118 research outputs found
Recovering Structured Probability Matrices
We consider the problem of accurately recovering a matrix B of size M by M ,
which represents a probability distribution over M2 outcomes, given access to
an observed matrix of "counts" generated by taking independent samples from the
distribution B. How can structural properties of the underlying matrix B be
leveraged to yield computationally efficient and information theoretically
optimal reconstruction algorithms? When can accurate reconstruction be
accomplished in the sparse data regime? This basic problem lies at the core of
a number of questions that are currently being considered by different
communities, including building recommendation systems and collaborative
filtering in the sparse data regime, community detection in sparse random
graphs, learning structured models such as topic models or hidden Markov
models, and the efforts from the natural language processing community to
compute "word embeddings".
Our results apply to the setting where B has a low rank structure. For this
setting, we propose an efficient algorithm that accurately recovers the
underlying M by M matrix using Theta(M) samples. This result easily translates
to Theta(M) sample algorithms for learning topic models and learning hidden
Markov Models. These linear sample complexities are optimal, up to constant
factors, in an extremely strong sense: even testing basic properties of the
underlying matrix (such as whether it has rank 1 or 2) requires Omega(M)
samples. We provide an even stronger lower bound where distinguishing whether a
sequence of observations were drawn from the uniform distribution over M
observations versus being generated by an HMM with two hidden states requires
Omega(M) observations. This precludes sublinear-sample hypothesis tests for
basic properties, such as identity or uniformity, as well as sublinear sample
estimators for quantities such as the entropy rate of HMMs
Near-Infrared Super Resolution Imaging with Metallic Nanoshell Particle Chain Array
We propose a near-infrared super resolution imaging system without a lens or
a mirror but with an array of metallic nanoshell particle chain. The imaging
array can plasmonically transfer the near-field components of dipole sources in
the incoherent and coherent manners and the super resolution images can be
reconstructed in the output plane. By tunning the parameters of the metallic
nanoshell particle, the plasmon resonance band of the isolate nanoshell
particle red-shifts to the near-infrared region. The near-infrared super
resolution images are obtained subsequently. We calculate the field intensity
distribution at the different planes of imaging process using the finite
element method and find that the array has super resolution imaging capability
at near-infrared wavelengths. We also show that the image formation highly
depends on the coherence of the dipole sources and the image-array distance.Comment: 15 pages, 6 figure
A simulation model of colorectal cancer surveillance and recurrence
BACKGROUND: Approximately one-third of those treated curatively for colorectal cancer (CRC) will experience recurrence. No evidence-based consensus exists on how best to follow patients after initial treatment to detect asymptomatic recurrence. Here, a new approach for simulating surveillance and recurrence among CRC survivors is outlined, and development and calibration of a simple model applying this approach is described. The model’s ability to predict outcomes for a group of patients under a specified surveillance strategy is validated. METHODS: We developed an individual-based simulation model consisting of two interacting submodels: a continuous-time disease-progression submodel overlain by a discrete-time Markov submodel of surveillance and re-treatment. In the former, some patients develops recurrent disease which probabilistically progresses from detectability to unresectability, and which may produce early symptoms leading to detection independent of surveillance testing. In the latter submodel, patients undergo user-specified surveillance testing regimens. Parameters describing disease progression were preliminarily estimated through calibration to match five-year disease-free survival, overall survival at years 1–5, and proportion of recurring patients undergoing curative salvage surgery from one arm of a published randomized trial. The calibrated model was validated by examining its ability to predict these same outcomes for patients in a different arm of the same trial undergoing less aggressive surveillance. RESULTS: Calibrated parameter values were consistent with generally observed recurrence patterns. Sensitivity analysis suggested probability of curative salvage surgery was most influenced by sensitivity of carcinoembryonic antigen assay and of clinical interview/examination (i.e. scheduled provider visits). In validation, the model accurately predicted overall survival (59% predicted, 58% observed) and five-year disease-free survival (55% predicted, 53% observed), but was less accurate in predicting curative salvage surgery (10% predicted; 6% observed). CONCLUSIONS: Initial validation suggests the feasibility of this approach to modeling alternative surveillance regimens among CRC survivors. Further calibration to individual-level patient data could yield a model useful for predicting outcomes of specific surveillance strategies for risk-based subgroups or for individuals. This approach could be applied toward developing novel, tailored strategies for further clinical study. It has the potential to produce insights which will promote more effective surveillance—leading to higher cure rates for recurrent CRC
A Unique ATPase, ArtR (PA4595), Represses the Type III Secretion System in Pseudomonas aeruginosa
Pseudomonas aeruginosa is an important human pathogen which uses the type III secretion system (T3SS) as a primary virulence factor to establish infections in humans. The results presented in this report revealed that the ATP-binding protein PA4595 (named ArtR, a Regulator that is an ATP-activated Repressor of T3SS) represses T3SS expression in P. aeruginosa. The expression of T3SS genes, including exoS, exoY, exoT, exsCEBA, and exsD-pscB-L, increased significantly when artR was knockout. The effect of ArtR on ExsA is at the transcriptional level, not at the translational level. The regulatory role and cytoplasm localization of ArtR suggest it belongs to the REG sub-family of ATP-binding cassette (ABC) family. Purified GST-tagged ArtR showed ATPase activity in vitro. The conserved aspartate residues in the dual Walker B motifs prove to be essential for the regulatory function of ArtR. The regulation of T3SS by ArtR is unique, which does not involve the known GacS/A-RsmY/Z-RsmA-ExsA pathway or Vfr. This is the first REG subfamily of ATP-binding cassette that is reported to regulate T3SS genes in bacteria. The results specify a novel player in the regulatory networks of T3SS in P. aeruginosa
Designing Artificial Two-Dimensional Landscapes via Room-Temperature Atomic-Layer Substitution
Manipulating materials with atomic-scale precision is essential for the
development of next-generation material design toolbox. Tremendous efforts have
been made to advance the compositional, structural, and spatial accuracy of
material deposition and patterning. The family of 2D materials provides an
ideal platform to realize atomic-level material architectures. The wide and
rich physics of these materials have led to fabrication of heterostructures,
superlattices, and twisted structures with breakthrough discoveries and
applications. Here, we report a novel atomic-scale material design tool that
selectively breaks and forms chemical bonds of 2D materials at room
temperature, called atomic-layer substitution (ALS), through which we can
substitute the top layer chalcogen atoms within the 3-atom-thick
transition-metal dichalcogenides using arbitrary patterns. Flipping the layer
via transfer allows us to perform the same procedure on the other side,
yielding programmable in-plane multi-heterostructures with different
out-of-plane crystal symmetry and electric polarization. First-principle
calculations elucidate how the ALS process is overall exothermic in energy and
only has a small reaction barrier, facilitating the reaction to occur at room
temperature. Optical characterizations confirm the fidelity of this design
approach, while TEM shows the direct evidence of Janus structure and suggests
the atomic transition at the interface of designed heterostructure. Finally,
transport and Kelvin probe measurements on MoXY (X,Y=S,Se; X and Y
corresponding to the bottom and top layers) lateral multi-heterostructures
reveal the surface potential and dipole orientation of each region, and the
barrier height between them. Our approach for designing artificial 2D landscape
down to a single layer of atoms can lead to unique electronic, photonic and
mechanical properties previously not found in nature
Graphene-Based Nanocomposites for Energy Storage
Since the first report of using micromechanical cleavage method to produce graphene sheets in 2004, graphene/graphene-based nanocomposites have attracted wide attention both for fundamental aspects as well as applications in advanced energy storage and conversion systems. In comparison to other materials, graphene-based nanostructured materials have unique 2D structure, high electronic mobility, exceptional electronic and thermal conductivities, excellent optical transmittance, good mechanical strength, and ultrahigh surface area. Therefore, they are considered as attractive materials for hydrogen (H2) storage and high-performance electrochemical energy storage devices, such as supercapacitors, rechargeable lithium (Li)-ion batteries, Li–sulfur batteries, Li–air batteries, sodium (Na)-ion batteries, Na–air batteries, zinc (Zn)–air batteries, and vanadium redox flow batteries (VRFB), etc., as they can improve the efficiency, capacity, gravimetric energy/power densities, and cycle life of these energy storage devices. In this article, recent progress reported on the synthesis and fabrication of graphene nanocomposite materials for applications in these aforementioned various energy storage systems is reviewed. Importantly, the prospects and future challenges in both scalable manufacturing and more energy storage-related applications are discussed
The Application of Education for International Understanding of Chinese Language Teaching: A Critical Study
Education for International Understanding can provide practical paths for Chinese language teachers, teaching materials, and pedagogy to tell China's stories well. In order to improve the dissemination effect of Chinese stories in teaching Chinese as a foreign language, We started with teachers, teaching materials and teaching methods and obtained the following results from the research: Chinese language teachers should improve their intercultural communication skills and become practitioners of international understanding education and tellers of China's stories; international Chinese language teaching materials should be developed by The Framework of Reference for Culture and Society Chinese in International Chinese Language Education and seek to integrate Chinese stories and local stories based on international understanding education; The Chinese pedagogy should gradually adopt a "Concept-based Teaching and Learning" pedagogy to promote the construction of learners' conceptual framework and help them understand China's stories
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