Taylor expansions in chemical potential

Properties of QCD at finite chemical potential are extracted using Taylor series expansions. The continuum limits of lattice results are presented. The result of expanding the free energy density, ie, the pressure, to 6th order in the expansion is shown. The Taylor coefficients of the chiral condensate are also shown. Relations between various Taylor coefficients are demonstrated. All this information is utilised to remove various lattice artifacts from the determination of the Wroblewski parameter in strangeness production.Comment: for proceedings of "Finite Density QCD at Nara

Plot3asic, three level QC data plotting and analysis freeware, for addressing cost of quality issues in diagnostic laboratories at resource constrained settings

Objectives: In the rapidly evolving field of laboratory medicine, Quality Control (QC) is paramount in ensuring result accuracy and precision. However, QC procedures incur high cost of quality (COQ) which is often a hurdle to laboratories in resource constrained settings. Proprietary QC software is either expensive or tethered to proprietary platforms. Open source statistical libraries require considerable coding expertise often unavailable with laboratory personnel. Therefore, Plot3asic was developed as a freeware for generating publication quality QC plots with Westgard rule violation checks across three control levels. Methods: Plot3asic was developed using Python3 with ‘plotly’, an open source visualization toolbox. QC rules implemented by Plot3asic are adapted from Westgard rules. Mathematical calculations were independently verified by two investigators. Artificial datasets with known QC violations were analyzed using Plot3asic. Commercial QC material run data for the month of June 2019 were simultaneously analyzed on MultiXLv2017.01A(EM200) platform (Transasia/Erba Mannheim) and Plot3asic. Results: The results were generated as HTML files. The application was able to identify all QC violations as claimed. There was 100% corroboration between the violations flagged by MultiXLv2017.01A(EM200) platform and Plot3asic. The application also calculates sigma metric should the user choose to do so. Conclusion: To the best of our knowledge, Plot3asic provides features that no other freeware does till date. Determination of sigma metric helps streamline QC and reduce COQ. Plot3asic does not interface with proprietary platforms and is particularly helpful in semi-automated and manual assay data analysis in resource constrained settings

Emerging Biomedical Applications of the Vesicular Stomatitis Virus Glycoprotein

Nanoparticles (NPs) made of metals, polymers, micelles, and liposomes are increasingly being used in various biomedical applications. However, most of these NPs are hazardous for long- and short-term use and hence have restricted biomedical applications. Therefore, naturally derived, biocompatible, and biodegradable nanoconstructs are being explored for such applications. Inspired by the biology of viruses, researchers are exploring the viral proteins that hold considerable promise in biomedical applications. The viral proteins are highly stable and further amenable to suit specific biological applications. Among various viral proteins, vesicular stomatitis virus glycoprotein (VSV-G) has emerged as one of the most versatile platforms for biomedical applications. Starting with their first major use in lentivirus/retrovirus packaging systems, the VSV-G-based reagents have been tested for diverse biomedical use, many of which are at various stages of clinical trials. This manuscript discusses the recent advancements in the use of the VSV-Gbased reagents in medical, biological research, and clinical applications particularly highlighting emerging applications in biomedical imaging

Blimp-1–mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis

CD8, but not CD4, T cells are considered critical for control of chronic toxoplasmosis. Although CD8 exhaustion has been previously reported inToxoplasma encephalitis (TE)–susceptible model, our current work demonstrates that CD4 not only become exhausted during chronic toxoplasmosis but this dysfunction is more pronounced than CD8 T cells. Exhausted CD4 population expressed elevated levels of multiple inhibitory receptors concomitant with the reduced functionality and up-regulation of Blimp-1, a transcription factor. Our data demonstrates for the first time that Blimp-1 is a critical regulator for CD4 T cell exhaustion especially in the CD4 central memory cell subset. Using a tamoxifen-dependent conditional Blimp-1 knockout mixed bone marrow chimera as well as an adoptive transfer approach, we show that CD4 T cell–intrinsic deletion of Blimp-1 reversed CD8 T cell dysfunction and resulted in improved pathogen control. To the best of our knowledge, this is a novel finding, which demonstrates the role of Blimp-1 as a critical regulator of CD4 dysfunction and links it to the CD8 T cell dysfunctionality observed in infected mice. The critical role of CD4-intrinsic Blimp-1 expression in mediating CD4 and CD8 T cell exhaustion may provide a rational basis for designing novel therapeutic approaches

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

Peer reviewe

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe