213 research outputs found
Low temperature or GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor and DnaK
AbstractEscherichia coli trigger factor (TF) and DnaK cooperate in the folding of newly synthesized proteins. The combined deletion of the TF-encoding tig gene and the dnaK gene causes protein aggregation and synthetic lethality at 30°C. Here we show that the synthetic lethality of ÎtigÎdnaK52 cells is abrogated either by growth below 30°C or by overproduction of GroEL/GroES. At 23°C ÎtigÎdnaK52 cells were viable and showed only minor protein aggregation. Overproduction of GroEL/GroES, but not of other chaperones, restored growth of ÎtigÎdnaK52 cells at 30°C and suppressed protein aggregation including proteins â„60 kDa, which normally require TF and DnaK for folding. GroEL/GroES thus influences the folding of proteins previously identified as DnaK/TF substrates
Experimental Study of the Shortest Reset Word of Random Automata
In this paper we describe an approach to finding the shortest reset word of a
finite synchronizing automaton by using a SAT solver. We use this approach to
perform an experimental study of the length of the shortest reset word of a
finite synchronizing automaton. The largest automata we considered had 100
states. The results of the experiments allow us to formulate a hypothesis that
the length of the shortest reset word of a random finite automaton with
states and 2 input letters with high probability is sublinear with respect to
and can be estimated as $1.95 n^{0.55}.
Numerical simulations of the Warm-Hot Intergalactic Medium
In this paper we review the current predictions of numerical simulations for
the origin and observability of the warm hot intergalactic medium (WHIM), the
diffuse gas that contains up to 50 per cent of the baryons at z~0. During
structure formation, gravitational accretion shocks emerging from collapsing
regions gradually heat the intergalactic medium (IGM) to temperatures in the
range T~10^5-10^7 K. The WHIM is predicted to radiate most of its energy in the
ultraviolet (UV) and X-ray bands and to contribute a significant fraction of
the soft X-ray background emission. While O VI and C IV absorption systems
arising in the cooler fraction of the WHIM with T~10^5-10^5.5 K are seen in
FUSE and HST observations, models agree that current X-ray telescopes such as
Chandra and XMM-Newton do not have enough sensitivity to detect the hotter
WHIM. However, future missions such as Constellation-X and XEUS might be able
to detect both emission lines and absorption systems from highly ionised atoms
such as O VII, O VIII and Fe XVII.Comment: 18 pages, 5 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 14; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
Benford's law predicted digit distribution of aggregated income taxes: the surprising conformity of Italian cities and regions
The yearly aggregated tax income data of all, more than 8000, Italian
municipalities are analyzed for a period of five years, from 2007 to 2011, to
search for conformity or not with Benford's law, a counter-intuitive phenomenon
observed in large tabulated data where the occurrence of numbers having smaller
initial digits is more favored than those with larger digits. This is done in
anticipation that large deviations from Benford's law will be found in view of
tax evasion supposedly being widespread across Italy. Contrary to expectations,
we show that the overall tax income data for all these years is in excellent
agreement with Benford's law. Furthermore, we also analyze the data of
Calabria, Campania and Sicily, the three Italian regions known for strong
presence of mafia, to see if there are any marked deviations from Benford's
law. Again, we find that all yearly data sets for Calabria and Sicily agree
with Benford's law whereas only the 2007 and 2008 yearly data show departures
from the law for Campania. These results are again surprising in view of
underground and illegal nature of economic activities of mafia which
significantly contribute to tax evasion. Some hypothesis for the found
conformity is presented.Comment: 18 pages, 5 tables, 4 figures, 61 references, To appear in European
Physical Journal
Star Formation and Dynamics in the Galactic Centre
The centre of our Galaxy is one of the most studied and yet enigmatic places
in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre
(GC) is the ideal environment to study the extreme processes that take place in
the vicinity of a supermassive black hole (SMBH). Despite the hostile
environment, several tens of early-type stars populate the central parsec of
our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and
inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the
SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The
formation of such early-type stars has been a puzzle for a long time: molecular
clouds should be tidally disrupted by the SMBH before they can fragment into
stars. We review the main scenarios proposed to explain the formation and the
dynamical evolution of the early-type stars in the GC. In particular, we
discuss the most popular in situ scenarios (accretion disc fragmentation and
molecular cloud disruption) and migration scenarios (star cluster inspiral and
Hills mechanism). We focus on the most pressing challenges that must be faced
to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in
expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A.,
'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201
NA49 Results on Single Particle and Correlation Measurements in Central Pb+Pb Collisions
Single-particle spectra and two-particle correlation functions measured by the NA49 collaboration in central Pb+Pb collisions at 158 GeV/nucleon are presented. These measurements are used to study the kinetic and chemical freeze-out conditions in heavy ion collisions. We conclude that large baryon stopping, high baryon density and strong transverse radial flow are achieved in central Pb+Pb collisions at the SPS.Single-particle spectra and two-particle correlation functions measured by the NA49 collaboration in central Pb+Pb collisions at 158 GeV/nucleon are presented. These measurements are used to study the kinetic and chemical freeze-out conditions in heavy ion collisions. We conclude that large baryon stopping, high baryon density and strong transverse radial flow are achieved in central Pb+Pb collisions at the SPS
Xi and Xi-bar Production in 158 GeV/Nucleon Pb+Pb Collisions
We report measurements of Xi and Xi-bar hyperon absolute yields as a function
of rapidity in 158 GeV/c Pb+Pb collisions. At midrapidity, dN/dy = 2.29 +/-
0.12 for Xi, and 0.52 +/- 0.05 for Xi-bar, leading to the ratio of Xi-bar/Xi =
0.23 +/- 0.03. Inverse slope parameters fitted to the measured transverse mass
spectra are of the order of 300 MeV near mid-rapidity. The estimated total
yield of Xi particles in Pb+Pb central interactions amounts to 7.4 +/- 1.0 per
collision. Comparison to Xi production in properly scaled p+p reactions at the
same energy reveals a dramatic enhancement (about one order of magnitude) of Xi
production in Pb+Pb central collisions over elementary hadron interactions.Comment: 15 page
Measurement of the cross section for isolated-photon plus jet production in pp collisions at âs=13 TeV using the ATLAS detector
The dynamics of isolated-photon production in association with a jet in protonâproton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fbâ1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photonâjet invariant mass and the scattering angle in the photonâjet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements
A search for resonances decaying into a Higgs boson and a new particle X in the XH â qqbb final state with the ATLAS detector
A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fbâ1 of protonâproton collision data at collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the resonance
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