mohammadpourhodki Reza
- Mohamud Wan Nazaimoon Wan
- Mohan Viswanathan
- Mohanna Salim
- Mohebbi Iraj
- Mohebi Farnam
- Moitry Marie
- Mollehave Line T.
- Molnar Denes
- Momenan Amirabbas
- Mondo Charles K.
- Monterrubio-Flores Eric
- Monyeki Kotsedi Daniel K.
- Moon Jin Soo
- Moosazadeh Mahmood
- Moreira Leila B.
- Morejon Alain
- Moreno Luis A.
- Morgan Karen
- Moschonis George
- Mossakowska Malgorzata
- Mostafa Aya
- Mostafavi Seyed-Ali
- Mota Jorge
- Motlagh Mohammad Esmaeel
- Motta Jorge
- Mridha Malay K.
- Msyamboza Kelias P.
- Mu Thet Thet
- Muhihi Alfa J.
- Muiesan Maria L.
- Muller-Nurasyid Martina
- Murphy Neil
- Mursu Jaakko
- Musa Kamarul Imran
- Musil Vera
- Mustafa Norlaila
- Nabipour Iraj
- Naderimagham Shohreh
- Nagel Gabriele
- Naidu Balkish M.
- Najafi Farid
- Nakamura Harunobu
- Namesna Jana
- Nang Ei Ei K.
- Nangia Vinay B.
- Narake Sameer
- Ndiaye Ndeye Coumba
- Neal William A.
- Nejatizadeh Azim
- Nenko Ilona
- Neovius Martin
- Neuhauser Hannelore
- Neuhauser Hannelore K.
- Nguyen Chung T.
- Nguyen Nguyen D.
- Nguyen Quang Ngoc
- Nguyen Quang V.
- Nieto-Martinez Ramfis E.
- Niiranen Teemu J.
- Nikitin Yury P.
- Ninomiya Toshiharu
- Nishtar Sania
- Njelekela Marina A.
- Noale Marianna
- Noboa Oscar A.
- Noorbala Ahmad Ali
- Norat Teresa
- Nordendahl Maria
- Nordestgaard Borge G.
- Noto Davide
- Nowak-Szczepanska Natalia
- Nunes Baltazar
- O'Neill Terence W.
- O'Reilly Dermot
- Ochimana Caleb
- Oda Eiji
- Odili Augustine N.
- Oh Kyungwon
- Ohara Kumiko
- Ohtsuka Ryutaro
- Olie Valerie
- Olinto Maria Teresa A.
- Oliveira Isabel O.
- Omar Mohd Azahadi
- Onat Altan
- Ong Sok King
- Ono Lariane M.
- Ordunez Pedro
- Ornelas Rui
- Ortiz Pedro J.
- Osmond Clive
- Ostojic Sergej M.
- Ostovar Afshin
- Otero Johanna A.
- Overvad Kim
- Owusu-Dabo Ellis
- Paccaud Fred Michel
- Paciorek Christopher J.
- Padez Cristina
- Pahomova Elena
- Pajak Andrzej
- Palli Domenico
- Palmieri Luigi
- Pan Wen-Harn
- Panda-Jonas Songhomitra
- Panza Francesco
- Paoli Mariela
- Papandreou Dimitrios
- Park Soon-Woo
- Park Suyeon
- Parnell Winsome R.
- Parsaeian Mahboubeh
- Pasquet Patrick
- Patel Nikhil D.
- Pavlyshyn Halyna
- Pecin Ivan
- Pednekar Mangesh S.
- Pedro Joao M.
- Peer Nasheeta
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C.
- Peres Karen G. D. A.
- Peres Marco A.
- Peters Annette
- Petkeviciene Janina
- Peykari Niloofar
- Pham Son Thai
- Pichardo Rafael N.
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pitakaka Freda
- Piwonska Aleksandra
- Pizarro Andreia N.
- Plans-Rubio Pedro
- Polasek Ozren
- Porta Miquel
- Poudyal Anil
- Pourfarzi Farhad
- Pourshams Akram
- Poustchi Hossein
- Pradeepa Rajendra
- Price Alison J.
- Price Jacqueline F.
- Providencia Rui
- Puhakka Soile E.
- Puiu Maria
- Punab Margus
- Qasrawi Radwan F.
- Qorbani Mostafa
- Queiroz Daniel
- Radic Ivana
- Radisauskas Ricardas
- Rahim Hanan F. Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Raitakari Olli
- Raj Manu
- Rakhimova Ellina M.
- Ramachandran Ambady
- Ramos Elisabete
- Rampal Lekhraj
- Rampal Sanjay
- Rangel Reina Daniel A.
- Rao Sudha Ramachandra
- Rarra Vayia
- Rech Cassiano Ricardo
- Redon Josep
- Reganit Paul Ferdinand M.
- Regecova Valeria
- Revilla Luis
- Rezaianzadeh Abbas
- Ribeiro Robespierre
- Riboli Elio
- Richter Adrian
- Rigo Fernando
- Riley Leanne M.
- Ritti-Dias Raphael M.
- Robitaille Cynthia
- Rodriguez-Artalejo Fernando
- Rodriguez-Villamizar Laura A.
- Roggenbuck Ulla
- Rojas-Martinez Rosalba
- Romaguera Dora
- Romeo Elisabetta L.
- Rosengren Annika
- Roy Joel G. R.
- Rubinstein Adolfo
- Ruidavets Jean-Bernard
- Ruiz-Castell Maria
- Rusakova Iuliia A.
- Russo Paola
- Rutkowski Marcin
- Sabanayagam Charumathi
- Sabbaghi Hamideh
- Sachdev Harshpal S.
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saidi Olfa
- Sakarya Sibel
- Saki Nader
- Salanave Benoit
- Salazar Martinez Eduardo
- Salmeron Diego
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Sanchez-Abanto Jose
- Sandra Ruiz-Betancourt Blanca
- Sans Susana
- Santos Silva Diego Augusto
- Santos Diana A.
- Santos Ina S.
- Santos Lelita C.
- Santos Maria Paula
- Santos Rute
- Saramies Jouko L.
- Sardinha Luis B.
- Sarganas Giselle
- Sarrafzadegan Nizal
- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Sawada Norie
- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D.
- Schargrodsky Herman
- Schipf Sabine
- Schmidt Carsten O.
- Schnohr Peter
- Schoettker Ben
- Schramm Sara
- Schultsz Constance
- Schutte Aletta E.
- Sebert Sylvain
- Sein Aye Aye
- Sen Abhijit
- Senbanjo Idowu O.
- Sepanlou Sadaf G.
- Servais Jennifer
- Shalnova Svetlana A.
- Shamah-Levy Teresa
- Shamshirgaran Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shirani Majid
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Simon Mary
- Simons Judith
- Simons Leon A.
- Singleton Rosie K.
- Sjostrom Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobngwi Eugene
- Soderberg Stefan
- Soemantri Agustinus
- Sofat Reecha
- Solfrizzi Vincenzo
- Solomon Bethlehem
- Somi Mohammad Hossein
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K.
- Sorensen Thorkild I. A.
- Sorgjerd Elin P.
- Soric Maroje
- Soumare Aicha
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Staessen Jan A.
- Starc Gregor
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D.
- Stergiou George S.
- Stessman Jochanan
- Stevens Gretchen A.
- Stieber Jutta
- Stocks Tanja
- Stoeckl Doris
- Stokwiszewski Jakub
- Stronks Karien
- Strufaldi Maria Wany
- Suka Machi
- Sun Chien-An
- Sundstrom Johan
- Sundstrom Johan
- Sung Yn-Tz
- Suriyawongpaisal Paibul
- Sy Rody G.
- Syddall Holly E.
- Sylva Rene Charles
- Szklo Moyses
- Tai E. Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H.
- Timmermans Erik J.
- Tjandrarini Dwi H.
- Tjonneland Anne
- Toft Ulla
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topor-Madry Roman
- Tornaritis Michael J.
- Torrent Maties
- Torres-Collado Laura
- Touloumi Giota
- Traissac Pierre
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M.
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu M. T.
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M.
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T.
- Van Herck Koen
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- van Zutphen Elisabeth M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K.
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren W. M. Monique
- Verstraeten Roosmarijn
- Victora Cesar G.
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Walton Janette
- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/01/2021
- Field of study
Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. Copyright (C) 2021 World Health Organization; licensee Elsevier
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N.
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Andre Moura-dos-Santos Marcos
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
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- Rampal Lekhraj
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- Rao Sudha Ramachandra
- Rarra Vayia
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- Ribeiro Robespierre
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- Roggenbuck Ulla
- Rojas-Martinez Rosalba
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- Rubinstein Adolfo
- Ruidavets Jean-Bernard
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- Sabanayagam Charumathi
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- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saidi Olfa
- Sakarya Sibel
- Saki Nader
- Salanave Benoit
- Salazar Martinez Eduardo
- Salmeron Diego
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- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
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- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D.
- Schargrodsky Herman
- Schipf Sabine
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- Schnohr Peter
- Schoettker Ben
- Schramm Sara
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- Schutte Aletta E.
- Sebert Sylvain
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- Servais Jennifer
- Shalnova Svetlana A.
- Shamah-Levy Teresa
- Shamshirgaran Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shirani Majid
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Simon Mary
- Simons Judith
- Simons Leon A.
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- Sjostrom Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
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- Sobngwi Eugene
- Soderberg Stefan
- Soemantri Agustinus
- Sofat Reecha
- Solfrizzi Vincenzo
- Solomon Bethlehem
- Somi Mohammad Hossein
- Son Thai Pham Son Thai Pham
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K.
- Sorensen Thorkild I. A.
- Sorgjerd Elin P.
- Soric Maroje
- Soumare Aicha
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Staessen Jan A.
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- Stehle Peter
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- Stevens Gretchen A.
- Stieber Jutta
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- Stoeckl Doris
- Stokwiszewski Jakub
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- Suka Machi
- Sun Chien-An
- Sundstrom Johan
- Sundstrom Johan
- Sung Yn-Tz
- Suriyawongpaisal Paibul
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- Szklo Moyses
- Tai E. Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
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- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M.
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu M. T.
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M.
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- Van der Heyden Johan
- van der Schouw Yvonne T.
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- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- van Zutphen Elisabeth M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K.
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren W. M. Monique
- Verstraeten Roosmarijn
- Victora Cesar G.
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Walton Janette
- Wambiya Elvis O. A.
- Wanderley Junior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Widyahening Indah S.
- Wiecek Andrzej
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Woodward Mark
- Wu Frederick C.
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuniga Cisneros Julio
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background
Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.
Methods
We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age.
Findings
The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran.
Interpretation
Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A
- Abdul Rahim Hanan F
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmadizar Fariba
- Ahmed Soheir H
- Ahrens Wolfgang
- Ajlouni Kamel
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Aly Eman
- Amarapurkar Deepak N
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araújo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E
- Arlappa Nimmathota
- Aryal Krishna K
- Aspelund Thor
- Assah Felix K
- Assunção Maria Cecília F
- Auvinen Juha
- Avdićová Mária
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V
- Bahijri Suhad
- Balakrishna Nagalla
- Balanova Yulia
- Bamoshmoosh Mohamed
- Banach Maciej
- Banadinović Maja
- Bandosz Piotr
- Banegas José R
- Baran Joanna
- Barbagallo Carlo M
- Barceló Alberto
- Barkat Amina
- Barreto Marta
- Barros Aluisio JD
- Barros Mauro Virgílio Gomes
- Bartosiewicz Anna
- Basit Abdul
- Bastos Joao Luiz D
- Bata Iqbal
- Batieha Anwar M
- Batyrbek Assembekov
- Baur Louise A
- Beaglehole Robert
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benet Mikhail
- Bennett James E
- Benson Lowell S
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloísa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bhargava Santosh K
- Bia Daniel
- Biasch Katia
- Bika Lele Elysée Claude
- Bikbov Mukharram M
- Bista Bihungum
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B
- Björkelund Cecilia
- Bloch Katia V
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
- Boggia Jose G
- Boissonnet Carlos P
- Bojesen Stig E
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Boyer Christopher B
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M
- Briceño Yajaira
- Brito Miguel
- Bruno Graziella
- Bueno Gloria
- Bueno-de-Mesquita H Bas
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cabrera de León Antonio
- Cacciottolo Joseph
- Cameron Christine
- Can Günay
- Capanzana Mario V
- Capuano Eduardo
- Capuano Vincenzo
- Cardoso Viviane C
- Carlsson Axel C
- Carrillo-Larco Rodrigo M
- Carvalho Joana
- Casanueva Felipe F
- Censi Laura
- Cervantes-Loaiza Marvin
- Chadjigeorgiou Charalambos A
- Chamukuttan Snehalatha
- Chan Angelique W
- Chan Queenie
- Chaturvedi Himanshu K
- Chaturvedi Nish
- Chee Miao Li
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Cherkaoui Dekkaki Imane
- Chetrit Angela
- Chien Kuo-Liong
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque María-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G
- Chudek Jerzy
- Cifkova Renata
- Cinteza Eliza
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Concin Hans
- Cooper Cyrus
- Coppinger Tara C
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J
- Cowell Chris
- Craig Cora L
- Crampin Amelia C
- Crujeiras Ana B
- Cruz Juan J
- Csilla Semánová
- Cui Liufu
- Cureau Felipe V
- Cuschieri Sarah
- Cândido Ana Paula C
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- De Curtis Amalia
- de Gaetano Giovanni
- De Henauw Stefaan
- de Oliveira Paula Duarte
- De Ridder David
- De Smedt Delphine
- Deepa Mohan
- Deev Alexander D
- DeGennaro Vincent Jr
- Delisle Hélène
- Demarest Stefaan
- Dennison Elaine
- Deschamps Valérie
- Dhimal Meghnath
- Di Castelnuovo Augusto F
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T
- Dika Zivka
- Djalalinia Shirin
- Do Ha TP
- Dobson Annette J
- Donfrancesco Chiara
- Donoso Silvana P
- Dorobantu Maria
- Doua Kouamelan
- Dragano Nico
- Drygas Wojciech
- Duante Charmaine A
- Duboz Priscilla
- Duda Rosemary B
- Dulskiene Virginija
- Dushpanova Anar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Döring Angela
- Dörr Marcus
- Džakula Aleksandar
- Eddie Ricky
- Eftekhar Ebrahim
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G
- Escobedo-de la Peña Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A
- Fall Caroline H
- Faramarzi Elnaz
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- Farzadfar Farshad
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- Ferguson Trevor S
- Fernandes Romulo A
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- Ferrer Eldridge
- Ferrieres Jean
- Figueiró Thamara Hubler
- Fink Günther
- Fischer Krista
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- Forsner Maria
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- Francis Damian K
- Franco Maria do Carmo
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D
- Fuchs Sandra C
- Fujita Yuki
- Fumihiko Matsuda
- Furdela Viktoriya
- Furer Ariel
- Furusawa Takuro
- Gaciong Zbigniew
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galvano Fabio
- Gao Jingli
- Gao Pei
- Garcia Pablo
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P
- Gaspoz Jean-Michel
- Gasull Magda
- Gazzinelli Andrea
- Gehring Ulrike
- Geleijnse Johanna M
- George Ronnie
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Ghimire Anup
- Gialluisi Alessandro
- Giampaoli Simona
- Gieger Christian
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- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
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- Goldberg Marcel
- Goldsmith Rebecca A
- Gomez Luis F
- Gomula Aleksandra
- Gonzalez Angel R
- Gonzalez-Chica David A
- Gonzalez-Gross Marcela
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- González-Villalpando Clicerio
- González-Villalpando María-Elena
- Gonçalves Cordeiro da Silva Bruna
- Gonçalves Helen
- Gonçalves Mauer
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- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dušan
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- Grammatikopoulou Maria G
- Gregg Edward W
- Gregor Ronald D
- Grodzicki Tomasz
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- Gruden Gabriella
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- Gutzwiller Felix
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- Hadaegh Farzad
- Haghshenas Rosa
- Hakimi Hamid
- Halkjær Jytte
- Hambleton Ian R
- Hamzeh Behrooz
- Hange Dominique
- Hanif Abu AM
- Hantunen Sari
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- Iacoviello Licia
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- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
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- Landrove Orlando
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- Laxmaiah Avula
- Le Coroller Gwenaëlle
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- Meyer Haakon E
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- Mohanna Salim
- Mohd Yusoff Muhammad Fadhli
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- O'Reilly Dermot
- Ochimana Caleb
- Oda Eiji
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- Oliveira Isabel O
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- Padez Cristina
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- Paiva Karina Mary de
- Pająk Andrzej
- Palli Domenico
- Palmieri Luigi
- Pan Wen-Harn
- Panda-Jonas Songhomitra
- Panza Francesco
- Paoli Mariela
- Papandreou Dimitrios
- Park Soon-Woo
- Park Suyeon
- Parnell Winsome R
- Parsaeian Mahboubeh
- Pasquet Patrick
- Patel Nikhil D
- Pavlyshyn Halyna
- Pednekar Mangesh S
- Pedro João M
- Peer Nasheeta
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C
- Peres Karen GDA
- Peres Marco A
- Peters Annette
- Petkeviciene Janina
- Peykari Niloofar
- Pećin Ivan
- Pham Son Thai
- Pichardo Rafael N
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pitakaka Freda
- Piwonska Aleksandra
- Pizarro Andreia n
- Plans-Rubió Pedro
- Polašek Ozren
- Porta Miquel
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- Price Jacqueline F
- Providencia Rui
- Puhakka Soile E
- Puiu Maria
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- Qorbani Mostafa
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- Quoc Bao Tran
- Radisauskas Ricardas
- Radić Ivana
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Raitakari Olli
- Raj Manu
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- Ramachandra Rao Sudha
- Ramachandran Ambady
- Ramos Elisabete
- Rampal Lekhraj
- Rampal Sanjay
- Rangel Reina Daniel A
- Rarra Vayia
- Rech Cassiano Ricardo
- Redon Josep
- Reganit Paul Ferdinand M
- Regecová Valéria
- Revilla Luis
- Rezaianzadeh Abbas
- Ribeiro Robespierre
- Riboli Elio
- Richter Adrian
- Rigo Fernando
- Riley Leanne M
- Rinke de Wit Tobias F
- Ritti-Dias Raphael M
- Robitaille Cynthia
- Rodriguez-Perez María del Cristo
- Rodríguez-Artalejo Fernando
- Rodríguez-Villamizar Laura A
- Roggenbuck Ulla
- Rojas-Martinez Rosalba
- Romaguera Dora
- Romeo Elisabetta L
- Rosengren Annika
- Roy Joel GR
- Rubinstein Adolfo
- Ruidavets Jean-Bernard
- Ruiz-Betancourt Blanca Sandra
- Ruiz-Castell Maria
- Rusakova Iuliia A
- Russo Paola
- Rutkowski Marcin
- Sabanayagam Charumathi
- Sabbaghi Hamideh
- Sachdev Harshpal S
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saidi Olfa
- Sakarya Sibel
- Saki Nader
- Salanave Benoit
- Salazar Martinez Eduardo
- Salmerón Diego
- Salomaa Veikko
- Salonen Jukka T
- Salvetti Massimo
- Sans Susana
- Santos Diana A
- Santos Ina S
- Santos Lèlita C
- Santos Maria Paula
- Santos Rute
- Saramies Jouko L
- Sardinha Luis B
- Sarganas Giselle
- Sarrafzadegan Nizal
- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Sawada Norie
- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D
- Schargrodsky Herman
- Schipf Sabine
- Schmidt Carsten O
- Schnohr Peter
- Schramm Sara
- Schultsz Constance
- Schutte Aletta E
- Schöttker Ben
- Sebert Sylvain
- Sein Aye Aye
- Sen Abhijit
- Senbanjo Idowu O
- Sepanlou Sadaf G
- Servais Jennifer
- Shalnova Svetlana A
- Shamah-Levy Teresa
- Shamshirgaran Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K
- Shaw Jonathan E
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shirani Majid
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M
- Silva Caroline Ramos de Moura
- Silva Diego Augusto Santos
- Simon Mary
- Simons Judith
- Simons Leon A
- Singleton Rosie K
- Sjöström Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobngwi Eugène
- Soemantri Agustinus
- Sofat Reecha
- Solfrizzi Vincenzo
- Solomon Bethlehem
- Somi Mohammad Hossein
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K
- Sorić Maroje
- Sossa Jérome Charles
- Soumaré Aïcha
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Staessen Jan A
- Starc Gregor
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D
- Stergiou George S
- Stessman Jochanan
- Stevens Gretchen A
- Stieber Jutta
- Stocks Tanja
- Stokwiszewski Jakub
- Stronks Karien
- Strufaldi Maria Wany
- Stöckl Doris
- Suka Machi
- Sun Chien-An
- Sundström Johan
- Sung Yn-Tz
- Suriyawongpaisal Paibul
- Sy Rody G
- Syddall Holly E
- Sylva René Charles
- Szklo Moyses
- Sánchez-Abanto Jose
- Söderberg Stefan
- Sørensen Thorkild IA
- Sørgjerd Elin P
- Tai E Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarqui-Mamani Carolina B
- Taylor Anne
- Taylor Julie
- Tebar William R
- Tell Grethe S
- Tello Tania
- Tham Yih Chung
- Thankappan KR
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thinggaard Mikael
- Thomas Nihal
- Thorand Barbara
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- Timmermans Erik J
- Tjandrarini Dwi H
- Tjonneland Anne
- Toft Ulla
- Tolonen Hanna K
- Tolstrup Janne S
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- Topór-Madry Roman
- Tormo María José
- Tornaritis Michael J
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- Torres-Collado Laura
- Touloumi Giota
- Traissac Pierre
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh TH
- Trivedi Atul
- Tshepo Lechaba
- Tsugane Shoichiro
- Tuliakova Azaliia M
- Tulloch-Reid Marshall K
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L
- Twig Gilad
- Tynelius Per
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ulmer Hanno
- Uusitalo Hannu MT
- Valdivia Gonzalo
- Valvi Damaskini
- van Dam Rob M
- van den Born Bert-Jan
- Van der Heyden Johan
- van der Schouw Yvonne T
- Van Herck Koen
- Van Minh Hoang
- Van Schoor Natasja M
- van Valkengoed Irene GM
- van Zutphen Elisabeth M
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varghese Cherian
- Vasan Senthil K
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Veronesi Giovanni
- Verschuren WM Monique
- Verstraeten Roosmarijn
- Victora Cesar G
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Voutilainen Ari
- Wade Alisha N
- Walton Janette
- Wambiya Elvis OA
- Wan Bebakar Wan Mohamad
- Wan Mohamud Wan Nazaimoon
- Wanderley Júnior Rildo de Souza
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S Goya
- Wareham Nicholas
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H
- Widhalm Kurt
- Widyahening Indah S
- Wiecek Andrzej
- Wilks Rainford J
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Tien Yin
- Wong-McClure Roy A
- Woo Jean
- Woodward Mark
- Wu Frederick C
- Wu Shouling
- Wyszynska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K
- Yoosefi Moein
- Yoshihara Akihiro
- You San-Lin
- Younger-Coleman Novie O
- Yusoff Ahmad Faudzi
- Zainuddin Ahmad A
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zapata Maria Elisa
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeljkovic Vrkic Tajana
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuñiga Cisneros Julio
- Čapková Naděžda
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/09/2021
- Field of study
Background
Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.
Methods
We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age.
Findings
The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran.
Interpretation
Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings
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- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
- Canete Fidelina
- Cani Alma
- Cano Anastasio Espejo
- Cao Deyan
- Cao Wenzhen
- Cao Ying
- Cao Zu Qing
- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
- Casaioli Simona
- Castelain Vincent
- Castiglione Giacomo
- Cata Juan
- Cavaco Raquel
- Cengiz Melike
- Cerezo Franklin Dean
- Cesar Helena
- Cespedes Laura
- Chaboyer Wendy
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- Yakubu Yakubu H.
- Yamamoto Ryohey
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- Yan Yan
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- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat