Studi In Silico Senyawa Aktif Daun Tagalolo (Ficus septica Burm F) sebagai Ligan Uji pada Enzim L-Histidin Decarboxylase

Histamine is one of the parameters in the tuna export trade that needs to be considered so that the product can be well received in the United States (USA), European Union (EU), and Japan. Histamine is used as a quality indicator for food safety of tuna products, because high histamine can cause toxic effects in humans. The leaves of the tagalolo/awar-awar plant (Ficus septica Burm. F) contain active compounds that function to cure several types of diseases such as ulcers, itching, wounds, diarrhea, dysentery and drugs to reduce fever and are used as inflammatory drugs. This study aims to determine the types of active compounds in tagalolo/awar-awar leaves from the literature search and their potential to react with the enzyme L-histidine decarboxylase through non-empirical research in silico. The compounds obtained from the literature search are Genistin, ß-amyrin, Pyrrolidine and Phenanthroindollizidine. These compounds were then tested In Silico with molecular docking. The results of the in silico study showed that the compounds Genistin, ß-amyrin, Pyrrolidine and Phenanthroindollizidine could not react with the L-histidine decarboxylase enzyme because all the tested ligands did not react or bind to the receptor.Keyword:     Tagalolo plant, Histamine, In Silico, Molecular Docking. Histamin merupakan salah satu parameter dalam perdagangan ekspor tuna yang perlu diperhatikan agar produk dapat diterima dengan baik di Amerika Serikat (USA), Uni Eropa (UE), maupun Jepang. Histamin dijadikan indikator mutu untuk keamanan pangan produk tuna, karena histamin yang tinggi dapat menyebabkan efek keracunan pada manusia. Daun tanaman tagalolo/awar-awar (Ficus septica Burm. F) mengandung senyawa aktif yang berfungsi menyembuhkan beberapa jenis penyakit seperti obat bisul, gatal-gatal, luka, diare, disentri dan obat untuk menurunkan demam serta digunakan sebagai obat radang atau inflamasi. Penelitian ini bertujuan untuk mengetahui jenis-jenis senyawa aktif daun tagalolo/awar-awar hasil penelusuran pustaka dan potensinya untuk bereaksinya dengan enzim L-histidin dekarboksilase melalui riset non-empirik secara in silico. Senyawa yang didapatkan dari penelusuran pustaka yaitu Genistin, β- amyrin, Pyrrolidine dan Phenanthroindollizidine. Senyawa-senyawa tersebut kemudian diuji secara In Silico dengan penambatan molekul (molecular docking). Hasil studi secara in silico menunjukkan bahwa senyawa Genistin, β- amyrin, Pyrrolidine dan Phenanthroindollizidine tidak dapat bereaksi dengan enzim L-histidin dekarbokasilase karena semua ligan uji tidak bereaksi atau terikat dengan reseptor.Kata kunci:  Tanaman Tagalolo, Histamin, In Silico, Molecular Docking

Direct Search for Charged Higgs Bosons in Decays of Top Quarks

We present a search for charged Higgs bosons in decays of pair-produced top quarks in pbar p collisions at sqrt(s) = 1.8 TeV using 62.2 pb^-1 of data recorded by the D0 detector at the Fermilab Tevatron collider. No evidence is found for signal, and we exclude at 95% confidence most regions of the (M higgs, tan beta) parameter space where the decay t->H b has a branching fraction greater than 0.36 and B(H -> tau nu) is large.Comment: 11 pages, 4 figures, submitted to Phys. Rev. Let

A Quasi-Model-Independent Search for New Physics at Large Transverse Momentum

We apply a quasi-model-independent strategy ("Sleuth") to search for new high p_T physics in approximately 100 pb^-1 of ppbar collisions at sqrt(s) = 1.8 TeV collected by the DZero experiment during 1992-1996 at the Fermilab Tevatron. Over thirty-two e mu X, W+jets-like, Z+jets-like, and 3(lepton/photon)X exclusive final states are systematically analyzed for hints of physics beyond the standard model. Simultaneous sensitivity to a variety of models predicting new phenomena at the electroweak scale is demonstrated by testing the method on a particular signature in each set of final states. No evidence of new high p_T physics is observed in the course of this search, and we find that 89% of an ensemble of hypothetical similar experimental runs would have produced a final state with a candidate signal more interesting than the most interesting observed in these data.Comment: 28 pages, 17 figures. Submitted to Physical Review

Search for R-parity Violating Supersymmetry in Dimuon and Four-Jets Channel

We present results of a search for R-parity-violating decay of the neutralino chi_1^0, taken to be the Lightest Supersymmetric Particle. It is assumed that this decay proceeds through one of the lepton-number violating couplings lambda-prime_2jk (j=1,2; k=1,2,3). This search is based on 77.5 pb-1 of data, collected by the D0 experiment at the Fermilab Tevatron in ppbar collisions at a center of mass energy of 1.8 TeV in 1992-1995.Comment: 10 pages, 3 figure

Search for New Physics Using Quaero: A General Interface to D0 Event Data

We describe Quaero, a method that i) enables the automatic optimization of searches for physics beyond the standard model, and ii) provides a mechanism for making high energy collider data generally available. We apply Quaero to searches for standard model WW, ZZ, and ttbar production, and to searches for these objects produced through a new heavy resonance. Through this interface, we make three data sets collected by the D0 experiment at sqrt(s)=1.8 TeV publicly available.Comment: 7 pages, submitted to Physical Review Letter

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Measurement of the top quark-pair production cross section with ATLAS in pp collisions at \sqrt{s}=7\TeV

A measurement of the production cross-section for top quark pairs(\ttbar) in $pp$ collisions at \sqrt{s}=7 \TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron $e$ or muon $\mu$) with large missing transverse energy and at least four jets, and dilepton ($ee$, $\mu\mu$ or $e\mu$) with large missing transverse energy and at least two jets. In a data sample of 2.9 pb-1, 37 candidate events are observed in the single-lepton topology and 9 events in the dilepton topology. The corresponding expected backgrounds from non-\ttbar Standard Model processes are estimated using data-driven methods and determined to be $12.2 \pm 3.9$ events and $2.5 \pm 0.6$ events, respectively. The kinematic properties of the selected events are consistent with SM \ttbar production. The inclusive top quark pair production cross-section is measured to be \sigmattbar=145 \pm 31 ^{+42}_{-27} pb where the first uncertainty is statistical and the second systematic. The measurement agrees with perturbative QCD calculations.Comment: 30 pages plus author list (50 pages total), 9 figures, 11 tables, CERN-PH number and final journal adde