175 research outputs found
Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats
Insulin resistance is a common finding in hypertensive humans and animal models. The Dahl salt-sensitive (S) rat is an ideal model of genetically predetermined insulin resistance and salt-sensitive hypertension. Along the insulin signaling pathway, the insulin receptor substrates 1 and 2 (IRS-1 and -2) are important mediators of insulin signaling. IRS-1 and/or IRS-2 genetic variant(s) and/or enhanced serine phosphorylation correlate with insulin resistance. The present commentary was designed to highlight the significance of IRS-1 and/or -2 in the pathogenesis of insulin resistance. An emphasis will be given to the putative role of IRS-1 and/or -2 genetic variant(s) and serine phosphorylation in precipitating insulin resistance
Light cone QCD sum rules study of the semileptonic heavy and transitions to and baryons
The semileptonic decays of heavy spin--1/2, and
baryons to the light spin-- 1/2, and baryons are investigated
in the framework of the light cone QCD sum rules. In particular, using the most
general form of the interpolating currents for the heavy baryons as well as the
distribution amplitudes of the and baryons, we calculate all
form factors entering the matrix elements of the corresponding effective
Hamiltonians in full QCD. Having calculated the responsible form factors, we
evaluate the decay rates and branching fractions of the related transitions.Comment: 30 Pages, 5 Figures and 18 Table
Study of J/Psi decays into eta Kstar Kstar-bar
We report the first observation of \mPJpsi \to \mPeta\mPKst\mAPKst decay in
a \mPJpsi sample of 58 million events collected with the BESII detector. The
branching fraction is determined to be . The selected signal event sample is further used to search for the
\mPY resonance through \mPJpsi \to \mPeta \mPY, \mPY\to\mPKst\mAPKst. No
evidence of a signal is seen. An upper limit of \mathrm{Br}(\mPJpsi \to \mPeta
\mPY)\cdot\mathrm{Br}(\mPY\to\mPKst\mAPKst) < 2.52\times 10^{-4} is set at the
90% confidence level.Comment: 11 pages, 4 figure
Search for the Xb and other hidden-beauty states in the π+π−ϒ(1S) channel at ATLAS
This Letter presents a search for a hidden-beauty counterpart of the X(3872) in the mass ranges of 10.05–10.31 GeV and 10.40–11.00 GeV, in the channel Xb→π+π−ϒ(1S)(→μ+μ−), using 16.2 fb−1 of pp collision data collected by the ATLAS detector at the LHC. No evidence for new narrow states is found, and upper limits are set on the product of the Xb cross section and branching fraction, relative to those of the ϒ(2S), at the 95% confidence level using the CLS approach. These limits range from 0.8% to 4.0%, depending on mass. For masses above 10.1 GeV, the expected upper limits from this analysis are the most restrictive to date. Searches for production of the ϒ(13DJ), , and states also reveal no significant signals
Polyimides membranes for pervaporation and biofuels separation
10.1016/j.progpolymsci.2009.06.001Progress in Polymer Science (Oxford)34111135-1160PRPS
Hydrothermal syntheses, crystal structures, and properties of two new coordination polymers constructed from a flexible pyridinecarboxylate ligand
Drop policies and multiple edge thresholds to enhance the performance of TCP over OBS networks with retransmission
Carbon nitride thin films deposited by nitrogen-ion-assisted KRF excimer ablation of graphite
Applied Surface Science138-1391-4494-498ASUS
Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (rs=0.283, P=0.049) and serum albumin (rs=0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; rs=-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE
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