Invariant measures for gauss maps associated with interval exchange maps

An explidt formula for an ergodic cr-finite measure inva.ria.nt by the Gauss map associated to a new induction on the interval exchange maps is given. The techniques devcloped allow another proof of Keane's conjecture which was first shown to be true by Veech and Mazur

Non-contact determination of the viscoelastic properties of agar culture media by Brillouin spectroscopy

This study aimed to investigate the potential of Brillouin spectroscopy as a non-contact and real-time tool for measuring the viscoelastic properties of agar culture media and using them to determine the percentages of their different components. The Brillouin spectrum of media samples with varying concentrations of different components was successfully acquired. A custom-designed refractometer was employed for assessing the refractive index of the gels. The study shows that the Brillouin spectrum and viscoelastic properties of the media vary in dependence on the concentration of their different components in a predictable and controllable way and that the variation is different for each of the additives tested. This approach has the advantage of correlating to the component percentages, providing a non-contact method for evaluating the evolution of the culture medium in real-time, without disturbing the growth of cells or microorganisms. The results of this study have the potential to encourage the design of new tools and methods targeting the prediction, measuring, and control of agar plate behavior during cell culture. This could include measuring and maintaining optimal humidity conditions for maintaining suitable agar plates for cell culture or monitoring cell growth by measuring the consumption of each substance.This work was supported by CMEMS-UMinho Strategic Project UIDB/04436/2020 and UIDP/04436/2020 and project MPhotonBiopsy, PTDC/FIS-OTI/1259/2020. Bruno Esteves was supported by FCT, PhD grant 2021.07239.BD

Pyrazoles as potential modulators of inflammation through the inhibition of COX2 activity and human leukocytes' oxidative burst

The inflammatory process is a complex and tightly regulated cascade of events that involves the production of prostaglandins (PG) by the inducible isoform cyclooxygenase 2 (COX-2) and the production of reactive pro-oxidant species. When the production of these mediators becomes excessive, it can lead to chronic inflammation and associated diseases such as diabetes, rheumatoid arthritis, and cancer. Unfortunately, many existing anti-inflammatory agents are associated with unwanted side effects. Therefore, there is a critical need to discover new and effective compounds that can modulate the inflammatory cascade. In this study, an extensive panel of structurally related pyrazoles holding diverse structures and substitutions were tested in vitro against human COX-2, and ex vivo in human whole blood, through the measurement of prostaglandin E2 (PGE2) production. Their potential inhibitory effect against human leukocytes’ oxidative burst was also studied. The results showed that some of the tested compounds had a significant inhibitory effect on COX2 activity, and pyrazoles 4 and 11 (Figure 1) excelled as the most potent inhibitors, with IC50 < 25 µM. Nonetheless, among the tested compounds only 1 was able to inhibit both the COX-2 activity and the PGE2 production. The tested pyrazoles, namely pyrazole 4, also demonstrated a potential inhibitory effect (IC50 < 5 µM) against human leukocytes’ oxidative burst. These results represent a significant contribution for the design and development of new anti-inflammatory molecules.info:eu-repo/semantics/publishedVersio

Is painless synovitis different from painful synovitis? A controlled, ultrasound, radiographic, clinical trial

OBJECTIVE: This study compares the clinical, ultrasonography, radiography, and laboratory outcomes of painless and painful chronic synovitis in patients with established rheumatoid arthritis. METHODS: This cross-sectional study involved 60 patients with rheumatoid arthritis and synovitis in the metacarpophalangeal joints; 30 of the patients did not experience pain, and 30 had experienced pain for at least 6 months prior to the study. The radiocarpal, distal radioulnar, and metacarpophalangeal joints were evaluated using the ultrasound gray scale, power Doppler, and radiography. Past and present clinical and laboratory findings were also evaluated. RESULTS: There were no statistically significant differences between the groups for most of the outcomes. The group with pain scored worse on the disease activity indices (e.g., DAS 28 and SDAI), function questionnaires (HAQ and Cochin), and pinch strength test. A logistic regression analysis revealed that the use of an immunobiological agent was associated with a 3-fold greater chance of belonging to the group that experienced pain. The painless group had worse erosion scores in the second and fifth metacarpophalangeal with odd ratios (ORs) of 6.5 and 3.5, respectively. The painless group had more cartilage with grade 4 damage in the third metacarpophalangeal. CONCLUSIONS: The rheumatoid arthritis patients with both painless and painful synovitis exhibited similar disease histories and radiographic and ultrasound findings. However, the ultrasonography evaluation revealed worse scores in the second and fifth metacarpophalangeal of the synovitis patients who did not experience pain.Fundacao de Amparo a Pesquisa do Estado de Sao PauloUNIFESP communityHospital do Servidor Publico Estadual (IAMSPE)Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de ReumatologiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Diagnostico por ImagemUNIFESP, EPM, Disciplina de ReumatologiaUNIFESP, EPM, Depto. de Diagnostico por ImagemFAPESP - 2012/04867-6SciEL

Is painless synovitis different from painful synovitis? A controlled, ultrasound, radiographic, clinical trial

OBJECTIVE: This study compares the clinical, ultrasonography, radiography, and laboratory outcomes of painless and painful chronic synovitis in patients with established rheumatoid arthritis. METHODS: This cross-sectional study involved 60 patients with rheumatoid arthritis and synovitis in the metacarpophalangeal joints; 30 of the patients did not experience pain, and 30 had experienced pain for at least 6 months prior to the study. The radiocarpal, distal radioulnar, and metacarpophalangeal joints were evaluated using the ultrasound gray scale, power Doppler, and radiography. Past and present clinical and laboratory findings were also evaluated. RESULTS: There were no statistically significant differences between the groups for most of the outcomes. The group with pain scored worse on the disease activity indices (e.g., DAS 28 and SDAI), function questionnaires (HAQ and Cochin), and pinch strength test. A logistic regression analysis revealed that the use of an immunobiological agent was associated with a 3-fold greater chance of belonging to the group that experienced pain. The painless group had worse erosion scores in the second and fifth metacarpophalangeal with odd ratios (ORs) of 6.5 and 3.5, respectively. The painless group had more cartilage with grade 4 damage in the third metacarpophalangeal. CONCLUSIONS: The rheumatoid arthritis patients with both painless and painful synovitis exhibited similar disease histories and radiographic and ultrasound findings. However, the ultrasonography evaluation revealed worse scores in the second and fifth metacarpophalangeal of the synovitis patients who did not experience pain

Efeitos da liderança transformacional na inovação: uma revisão sistemática de literatura / Effects of transformational leadership on innovation: a systematic literature review

O objetivo principal deste artigo é sistematizar o conhecimento existente na literatura que aborda as relações entre Liderança Transformacional (LT) e Inovação nas organizações. A metodologia escolhida para o desenvolvimento deste trabalho foi a pesquisa bibliográfica, por meio de uma revisão sistemática de literatura no banco de dados SCOPUS. Os resultados demonstram uma predominante influência da liderança transformacional nos processos de inovação, uma vez que, uma liderança bem preparada, treinada e capacitada para a gestão, desenvolve mecanismos para criar um ambiente propício para inovação e processos inovadores, aumentando desta forma, a performance criativa dos colaboradores

Updated cardiovascular prevention guideline of the Brazilian Society of Cardiology: 2019

Sem informação113478788

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe