16 research outputs found
Factors that influence the decision regarding hormone replacement therapy in postmenopausal women
- Author
- Publication venue
- University of New Hampshire Scholars\u27 Repository
- Publication date
- 01/01/1998
- Field of study
Cardiovascular disease is the leading cause of death in women in the United States today. Prior to menopause women have lower rates of heart disease than men; however, after menopause a woman\u27s risk for heart disease rises dramatically. This is thought to be due the ovaries\u27 decreased production of estradiol, but the mechanisms for this effect have not been fully elucidated. The need exists to investigate the impact of healthy lifestyles on attenuating the risk of cardiovascular disease in women as they age.
The majority of research on hormone replacement therapy (HRT) has focused on the biomedical model suggesting that menopause reflects an estrogen deficiency and is treatable by pharmaceutical intervention. Little information is available that views menopause from a broader perspective which includes psychological and social factors. This research tested the hypothesis that postmenopausal women who practice positive lifestyle interventions, such as health supporting diets and regular exercise, will demonstrate positive biological, social and psychological outcomes independent of HRT.
Seventy healthy postmenopausal women, aged 48-66, who had experienced a surgical or natural menopause were categorized into one of three groups: (1) no hormone replacement therapy (n = 36); (2) estrogen only (n = 11); and (3) estrogen and progestin (n = 23). Subjects donated a fasting blood sample and completed a comprehensive lifestyle and medical questionnaire that gathered information regarding health, menopause, decision making, self-esteem, and mood states. Subjects also completed a food frequency and three-day food diary. Anthropometric measurements were performed to determine body mass index and waist hip ratios. Biological assays of collected blood samples included estradiol and progesterone concentrations, lipid profiles, serum beta-carotene and vitamin E in total serum and in LDL, total antioxidants and the resistance of LDL to oxidation. Results indicated that lifestyle factors including quality of dietary intake, duration and intensity of exercise, and body weight may be better predictors of disease risk than use of HRT in postmenopausal women. Results suggest that, regardless of hormone use, positive lifestyle interventions will provide improved quality of life in women as they age
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
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- Turnbull A. (Victoria Hospital Kirkcaldy)
- Turrado-Rodriguez V.
- Turri G. (Azienda Ospedaliera Universitaria Integrata di Verona)
- Tweedle E. (Addenbrookeâs Hospital)
- Ugarte-Sierra B. (Hospital Universitario de Galdakao)
- UludaÄ S. S.
- Umair M.
- Universiti Sains Malaysia)
- University of Amsterdam)
- UniversitĂ di Ferrara)
- Université Mohammed V Rabat). Netherlands: Hompes R.
- Uras C. (Acibadem Maslak Hospital)
- Urbani A. (Azienda Ospedaliero Universitaria Sanâanna)
- Urbieta A. (Hospital Universitario la Paz)
- Uslu G.
- Utkan N. Z.
- Uyanik M. S. (Samsun Training and Research Hospital)
- Uzunoglu F. G. (University Medical Center HamburgâEppendorf). Greece: Antonakis P.
- Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
- Valero Soriano M. (Hospital General Reina SofĂa)
- Valle Rubio A. (Getafe University Hospital)
- Valverde S. (Hospital Clinic Barcelona)
- Van den Eynde J.
- Van den Eynde R. (Uz Leuven). Bulgaria: Sokolov M. (University Hospital Alexandrovska). Canada: Boutros M.
- Varma M. (University of California
- VasljeviÄ J.
- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e UniversitĂĄrio de SĂŁo JoĂŁo)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University âMagna Graeciaâ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). RĂ©union: Kassir R.
- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- VĂĄzquez FernĂĄndez A. (Hospital ClĂnico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (Kingâs Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St Georgeâs Hospital)
- Wilson M. (Forth Valley Royal Hospital)
- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.
- Author
- Aarnoud Huissoon
- Abigail Furnell
- Adam Mead
- Adam P. Levine
- Adnan Manzur
- Adrian Thrasher
- Alan Greenhalgh
- Alasdair Parker
- Alba Sanchis-Juan
- Alex Richter
- Alice Gardham
- Allan Lawrie
- Aman Sohal
- Amanda Creaser-Myers
- Amy Frary
- Andreas Greinacher
- Andreas Themistocleous
- Andrew J. Peacock
- Andrew Marshall
- Andrew Mumford
- Andrew Rice
- Andrew Webster
- Andy G. Lynch
- Angie Brady
- Ania Koziell
- Ania Manson
- Anita Chandra
- Anke Hensiek
- Anna Huis inât Veld
- Anna Maw
- Anne M. Kelly
- Anthony Moore
- Anton Vonk Noordegraaf
- Antony Attwood
- Archana Herwadkar
- Ardi Ghofrani
- Arjan C. Houweling
- Barbara Girerd
- Bruce Furie
- Carmen M. Treacy
- Carolyn M. Millar
- Carrock Sewell
- Catherine Roughley
- Catherine Titterton
- Catherine Williamson
- Charaka Hadinnapola
- Charu Deshpande
- Cheng-Hock Toh
- Chiara Bacchelli
- Chris Patch
- Chris Van Geet
- Christian Babbs
- Christine Bryson
- Christopher J. Penkett
- Christopher J. Rhodes
- Christopher Watt
- Claire Bethune
- Claire Booth
- Claire Lentaigne
- Coleen McJannet
- Colin Church
- Courtney French
- Crina Samarghitean
- Csaba Halmagyi
- Daniel Gale
- Daniel Greene
- Daniel Hart
- David Allsup
- David Bennett
- David Edgar
- David G. Kiely
- David Gosal
- David J. Perry
- David Keeling
- David Montani
- Debbie Shipley
- Deborah Whitehorn
- Debra Fletcher
- Deepa Krishnakumar
- Detelina Grozeva
- Dinakantha Kumararatne
- Dorothy Thompson
- Dragana Josifova
- Eamonn Maher
- Edwin K. S. Wong
- Elaine Murphy
- Eleanor Dewhurst
- Eleni Louka
- Elisabeth Rosser
- Elizabeth Chalmers
- Elizabeth Colby
- Elizabeth Drewe
- Elizabeth McDermott
- Ellen Thomas
- Emily Staples
- Emma Clement
- Emma Matthews
- Emma Wakeling
- Eric Oksenhendler
- Ernest Turro
- Evan Reid
- Evangeline Wassmer
- F. Lucy Raymond
- Fengyuan Hu
- Fiona Kennedy
- Florent Soubrier
- Frances Flinter
- Gabor Kovacs
- Gary Polwarth
- Gautum Ambegaonkar
- Gavin Arno
- Gavin Hudson
- Geoff Woods
- Gerry Coghlan
- Grant Hayman
- Gururaj Arumugakani
- Gwen Schotte
- H. Terry Cook
- Hana Alachkar
- Hana Lango Allen
- Hana Lango-Allen
- Hannah Stark
- Hans Stauss
- Harald Schulze
- Harm J. Boggard
- Helen Baxendale
- Helen Dolling
- Helen Firth
- Henning Gall
- Henry Watson
- Hilary Longhurst
- Hugh S. Markus
- Hugh Watkins
- Ilenia Simeoni
- Ingrid Emmerson
- Irene Roberts
- Isabella Quinti
- Ivy Wanjiku
- J. Simon R. Gibbs
- James H. R. Farmery
- James Thaventhiran
- James Whitworth
- Jane Hurst
- Janine Collins
- Jay Suntharalingam
- Jeanette Payne
- Jecko Thachil
- Jennifer M. Martin
- Jennifer Martin
- Jenny Carmichael
- Jesmeen Maimaris
- Joan Paterson
- Joanna Pepke-Zaba
- Johan W. M. Heemskerk
- Johanna Gebhart
- John Davis
- John Pasi
- John R. Bradley
- John Wharton
- Jonathan Stephens
- Julia Rankin
- Julie Anderson
- Julie Vogt
- Julie von Ziegenweldt
- Karola Rehnstrom
- Karyn Megy
- Kate Talks
- Kathelijne Peerlinck
- Katherine Yates
- Kathleen Freson
- Kathleen Stirrups
- Keith Gomez
- Kenneth G. C. Smith
- Keren Carss
- Kevin Rue-Albrecht
- Kimberley Gilmour
- Larahmie Masati
- Laura Scelsi
- Laura Southgate
- Lavanya Ranganathan
- Lionel Ginsberg
- Lisa Devlin
- Lisa Willcocks
- Liz Ormondroyd
- Lorena Lorenzo
- Lorraine Harper
- Louise Allen
- Louise Daugherty
- Manali Chitre
- Manju Kurian
- Marc Humbert
- Marc Tischkowitz
- Maria Bitner-Glindzicz
- Marie Erwood
- Marie Scully
- Marijke Veltman
- Mark Caulfield
- Mark Layton
- Mark McCarthy
- Mark Ponsford
- Mark Toshner
- Marta Bleda
- Martin Wilkins
- Mary Mathias
- Mary Reilly
- Maryam Afzal
- Matthew Brown
- Matthew Rondina
- Matthew Stubbs
- Matthias Haimel
- Melissa Lees
- Michael A. Laffan
- Michael Browning
- Michael Gattens
- Michael Richards
- Michel Michaelides
- Michele P. Lambert
- Mike L. Smith
- Mike Makris
- Minka De Vries
- Mohamed Mahdi-Rogers
- Moin Saleem
- Moira Thomas
- Muriel Holder
- MĂ©lanie Eyries
- Naomi Clements-Brod
- Natalie Canham
- Natalie Dormand
- Natalie Van Zuydam
- Nathalie Kingston
- Neeti Ghali
- Nichola Cooper
- Nicholas W. Morrell
- Nigel Yeatman
- Noémi Roy
- null null
- Olga Shamardina
- Omid S. Alavijeh
- Paolo Gresele
- Paquita Nurden
- Patrick Chinnery
- Patrick Deegan
- Patrick Yong
- Patrick Yu-Wai-Man
- Paul A. Corris
- Paul Calleja
- Paul Gissen
- Paula Bolton-Maggs
- Paula Rayner-Matthews
- Pavandeep K. Ghataorhe
- Pavel Gordins
- Penelope Stein
- Peter Collins
- Peter Dixon
- Peter Kelleher
- Phil Ancliff
- Ping Yu
- R. Campbell Tait
- Rachel Linger
- Rainer Doffinger
- Rajiv Machado
- Rashid Kazmi
- Ravishankar Sargur
- Remi Favier
- Rhea Tan
- Ri Liesner
- Richard Antrobus
- Richard Sandford
- Richard Scott
- Richard Trembath
- Rita Horvath
- Rob Hadden
- Rob V. MackenzieRoss
- Robert Henderson
- Robert MacLaren
- Roger James
- Rohit Ghurye
- Rosa DaCosta
- Rosie Hague
- Rutendo Mapeta
- Ruth Armstrong
- Sadia Noorani
- Sai Murng
- Saikat Santra
- Salih Tuna
- Sally Johnson
- Sam Chong
- Sara Lear
- Sara Walker
- Sarah Goddard
- Sarah Mangles
- Sarah Westbury
- Sarju Mehta
- Scott Hackett
- Sergey Nejentsev
- Shahin Moledina
- Shahnaz Bibi
- Sharon Meehan
- Shokri Othman
- Shoshana Revel-Vilk
- Simon Holden
- Simon McGowan
- Simon Staines
- Sinisa Savic
- Siobhan Burns
- Sofia Grigoriadou
- Sofia Papadia
- Sofie Ashford
- Sol Schulman
- Sonia Ali
- Soo-Mi Park
- Sophie Davies
- Sophie Stock
- Souad Ali
- Sri V. V. Deevi
- Stefan GrÀf
- Stefano Ghio
- Stephen J. Wort
- Stephen Jolles
- Steve Austin
- Steve Welch
- Stuart Meacham
- Stuart Rankin
- Suellen Walker
- Suranjith Seneviratne
- Susan Holder
- Suthesh Sivapalaratnam
- Sylvia Richardson
- Taco Kuijpers
- Taco W. Kuijpers
- Tadbir K. Bariana
- Tamam Bakchoul
- Tamara Everington
- Tara Renton
- Tim Young
- Timothy Aitman
- Timothy Q. Warner
- Tom Vale
- Tracey Hammerton
- Val Pollock
- Vera Matser
- Victoria Cookson
- Virginia Clowes
- Waseem Qasim
- Wei Wei
- Wendy N. Erber
- Willem H. Ouwehand
- William Astle
- William Egner
- Wojciech Turek
- Yvonne Henskens
- Yvonne Tan
- Publication venue
- Sci Rep
- Publication date
- 01/01/2018
- Field of study
Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented opportunity to glean new insights into telomere biology on a previously unimaginable scale. To this end, a number of approaches for estimating telomere length from whole-genome sequencing data have been proposed. Here we present Telomerecat, a novel approach to the estimation of telomere length. Previous methods have been dependent on the number of telomeres present in a cell being known, which may be problematic when analysing aneuploid cancer data and non-human samples. Telomerecat is designed to be agnostic to the number of telomeres present, making it suited for the purpose of estimating telomere length in cancer studies. Telomerecat also accounts for interstitial telomeric reads and presents a novel approach to dealing with sequencing errors. We show that Telomerecat performs well at telomere length estimation when compared to leading experimental and computational methods. Furthermore, we show that it detects expected patterns in longitudinal data, repeated measurements, and cross-species comparisons. We also apply the method to a cancer cell data, uncovering an interesting relationship with the underlying telomerase genotype
Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.
- Author
- Afzal Maryam
- Aitman Timothy
- Alachkar Hana
- Alavijeh Omid S
- Ali Sonia
- Ali Souad
- Allen Hana Lango
- Allen Louise
- Allsup David
- Ambegaonkar Gautum
- Ancliff Phil
- Anderson Julie
- Antrobus Richard
- Armstrong Ruth
- Arno Gavin
- Arumugakani Gururaj
- Ashford Sofie
- Astle William
- Attwood Antony
- Austin Steve
- Babbs Christian
- Bacchelli Chiara
- Bakchoul Tamam
- Bariana Tadbir K
- Baxendale Helen
- Bennett David
- Bethune Claire
- Bibi Shahnaz
- Bitner-Glindzicz Maria
- Bleda Marta
- Boggard Harm J
- Bolton-Maggs Paula
- Booth Claire
- Bradley John R
- Brady Angie
- Brown Matthew
- Browning Michael
- Bryson Christine
- Burns Siobhan
- Calleja Paul
- Canham Natalie
- Carmichael Jenny
- Carss Keren
- Caulfield Mark
- Chalmers Elizabeth
- Chandra Anita
- Chinnery Patrick
- Chitre Manali
- Chong Sam
- Church Colin
- Clement Emma
- Clements-Brod Naomi
- Clowes Virginia
- Coghlan Gerry
- Colby Elizabeth
- Collins Janine
- Collins Peter
- Cook H Terry
- Cookson Victoria
- Cooper Nichola
- Corris Paul A
- Creaser-Myers Amanda
- DaCosta Rosa
- Daugherty Louise
- Davies Sophie
- Davis John
- De Vries Minka
- Deegan Patrick
- Deevi Sri VV
- Deshpande Charu
- Devlin Lisa
- Dewhurst Eleanor
- Dixon Peter
- Doffinger Rainer
- Dolling Helen
- Dormand Natalie
- Drewe Elizabeth
- Edgar David
- Egner William
- Emmerson Ingrid
- Erber Wendy N
- Erwood Marie
- Everington Tamara
- Eyries Melanie
- Farmery James HR
- Favier Remi
- Firth Helen
- Fletcher Debra
- Flinter Frances
- Frary Amy
- French Courtney
- Freson Kathleen
- Furie Bruce
- Furnell Abigail
- Gale Daniel
- Gall Henning
- Gardham Alice
- Gattens Michael
- Gebhart Johanna
- Ghali Neeti
- Ghataorhe Pavandeep K
- Ghio Stefano
- Ghofrani Ardi
- Ghurye Rohit
- Gibbs J Simon R
- Gilmour Kimberley
- Ginsberg Lionel
- Girerd Barbara
- Gissen Paul
- Goddard Sarah
- Gomez Keith
- Gordins Pavel
- Gosal David
- Graf Stefan
- Greene Daniel
- Greenhalgh Alan
- Greinacher Andreas
- Gresele Paolo
- Grigoriadou Sofia
- Grozeva Detelina
- Hackett Scott
- Hadden Rob
- Hadinnapola Charaka
- Hague Rosie
- Haimel Matthias
- Halmagyi Csaba
- Hammerton Tracey
- Harper Lorraine
- Hart Daniel
- Hayman Grant
- Heemskerk Johan WM
- Henderson Robert
- Hensiek Anke
- Henskens Yvonne
- Herwadkar Archana
- Holden Simon
- Holder Muriel
- Holder Susan
- Horvath Rita
- Houweling Arjan C
- Hu Fengyuan
- Hudson Gavin
- Huissoon Aarnoud
- Humbert Marc
- Hurst Jane
- in't Veld Anna Huis
- James Roger
- Johnson Sally
- Jolles Stephen
- Josifova Dragana
- Kazmi Rashid
- Keeling David
- Kelleher Peter
- Kelly Anne M
- Kennedy Fiona
- Kiely David G
- Kingston Nathalie
- Kovacs Gabor
- Koziell Ania
- Krishnakumar Deepa
- Kuijpers Taco
- Kuijpers Taco W
- Kumararatne Dinakantha
- Kurian Manju
- Laffan Michael A
- Lambert Michele P
- Lango-Allen Hana
- Lawrie Allan
- Layton Mark
- Lear Sara
- Lees Melissa
- Lentaigne Claire
- Levine Adam P
- Liesner Ri
- Linger Rachel
- Longhurst Hilary
- Lorenzo Lorena
- Louka Eleni
- Lynch Andy G
- Machado Rajiv
- MackenzieRoss Rob V
- MacLaren Robert
- Mahdi-Rogers Mohamed
- Maher Eamonn
- Maimaris Jesmeen
- Makris Mike
- Mangles Sarah
- Manson Ania
- Manzur Adnan
- Mapeta Rutendo
- Markus Hugh S
- Marshall Andrew
- Martin Jennifer
- Martin Jennifer M
- Masati Larahmie
- Mathias Mary
- Matser Vera
- Matthews Emma
- Maw Anna
- McCarthy Mark
- McDermott Elizabeth
- McGowan Simon
- McJannet Coleen
- Meacham Stuart
- Mead Adam
- Meehan Sharon
- Megy Karyn
- Mehta Sarju
- Michaelides Michel
- Millar Carolyn M
- Moledina Shahin
- Montani David
- Moore Anthony
- Morrell Nicholas W
- Mumford Andrew
- Murng Sai
- Murphy Elaine
- Nejentsev Sergey
- Noorani Sadia
- Noordegraaf Anton Vonk
- Nurden Paquita
- Oksenhendler Eric
- Ormondroyd Liz
- Othman Shokri
- Ouwehand Willem H
- Papadia Sofia
- Park Soo-Mi
- Parker Alasdair
- Pasi John
- Patch Chris
- Paterson Joan
- Payne Jeanette
- Peacock Andrew J
- Peerlinck Kathelijne
- Penkett Christopher J
- Pepke-Zaba Joanna
- Perry David J
- Pollock Val
- Polwarth Gary
- Ponsford Mark
- Qasim Waseem
- Quinti Isabella
- Ranganathan Lavanya
- Rankin Julia
- Rankin Stuart
- Raymond F Lucy
- Rayner-Matthews Paula
- Rehnstrom Karola
- Reid Evan
- Reilly Mary
- Renton Tara
- Revel-Vilk Shoshana
- Rhodes Christopher J
- Rice Andrew
- Richards Michael
- Richardson Sylvia
- Richter Alex
- Roberts Irene
- Rondina Matthew
- Rosser Elisabeth
- Roughley Catherine
- Roy Noemi
- Rue-Albrecht Kevin
- Saleem Moin
- Samarghitean Crina
- Sanchis-Juan Alba
- Sandford Richard
- Santra Saikat
- Sargur Ravishankar
- Savic Sinisa
- Scelsi Laura
- Schotte Gwen
- Schulman Sol
- Schulze Harald
- Scott Richard
- Scully Marie
- Seneviratne Suranjith
- Sewell Carrock
- Shamardina Olga
- Shipley Debbie
- Simeoni Ilenia
- Sivapalaratnam Suthesh
- Smith Kenneth GC
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- Sohal Aman
- Soubrier Florent
- Southgate Laura
- Staines Simon
- Staples Emily
- Stark Hannah
- Stauss Hans
- Stein Penelope
- Stephens Jonathan
- Stirrups Kathleen
- Stock Sophie
- Stubbs Matthew
- Suntharalingam Jay
- Tait R Campbell
- Talks Kate
- Tan Rhea
- Tan Yvonne
- Thachil Jecko
- Thaventhiran James
- Themistocleous Andreas
- Thomas Ellen
- Thomas Moira
- Thompson Dorothy
- Thrasher Adrian
- Tischkowitz Marc
- Titterton Catherine
- Toh Cheng-Hock
- Toshner Mark
- Treacy Carmen M
- Trembath Richard
- Tuna Salih
- Turek Wojciech
- Turro Ernest
- Vale Tom
- Van Geet Chris
- Van Zuydam Natalie
- Veltman Marijke
- Vogt Julie
- von Ziegenweldt Julie
- Wakeling Emma
- Walker Sara
- Walker Suellen
- Wanjiku Ivy
- Warner Timothy Q
- Wassmer Evangeline
- Watkins Hugh
- Watson Henry
- Watt Christopher
- Webster Andrew
- Wei Wei
- Welch Steve
- Westbury Sarah
- Wharton John
- Whitehorn Deborah
- Whitworth James
- Wilkins Martin
- Willcocks Lisa
- Williamson Catherine
- Wong Edwin KS
- Woods Geoff
- Wort Stephen J
- Yates Katherine
- Yeatman Nigel
- Yong Patrick
- Young Tim
- Yu Ping
- Yu-Wai-Man Patrick
- Publication venue
- Sci Rep
- Publication date
- 01/01/2018
- Field of study
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
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- Zloza Andrew
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- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
The History and Components of Informed Consent
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- Advisory Committee on Human Radiation Experiments
- Alan Goldman
- Albert Jonsen
- Albert Jonsen
- Albert Jonsen
- Alex John London
- Alfred Tauber
- Allan M. Brandt
- Amy A. Ernst
- Andrew Thompson
- B. Sonny Bal
- Barron H. Lerner
- Barron H. Lerner
- Baruch A. Brody
- Benjamin Freedman
- Benjamin Freedman
- Bernard Gert
- Bernard Lo
- Bill Rogers
- Cara Dunne
- Charles McCarthy
- Clare M. Delany
- Constance MacIntosh
- Council for International Organizations of Medical Sciences (CIOMS) in collaboration with The World Health Organization (WHO)
- Dale Whittington
- Dan Brock
- Daniel W Fitzgerald
- David Buchanan
- David J. Rothman
- Debbie Schachter
- Debora Spar
- Debra Pinals
- Donald Evans
- E. H. Morreim
- Edmund Pellegrino
- Edwin G. Belzer
- Franklin Miller
- G. Whitney
- George Annas
- Gregory Pence
- H. Engelhardt
- H.C. Howard
- Hana Osman
- Howard Brody
- James Childress
- James Ross
- Janet Dolgin
- Janet L. Dolgin
- Jason Karlawish
- Jay Katz
- Jay Katz
- Jay Katz
- Jeffrey Carlisle
- Jeffrey Kahn
- Jerry Menikoff
- Jessica W. Berg
- John D. Arras
- John O. Beahrs
- John Williams
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- Kenneth Getz
- Laura Weiss Roberts
- Leon Eisenberg
- Lewis Vaughn
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- Margaret Swain
- Maria Patrao Neves
- Martha Macintyre
- Michelle Byrne
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- Nigel Cameron
- Onora O
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- Philip Reilly
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- Regine Kollek
- Richard McCormick
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- Ruth Faden
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- Spottswood W. Robinson
- Stephen Jay Gould
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- Susan Marr
- Terrence Ackerman
- The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research
- The Nuremberg Tribunal
- Thomas Grisso
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- Tom Beauchamp
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- Tom Beauchamp
- Tom L. Beauchamp
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- Ulf Schmidt
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- Wouter Leclercq
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- Tune G.
- Tune G. S.
- Uauy R.
- UKPDS
- van Hanswijck de Jonge L.
- van Hanswijck de Jonge L.
- van Marken Lichtenbelt W. D.
- Vangipuram S. D.
- Vangipuram S. D.
- Vanitallie T. B.
- Ventura S. J.
- Verlaeten O.
- Vickers M. H.
- Vickers M. H.
- Vioque J.
- Vioque J.
- von Kries R.
- Vorbrodt A. W.
- Vrbikova J.
- Wade G. N.
- Wadhera S.
- Wadhera S.
- Wang Z. Q.
- Waterland R. A.
- Waterland R. A.
- Waterland R. A.
- Watson N. F.
- Webb W. B.
- Weber E.
- West-Eberhard M. J.
- Westerterp-Plantenga M. S.
- Westerterp-Plantenga M. S.
- Whigham L. D.
- Whincup P. H.
- Wilkinson P. W.
- Wolff G. L.
- World H. O.
- Wu Z.
- Yang Q.
- Ziegler E. E.
- Zifferblatt S. M.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2009
- Field of study
The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors. Considering the role of such putative etiological factors of obesity may lead to comprehensive, cause specific, and effective strategies for prevention and treatment of this global epidemic
Delaying surgery for patients with a previous SARS-CoV-2 infection
- Author
- A A Ali Karar
- A A Kerawala
- A A Marra
- A Abad Gurumeta
- A Abad-Motos
- A Abdelmajeed
- A Abdelrahman
- A Abdelsamed
- A Abdulkareem
- A Aboelkassem Ibrahim
- A Abouassi
- A Abreu da Silva
- A Abubakar
- A Acher
- A Aderombi
- A Adeyeye
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- A Aggarwal
- A Aghayeva
- A Agnes
- A Agrawal
- A Ahmeidat
- A Aimé
- A Ajlan
- A Al-Habib
- A Al-Mohammad
- A Al-Mukhtar
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- A Alamri
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- A Antic
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- A Aprile
- A Arminio
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- A Ayman
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- A Azizi
- A B Martins
- A Bacon
- A Baker
- A Balakrishnan
- A Bandiera
- A Banerjee
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- A Bellacci
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- A C Soares
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- A Cano
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- A Chandock
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- A D Rajgor
- A D Zakaria
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- A S Yahaya
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- Adrian Marchbank
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- Akshay Patel
- Alan McNeill
- Alessandro Brunelli
- Alessandro Gronchi
- Alex Alamri
- Alex Wilkins
- Alexandra Colquhoun
- Alexis P Arnaud
- Aman S Coonar
- Amanpreet Brar
- Ana Minaya-Bravo
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- Ana Minaya-Bravo
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- Andreas A Schnitzbauer
- Andreas K Demetriades
- Andrew G Schache
- Andrew Knight
- Andrew Loehrer
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- Andrey Litvin
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- Angelos Kolias
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- Antonino Spinelli
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- Arda Isik
- Arnav Agarwal
- B A Fahey
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- B Alhassan
- B Ayub
- B B Ozmen
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- B Bakmaz
- B Banky
- B Barmayehvar
- B Barrat
- B Bartalucci
- B Bozkırlı
- B Brown
- B Caimari
- B Challacombe
- B Chumbinho
- B Cimenoglu
- B Cirillo
- B Citgez
- B Collard
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- B Cros
- B Davidson
- B De Andrés Asenjo
- B De Simone
- B Devauchelle
- B Dias
- B Diéguez
- B DĂaz-Feijoo
- B El Ahmadi
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- B Giray
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- B Grotenhuis
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- B J Mehigan
- B Jayasankar
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- B KajmakoviÄ
- B Keeler
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- B Lamb
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- B Lieske
- B Malgras
- B Manku
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- B Martin-Perez
- B McAree
- B Narice
- B Nunez-Garcia
- B PatrĂcio
- B Pramodana
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- B Rai
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- B Seeliger
- B Sheu
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- B Vieira
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- Symeon Metallidis
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- T Abbott
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- T Cuming
- T Curl-Roper
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- T Grove
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- T Hilton
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- T Jones
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- T Kato
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- T Williams
- Tabassum Khan
- Tatiana Garmanova
- Thomas D Pinkney
- Thomas Konney
- Thomas M Drake
- Tobias Klatte
- Tom Ef Abbott
- U Akgor
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- U Speth
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- W Yang
- Willemijn van der Plas
- Wong Mpk
- X De Sousa
- X Morales
- X S Tan
- Y Aawsaj
- Y Al-Tamimi
- Y Arkha
- Y Ayasra
- Y Bashir
- Y El Bouazizi
- Y Fayed
- Y H Lam
- Y Kanemitsu
- Y Kara
- Y Kirmizi
- Y Levy-Zauberman
- Y Litvina
- Y Perez
- Y T Liew
- Y Tanase
- Y Viswanath
- Y Ying
- Z Al-Ishaq
- Z Aldayri
- Z Aliyeva
- Z Bayhan
- Z Chia
- Z Dzamic
- Z H Belkhadir
- Z Inic
- Z Jawad
- Z Jezdic
- Z Katusic
- Z Krivokapic
- Z Lakkis
- Z Li
- Z M Barrett-Brown
- Z Mahasin
- Z Seymour
- Z Vilendecic
- Z Zakaria
- Ă De la Hoz RodrĂguez
- à Fernåndez Camuñas
- Ă Ryan
- Ćœ GrubaÄ
- Đ ĐĐ°ĐŒĐ°Đ»ĐŸĐČ
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
- Ahmed A
- Ahmed A
- Ahmed K
- Ahmed ME
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
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- Albertsmeier Markus
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- Alkadiki Ghadah Z
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- Alser Osaid
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- Fowler GE
- Frade S
- Fragoso M
- Francone E
- Franken J
- Frantzeskou K
- Franzini M
- Frasson M
- Frattaruolo C
- FrazĂŁo J
- Fredon F
- Freedman J
- Freitas A
- Frena A
- Freyschlag Christian
- Fritzmann J
- Frongia F
- Frountzas M
- Fujiwara Keiichi
- Fuks D
- Furbetta N
- Futaba K
- GabreâKidan A
- Gacic S
- Gahunia S
- Gahwagi M
- Gala T
- Galindo Jara P
- Galliamov E
- Gallo G
- Gallo Gaetano
- Gallo Gaetano
- Galvan Perez A
- GalvĂŁo D
- Gani J
- Ganly Ian
- Garba S
- Garcia Egea J
- Garcia Santos EP
- Garcia J
- GarciaâSancho Tellez L
- GarcĂa Alonso M
- GarcĂa DomĂnguez M
- GarcĂa PĂ©rez JM
- GarcĂa Septiem J
- GarcĂa JS
- GarcĂaâConde M
- GarcĂaâPlaza AGP
- GarcĂaâQuijada J
- Garfinkle R
- Garg PK
- Garino M
- Garmanova T
- Garmanova Tatiana
- Garrett WV
- Garrido R
- Gascon Ferrer I
- Gash K
- Gass M
- Gata V
- Gattolin A
- Gaunt A
- Gauri N
- Gaziants V
- GegĂșndez SimĂłn A
- Gelarda E
- Gemmell C
- Gemmill E
- Gennari S
- Gentilli S
- George G
- Gerns N
- Geroukalis A
- Ghaly G
- Ghamgh R
- Ghanbari A
- Ghannam A
- Ghebre Rahel
- Ghitulescu G
- Ghosh Dhruva
- Ghosh Dhruva
- Giacometti M
- Giaglaras A
- Gialamas E
- Gianardi D
- Gil CatalĂĄn A
- Gil MartĂnez J
- Gill R
- Gilliland J
- Gillis AE
- Gimenez Maurel T
- Giménez Francés C
- Ginghina O
- Giraudo G
- Giuffrida M
- Giuffrida MC
- Giunta A
- Gklavas A
- Glasbey James C
- Glasbey James C
- Glasbey James C
- Glasbey James C
- Glass N
- Gleeson E
- Glehen O
- Goksoy B
- Golda T
- GoldâDeutch R
- Gomes GMA
- Gomes Gustavo Mendonça AtaĂde
- Gomes J
- Gomez Fernandez L
- Gomez Ruiz M
- GomezâMayorga JL
- GomezâRosado J
- Gonzalez J
- Gonzalez R
- GonzalezâGonzalez E
- GonzalezâMuñoz JI
- GonzĂĄlez Argente FX
- GonzĂĄlez de Miguel M
- GonzĂĄlezâNicolĂĄs TrĂ©bol MT
- Goodrum S
- Goran M
- Gori A
- GortĂĄzar de las Casas S
- Gossedge G
- Gourbault L
- Gouvas N
- GraciaâRoche C
- Grainger C
- Grama F
- Grasset E
- Grasso M
- GrauâTalens EJ
- Grechenig M
- Grechi A
- Grecinos Gustavo
- Green L
- Green S
- Gregoric P
- Gribnev P
- Grieco C
- Griffiths Ewen A
- Griffiths Ewen A
- Griffiths O
- Grilo JV
- Grimley E
- Gronchi Alessandro
- Groot G
- Grossi U
- Grotenhuis BA
- Grove T
- GrubaÄ Ćœ
- Gruber R
- Gruendl Magdalena
- Guadagni S
- Guaglio M
- Guariglia CA
- Guerci C
- Guerra GR
- Guevara O
- GuevaraâMartĂnez J
- Guglielmetti L
- Guglielmi A
- Guidi G
- Guillamot Ruano P
- Gujjuri Rohan R
- Gultekin FA
- Gundara J
- Guner A
- Gupta A
- Gupta S
- Gutelkin Murat
- Gutierrez Samaniego M
- Gutiérrez Fernåndez AI
- Guven O
- GuĂ rdia N
- GĂłmez DĂaz CJ
- GĂłmez Sanz T
- GönĂŒllĂŒ E
- GĂŒler SA
- GĂŒreĆin A
- Hacım NA
- Hagger R
- Hainsworth A
- Haji A
- Hakami I
- Halkias C
- Halkias Constantine
- Hall J
- Hamdan KH
- Hamdy R
- Hammed A
- Hammed S
- Hammer C
- Hamza HM
- Hamzaoglu I
- Handa S
- Hanly A
- Hanna M
- Hanson A
- Haq A
- Haque PD
- Harald M
- Harbjerg JL
- Hardie CM
- Hardy NP
- Harries R
- Harris Benjamin
- Harris Benjamin
- Harris G
- Harrison Ewen M
- Hart C
- Hartveld L
- Hassan E
- Hawkin P
- Hawkins AT
- Hayati F
- Haynes AB
- Heer B
- Heinius G
- Helminen O
- Heneghan H
- Henriques P
- Henriques S
- Heras Aznar J
- Heritage Emily
- Herman A
- Hernandez Bartolome MA
- Hernandez Gutierrez J
- Hernandez P
- Hernandez R
- HernĂĄndezâGarcĂa M
- Herrera Mora DR
- Herrero Lopez M
- Herrod P
- Herzberg J
- Hill C
- Hirji S
- Hisham Intisar
- Hmedat A
- Ho D
- Ho MF
- Ho Michael
- Hoffmann PV
- Hogan A
- Hompes R
- Hon S
- Honarpisheh H
- Horn C
- Houlden C
- Hraishawi I
- Huhta H
- Humes D
- Humphreys L
- Hunt A
- Hunt L
- Hussain AH
- Hutchinson Peter
- Hutchinson Peter J
- Huynh KT
- Hwang Shelley
- I Sharara M
- Iannone I
- Ibrahim AF
- Ibrahim B
- Ibrahim S
- IbåñezâAguirre FJ
- IflazoÄlu N
- Ijichi TR
- Ikram H
- Illingworth B
- Impellizzeri H
- Inama M
- Incollingo P
- Inzunza M
- Ioannidis O
- Iordache N
- Iosifescu RV
- Ip M
- Ipponi P
- Isaac John
- Isik Arda
- Islam AA
- Ismail O
- Isolani SM
- Isoton JC
- Ivancevic N
- Iversen LH
- Izbicki J
- Izzo F
- Jackman J
- Jain A
- Jain D
- Jain M
- Jaloun H
- Jamal A
- James A
- Jang S
- Janik M
- Jayarajah U
- Jayasankar B
- Jayasilan J
- Jayasinghe JD
- Jeftic N
- Jelenkovic J
- Jenkinson Michael D
- Jenkinson Michael D
- Jenny HE
- Jeri S
- Jesudason MR
- Jeyaraj P
- Jeyarajan E
- Jezieniecki C
- Jha M
- Jia F
- Jimenez Higuera E
- Jimenez MiramĂłn J
- Jimenez Ramirez LJ
- Jimenez Toscano M
- Jimenez V
- Jiménez A
- Jobran F
- Jocson R
- Johnstone J
- Jones Conor S
- Jonescheit J
- Jonker Pascal
- Jordan P
- Jordan S
- Jouffret L
- Jover JM
- Jovine E
- JW Wilkin Richard
- JĂĄcome F
- JĂ€ger T
- Kaafarani H
- Kaafarani Haytham MA
- Kacem MJ
- Kakotkin V
- Kalayarasan R
- Kalfountzos C
- Kam da Silva Andrade A
- Kamal M
- Kamal N
- Kamalov A
- Kamarajah Sivesh K
- Kamarajah Sivesh K
- KamburoÄlu MB
- Kamel F
- Kamera BS
- Kamoka E
- Kamphues C
- Kanemitsu Y
- Kannummal Veetil S
- Kanthasamy S
- Kapoor S
- Kappenberger A
- Kara H
- Kara Y
- Karahasanoglu T
- Karaitianos IG
- Karamarkovic A
- Karandikar S
- Karim A
- Karimuddin A
- KarloviÄ D
- Kashif M
- Kasivisvanathan Veeru
- Kassir R
- Katory M
- Kattakayam A
- Katusic Z
- Kaul S
- Kauppila JH
- Kauppila JH
- Kaushal M
- Kavanagh D
- Kaya T
- Kayyal MY
- Kazachenko E
- Keatley James M
- Kebabçı E
- KecmanoviÄ D
- Keeler BD
- Keller Debby
- Keller Debby
- Kembuan G
- Kenic M
- Kennelly R
- Kent A
- Kerawala AA
- Khajuria A
- Khan A
- Khan AH
- Khan F
- Khan J
- Khan K
- Khan S
- Khan Tabassum
- Khatri Chetan
- Khaw Rachel A
- Khokhar MI
- Kiconco H
- Kilani AI
- Kilinc Tuncer G
- Killeen S
- Kim NJ
- Kirmizi Y
- Kjaer DW
- Klaristenfeld D
- Klatte Tobias
- Kleeff J
- Kler A
- Klimopoulos S
- Kloppers C
- KmeziÄ S
- Knezevic D
- Knight Andrew
- Knights E
- Knowles C
- Knowles J
- Kocatas A
- Koh A
- Kokkinos G
- Kokobelyan AK
- Kokoropoulos P
- Koleva Radica M
- Kolias Angelos
- Kolias Angelos
- Kolla C
- Kollengode VV
- Kolli VS
- Konney Thomas
- Konstadoulakis M
- Konstantinou C
- Konsten J
- Kontovounisios C
- Kornblith LZ
- Kottayasamy Seenivasagam R
- Koukoulis G
- Kourdouli A
- Kovacevic B
- Kowalewski P
- Krarup P
- Krdzic I
- Kredan A
- Kretzmer L
- Krishnan E
- Kristensen HĂ
- Krivokapic Z
- Kroon HM
- Kruijff Schelto
- KrĆĄul D
- Kubiliute E
- Kubyshkin V
- Kucuk GO
- Kudchadkar S
- Kuiper S
- Kulkarni N
- Kulkarni R
- Kulle CB
- Kumar A
- Kumar L
- Kumar S
- Kumar V
- KutkeviÄius J
- Kuttanchettiyar KG
- KwanâFeinberg R
- Kwiatkowski A
- Kyriacou H
- KÀlviÀinen H
- Königsrainer A
- KĂŒĂ§ĂŒk IF
- La Regina D
- La Torre F
- Labib PL
- Lacy AM
- Ladd MR
- Laface L
- Laforest A
- Laharwal A
- Lakkis Z
- Lala AK
- Lalou L
- Lamb Benjamin
- Landaluceâolavarria A
- Lapolla P
- Laporte G
- Larentzakis A
- Larkin J
- Laskar N
- Lasses MartĂnez B
- LatinÄiÄ S
- Lauretta A
- Lauscher J
- Lavy R
- Law J
- Lawani Ismail
- Lawday S
- Lawday Samuel
- Lawday Samuel
- Layton Georgia R
- Le Roy B
- Lecolle K
- Lederhuber Hans
- Lederhuber Hans
- Ledesma FS
- Lee M
- Lee N
- Leede E
- Lenzi E
- Leon R
- Leung Elaine YL
- Leventoglu Sezai
- Leventoglu Sezai
- LewisâLloyd C
- Li Elizabeth
- Li Elizabeth
- Li M
- Li Z
- Liakakos T
- Liao CCL
- Lieske B
- Lim M
- Lim RZM
- Lima Buarque I
- Lima da Cruz L
- Lima da Silva C
- Lima MJ
- Linari C
- Lippa Laura
- Lira dos Santos Leite A
- Litta F
- Litvin A
- Litvin Andrey
- Litvina Y
- Liu J
- Liu T
- Lizzi V
- Locatelli A
- Loch FN
- Loehrer A
- Loehrer Andrew
- Loncar Z
- Long C
- Longhi M
- Longhini A
- Longstaff L
- Lopes L
- Lopez Abad A
- LoraâCumplido P
- Lorena Maria Aguilera
- Lorenzon L
- Losada M
- Lott N
- Loubani M
- Loutzidou L
- Lowery A
- Lozano Lominchar P
- Lucchini SM
- Luglio G
- Lule H
- Lun EWY
- Lunevicius R
- Lunghi EG
- Lynch N
- Lyons A
- LĂĄzaro A
- López Antoñanzas L
- Löffler Markus W
- Löffler MW
- Löfgren N
- M. elghazaly S
- Maa Albared S
- Maccabe TA
- MacDonald L
- Machado D
- Machado N
- Macina S
- Madani Kia T
- Madani R
- Madonini M
- Maffioli A
- Magee C
- Maghrebi H
- Magowan D
- Mahajan A
- Mahendran V
- Mahmood M
- Mahmoud Ali F
- Mahvi D
- Maida P
- Maiga A
- Maimbo Mayaba
- Majbar AM
- Majkowska A
- Major P
- Major Piotr
- Majrashi S
- Majumdar KS
- Mak TWC
- Malapati H
- Malcolm FL
- Malgras B
- Malibary N
- Mall JW
- Maltinti G
- Manatakis DK
- Manfredelli S
- Manku B
- Mann Harvinder S
- Manrique E
- Manso I
- Manson J
- Mantoglu B
- Manu N
- Maqueda GonzĂĄlez R
- Marafante C
- Marano A
- Marchbank Adrian
- MarcosâSantos P
- Marcus Hani J
- Mardare M
- Margalit A
- Mari G
- Marialva J
- Mariani NM
- MarieâMacron L
- Marinello P
- Marino Cosentino L
- Marino M
- Marino MV
- Markaryan D
- Markovic I
- Markovic V
- Marques R
- Marques T
- Marqueta De Salas M
- Marra AA
- Marra E
- Marreiro A
- Marson Ella J
- Marte G
- Martel A
- Martin E
- Martin E
- Martin Janet
- Martin ST
- Martinek L
- Martinez German A
- Martins dos Santos G
- Martins JordĂŁo D
- Martins A
- Martins D
- Martins R
- MartinâPerez B
- MartinâPerez E
- MartĂn Anoro LF
- MartĂn L
- MartĂnez Chicote C
- MartĂnezâHurtado E
- MartĂnezâPinedo C
- MartĂnezâPĂ©rez P
- MartĂnâArĂ©valo J
- Marx W
- Marzi F
- Marçal A
- MarĂn H
- Masciandaro A
- Mashat A
- Mashbari Hassan N
- Massey LH
- Massie E
- Massobrio A
- Mastoridis S
- Math S
- Mathew S
- MatiÄ S
- Matos Costa P
- Matute M
- Maté Mate P
- MatĂasâGarcĂa B
- Maw A
- Mazingi Dennis
- Mazzotta E
- Mazzotti F
- McAleer J
- McAree B
- McCanny A
- Mccluney S
- Mccormick P
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- McElhinney K
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- McGivern K
- McGrath John S
- McIlmunn C
- McIntosh S
- McIntyre J
- McKay Siobhan
- Mckay Siobhan C
- McKevitt K
- McLean Kenneth A
- McNaught C
- McNeill Alan
- McNicol F
- MdRazali. I null
- Mehigan BJ
- Mehraj A
- Meimaâvan Praag EM
- Mekhael M
- MelchorâRuan J
- Melenhorst J
- Melhem S
- Memon AS
- Memos N
- Mendes F
- Mendes JR
- MendozaâMoreno F
- Meneghini S
- Mercado MĂ
- Merdrignac A
- Merh R
- Meriç S
- Messner F
- Metallidis Symeon
- Metwalli M
- Metzger J
- Michalopoulos N
- Michalski C
- Michel M
- Micic D
- Migliore M
- Mignot G
- Miguel T
- Mihanovic J
- Mihmanli M
- Miladinov M
- MilanoviÄ M
- Milic LJ
- Mills Emily C
- Mills SJ
- Milne K
- Minaya Bravo AM
- MinayaâBravo Ana
- MinayaâBravo Ana
- MinayaâBravo Ana
- Mingoli A
- Minicozzi A
- Minto G
- Mir I
- Mirabella A
- Miranda P
- Mirica RM
- Mirnezami R
- Mishra N
- Mishra S
- Mishra T
- Misra S
- Mitchell D
- Mitchell S
- Mithany R
- Mitra JK
- Mitrofan C
- Mittal R
- Mittal Rohin
- Miu V
- Mochet S
- Modolo Maria Marta
- Modolo Maria Marta
- Moftah M
- Moggia E
- Mohamed Sidek AS
- Mohammad Z
- Mohammed MM
- MohammedJibreel M
- Mohan H
- Mohan Helen M
- Mohan Helen M
- Mohd Azman ZA
- Mohd Yunus MF
- Mohsine R
- Mongelli F
- Montauban P
- Montelatici M
- Monteleone M
- Montella MT
- Montori G
- Montuori M
- Moore Rachel
- Moorthy M
- Morais H
- Moras L
- MoraâGuzmĂĄn I
- Morelli L
- Moretto G
- Morgan R
- Moritani K
- MoroâValdezate D
- Morris A
- Morsi A
- Mosley F
- Moss J
- Moszkowicz David
- Moug S
- Moug Susan
- Moug Susan
- Moura F
- Mourad M
- Mshelbwala P
- Msherghi A
- Mudawi I
- Muduly D
- Muguerza JM
- Muiesan P
- Mukherjee S
- Muller B
- Mulligan CS
- Mungo S
- Muratore A
- Murawa D
- Murgese A
- Murphy C
- Musetti S
- Mustafa A
- Mutter D
- Muzamil J
- Muñoz Camarena JM
- MuñozâAtienza V
- MuñozâBellvis L
- Naar L
- Nacif L
- Nafees Ahmed R
- Nageh MA
- Nahm C
- Najarian M
- Nally D
- Namazov Ä°
- Nankivell Paul
- Narahari Krishna
- Nassa H
- Nassif M
- Natale J
- Naumann D
- Navaratne L
- Nazir S
- Neary P
- Neary PM
- Neely D
- Negoi I
- Negoi Ionut
- Negoita VM
- Nel D
- Nelli T
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri J
- Nespoli LC
- Nessim C
- Neville Iuri
- Newman S
- Newman T
- Newton C
- Newton K
- Ng HJ
- Ng Joe
- Ng S
- Ng V
- Ng V
- Ngo CW
- NgâKamstra Joshua S
- NicolĂĄsâLĂłpez T
- Nikaj H
- Nikolaou S
- Nikolic S
- Niquen Milagros
- Nisar P
- Nitschke C
- Nogueira O
- Nogueiro J
- Nogués A
- Noiret B
- Nolan GJ
- Norcini C
- Nordberg M
- Notte F
- Nouh T
- Novello S
- Novikova A
- Nowak K
- Ntirenganya Faustin
- Nugent E
- Nunes Coelho M
- Nunes R
- NunezâGarcia B
- NunooâMensah JW
- Nuñez Del Barrio H
- Nwabuoku SE
- NĂșñez J
- Obeidat K
- Ocaña J
- OchagavĂa S
- Oguttu B
- Okafor B
- Okunlola A
- Olaogun J
- Olasehinde O
- Oldfield F
- Oliva Mompean F
- Oliveira A
- Olivier J
- Olivieri M
- Olivos Maricarmen
- Olori S
- Olson KA
- Olute A
- Omar W
- Omeroglu S
- Ong SL
- Onos L
- Oosterlinck W
- Oosterling S
- Opocher E
- Ortega VĂĄzquez I
- Ortiz de SolĂłrzano Aurusa FJ
- Ortiz LĂłpez D
- Osagie O
- Oseira A
- Osman N
- Osorio Ramos A
- Otero A
- Otoniel LR
- Oussama Kacimi
- Outani Oumaima
- Ovejero Merino E
- Owen H
- Owens P
- Oyende O
- Ozben V
- Ozcelık MF
- Ozgediz D
- Ozmen BB
- OâBrien H
- OâBrien S
- OâDonnell S
- OâMalley S
- OâRiordan J
- OâShea M
- P Delrio
- Pacheco SĂĄnchez D
- PadillaâValverde D
- Padmore G
- Pagano G
- Pajan H
- Palagi S
- Palma P
- Palmeri M
- Panahi P
- Pandey D
- Paniagua GarcĂa Señorans M
- Papaconstantinou I
- Papadopoulos V
- Papagni V
- Papatheodorou P
- Paquette N
- Parasyris S
- Pareek P
- Pareja Rene
- Parello A
- Parente A
- Parini S
- Parise P
- Park J
- Parkin E
- Parkins K
- Parlanti D
- Parmar C
- Parra Baños PA
- Parray FQ
- Parreira R
- ParreñoâSacdalan Marie Dione
- ParreñoâSacdalan Marie Dione
- Parseliunas A
- Parwaiz I
- Pasini F
- Paspaliari D
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Patel K
- Patel M
- Patel P
- Patil S
- Patrone R
- PatrĂcio B
- Pattyn P
- Pattyn P
- Pavlov M
- Pedrazzani C
- Pedro J
- Pedro V
- Peirce C
- Pejnovic L
- Pejovic I
- Pellegrino L
- Pellino G
- Pellino Gianluca
- Peluso C
- Penumadu P
- Pera R
- Peralta Ferreira M
- Pereca J
- Pereira Rodrigues A
- Pereira A
- Pereira C
- Pereira I
- Pereira R
- Perez Gonzalez M
- Perez D
- Pergolini I
- Perivoliotis K
- Peros G
- Perotto LO
- Perra T
- Perrone G
- Persad A
- Persiani R
- Pertile D
- Peteja M
- Petrillo A
- Peyroteo M
- Pezzuto AP
- Peña Ros E
- Peña Soria MJ
- Pham H
- Phan D
- Phang PT
- Phillips E
- Picardo AL
- Picciariello A
- Picciochi Maria
- Pickett L
- PicĂłn RodrĂguez R
- Pieniowski E
- Piessen G
- Pina S
- Pinilla Morales RE
- Pinkney Thomas D
- Pinotti E
- Pinto J
- Pipara A
- Piper Rory J
- Pipitone Federico NS
- Pirozzolo G
- Pirzada A
- Pisani Ceretti A
- Pisanu A
- Pius Ogolekwu I
- PlaâMarti V
- Pockney P
- Pockney Peter
- Pockney Peter
- Pockney Peter
- Podda M
- Poeze M
- Poggioli G
- Police A
- Polydorou A
- PolâFachin L
- Ponchietti L
- Popoola AA
- Porcu A
- Portinari M
- PosadasâTrujillo OE
- PosmaâBouman L
- Potter R
- Pourcher G
- Powell S
- Pozotou I
- Praetorius C
- Pramesh CS
- Prando D
- Presl J
- Price C
- Price Stephen J
- Prieto Calvo M
- Prieto Nieto MI
- Pronk AJM
- Prosperi P
- Provozina A
- Pruvot FR
- Pujari R
- Pujol Cano N
- PĂ©rez SĂĄnchez MA
- PĂ©rezâSaborido B
- Qadan M
- Qasem A
- Qatora MS
- Quante M
- Quintana Martinic M
- QuirogaâValcĂĄrcel A
- Qureshi Ahmad
- Qureshi AU
- RabyâSmith W
- Radenkovic Dejan
- Raggio E
- Rai L
- Rajan S
- Rajaretnam N
- Rakvin I
- Ramachandran A
- Ramalho de Almeida F
- Ramamoorthy R
- Ramasamy S
- Ramcharan S
- Ramesh P
- Ramirez Faraco M
- Ramirez Romero P
- Ramos Bonilla A
- Ramos D
- RamosâDe la Medina Antonio
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- Zengin AK
- Zerbib P
- Zervas K
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- Zhang H
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- Zonta S
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- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Outcomes from elective colorectal cancer surgery during the SARSâCoVâ2 pandemic
- Author
- 6\u11f\ufcc\ufc H
- 6fner D
- 6hlberger L
- \u106oza I
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Aim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58â14.06), postoperative SARS-CoV-2 (16.90, 7.86â36.38), male sex (2.46, 1.01â5.93), age >70 years (2.87, 1.32â6.20) and advanced cancer stage (3.43, 1.16â10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks